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  1. Article ; Online: Editorial. Impact of COVID-19 on neurosurgery resident research training.

    Clark, Victoria E

    Journal of neurosurgery

    2020  , Page(s) 1–2

    Keywords covid19
    Language English
    Publishing date 2020-04-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2020.4.JNS201034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Virtual Surgical Planning of Superior Orbital Rim Fractures in Calvarial and Maxillofacial Trauma.

    Ji, Yisi D / Clark, Victoria E / Stapleton, Christopher J / Hajibandeh, Jeffrey

    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

    2023  Volume 81, Issue 8, Page(s) 1021–1024

    Abstract: Background: Superior orbital rim fractures are challenging fractures as they often concomitantly occur with additional calvaria fractures. Virtual surgical planning (VSP) has been underutilized in this area of craniomaxillofacial trauma for ... ...

    Abstract Background: Superior orbital rim fractures are challenging fractures as they often concomitantly occur with additional calvaria fractures. Virtual surgical planning (VSP) has been underutilized in this area of craniomaxillofacial trauma for reconstruction.
    Purpose: The purpose of this study is to qualitatively describe the use of VSP and anatomically perfected stereolithic models in treatment of superior orbital rim fractures in combined neurosurgery/oral and maxillofacial surgery cases.
    Study design, setting, sample: This study is a retrospective case series of subjects who were treated at the Massachusetts General Hospital (July 2022 to November 2022). Inclusion criteria include subjects who had both calvaria and maxillofacial injuries requiring concurrent operative intervention on their superior orbital rim fractures and the use of VSP.
    Predictor/exposure/independent variable: Not applicable.
    Main outcome variable: The outcome variable of interest is the difference in the planned position of the orbital rim repair compared to the actual position achieved.
    Covariates: None.
    Analyses: Heat map analysis was used to compare the difference in the planned position versus the actual position achieved.
    Results: There were six orbits (five subjects, mean age 33.8 ± 21.49 years) that met the criteria. The mean difference in planned versus actual orbital volume achieved was 2.52 ± 2.48 cm
    Conclusion and relevance: This study has demonstrated the use of VSP in combined neurosurgery and oral and maxillofacial surgery procedures in the fixation of superior orbital rim fractures. This case series highlights that the postoperative position achieved in the six orbits was within 84% of the planned position.
    MeSH term(s) Humans ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Plastic Surgery Procedures ; Retrospective Studies ; Orbit/surgery ; Maxillofacial Injuries/surgery ; Orbital Fractures/diagnostic imaging ; Orbital Fractures/surgery
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392404-x
    ISSN 1531-5053 ; 0278-2391
    ISSN (online) 1531-5053
    ISSN 0278-2391
    DOI 10.1016/j.joms.2023.05.001
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  4. Article ; Online: Fluorescence and immune-cell infiltration of nonneoplastic, postbrachytherapy brain tissue in 5-ALA-guided resection of recurrent anaplastic meningioma: illustrative case.

    Ramapriyan, Rishab / Clark, Victoria E / Martinez-Lage, Maria / Hsueh, Brian / Nahed, Brian V / Curry, William T / Choi, Bryan D / Carter, Bob S

    Journal of neurosurgery. Case lessons

    2024  Volume 7, Issue 9

    Abstract: Background: 5-Aminolevulinic acid (5-ALA) fluorescence-guided surgery is a well-established technique for resecting high-grade gliomas. However, its application in meningiomas, especially those previously treated with radiation therapy, remains under ... ...

    Abstract Background: 5-Aminolevulinic acid (5-ALA) fluorescence-guided surgery is a well-established technique for resecting high-grade gliomas. However, its application in meningiomas, especially those previously treated with radiation therapy, remains under investigation.
    Observations: A 48-year-old female with recurrent anaplastic meningioma, World Health Organization grade 3, underwent a right-sided craniotomy using off-label 5-ALA as a surgical adjunct. The patient had previously undergone brachytherapy seed implantation (20 × cesium 131) for tumor management. During the surgery, a large fluorescent tumor mass adjacent to the brachytherapy-treated area was resected, and the prior brachytherapy seeds were removed. Interestingly, the surrounding brain tissue in the irradiated area showed robust 5-ALA fluorescence. Pathological examination confirmed that the fluorescent brain tissue was nonneoplastic and associated with lymphocyte and macrophage infiltration.
    Lessons: This case report presents unique 5-ALA fluorescence in nonneoplastic tissue following brachytherapy, which was found during the resection of recurrent anaplastic meningioma. This phenomenon may reflect an intricate interplay among radiation therapy, immune cells, the tumor microenvironment, and 5-ALA metabolism. Given that false-positive findings in fluorescence-guided surgery can lead to unnecessary tissue resection and increased surgical morbidity, further research is warranted to elucidate the mechanisms underlying this phenomenon and its implications for meningioma surgery.
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE23550
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  5. Article ; Online: Temporal Patterns in Youth Suicide Deaths Reported in the National Violent Death Reporting System.

    Hatton, Victoria R / Clark, Elaine / Huber, Rebekah S

    The Journal of adolescent health : official publication of the Society for Adolescent Medicine

    2024  Volume 74, Issue 5, Page(s) 1049–1052

    Abstract: Purpose: Suicide is a leading cause of death in children and adolescents. Prevention efforts may benefit from examining temporal patterns and precipitating circumstances of youth suicide deaths. The purpose of this study was to investigate if there are ... ...

    Abstract Purpose: Suicide is a leading cause of death in children and adolescents. Prevention efforts may benefit from examining temporal patterns and precipitating circumstances of youth suicide deaths. The purpose of this study was to investigate if there are distinct temporal patterns of suicide death for youth.
    Methods: We examined the distributions of suicide deaths across months of the year and days of the week in youth ages 10-18 using data from the National Violent Death Reporting System.
    Results: We found that youth suicides peaked during March, April, and October on Monday, Tuesday, and Wednesday. When disaggregated by separate years of age, we discovered unique patterns in 18-year-olds and 10-year-olds. Suicides peaked during July for 18-year-olds and on Saturday for 10-year-olds.
    Discussion: These findings suggest a need to examine temporal patterns by separate years of age, as grouping ages together may mask unique trends.
    MeSH term(s) Child ; Humans ; Adolescent ; United States/epidemiology ; Suicide ; Homicide ; Cause of Death ; Violence ; Population Surveillance
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1063374-1
    ISSN 1879-1972 ; 1054-139X
    ISSN (online) 1879-1972
    ISSN 1054-139X
    DOI 10.1016/j.jadohealth.2023.12.028
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  6. Article ; Online: Signature reversion of three disease-associated gene signatures prioritizes cancer drug repurposing candidates.

    Fisher, Jennifer L / Wilk, Elizabeth J / Oza, Vishal H / Gary, Sam E / Howton, Timothy C / Flanary, Victoria L / Clark, Amanda D / Hjelmeland, Anita B / Lasseigne, Brittany N

    FEBS open bio

    2024  

    Abstract: ... i.e., limma, DESeq2, and MultiPLIER) and prioritized the resulting drug repurposing candidates ...

    Abstract Drug repurposing is promising because approving a drug for a new indication requires fewer resources than approving a new drug. Signature reversion detects drug perturbations most inversely related to the disease-associated gene signature to identify drugs that may reverse that signature. We assessed the performance and biological relevance of three approaches for constructing disease-associated gene signatures (i.e., limma, DESeq2, and MultiPLIER) and prioritized the resulting drug repurposing candidates for four low-survival human cancers. Our results were enriched for candidates that had been used in clinical trials or performed well in the PRISM drug screen. Additionally, we found that pamidronate and nimodipine, drugs predicted to be efficacious against the brain tumor glioblastoma (GBM), inhibited the growth of a GBM cell line and cells isolated from a patient-derived xenograft (PDX). Our results demonstrate that by applying multiple disease-associated gene signature methods, we prioritized several drug repurposing candidates for low-survival cancers.
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2651702-4
    ISSN 2211-5463 ; 2211-5463
    ISSN (online) 2211-5463
    ISSN 2211-5463
    DOI 10.1002/2211-5463.13796
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  7. Article ; Online: Extent of Resection Versus Molecular Classification: What Matters When?

    Clark, Victoria E / Cahill, Daniel P

    Neurosurgery clinics of North America

    2018  Volume 30, Issue 1, Page(s) 95–101

    Abstract: For malignant gliomas, the survival benefit of new combination therapies after surgical resection is measured in weeks to months. In contrast, optimizing treatment for low-grade gliomas can potentially provide additional years of life. The relatively ... ...

    Abstract For malignant gliomas, the survival benefit of new combination therapies after surgical resection is measured in weeks to months. In contrast, optimizing treatment for low-grade gliomas can potentially provide additional years of life. The relatively indolent but not benign clinical course provides the opportunity for clinicians and scientists to focus not only on the duration of survival, but also to maximize quality of life. Ideal management of low-grade gliomas among the most important yet paradoxically most neglected subjects in neuro-oncology. This article examines the molecular underpinnings of these tumors and evaluates the role of extensive surgery in maximizing outcomes.
    MeSH term(s) Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Glioma/drug therapy ; Glioma/pathology ; Glioma/surgery ; Humans ; Neoplasm Grading ; Neurosurgical Procedures ; Quality of Life ; Treatment Outcome
    Language English
    Publishing date 2018-11-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196855-2
    ISSN 1558-1349 ; 1042-3680
    ISSN (online) 1558-1349
    ISSN 1042-3680
    DOI 10.1016/j.nec.2018.08.006
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  8. Article: Evaluation of Instructions and Video Modeling to Train Parents to Implement a Structured Meal Procedure for Food Selectivity Among Children With Autism.

    Clark, Ronald J / Wilder, David A / Kelley, Michael E / Ryan, Victoria

    Behavior analysis in practice

    2020  Volume 13, Issue 3, Page(s) 674–678

    Abstract: We evaluated written instructions plus video modeling-and when necessary, in vivo prompting and feedback-to teach 3 parents to implement a structured meal procedure to decrease food selectivity among their children with autism. In addition to data on ... ...

    Abstract We evaluated written instructions plus video modeling-and when necessary, in vivo prompting and feedback-to teach 3 parents to implement a structured meal procedure to decrease food selectivity among their children with autism. In addition to data on correct parent implementation, we also collected data on child bite acceptance. Results showed that instructions and video modeling were effective to achieve the mastery criteria for 1 parent; the other 2 parents required in vivo prompts and feedback. Two of the children exhibited an increase in bite acceptance during the structured meal procedure.
    Language English
    Publishing date 2020-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2583900-7
    ISSN 2196-8934 ; 1998-1929
    ISSN (online) 2196-8934
    ISSN 1998-1929
    DOI 10.1007/s40617-020-00419-w
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  9. Article ; Online: Meiotic DNA break repair can utilize homolog-independent chromatid templates in C. elegans.

    Toraason, Erik / Horacek, Anna / Clark, Cordell / Glover, Marissa L / Adler, Victoria L / Premkumar, Tolkappiyan / Salagean, Alina / Cole, Francesca / Libuda, Diana E

    Current biology : CB

    2021  Volume 31, Issue 7, Page(s) 1508–1514.e5

    Abstract: During meiosis, the maintenance of genome integrity is critical for generating viable haploid gametes. ...

    Abstract During meiosis, the maintenance of genome integrity is critical for generating viable haploid gametes.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins ; Chromatids/genetics ; DNA Breaks, Double-Stranded ; DNA Helicases ; DNA Repair ; Meiosis/genetics
    Chemical Substances Caenorhabditis elegans Proteins ; XPF-1 protein, C elegans (EC 3.1.-) ; DNA Helicases (EC 3.6.4.-)
    Language English
    Publishing date 2021-03-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2021.03.008
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  10. Article ; Online: Reliability of the breathing pattern assessment tool for in-person or remote assessment in people with asthma.

    Bondarenko, Janet / Hew, Mark / Button, Brenda / Webb, Elizabeth / Jackson, Victoria / Clark, Rebecca / Holland, Anne E

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2021  Volume 51, Issue 9, Page(s) 1218–1220

    MeSH term(s) Asthma/diagnosis ; Asthma/physiopathology ; Humans ; Prospective Studies ; Reproducibility of Results ; Respiration
    Language English
    Publishing date 2021-03-08
    Publishing country England
    Document type Letter
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.13856
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