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  1. Article ; Online: ASAS-NANP SYMPOSIUM: Review of systems thinking concepts and their potential value in animal science research.

    Stephens, Emma C

    Journal of animal science

    2021  Volume 99, Issue 2

    Abstract: Worldwide, our collective research and policy institutions, including the American Society of Animal Science (ASAS), are calling for more systems-based research and analysis of society's most pressing and complex problems. However, the use of systems ... ...

    Abstract Worldwide, our collective research and policy institutions, including the American Society of Animal Science (ASAS), are calling for more systems-based research and analysis of society's most pressing and complex problems. However, the use of systems analysis within animal science remains limited and researchers may not have the tools to answer this call. This review thus introduces important concepts in systems thinking methodology, such as policy resistance, feedback processes, and dynamic complexity. An overall rationale for systems thinking and analysis is presented, along with examples of the application of these concepts in current animal science research. In order to contrast systems approaches to more frequently employed event-oriented research frameworks, both frameworks are then applied to the ASAS' identified "Grand Challenge" problem of antimicrobial resistance (AMR) in order to compare these two kinds of analyses. Systems thinking stresses the importance of underlying system structures that lead to persistent problem behaviors vs a focus on unidirectional cause-and-effect relationships. A potential systems framework for animal production decisions to use antimicrobials is shown that more explicitly accounts for AMR in a way that can lead to different animal production decisions than the event-oriented framework. Acknowledging and accounting for fundamental system structures that can explain persistent AMR will lead to different potential solutions to this problem than would be suggested from more linear approaches. The challenges and benefits of incorporating systems methods into animal science research are then discussed.
    MeSH term(s) Animals ; Systems Analysis ; United States
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 390959-1
    ISSN 1525-3163 ; 0021-8812
    ISSN (online) 1525-3163
    ISSN 0021-8812
    DOI 10.1093/jas/skab021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Impacts of COVID-19 on agricultural and food systems worldwide and on progress to the sustainable development goals.

    Stephens, Emma C / Martin, Guillaume / van Wijk, Mark / Timsina, Jagadish / Snow, Val

    Agricultural systems

    2020  Volume 183, Page(s) 102873

    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country England
    Document type Editorial
    ZDB-ID 413255-5
    ISSN 0308-521X
    ISSN 0308-521X
    DOI 10.1016/j.agsy.2020.102873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The immediate impact of the first waves of the global COVID-19 pandemic on agricultural systems worldwide: Reflections on the COVID-19 special issue for agricultural systems

    Stephens, Emma C. / Timsina, Jagadish / Snow, Val / Martin, Guillaume / van Wijk, Mark / Klerkx, Laurens / Reidsma, Pytrik

    Agricultural systems. 2022 May 19,

    2022  

    Abstract: In May 2020, approximately four months into the COVID-19 pandemic, the journal's editorial team realized there was an opportunity to collect information from a diverse range of agricultural systems on how the pandemic was playing out and affecting the ... ...

    Abstract In May 2020, approximately four months into the COVID-19 pandemic, the journal's editorial team realized there was an opportunity to collect information from a diverse range of agricultural systems on how the pandemic was playing out and affecting the functioning of agricultural systems worldwide. The objective of the special issue was to rapidly collect information, analysis and perspectives from as many regions as possible on the initial impacts of the pandemic on global agricultural systems, The overall goal for the special issue was to develop a useful repository for this information as well as to use the journal's international reach to share this information with the agricultural systems research community and journal readership. The editorial team put out a call for a special issue to capture the initial effects of the pandemic on the agricultural sector. We also recruited teams from eight global regions to write papers summarizing the impacts of the first waves of the pandemic in their area. The work of the regional teams and the broader research community resulted in eight regional summary papers, as well as thirty targeted research articles. In these papers, we find that COVID-19 and global pandemic mitigation measures have had significant and sometimes unexpected impacts on our agricultural systems via shocks to agricultural labour markets, trade and value chains. And, given the high degree of overlap between low income populations and subsistence agricultural production in many regions, we also document significant shocks to food security for these populations, and the high potential for long term losses in terms of human, natural, institutional and economic capital. While we also documented instances of agricultural system resilience capacities, they were not universally accessible. We see particular need to shore up vulnerable agricultural systems and populations most negatively affected by the pandemic and to mitigate pandemic-related losses to preserve other agricultural systems policy objectives, such as improving food security, or addressing climate change. Despite rapid development of vaccines, the pandemic continues to roll on as of the time of writing (early 2022). Only time will tell how the dynamics described in this Special Issue will play out in the coming years. Evidence of agricultural system resilience capacities provides some hopeful perspectives, but also highlights the need to boost these capacities across a wider cross section of agricultural systems and encourage agri-food systems transformation to prepare for more challenges ahead.
    Keywords COVID-19 infection ; agricultural industry ; capital ; climate change ; farm labor ; food security ; humans ; income ; issues and policy ; pandemic ; trade
    Language English
    Dates of publication 2022-0519
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 413255-5
    ISSN 0308-521X
    ISSN 0308-521X
    DOI 10.1016/j.agsy.2022.103436
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Agricultural Systems Editors' Picks for World Soil Day 2020

    Snow, Val / Stephens, Emma C. / Martin, Guillaume / van Wijk, Mark / Timsina, Jagadish / Klerkx, Laurens

    Agricultural Systems

    2021  Volume 187

    Keywords Life Science
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 413255-5
    ISSN 0308-521X
    ISSN 0308-521X
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Two hundred volumes of Agricultural Systems

    Snow, Val / Stephens, Emma C. / Martin, G. / Wijk, Mark T. van / Timsina, J. / Reidsma, P. / Klerkx, Laurens / Topp, C. / Taffi, M.

    Agricultural Systems

    Common themes and trends

    2022  

    Keywords agriculture ; farming systems ; research
    Language English
    Publishing date 2022-09-06T16:52:23Z
    Publisher Elsevier
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Agricultural systems research and global food security in the 21st century: An overview and roadmap for future opportunities

    Stephens, Emma C / Andrew D. Jones / David Parsons

    Agricultural systems. 2018 June, v. 163

    2018  

    Abstract: This article presents a brief history and overview of some key intersections between agricultural systems research and the literature on global food security. It also serves to contextualize the submissions for this special issue, which comprise selected ...

    Abstract This article presents a brief history and overview of some key intersections between agricultural systems research and the literature on global food security. It also serves to contextualize the submissions for this special issue, which comprise selected relevant research presented at the 2nd International Conference on Global Food Security, held at Cornell University in October 2015.
    Keywords agricultural research ; crop production ; food security ; models
    Language English
    Dates of publication 2018-06
    Size p. 1-6.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 413255-5
    ISSN 0308-521X
    ISSN 0308-521X
    DOI 10.1016/j.agsy.2017.01.011
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Placental Streptococcus agalactiae DNA is associated with neonatal unit admission and foetal pro-inflammatory cytokines in term infants.

    Gaccioli, Francesca / Stephens, Katie / Sovio, Ulla / Jessop, Flora / Wong, Hilary S / Lager, Susanne / Cook, Emma / de Goffau, Marcus C / Le Doare, Kirsty / Peacock, Sharon J / Parkhill, Julian / Charnock-Jones, D Stephen / Smith, Gordon C S

    Nature microbiology

    2023  Volume 8, Issue 12, Page(s) 2338–2348

    Abstract: Streptococcus agalactiae (Group B Streptococcus; GBS) is a common cause of sepsis in neonates. Previous work detected GBS DNA in the placenta in ~5% of women before the onset of labour, but the clinical significance of this finding is unknown. Here we re- ...

    Abstract Streptococcus agalactiae (Group B Streptococcus; GBS) is a common cause of sepsis in neonates. Previous work detected GBS DNA in the placenta in ~5% of women before the onset of labour, but the clinical significance of this finding is unknown. Here we re-analysed this dataset as a case control study of neonatal unit (NNU) admission. Of 436 infants born at term (≥37 weeks of gestation), 7/30 with placental GBS and 34/406 without placental GBS were admitted to the NNU (odds ratio (OR) 3.3, 95% confidence interval (CI) 1.3-7.8). We then performed a validation study using non-overlapping subjects from the same cohort. This included a further 239 cases of term NNU admission and 686 term controls: 16/36 with placental GBS and 223/889 without GBS were admitted to the NNU (OR 2.4, 95% CI 1.2-4.6). Of the 36 infants with placental GBS, 10 were admitted to the NNU with evidence of probable but culture-negative sepsis (OR 4.8, 95% CI 2.2-10.3), 2 were admitted with proven GBS sepsis (OR 66.6, 95% CI 7.3-963.7), 6 were admitted and had chorioamnionitis (inflammation of the foetal membranes) (OR 5.3, 95% CI 2.0-13.4), and 5 were admitted and had funisitis (inflammation of the umbilical cord) (OR 6.7, 95% CI 12.5-17.7). Foetal cytokine storm (two or more pro-inflammatory cytokines >10 times median control levels in umbilical cord blood) was present in 36% of infants with placental GBS DNA and 4% of cases where the placenta was negative (OR 14.2, 95% CI 3.6-60.8). Overall, ~1 in 200 term births had GBS detected in the placenta, which was associated with infant NNU admission and morbidity.
    MeSH term(s) Infant, Newborn ; Humans ; Pregnancy ; Infant ; Female ; Placenta ; Streptococcus agalactiae/genetics ; Case-Control Studies ; Streptococcal Infections ; Inflammation ; Sepsis
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Journal Article
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-023-01528-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Food security outcomes in agricultural systems models

    Nicholson, Charles F. / Stephens Emma C. / Kopainsky, Birgit / Jones, Andrew D. / Parsons, David / Garrett, James

    Agricultural Systems

    Current status and recommended improvements

    2021  

    Abstract: Improvement of food security is a common objective for many agricultural systems analyses, but how food security has been conceptualized and evaluated within agricultural systems has not been systematically evaluated. We reviewed the literature on ... ...

    Abstract Improvement of food security is a common objective for many agricultural systems analyses, but how food security has been conceptualized and evaluated within agricultural systems has not been systematically evaluated. We reviewed the literature on agricultural systems analyses of food security at the household- and regional-levels, finding that the primary focus is on only one dimension of food security—agricultural output as a proxy for food availability. Given that food security comprises availability, access, utilization and stability dimensions, improved practice would involve more effort to incorporate food access and stability indicators into agricultural systems models. The empirical evidence base for including food access indicators and their determinants within agricultural systems models requires further development through appropriate short and long-term investments in data collection and analysis. Assessment of the stability dimension of food security (through time) is also particularly under-represented in previous work and requires the development and application of appropriate dynamic models of agricultural systems that include food security indicators, coupled with more formalized treatment of robustness and adaptability at both the regional and household levels. We find that agricultural systems models often conflate analysis of food security covariates that have the potential to improve food security (like agricultural yields) with an assessment of food security itself. Agricultural systems modelers should exercise greater caution in referring to analyses of agricultural output and food availability as representing food security more generally.
    Keywords food security ; farming systems ; food access ; stability ; seguridad alimentaria ; sistemas de explotación ; acceso a los alimentos
    Language English
    Publishing date 2021-07-20T10:55:25Z
    Publisher Elsevier
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Quality assurance in surgical trials of arteriovenous grafts for haemodialysis: A systematic review, a narrative exploration and expert recommendations.

    Kingsmore, David B / Edgar, Ben / Aitken, Emma / Calder, Francis / Franchin, Marco / Geddes, Colin / Inston, Nick / Jackson, Andrew / Jones, Rob G / Karydis, Nikolaos / Kasthuri, Ram / Mestres, Gaspar / Papadakis, Georgios / Sivaprakasam, Rajesh / Stephens, Mike / Stevenson, Karen / Stove, Callum / Szabo, Lazslo / Thomson, Peter C /
    Tozzi, Matteo / White, Richard D

    The journal of vascular access

    2024  , Page(s) 11297298241236521

    Abstract: Background: Introducing new procedures and challenging established paradigms requires well-designed randomised controlled trials (RCT). However, RCT in surgery present unique challenges with much of treatment tailored to the individual patient ... ...

    Abstract Background: Introducing new procedures and challenging established paradigms requires well-designed randomised controlled trials (RCT). However, RCT in surgery present unique challenges with much of treatment tailored to the individual patient circumstances, refined by experience and limited by organisational factors. There has been considerable debate over the outcomes of arteriovenous grafts (AVG) compared to AVF, but any differences may reflect differing practice and potential variability. It is essential, therefore, when considering an RCT of a novel surgical procedure or device that
    Method: The methods of this have been previously registered (PROSPERO: CRD420234284280) and published. In summary, a four-stage review was performed: identification of RCT of AVG, initial review, multidisciplinary appraisal of QA methods and reconciliation. QA measures were sought in four areas - generic, credentialing, standardisation and monitoring, with data abstracted by a multi-national, multi-speciality review body.
    Results: QA in RCT involving AVG in all four domains is highly variable, often sub-optimally described and has not improved over the past three decades. Few RCT established or defined a pre-RCT level of experience, none documented a pre-trial education programme, or had minimal standards of peri-operative management, no study had a defined pre-trial monitoring programme, and none assessed technical performance.
    Conclusion: QA in RCT is a relatively new area that is expanding to ensure evidence is reliable and reproducible. This review demonstrates that QA has not previously been detailed, but can be measured in surgical RCT of vascular access, and that a four-domain approach can easily be implemented into future RCT.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2252820-9
    ISSN 1724-6032 ; 1129-7298
    ISSN (online) 1724-6032
    ISSN 1129-7298
    DOI 10.1177/11297298241236521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Randomized clinical trial: Direct-acting antivirals as treatment for hepatitis C in people who inject drugs: Delivered in needle and syringe programs via directly observed therapy versus fortnightly collection.

    Beer, Lewis / Inglis, Sarah / Malaguti, Amy / Byrne, Christopher / Sharkey, Christian / Robinson, Emma / Gillings, Kirsty / Radley, Andrew / Hapca, Adrian / Stephens, Brian / Dillon, John

    Journal of viral hepatitis

    2022  Volume 29, Issue 8, Page(s) 646–653

    Abstract: Hepatitis C virus (HCV) treatment in people who inject drugs (PWID) is delivered within settings ...

    Abstract Hepatitis C virus (HCV) treatment in people who inject drugs (PWID) is delivered within settings frequented by PWID, such as needle and syringe programs (NSP). The optimal direct-acting antiviral (DAA) dispensing regimen among NSP clients is unknown. This study compared cures (Sustained virologic response 12 weeks post-treatment, [SVR
    MeSH term(s) Antiviral Agents/therapeutic use ; Directly Observed Therapy ; Drug Users ; Hepacivirus ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Hepatitis C, Chronic/drug therapy ; Humans ; Substance Abuse, Intravenous/epidemiology ; Syringes
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-05-26
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212497-7
    ISSN 1365-2893 ; 1352-0504
    ISSN (online) 1365-2893
    ISSN 1352-0504
    DOI 10.1111/jvh.13701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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