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Article: Dipyridamole plus aspirin: the best regimen for stroke prevention after noncardioembolic focal cerebral ischemia.

Jonas, Saran / Grieco, Giacinto

Cerebrovascular diseases (Basel, Switzerland)

2006 Volume 22, Issue 1, Page(s) 1–3

MeSH term(s)	Aspirin/administration & dosage ; Aspirin/therapeutic use ; Brain Ischemia/complications ; Delayed-Action Preparations ; Dipyridamole/administration & dosage ; Dipyridamole/therapeutic use ; Drug Therapy, Combination ; Humans ; Platelet Aggregation Inhibitors/administration & dosage ; Platelet Aggregation Inhibitors/therapeutic use ; Stroke/etiology ; Stroke/prevention & control
Chemical Substances	Delayed-Action Preparations ; Platelet Aggregation Inhibitors ; Dipyridamole (64ALC7F90C) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2006
Publishing country	Switzerland
Document type	Comment ; Editorial
ZDB-ID	1069462-6
ISSN	1421-9786 ; 1015-9770
ISSN (online)	1421-9786
ISSN	1015-9770
DOI	10.1159/000092330
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Responsiveness of Developing T Cells to IL-7 Signals Is Sustained by miR-17∼92.

Regelin, Malte / Blume, Jonas / Pommerencke, Jens / Vakilzadeh, Ramin / Witzlau, Katrin / Łyszkiewicz, Marcin / Ziętara, Natalia / Saran, Namita / Schambach, Axel / Krueger, Andreas

Journal of immunology (Baltimore, Md. : 1950)

2015 Volume 195, Issue 10, Page(s) 4832–4840

Abstract: miRNAs regulate a large variety of developmental processes including development of the immune system. T cell development is tightly controlled through the interplay of transcriptional programs and cytokine-mediated signals. However, the role of ... ...

Abstract	miRNAs regulate a large variety of developmental processes including development of the immune system. T cell development is tightly controlled through the interplay of transcriptional programs and cytokine-mediated signals. However, the role of individual miRNAs in this process remains largely elusive. In this study, we demonstrated that hematopoietic cell-specific loss of miR-17∼92, a cluster of six miRNAs implicated in B and T lineage leukemogenesis, resulted in profound defects in T cell development both at the level of prethymic T cell progenitors as well as intrathymically. We identified reduced surface expression of IL-7R and concomitant limited responsiveness to IL-7 signals as a common mechanism resulting in reduced cell survival of common lymphoid progenitors and thymocytes at the double-negative to double-positive transition. In conclusion, we identified miR-17∼92 as a critical modulator of multiple stages of T cell development.
MeSH term(s)	Animals ; Animals, Genetically Modified ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; Cell Survival/genetics ; Cell Survival/immunology ; Interleukin-7/genetics ; Interleukin-7/immunology ; Mice ; MicroRNAs/genetics ; MicroRNAs/immunology ; Receptors, Interleukin-17/genetics ; Receptors, Interleukin-17/immunology ; Signal Transduction/physiology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology
Chemical Substances	Il17r protein, mouse ; Interleukin-7 ; MicroRNAs ; Mirn17 microRNA, mouse ; Receptors, Interleukin-17 ; interleukin-7, mouse
Language	English
Publishing date	2015-11-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1402248
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Article ; Online: Editorial comment--an approach to the estimation of the risk of TTP during clopidogrel therapy.

Jonas, Saran / Grieco, Giacinto

Stroke

2004 Volume 35, Issue 2, Page(s) 537–538

MeSH term(s)	Drug Utilization/statistics & numerical data ; Humans ; Incidence ; Platelet Aggregation Inhibitors/adverse effects ; Product Surveillance, Postmarketing/statistics & numerical data ; Purpura, Thrombotic Thrombocytopenic/chemically induced ; Purpura, Thrombotic Thrombocytopenic/epidemiology ; Risk Assessment ; Ticlopidine/adverse effects ; Ticlopidine/analogs & derivatives ; United States/epidemiology
Chemical Substances	Platelet Aggregation Inhibitors ; clopidogrel (A74586SNO7) ; Ticlopidine (OM90ZUW7M1)
Language	English
Publishing date	2004-02
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
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Article ; Online: miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1.

Blume, Jonas / Ziętara, Natalia / Witzlau, Katrin / Liu, Yanshan / Sanchez, Oskar Ortiz / Puchałka, Jacek / Winter, Samantha J / Kunze-Schumacher, Heike / Saran, Namita / Düber, Sandra / Roy, Bishnudeo / Weiss, Siegfried / Klein, Christoph / Wurst, Wolfgang / Łyszkiewicz, Marcin / Krueger, Andreas

European journal of immunology

2018 Volume 49, Issue 1, Page(s) 121–132

Abstract: The interdependence of posttranscriptional gene regulation via miRNA and transcriptional regulatory networks in lymphocyte development is poorly understood. Here, we identified miR-191 as direct upstream modulator of a transcriptional module comprising ... ...

Abstract	The interdependence of posttranscriptional gene regulation via miRNA and transcriptional regulatory networks in lymphocyte development is poorly understood. Here, we identified miR-191 as direct upstream modulator of a transcriptional module comprising the transcription factors Foxp1, E2A, and Egr1. Deletion as well as ectopic expression of miR-191 resulted in developmental arrest in B lineage cells, indicating that fine tuning of the combined expression levels of Foxp1, E2A, and Egr1, which in turn control somatic recombination and cytokine-driven expansion, constitutes a prerequisite for efficient B-cell development. In conclusion, we propose that miR-191 acts as a rheostat in B-cell development by fine tuning a key transcriptional program.
MeSH term(s)	Animals ; B-Lymphocytes/physiology ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Differentiation ; Cells, Cultured ; Early Growth Response Protein 1/genetics ; Early Growth Response Protein 1/metabolism ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Gene Regulatory Networks ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; MicroRNAs/genetics ; RNA, Small Interfering/genetics ; Recombination, Genetic ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Transcription, Genetic ; Transgenes/genetics
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; Early Growth Response Protein 1 ; Egr1 protein, mouse ; Forkhead Transcription Factors ; Foxp1 protein, mouse ; MIRN191 microRNA, mouse ; MicroRNAs ; RNA, Small Interfering ; Repressor Proteins ; Tcf3 protein, mouse
Language	English
Publishing date	2018-10-22
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.201847660
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Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Serum Taurine and Stroke Risk in Women

Fen Wu / Karen L Koenig / Anne Zeleniuch-Jacquotte / Saran Jonas / Yelena Afanasyeva / Oktawia P Wójcik / Max Costa / Yu Chen

PLoS ONE, Vol 11, Iss 2, p e

A Prospective, Nested Case-Control Study.

2016 Volume 0149348

Abstract: BACKGROUND:Taurine (2-aminoethanesulfonic acid), a conditionally essential sulfur-containing amino acid, is mainly obtained from diet in humans. Experimental studies have shown that taurine's main biological actions include bile salt conjugation, blood ... ...

Abstract	BACKGROUND:Taurine (2-aminoethanesulfonic acid), a conditionally essential sulfur-containing amino acid, is mainly obtained from diet in humans. Experimental studies have shown that taurine's main biological actions include bile salt conjugation, blood pressure regulation, anti-oxidation, and anti-inflammation. METHODS:We conducted a prospective case-control study nested in the New York University Women's Health Study, a cohort study involving 14,274 women enrolled since 1985. Taurine was measured in pre-diagnostic serum samples of 241 stroke cases and 479 matched controls. RESULTS:There was no statistically significant association between serum taurine and stroke risk in the overall study population. The adjusted ORs for stroke were 1.0 (reference), 0.87 (95% CI, 0.59-1.28), and 1.03 (95% CI, 0.69-1.54) in increasing tertiles of taurine (64.3-126.6, 126.7-152.9, and 153.0-308.5 nmol/mL, respectively). A significant inverse association between serum taurine and stroke risk was observed among never smokers, with an adjusted OR of 0.66 (95% CI, 0.37-1.18) and 0.50 (95% CI, 0.26-0.94) for the second and third tertile, respectively (p for trend = 0.01), but not among past or current smokers (p for interaction < 0.01). CONCLUSIONS:We observed no overall association between serum taurine and stroke risk, although a protective effect was observed in never smokers, which requires further investigation. Taurine, Stroke, Epidemiology, Prospective, Case-control study, NYUWHS.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Serum Taurine and Stroke Risk in Women: A Prospective, Nested Case-Control Study.

Wu, Fen / Koenig, Karen L / Zeleniuch-Jacquotte, Anne / Jonas, Saran / Afanasyeva, Yelena / Wójcik, Oktawia P / Costa, Max / Chen, Yu

PloS one

2016 Volume 11, Issue 2, Page(s) e0149348

Abstract: Background: Taurine (2-aminoethanesulfonic acid), a conditionally essential sulfur-containing amino acid, is mainly obtained from diet in humans. Experimental studies have shown that taurine's main biological actions include bile salt conjugation, blood ...

Abstract	Background: Taurine (2-aminoethanesulfonic acid), a conditionally essential sulfur-containing amino acid, is mainly obtained from diet in humans. Experimental studies have shown that taurine's main biological actions include bile salt conjugation, blood pressure regulation, anti-oxidation, and anti-inflammation. Methods: We conducted a prospective case-control study nested in the New York University Women's Health Study, a cohort study involving 14,274 women enrolled since 1985. Taurine was measured in pre-diagnostic serum samples of 241 stroke cases and 479 matched controls. Results: There was no statistically significant association between serum taurine and stroke risk in the overall study population. The adjusted ORs for stroke were 1.0 (reference), 0.87 (95% CI, 0.59-1.28), and 1.03 (95% CI, 0.69-1.54) in increasing tertiles of taurine (64.3-126.6, 126.7-152.9, and 153.0-308.5 nmol/mL, respectively). A significant inverse association between serum taurine and stroke risk was observed among never smokers, with an adjusted OR of 0.66 (95% CI, 0.37-1.18) and 0.50 (95% CI, 0.26-0.94) for the second and third tertile, respectively (p for trend = 0.01), but not among past or current smokers (p for interaction < 0.01). Conclusions: We observed no overall association between serum taurine and stroke risk, although a protective effect was observed in never smokers, which requires further investigation. Taurine, Stroke, Epidemiology, Prospective, Case-control study, NYUWHS.
MeSH term(s)	Adult ; Aged ; Anti-Inflammatory Agents/chemistry ; Antioxidants/chemistry ; Bile Acids and Salts/chemistry ; Blood Pressure ; Case-Control Studies ; Diet ; Endarterectomy, Carotid ; Female ; Humans ; Inflammation ; Middle Aged ; Postmenopause ; Prospective Studies ; Risk Factors ; Stroke/blood ; Stroke/complications ; Stroke/diagnosis ; Stroke/prevention & control ; Surveys and Questionnaires ; Taurine/blood
Chemical Substances	Anti-Inflammatory Agents ; Antioxidants ; Bile Acids and Salts ; Taurine (1EQV5MLY3D)
Language	English
Publishing date	2016-02-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0149348
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Potential value of triple antiplatelet therapy for secondary stroke prevention.

Jonas, Saran / Grieco, Giacinto

Stroke

2003 Volume 34, Issue 10, Page(s) e182–3

MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Aspirin/therapeutic use ; Clinical Trials as Topic/statistics & numerical data ; Dipyridamole/therapeutic use ; Drug Therapy, Combination ; Humans ; Platelet Aggregation Inhibitors/therapeutic use ; Risk ; Stroke/drug therapy ; Stroke/prevention & control ; Treatment Outcome
Chemical Substances	Platelet Aggregation Inhibitors ; Adenosine Monophosphate (415SHH325A) ; Dipyridamole (64ALC7F90C) ; cangrelor (6AQ1Y404U7) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2003-10
Publishing country	United States
Document type	Letter ; Meta-Analysis
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/01.STR.0000092896.70446.87
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Article: Addendum to Our Editorial ‘Dipyridamole plus Aspirin’

Grieco, Giacinto / Jonas, Saran

Cerebrovascular Diseases

2006 Volume 22, Issue 4, Page(s) 317–317

Institution	Section of Quantitative Investigation, Department of Neurology, New York University School of Medicine, New York, N.Y., USA
Language	English
Publishing date	2006-08-30
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Addendum
ZDB-ID	1069462-6
ISSN	1421-9786 ; 1015-9770
ISSN (online)	1421-9786
ISSN	1015-9770
DOI	10.1159/000094605
Database	Karger publisher's database

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Article ; Online: Neuroprotection by inhaled nitric oxide in a murine stroke model is concentration and duration dependent.

Li, Yong-Sheng / Shemmer, Benjamin / Stone, Eric / A Nardi, Michael / Jonas, Saran / Quartermain, David

Brain research

2013 Volume 1507, Page(s) 134–145

Abstract: Inhaled nitric oxide (iNO) has been shown to reduce ischemia/reperfusion (I/R) injury in several different organ systems including the brain. We investigated whether iNO was neuroprotective in a mouse model of transient focal ischemia. Male Swiss Webster ...

Abstract	Inhaled nitric oxide (iNO) has been shown to reduce ischemia/reperfusion (I/R) injury in several different organ systems including the brain. We investigated whether iNO was neuroprotective in a mouse model of transient focal ischemia. Male Swiss Webster mice underwent middle cerebral artery occlusion for 1 h followed by reperfusion for 47 h. Mice were divided into 5 concentration groups and administered nitric oxide (NO) at either 10, 20, 40, 60 or 80 ppm. Each of the 5 concentration groups was subdivided into 4 duration groups which were treated with iNO for 5, 8, 16 or 24 h beginning immediately after artery occlusion. Results showed both concentration and duration determined efficacy. At 10 ppm only the 24hr duration group exhibited reduced infarct volume while at 20, 40 and 60 ppm only 8 and 16 h of exposure led to smaller infarctions. At these concentrations the dose response curves were strongly U shaped indicating a loss of benefit at long durations. At 80 ppm, reduction in infarct volume was not observed at any duration. Additional experiments showed that 60 ppm iNO could be transported from lung to brain and that iNO administered for 8h improved recovery from subarachnoid hemorrhage and reduced the inflammatory response accompanying ischemic stroke. Enhanced blood flow during reperfusion may be an important mediator of these effects.
MeSH term(s)	Administration, Inhalation ; Animals ; Brain/blood supply ; Brain/drug effects ; Disease Models, Animal ; Infarction, Middle Cerebral Artery/drug therapy ; Male ; Mice ; Neuroprotective Agents/administration & dosage ; Neuroprotective Agents/therapeutic use ; Nitric Oxide/administration & dosage ; Nitric Oxide/therapeutic use ; Reperfusion Injury/drug therapy ; Stroke/drug therapy
Chemical Substances	Neuroprotective Agents ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2013-04-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2013.02.031
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Article: Dipyridamole plus Aspirin: The Best Regimen for Stroke Prevention after Noncardioembolic Focal Cerebral Ischemia

Jonas, Saran / Grieco, Giacinto

Cerebrovascular Diseases

2006 Volume 22, Issue 1, Page(s) 1–3

Institution	Section of Quantitative Investigation, Department of Neurology, New York University School of Medicine, New York, N.Y., USA
Language	English
Publishing date	2006-04-26
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Editorial
ZDB-ID	1069462-6
ISSN	1421-9786 ; 1015-9770
ISSN (online)	1421-9786
ISSN	1015-9770
DOI	10.1159/000092330
Database	Karger publisher's database

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