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  1. Book ; Online: Immune-Modulatory Effects of Vitamin D

    Zughaier, Susu M. / Lubberts, Erik / Bener, Abdulbari

    2020  

    Keywords Medicine ; Immunology ; vitamin D ; immune modulation ; monocytes ; T cells ; infection
    Size 1 electronic resource (177 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230904
    ISBN 9782889661749 ; 2889661741
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: The Role of Iron in Bacterial Pathogenesis

    Cornelis, Pierre / Zughaier, Susu M.

    2018  

    Keywords Infectious and parasitic diseases ; Science (General)
    Size 1 electronic resource (156 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101961
    ISBN 9782889456628 ; 2889456625
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: ApoM binds endotoxin contributing to neutralization and clearance by High Density Lipoprotein.

    Mousa, Hanaa / Thanassoulas, Angelos / Zughaier, Susu M

    Biochemistry and biophysics reports

    2023  Volume 34, Page(s) 101445

    Abstract: Background: HDL possesses anti-inflammatory properties, however, the exact mechanism is not fully understood. Endotoxin is a potent inducers of TLR4 signaling, leading to inflammatory mediators' release. It has been estimated that TLR4 recognizes about ... ...

    Abstract Background: HDL possesses anti-inflammatory properties, however, the exact mechanism is not fully understood. Endotoxin is a potent inducers of TLR4 signaling, leading to inflammatory mediators' release. It has been estimated that TLR4 recognizes about 5% of circulating lipopolysaccharide whereas 95% is cleared by plasma lipoproteins, mainly HDL. ApoM is required for HDL biogenesis and 95% of plasma ApoM is found associated with HDL, both are significantly reduced during sepsis.
    Aim: The aim of this study is to investigate whether ApoM binds endotoxin and contributes to anti-inflammatory activity of HDL.
    Methods: Isothermal Titration Calorimetry (ITC) was used to determine the binding of ultrapure
    Result: ApoM shows high affinity for
    Conclusion: ApoM binds LPS to facilitate endotoxin neutralization and clearance by HDL.
    Language English
    Publishing date 2023-02-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2023.101445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial: Global excellence in children and health.

    Bener, Abdulbari / Tewfik, Ihab / Zughaier, Susu M / Day, Andrew S

    Frontiers in public health

    2023  Volume 11, Page(s) 1286481

    MeSH term(s) Humans ; Child ; Vitamin D ; Vitamin D Deficiency
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2023-09-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1286481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: ApoM binds endotoxin contributing to neutralization and clearance by High Density Lipoprotein

    Hanaa Mousa / Angelos Thanassoulas / Susu M. Zughaier

    Biochemistry and Biophysics Reports, Vol 34, Iss , Pp 101445- (2023)

    2023  

    Abstract: Background: HDL possesses anti-inflammatory properties, however, the exact mechanism is not fully understood. Endotoxin is a potent inducers of TLR4 signaling, leading to inflammatory mediators’ release. It has been estimated that TLR4 recognizes about 5% ...

    Abstract Background: HDL possesses anti-inflammatory properties, however, the exact mechanism is not fully understood. Endotoxin is a potent inducers of TLR4 signaling, leading to inflammatory mediators’ release. It has been estimated that TLR4 recognizes about 5% of circulating lipopolysaccharide whereas 95% is cleared by plasma lipoproteins, mainly HDL. ApoM is required for HDL biogenesis and 95% of plasma ApoM is found associated with HDL, both are significantly reduced during sepsis. Aim: The aim of this study is to investigate whether ApoM binds endotoxin and contributes to anti-inflammatory activity of HDL. Methods: Isothermal Titration Calorimetry (ITC) was used to determine the binding of ultrapure E. coli LPS to the recombinant ApoM protein. Purified human HDL and recombinant ApoM was used to investigate LPS neutralization using human and murine macrophages and computational simulation was performed. Result: ApoM shows high affinity for E. coli LPS, forming 1:1 complexes with Kd values below 1 μΜ, as revealed by ITC. The binding process is strongly exothermic and enthalpy-driven (ΔrH = −36.5 kJ/mol), implying the formation of an extensive network of interactions between ApoM and LPS in the bound state. Computational simulation also predicted high-affinity binding between ApoM and E. coli LPS and the best scoring models showed E. coli LPS docking near the calyx of ApoM without blocking the pocket. The biological significance of this interaction was further demonstrated in macrophages where purified HDL neutralized an E. coli LPS effect and significantly reduced TNFα release from human THP-1 cells. Conclusion: ApoM binds LPS to facilitate endotoxin neutralization and clearance by HDL.
    Keywords ApoM ; Endotoxin ; Isothermal calorimetry ; Lipopolysaccharide ; HDL ; Neutralization ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Subject code 630
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Vitamin D status affects proteomic profile of HDL-associated proteins and inflammatory mediators in dyslipidemia.

    Mousa, Hanaa / Al Saei, Aisha / Razali, Rozaimi Mohamad / Zughaier, Susu M

    The Journal of nutritional biochemistry

    2023  Volume 123, Page(s) 109472

    Abstract: Vitamin D deficiency and dyslipidemia have substantial implications for human health globally. Vitamin D is essential for bone metabolism and immune modulation, and its insufficiency is linked to various chronic inflammatory conditions. Dyslipidemia, ... ...

    Abstract Vitamin D deficiency and dyslipidemia have substantial implications for human health globally. Vitamin D is essential for bone metabolism and immune modulation, and its insufficiency is linked to various chronic inflammatory conditions. Dyslipidemia, characterized by low levels of high-density lipoprotein (HDL) and elevated levels of low-density lipoprotein (LDL) and triglycerides, is also prevalent. Previous research has shown a connection between vitamin D deficiency and low HDL, but the precise mechanism by which vitamin D influences HDL production and its anti-inflammatory properties remains unclear. This study aimed to investigate the proteomic profiles of individuals with and without vitamin D deficiency and dyslipidemia, specifically focusing on the effects of vitamin D on HDL production, its anti-inflammatory potential, and the molecular pathways associated with vitamin D deficiency and dyslipidemia, particularly inflammation and cancer pathways. By analyzing the proteomic profiles of 274 participants from the Qatar Biobank database, we identified 1301 proteins. Our findings indicated a decrease in HDL-associated apolipoproteins (ApoM and ApoD) in individuals with both dyslipidemia and vitamin D deficiency. Conversely, participants with these conditions exhibited increased expression of acute-phase proteins (SAA1 and SOD1), which are associated with inflammation. Pathway enrichment analysis revealed heightened inflammatory activity in individuals with vitamin D deficiency and dyslipidemia, with notable enrichments in pathways such as MAPK, JAK-STAT, Ras signaling, cytokine-cytokine receptor interaction, AGE-RAGE, ErbB signaling, and cancer pathways. Overall, cases of vitamin D deficiency showed enrichment in inflammation pathways, while individuals with both vitamin D deficiency and dyslipidemia demonstrated enhanced activation of cancer and inflammation pathways.
    MeSH term(s) Humans ; Vitamin D ; Lipoproteins, HDL ; Proteomics ; Vitamins ; Vitamin D Deficiency/complications ; Triglycerides ; Dyslipidemias ; Lipoproteins, LDL ; Inflammation/complications ; Anti-Inflammatory Agents ; Neoplasms
    Chemical Substances Vitamin D (1406-16-2) ; Lipoproteins, HDL ; Vitamins ; Triglycerides ; Lipoproteins, LDL ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1014929-6
    ISSN 1873-4847 ; 0955-2863
    ISSN (online) 1873-4847
    ISSN 0955-2863
    DOI 10.1016/j.jnutbio.2023.109472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2838: Show issues Location:
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  7. Article ; Online: Analysis of novel meningococcal vaccine formulations.

    Zughaier, Susu M

    Human vaccines & immunotherapeutics

    2017  Volume 13, Issue 7, Page(s) 1728–1732

    Abstract: The protective effect of meningococcal vaccines targeting disease causing serogroups exemplified by the introduction of MenAfriVac™ in Africa, is well established and documented in large population-based studies. Due to the emergence of other ... ...

    Abstract The protective effect of meningococcal vaccines targeting disease causing serogroups exemplified by the introduction of MenAfriVac™ in Africa, is well established and documented in large population-based studies. Due to the emergence of other meningococcal disease causing serogroups, novel vaccine formulations are needed. There is a high potential for novel nanotechnology-based meningococcal vaccine formulations that can provide wider vaccine coverage. The proposed meningococcal vaccine formulation contains spherical shaped micro and nanoparticles that are biological mimics of Niesseria meningitidis, therefore present to immune system as invader and elicit robust immune responses. Vaccine nanoparticles encapsulate meningococcal CPS polymers in a biodegradable material that slowly release antigens, therefore enhance antigen presentation by exerting antigen depot effect. The antigenicity of meningococcal vaccine delivered in nanoparticles is significantly higher when compared to vaccine delivered in solution. Preclinical studies are required to assess the immunogenicity of novel vaccine formulations. Therefore, implementing various in-vitro human immune cell-based assays that mimic in-vivo interactions, would provide good insight on optimal antigen dose, effective antigen presentation, facilitate screening of various vaccine and adjuvant combinations and predict in-vivo immunogenicity. This rapid approach is cost-effective and provides data required for the preclinical immunogenicity assessment of novel meningococcal vaccine formulations.
    Language English
    Publishing date 2017-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2017.1305528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6967: Show issues Location:
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  8. Article ; Online: A Path towards Timely VAP Diagnosis: Proof-of-Concept Study on Pyocyanin Sensing with Cu-Mg Doped Graphene Oxide.

    Noorizadeh, Mohammad / Geetha, Mithra / Bensaali, Faycal / Meskin, Nader / Sadasivuni, Kishor K / Zughaier, Susu M / Elgamal, Mahmoud / Ait Hssain, Ali

    Biosensors

    2024  Volume 14, Issue 1

    Abstract: In response to the urgent requirement for rapid, precise, and cost-effective detection in intensive care units (ICUs) for ventilated patients, as well as the need to overcome the limitations of traditional detection methods, researchers have turned their ...

    Abstract In response to the urgent requirement for rapid, precise, and cost-effective detection in intensive care units (ICUs) for ventilated patients, as well as the need to overcome the limitations of traditional detection methods, researchers have turned their attention towards advancing novel technologies. Among these, biosensors have emerged as a reliable platform for achieving accurate and early diagnoses. In this study, we explore the possibility of using Pyocyanin analysis for early detection of pathogens in ventilator-associated pneumonia (VAP) and lower respiratory tract infections in ventilated patients. To achieve this, we developed an electrochemical sensor utilizing a graphene oxide-copper oxide-doped MgO (
    MeSH term(s) Humans ; Pyocyanine ; Pneumonia, Ventilator-Associated ; Copper ; Magnesium Oxide ; Graphite
    Chemical Substances Pyocyanine (9OQM399341) ; graphene oxide ; Copper (789U1901C5) ; Magnesium Oxide (3A3U0GI71G) ; Graphite (7782-42-5)
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios14010048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Highly Sensitive Detection and Differentiation of Endotoxins Derived from Bacterial Pathogens by Surface-Enhanced Raman Scattering.

    Wu, Xiaomeng / Zhao, Yiping / Zughaier, Susu M

    Biosensors

    2021  Volume 11, Issue 7

    Abstract: Bacterial endotoxins, as major components of Gram-negative bacterial outer membrane leaflets and a well-characterized TLR4-MD-2 ligand, are lipopolysaccharides (LPSs) that are constantly shed from bacteria during growth and infection. For the first time, ...

    Abstract Bacterial endotoxins, as major components of Gram-negative bacterial outer membrane leaflets and a well-characterized TLR4-MD-2 ligand, are lipopolysaccharides (LPSs) that are constantly shed from bacteria during growth and infection. For the first time, we report that unique surface-enhanced Raman scattering (SERS) spectra of enteric LPSs from
    MeSH term(s) Bacteria ; Cell Differentiation ; Endotoxins/analysis ; Escherichia coli ; Lipopolysaccharides ; Silver ; Spectrum Analysis, Raman
    Chemical Substances Endotoxins ; Kdo2-lipid A ; Lipopolysaccharides ; Silver (3M4G523W1G)
    Language English
    Publishing date 2021-07-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios11070234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of phthalate metabolites on vitamin D levels and subclinical inflammation: national health and nutrition examination survey, 2013-2018.

    Mahmoud, Elhassan / Elsayed, Abdalla Moustafa / Kaleem, Muhammad Zain / Alkorbi, Hamad A / Elshoeibi, Amgad M / Chivese, Tawanda / Zughaier, Susu M

    International journal of environmental health research

    2024  , Page(s) 1–11

    Abstract: This study explores the association between phthalates and total vitamin D levels and the link between phthalates exposure and subclinical inflammation using monocyte percentage to high-density lipoprotein cholesterol ratio (MHR), utilizing three ... ...

    Abstract This study explores the association between phthalates and total vitamin D levels and the link between phthalates exposure and subclinical inflammation using monocyte percentage to high-density lipoprotein cholesterol ratio (MHR), utilizing three National Health and Nutrition Examination Survey (NHANES) survey cycles 2013-2018. This study is cross-sectional, utilizing one-time urine samples from randomly selected NHANES participants to assess phthalate metabolites. An inverse association between vitamin D and all Di(2-ethylhexyl) phthalate (DEHP) metabolites was found. The molar sum of DEHP metabolites was inversely associated with vitamin D (β -2.329; 95% CI -3.937,-0.720). An inverse association was observed between monocarboxynonyl phthalate and vitamin D (β -0.0278; 95% CI -0.0527,-0.00298). A similar relationship was found between monocarboxyoctyl phthalate and vitamin D (β -0.0160; 95% CI -0.0242,-0.00775). There was no association between phthalate metabolites and MHR. Stratified analysis showed that the association between phthalate metabolites and MHR may vary according to vitamin D status.
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1104887-6
    ISSN 1369-1619 ; 0960-3123
    ISSN (online) 1369-1619
    ISSN 0960-3123
    DOI 10.1080/09603123.2023.2299216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3517: Show issues Location:
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