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  1. Article ; Online: Editorial: Insights in T Cell Biology: 2021.

    Tuosto, Loretta

    Frontiers in immunology

    2022  Volume 13, Page(s) 1039602

    MeSH term(s) CD8-Positive T-Lymphocytes ; Receptors, Antigen, T-Cell, alpha-beta
    Chemical Substances Receptors, Antigen, T-Cell, alpha-beta
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1039602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Faculty Opinions recommendation of Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals.

    Tuosto, Loretta

    Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

    2020  

    Keywords covid19
    Publisher Faculty Opinions Ltd
    Publishing country uk
    Document type Book ; Online
    DOI 10.3410/f.737980938.793574910
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Targeting staphylococcal enterotoxin B binding to CD28 as a new strategy for dampening superantigen-mediated intestinal epithelial barrier dysfunctions.

    Amormino, Carola / Russo, Emanuela / Tedeschi, Valentina / Fiorillo, Maria Teresa / Paiardini, Alessandro / Spallotta, Francesco / Rosanò, Laura / Tuosto, Loretta / Kunkl, Martina

    Frontiers in immunology

    2024  Volume 15, Page(s) 1365074

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    MeSH term(s) Humans ; Superantigens ; CD28 Antigens ; Caco-2 Cells ; Enterotoxins ; Cytokines
    Chemical Substances enterotoxin B, staphylococcal (39424-53-8) ; Superantigens ; CD28 Antigens ; Enterotoxins ; Cytokines
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1365074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Membrane Lipids in T Cell Functions.

    Tuosto, Loretta / Xu, Chenqi

    Frontiers in immunology

    2018  Volume 9, Page(s) 1608

    Language English
    Publishing date 2018
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.01608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Corrigendum: Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells.

    Kunkl, Martina / Amormino, Carola / Spallotta, Francesco / Caristi, Silvana / Fiorillo, Maria Teresa / Paiardini, Alessandro / Kaempfer, Raymond / Tuosto, Loretta

    Frontiers in immunology

    2023  Volume 14, Page(s) 1273921

    Abstract: This corrects the article DOI: 10.3389/fimmu.2023.1170821.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2023.1170821.].
    Language English
    Publishing date 2023-08-15
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1273921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells.

    Kunkl, Martina / Amormino, Carola / Spallotta, Francesco / Caristi, Silvana / Fiorillo, Maria Teresa / Paiardini, Alessandro / Kaempfer, Raymond / Tuosto, Loretta

    Frontiers in immunology

    2023  Volume 14, Page(s) 1170821

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureu
    MeSH term(s) Superantigens ; CD28 Antigens ; Artificial Intelligence ; Staphylococcus/metabolism ; Antigen-Presenting Cells/metabolism ; Receptors, Antigen, T-Cell
    Chemical Substances Superantigens ; CD28 Antigens ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-05-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1170821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Astrocytes and Inflammatory T Helper Cells: A Dangerous Liaison in Multiple Sclerosis.

    Kunkl, Martina / Amormino, Carola / Tedeschi, Valentina / Fiorillo, Maria Teresa / Tuosto, Loretta

    Frontiers in immunology

    2022  Volume 13, Page(s) 824411

    Abstract: Multiple Sclerosis (MS) is a neurodegenerative autoimmune disorder of the central nervous system (CNS) characterized by the recruitment of self-reactive T lymphocytes, mainly inflammatory T helper (Th) cell subsets. Once recruited within the CNS, ... ...

    Abstract Multiple Sclerosis (MS) is a neurodegenerative autoimmune disorder of the central nervous system (CNS) characterized by the recruitment of self-reactive T lymphocytes, mainly inflammatory T helper (Th) cell subsets. Once recruited within the CNS, inflammatory Th cells produce several inflammatory cytokines and chemokines that activate resident glial cells, thus contributing to the breakdown of blood-brain barrier (BBB), demyelination and axonal loss. Astrocytes are recognized as key players of MS immunopathology, which respond to Th cell-defining cytokines by acquiring a reactive phenotype that amplify neuroinflammation into the CNS and contribute to MS progression. In this review, we summarize current knowledge of the astrocytic changes and behaviour in both MS and experimental autoimmune encephalomyelitis (EAE), and the contribution of pathogenic Th1, Th17 and Th1-like Th17 cell subsets, and CD8
    MeSH term(s) Animals ; Astrocytes/physiology ; CD8-Positive T-Lymphocytes/immunology ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/physiopathology ; Humans ; Inflammation/immunology ; Multiple Sclerosis/immunology ; Multiple Sclerosis/physiopathology ; T-Lymphocytes, Helper-Inducer/classification ; T-Lymphocytes, Helper-Inducer/immunology
    Language English
    Publishing date 2022-02-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.824411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: NF-κB family of transcription factors: biochemical players of CD28 co-stimulation.

    Tuosto, Loretta

    Immunology letters

    2011  Volume 135, Issue 1-2, Page(s) 1–9

    Abstract: The signalling pathways that lead from antigen-receptor and/or co-receptor triggering to the activation of transcription factors of the NF-κB family have a crucial role in the regulation of immune responses. The understanding of the molecular mechanisms ... ...

    Abstract The signalling pathways that lead from antigen-receptor and/or co-receptor triggering to the activation of transcription factors of the NF-κB family have a crucial role in the regulation of immune responses. The understanding of the molecular mechanisms that control NF-κB activation in lymphocytes has, therefore, important implications for the therapy of immune diseases. CD28 is one of the most important co-stimulatory receptors necessary for full T lymphocyte activation. CD28-mediated signals lower T cell receptor (TCR) activation threshold, thus leading to the enhancement of several T cell functions, including cytokine production, cell cycle progression, survival and regulation of both cytotoxic and humoral T cell responses. However, most of these pathways are under the tight control of TCR and may be bypassed by repeated antigen stimulation. On the contrary, the activation of the NF-κB pathway and NF-κB-regulated genes is a unique feature of CD28. The ultimate nature of CD28 signalling relies on its cytoplasmic tail and on its ability to recruit several signalling mediators involved in coupling CD28 to distinct NF-κB cascades. This review will focus on the current knowledge of the molecular mechanisms whereby CD28 co-operates with the TCR in activating NF-κB. We also describe recent finding on the existence of autonomous signals emanating from CD28, which through a non-conventional NF-κB cascade may account for the critical role of CD28 in regulating cytokine/chemokine production and T cell survival.
    MeSH term(s) Animals ; CD28 Antigens/immunology ; CD28 Antigens/metabolism ; Cell Cycle/physiology ; Cell Survival/physiology ; Cytokines/biosynthesis ; Cytokines/immunology ; Humans ; Lymphocyte Activation/physiology ; NF-kappa B/immunology ; NF-kappa B/metabolism ; Protein Structure, Tertiary ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction/physiology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
    Chemical Substances CD28 Antigens ; Cytokines ; NF-kappa B ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2011-03-30
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2010.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1512: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: CD8

    Tedeschi, Valentina / Paldino, Giorgia / Kunkl, Martina / Paroli, Marino / Sorrentino, Rosa / Tuosto, Loretta / Fiorillo, Maria Teresa

    International journal of molecular sciences

    2022  Volume 23, Issue 6

    Abstract: ... ...

    Abstract CD8
    MeSH term(s) Autoimmune Diseases ; CD28 Antigens ; CD8-Positive T-Lymphocytes ; COVID-19 ; Cellular Senescence ; HIV Infections/drug therapy ; Humans ; Neoplasms ; SARS-CoV-2 ; Tumor Microenvironment ; Virus Diseases
    Chemical Substances CD28 Antigens
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23063374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: T Helper Cells: The Modulators of Inflammation in Multiple Sclerosis.

    Kunkl, Martina / Frascolla, Simone / Amormino, Carola / Volpe, Elisabetta / Tuosto, Loretta

    Cells

    2020  Volume 9, Issue 2

    Abstract: Multiple sclerosis (MS) is a chronic neurodegenerative disease characterized by the progressive loss of axonal myelin in several areas of the central nervous system (CNS) that is responsible for clinical symptoms such as muscle spasms, optic neuritis, ... ...

    Abstract Multiple sclerosis (MS) is a chronic neurodegenerative disease characterized by the progressive loss of axonal myelin in several areas of the central nervous system (CNS) that is responsible for clinical symptoms such as muscle spasms, optic neuritis, and paralysis. The progress made in more than one decade of research in animal models of MS for clarifying the pathophysiology of MS disease validated the concept that MS is an autoimmune inflammatory disorder caused by the recruitment in the CNS of self-reactive lymphocytes, mainly CD4
    MeSH term(s) Animals ; Blood-Brain Barrier/immunology ; Humans ; Immunotherapy/methods ; Inflammation/immunology ; Interferon-beta/metabolism ; Interferon-beta/therapeutic use ; Molecular Targeted Therapy/methods ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/immunology ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/immunology ; Signal Transduction/drug effects ; T-Lymphocytes, Helper-Inducer/classification ; T-Lymphocytes, Helper-Inducer/drug effects ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Interferon-beta (77238-31-4)
    Language English
    Publishing date 2020-02-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9020482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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