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  1. Book ; Online: Cell-based Therapies for Stroke: Promising Solution or Dead End?

    Henrique Rosado-de-Castro, Paulo / Clarkson, Andrew N. / Boltze, Johannes / Abe, Koji / Janowski, Miroslaw / Pimentel-Coelho, Pedro M. / Detante, Olivier

    2020  

    Keywords Medicine ; Neurology & clinical neurophysiology ; stem cell ; Stroke ; Mesenchymal stem cells (MSC) ; Brain ; Treatment
    Size 1 electronic resource (132 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231287
    ISBN 9782889637386 ; 2889637387
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?

    Rosado-de-Castro, Paulo Henrique / Pimentel-Coelho, Pedro M. / Armstrong, Paul / Alencar, Carlos H. / Heukelbach, Jorg / Salomon, Oscar D. / Villamil-Jimenez, Luis C. / Saiz, Juan-Carlos / Bueno-Mari, Ruben

    2018  

    Abstract: The considerable number of viral infectious disease threats that have emerged since the beginning of the 21st century have shown the need to dispose global and coordinated responses to fight properly and efficiently against them. Severe acute respiratory ...

    Abstract The considerable number of viral infectious disease threats that have emerged since the beginning of the 21st century have shown the need to dispose global and coordinated responses to fight properly and efficiently against them. Severe acute respiratory syndrome (2003), avian influenza in humans (2005), A(H1N1) pandemic influenza (2009), Middle East respiratory syndrome coronavirus (MERS-CoV) (2012 onward) and Ebola virus disease (2014-2015) are some of the most important examples. The latest emerging and devastating threat was Zika virus, an arbovirus that provoked more than 500,000 suspicious cases in the Americas in 2016 and notable processes of social and medical alarms due to the evidence of a causal link between Zika virus and several congenital injuries, like microcephaly, as well as due to its association with neurological disorders such as Guillain-Barré syndrome in adults (PAHO, 2017). In the framework of this global response and multistrategic approach, the purpose of this Research Topic is to provide updated information and novel researches about control strategies, encompassing virological, entomological and epidemiological data, in order to reach the triad of protagonists of transmission cycles (virus, mosquitoes and humans)
    Keywords Science (General) ; Microbiology ; Infectious and parasitic diseases ; Neurology. Diseases of the nervous system ; Medicine (General) ; Public aspects of medicine
    Size 1 electronic resource (253 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101795
    ISBN 9782889454808 ; 2889454800
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Incidental finding of COVID-19 infection after [

    Stasiak, Camila Edith Stachera / Cardoso, Fabrícius Rocha / de Almeida, Sergio Altino / Rosado-de-Castro, Paulo Henrique

    European journal of nuclear medicine and molecular imaging

    2020  Volume 48, Issue 2, Page(s) 653–654

    MeSH term(s) Asymptomatic Infections ; COVID-19/complications ; COVID-19/diagnostic imaging ; Edetic Acid/analogs & derivatives ; Gallium Isotopes ; Gallium Radioisotopes ; Humans ; Incidental Findings ; Lung/diagnostic imaging ; Male ; Middle Aged ; Oligopeptides ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/diagnostic imaging ; Radiopharmaceuticals
    Chemical Substances Gallium Isotopes ; Gallium Radioisotopes ; Oligopeptides ; Radiopharmaceuticals ; gallium 68 PSMA-11 ; Edetic Acid (9G34HU7RV0)
    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-020-04932-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Use of PET/CT to detect myocardial inflammation and the risk of malignant arrhythmia in chronic Chagas disease.

    de Oliveira, Renée Sarmento / Moll-Bernardes, Renata / de Brito, Adriana Xavier / Pinheiro, Martha Valéria Tavares / de Almeida, Sergio Altino / da Silva Gomes, Natália Lins / de Oliveira Terzi, Flavia Vernin / Moreira, Otacílio Cruz / Xavier, Sergio Salles / Rosado-de-Castro, Paulo Henrique / de Sousa, Andréa Silvestre

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2023  Volume 30, Issue 6, Page(s) 2702–2711

    Abstract: Background: Chagas heart disease (CHD) is characterized by progressive myocardial inflammation associated with myocardial fibrosis and segmental abnormalities that may lead to malignant ventricular arrhythmia and sudden cardiac death. This arrhythmia ... ...

    Abstract Background: Chagas heart disease (CHD) is characterized by progressive myocardial inflammation associated with myocardial fibrosis and segmental abnormalities that may lead to malignant ventricular arrhythmia and sudden cardiac death. This arrhythmia might be related to the persistence of parasitemia or inflammation in the myocardium in late-stage CHD. Positron emission tomography/computed tomography (PET/CT) has been used to detect myocardial inflammation in non-ischemic cardiomyopathies, such as sarcoidosis, and might be useful for risk prediction in patients with CHD.
    Methods and results: Twenty-four outpatients with chronic CHD were enrolled in this prospective cross-sectional study between May 2019 and March 2022. The patients were divided into two groups: those with sustained ventricular tachycardia and/or aborted sudden cardiac death who required implantable cardioverter-defibrillators, and those with the same stages of CHD and no complex ventricular arrhythmia. Patients underwent
    Conclusion: 18
    MeSH term(s) Humans ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Positron-Emission Tomography/methods ; Gallium Radioisotopes ; Cross-Sectional Studies ; Parasitemia ; Prospective Studies ; Myocarditis/diagnostic imaging ; Arrhythmias, Cardiac/diagnostic imaging ; Inflammation/diagnostic imaging ; Heart Diseases ; Death, Sudden, Cardiac ; Chagas Disease/complications ; Chagas Disease/diagnostic imaging
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Gallium Radioisotopes
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-023-03350-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Hyperacute transplantation of umbilical cord mesenchymal stromal cells in a model of severe intracerebral hemorrhage.

    Mello, Tanira Giara / Rosado-de-Castro, Paulo Henrique / Vasques, Juliana Ferreira / Pinhão, Carolina / Santos, Tayná Monteiro / de Lima, Renata Rodrigues / Foerster, Bernd Uwe / Paiva, Fernando Fernandes / Mendez-Otero, Rosalia / Pimentel-Coelho, Pedro Moreno

    Future science OA

    2022  Volume 8, Issue 4, Page(s) FSO793

    Abstract: Aim: Intracerebral hemorrhage (ICH) has limited therapeutic options. We have shown that an intravenous injection of human umbilical cord-derived mesenchymal stromal cells (hUC-MSC) 24 h after an ICH in rats reduced the residual hematoma volume after a ... ...

    Abstract Aim: Intracerebral hemorrhage (ICH) has limited therapeutic options. We have shown that an intravenous injection of human umbilical cord-derived mesenchymal stromal cells (hUC-MSC) 24 h after an ICH in rats reduced the residual hematoma volume after a moderate hemorrhage but was inefficient in severe ICH. Here, we investigated whether a treatment in the hyperacute phase would be more effective in severe ICH.
    Materials & methods: Wistar rats were randomly selected to receive an intravenous injection of hUC-MSC or the vehicle 1 h after a severe ICH.
    Results: The hyperacute treatment with hUC-MSC did not affect the 22-day survival rate, the motor function or the residual hematoma volume.
    Conclusion: These results indicate the need for optimization of hUC-MSC-based therapies for severe ICH.
    Language English
    Publishing date 2022-03-24
    Publishing country England
    Document type Journal Article
    ISSN 2056-5623
    ISSN 2056-5623
    DOI 10.2144/fsoa-2021-0121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Autonomic denervation, myocardial hypoperfusion and fibrosis may predict ventricular arrhythmia in the early stages of Chagas cardiomyopathy.

    de Brito, Adriana Soares Xavier / Moll-Bernardes, Renata Junqueira / Pinheiro, Martha Valéria Tavares / Camargo, Gabriel Cordeiro / Siqueira, Fabio Paiva Rossini / Oliveira, Renee Sarmento / Glavam, Adriana Pereira / de Almeida, Sergio Altino / de Holanda, Marcelo Teixeira / Sangenis, Luiz Henrique Conde / Mendes, Fernanda de Souza Nogueira Sardinha / Rosado-de-Castro, Paulo Henrique / de Sousa, Andrea Silvestre

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2023  Volume 30, Issue 6, Page(s) 2379–2388

    Abstract: Background: Sudden cardiac death (SCD) can be the first clinical event of Chagas heart disease (CHD). However, current guidelines contain no clear recommendation for early cardioverter-defibrillator implantation. Using imaging modalities, we evaluated ... ...

    Abstract Background: Sudden cardiac death (SCD) can be the first clinical event of Chagas heart disease (CHD). However, current guidelines contain no clear recommendation for early cardioverter-defibrillator implantation. Using imaging modalities, we evaluated associations among autonomic denervation, myocardial hypoperfusion, fibrosis and ventricular arrhythmia in CHD.
    Methods and results: Twenty-nine patients with CHD and preserved left ventricular function underwent 123I-metaiodobenzylguanidine (MIBG) scintigraphy, 99mTc-methoxyisobutylisonitrile (MIBI) myocardial perfusion and cardiac magnetic resonance imaging (MRI). They were divided into arrhythmic (≥ 6 ventricular premature complexes/h and/or non-sustained ventricular tachycardia on 24-hour Holter, n = 15) and non-arrhythmic (< 6 ventricular premature complexes/h and no ventricular tachycardia; n = 14) groups. The arrhythmic group had higher denervation scores from MIBG imaging (23.2 ± 18.7 vs 5.6 ± 4.9; P < .01), hypoperfusion scores from MIBI SPECT (4.7 ± 6.8 vs 0.29 ± 0.6: P = .02), innervation/perfusion mismatch scores (18.5 ± 17.5 vs 5.4 ± 4.8; P = .01) and fibrosis by late gadolinium enhancement on MRI (14.3% ± 13.5% vs 4.0% ± 2.9%; P = .04) than the non-arrhythmic group.
    Conclusion: These imaging parameters were associated with ventricular arrhythmia in early CHD and may enable risk stratification and the implementation of primary preventive strategies for SCD.
    MeSH term(s) Humans ; Chagas Cardiomyopathy/complications ; Chagas Cardiomyopathy/diagnostic imaging ; 3-Iodobenzylguanidine ; Contrast Media ; Ventricular Premature Complexes ; Gadolinium ; Myocardial Ischemia ; Coronary Artery Disease ; Death, Sudden, Cardiac/prevention & control ; Fibrosis ; Chagas Disease/complications ; Chagas Disease/diagnostic imaging ; Autonomic Denervation
    Chemical Substances 3-Iodobenzylguanidine (35MRW7B4AD) ; Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-023-03281-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article: Incidental finding of COVID-19 infection after [68Ga]Ga-PSMA-11 PET/CT imaging in a patient with prostate cancer

    Stasiak, Camila Edith Stachera / Cardoso, Fabrícius Rocha / de Almeida, Sergio Altino / Rosado-de-Castro, Paulo Henrique

    Eur. j. nucl. med. mol. imaging

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #671666
    Database COVID19

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  8. Article ; Online: New Imaging Parameters to Predict Sudden Cardiac Death in Chagas Disease.

    Moll-Bernardes, Renata J / Rosado-de-Castro, Paulo Henrique / Camargo, Gabriel Cordeiro / Mendes, Fernanda Souza Nogueira Sardinha / Brito, Adriana S X / Sousa, Andréa Silvestre

    Tropical medicine and infectious disease

    2020  Volume 5, Issue 2

    Abstract: Chronic Chagas' cardiomyopathy is the most severe and frequent manifestation of Chagas disease, and has a high social and economic burden. New imaging modalities, such as strain echocardiography, nuclear medicine, computed tomography and cardiac magnetic ...

    Abstract Chronic Chagas' cardiomyopathy is the most severe and frequent manifestation of Chagas disease, and has a high social and economic burden. New imaging modalities, such as strain echocardiography, nuclear medicine, computed tomography and cardiac magnetic resonance imaging, may detect the presence of myocardial fibrosis, inflammation or sympathetic denervation, three conditions associated with risk of sudden death, providing additional diagnostic and/or prognostic information. Unfortunately, despite its high mortality, there is no clear recommendation for early cardioverter-defibrillator implantation in patients with Chagas heart disease in the current guidelines. Ideally, the risk of sudden cardiac death may be evaluated in earlier stages of the disease using new image methods to allow the implementation of primary preventive strategies.
    Language English
    Publishing date 2020-05-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed5020074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Case Report: Incidental Finding of COVID-19 Infection after Positron Emission Tomography/CT Imaging in a Patient with a Diagnosis of Histoplasmosis and Recurring Fever.

    Stasiak, Camila Edith Stachera / Nigri, David Henrique / Cardoso, Fabrícius Rocha / Mattos, Raphael Santos de Almeida Rezende de / Gonçalves Martins, Philippe Alcântara / Carvalho, Alysson Roncally Silva / Altino de Almeida, Sérgio / Rodrigues, Rosana Souza / Rosado-de-Castro, Paulo Henrique

    The American journal of tropical medicine and hygiene

    2021  Volume 104, Issue 5, Page(s) 1651–1654

    Abstract: This is a case report of a 37-year-old woman evaluated with 18F-fludeoxyglucose (18F-FDG) positron emission computed tomography/CT with recurrent fever after treatment with itraconazole for 6 weeks for histoplasmosis. The examination demonstrated a ... ...

    Abstract This is a case report of a 37-year-old woman evaluated with 18F-fludeoxyglucose (18F-FDG) positron emission computed tomography/CT with recurrent fever after treatment with itraconazole for 6 weeks for histoplasmosis. The examination demonstrated a decrease in the dimensions of the pulmonary opacities previously identified in the left lower lobe and attributed to histoplasmosis. In addition to these pulmonary opacities, increased FDG uptake was also observed in lymph nodes present in the cervical region, mediastinum, left lung hilum, and hepatic hilum. Notably, other pulmonary opacities with ground-glass pattern that were not present in the previous computed tomography were detected in the right lower lobe, with mild 18F-FDG uptake. Nasal swab performed shortly after the examination was positive for COVID-19. In this case, the 18F-FDG positron emission computed tomography/CT study demonstrated findings consistent with active COVID-19 infection coexisting with inflammatory changes associated with histoplasmosis infection.
    MeSH term(s) Adult ; COVID-19/diagnostic imaging ; Female ; Fever/etiology ; Fluorodeoxyglucose F18 ; Histoplasmosis/diagnostic imaging ; Histoplasmosis/drug therapy ; Humans ; Positron Emission Tomography Computed Tomography/methods ; Recurrence ; SARS-CoV-2
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-0952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.61: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Preoperative evaluation of prostate cancer by

    Stasiak, Camila Edith Stachera / Cardillo, Athos / de Almeida, Sergio Altino / Rodrigues, Rosana Souza / de Castro, Paulo Henrique Rosado / Parente, Daniella Braz

    Radiologia brasileira

    2023  Volume 56, Issue 4, Page(s) 171–178

    Abstract: Objective: To evaluate the accuracy of preoperative positron emission tomography/computed tomography with : Materials and methods: In this retrospective study, 65 patients with prostate cancer were analyzed.: Results: The accuracy of : ... ...

    Abstract Objective: To evaluate the accuracy of preoperative positron emission tomography/computed tomography with
    Materials and methods: In this retrospective study, 65 patients with prostate cancer were analyzed.
    Results: The accuracy of
    Conclusion: 68
    Language English
    Publishing date 2023-06-19
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2078806-X
    ISSN 1678-7099 ; 0100-3984
    ISSN (online) 1678-7099
    ISSN 0100-3984
    DOI 10.1590/0100-3984.2022.0122-en
    Database MEDical Literature Analysis and Retrieval System OnLINE

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