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Book ; Online: On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories

Arosa, Fernando A.

2018

Abstract: Human CD8+ T cells expressing NK receptors and receptors found on innate immune cells, and designated as NK-like or innate CD8+ T cells, have been long considered as terminally differentiated lymphocytes responsible for tissue inflammation and ... ...

Abstract	Human CD8+ T cells expressing NK receptors and receptors found on innate immune cells, and designated as NK-like or innate CD8+ T cells, have been long considered as terminally differentiated lymphocytes responsible for tissue inflammation and destruction. However, a growing body of knowledge is unveiling that NK-like CD8+ T cells have many, sometimes contrasting, functions. The limited knowledge of the biology of this type of CD8+ T cells and the role they play within peripheral tissues and organs under homeostatic conditions has hampered our understanding of disease and therefore the possible development of disease diagnostic tools and effective immunotherapies. In this Research Topic are presented a variety of topics and views, some of them overlooked for many years, on human NK-like CD8+ T cells, which may open new and novel avenues of research to further our understanding of these polyfunctional T cells
Keywords	Immunologic diseases. Allergy ; Medicine (General)
Size	1 electronic resource (121 p.)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020099591
ISBN	9782889453962 ; 2889453960
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Editorial: On the Origin and Function of Human NK-Like CD8+ T Cells: Charting New Territories.

Arosa, Fernando A

Frontiers in immunology

2017 Volume 8, Page(s) 1588

Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2017.01588
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: CD8

Cardoso, Elsa M / Arosa, Fernando A

Frontiers in immunology

2017 Volume 8, Page(s) 145

Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2017.00145
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Novel Bionebulizer Approach to Study the Effects of Natural Mineral Water on a 3D In Vitro Nasal Model from Allergic Rhinitis Patients.

Viegas, Joana / Cardoso, Elsa M / Bonneau, Lucile / Esteves, Ana Filipa / Ferreira, Catarina L / Alves, Gilberto / Santos-Silva, António Jorge / Vitale, Marco / Arosa, Fernando A / Taborda-Barata, Luís

Biomedicines

2024 Volume 12, Issue 2

Abstract: Sulfurous thermal waters (STWs) are used as a complementary treatment for allergic rhinitis. However, there is scant data on the effects of STW on nasal epithelial cells, and in vitro models are warranted. The main aim of this study was to evaluate the ... ...

Abstract	Sulfurous thermal waters (STWs) are used as a complementary treatment for allergic rhinitis. However, there is scant data on the effects of STW on nasal epithelial cells, and in vitro models are warranted. The main aim of this study was to evaluate the dose and time effects of exposure to 3D nasal inserts (MucilAir
Language	English
Publishing date	2024-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12020408
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Article ; Online: Open MHC Class I Conformers: A Look through the Looking Glass.

Arosa, Fernando A / Esgalhado, André J / Reste-Ferreira, Débora / Cardoso, Elsa M

International journal of molecular sciences

2021 Volume 22, Issue 18

Abstract: Studies carried out during the last few decades have consistently shown that cell surface MHC class I (MHC-I) molecules are endowed with functions unrelated with antigen presentation. These include cis-trans-interactions with inhibitory and activating ... ...

Abstract	Studies carried out during the last few decades have consistently shown that cell surface MHC class I (MHC-I) molecules are endowed with functions unrelated with antigen presentation. These include cis-trans-interactions with inhibitory and activating KIR and LILR, and cis-interactions with receptors for hormones, growth factors, cytokines, and neurotransmitters. The mounting body of evidence indicates that these non-immunological MHC-I functions impact clinical and biomedical settings, including autoimmune responses, tumor escape, transplantation, and neuronal development. Notably, most of these functions appear to rely on the presence in hematopoietic and non-hematopoietic cells of heavy chains not associated with β2m and the peptide at the plasma membrane; these are known as open MHC-I conformers. Nowadays, open conformers are viewed as functional cis-trans structures capable of establishing physical associations with themselves, with other surface receptors, and being shed into the extracellular milieu. We review past and recent developments, strengthening the view that open conformers are multifunctional structures capable of fine-tuning cell signaling, growth, differentiation, and cell communication.
MeSH term(s)	Alleles ; Histocompatibility Antigens Class I/chemistry ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class I/metabolism ; Humans ; Immunity ; Immunomodulation ; Protein Binding ; Protein Conformation ; Protein Multimerization ; Signal Transduction ; Structure-Activity Relationship
Chemical Substances	Histocompatibility Antigens Class I
Language	English
Publishing date	2021-09-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22189738
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Circadian rhythmicity of amyloid-beta-related molecules is disrupted in the choroid plexus of a female Alzheimer's disease mouse model.

Furtado, André / Esgalhado, André J / Duarte, Ana C / Costa, Ana R / Costa-Brito, Ana R / Carro, Eva / Ishikawa, Hiroshi / Schroten, Horst / Schwerk, Christian / Gonçalves, Isabel / Arosa, Fernando A / Santos, Cecília R A / Quintela, Telma

Journal of neuroscience research

2022 Volume 101, Issue 4, Page(s) 524–540

Abstract: The choroid plexus (CP) is part of the blood-cerebrospinal fluid barrier (BCSFB) and was recently described as an important component of the circadian clock system. It is the principal source of cerebrospinal fluid (CSF) and responsible for the synthesis ...

Abstract	The choroid plexus (CP) is part of the blood-cerebrospinal fluid barrier (BCSFB) and was recently described as an important component of the circadian clock system. It is the principal source of cerebrospinal fluid (CSF) and responsible for the synthesis and secretion of various neuroprotective peptides including those involved in amyloid-β (Aβ) transport/degradation, contributing to Aβ homeostasis. Inadequate Aβ metabolic clearance and transport across the BCSFB have been associated with circadian dysfunctions in Alzheimer's disease (AD) patients. To investigate whether AD pathology influences Aβ scavengers circadian expression, we collected CP at different time points from an AD mouse model (APP/PS1) (female and male animals, aged 6- and 12-months-old) and analyzed their mRNA expression by Real-time RT-PCR. Only angiotensin-converting enzyme (Ace) expression in 6-month-old female wild-type mice and transthyretin (Ttr) expression in 12-month-old female wild-type mice presented significant rhythmicity. The circadian rhythmicity of Ace and Ttr, prompt us to analyze the involvement of circadian rhythm in Aβ uptake. A human CP papilloma (HIBCPP) cell line was incubated with Aβ-488 and uptake was evaluated at different time points using flow cytometry. Aβ uptake displayed circadian rhythmicity. Our results suggest that AD might affect Aβ scavengers rhythmicity and that Aβ clearance is a rhythmic process possibly regulated by the rhythmic expression of Aβ scavengers.
MeSH term(s)	Humans ; Male ; Female ; Mice ; Animals ; Infant ; Alzheimer Disease/metabolism ; Choroid Plexus/metabolism ; Amyloid beta-Peptides/metabolism ; Blood-Brain Barrier/metabolism ; Circadian Rhythm ; Mice, Transgenic ; Amyloid beta-Protein Precursor/genetics ; Disease Models, Animal
Chemical Substances	Amyloid beta-Peptides ; Amyloid beta-Protein Precursor
Language	English
Publishing date	2022-12-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195324-2
ISSN	1097-4547 ; 0360-4012
ISSN (online)	1097-4547
ISSN	0360-4012
DOI	10.1002/jnr.25164
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1232: Show issues

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Article ; Online: HLA-A23/HLA-A24 serotypes and dementia interaction in the elderly: Association with increased soluble HLA class I molecules in plasma.

Cardoso, Elsa M / Lourenço-Gomes, Vânia / Esgalhado, André J / Reste-Ferreira, Débora / Oliveira, Nádia / Amaral, Ana Saraiva / Martinho, António / Gama, Jorge M R / Verde, Ignácio / Lourenço, Olga / Fonseca, Ana M / Buchli, Rico / Arosa, Fernando A

HLA

2023 Volume 102, Issue 6, Page(s) 660–670

Abstract: MHC class I molecules regulate brain development and plasticity in mice and HLA class I molecules are associated with brain disorders in humans. We investigated the relationship between plasma-derived soluble human HLA class I molecules (sHLA class I), ... ...

Abstract	MHC class I molecules regulate brain development and plasticity in mice and HLA class I molecules are associated with brain disorders in humans. We investigated the relationship between plasma-derived soluble human HLA class I molecules (sHLA class I), HLA class I serotypes and dementia. A cohort of HLA class I serotyped elderly subjects with no dementia/pre-dementia (NpD, n = 28), or with dementia (D, n = 28) was studied. Multivariate analysis was used to examine the influence of dementia and HLA class I serotype on sHLA class I levels, and to compare sHLA class I within four groups according to the presence or absence of HLA-A23/A24 and dementia. HLA-A23/A24 and dementia, but not age, significantly influenced the level of sHLA class I. Importantly, the concurrent presence of HLA-A23/A24 and dementia was associated with higher levels of sHLA class I (p < 0.001). This study has shown that the simultaneous presence of HLA-A23/HLA-A24 and dementia is associated with high levels of serum sHLA class I molecules. Thus, sHLA class I could be considered a biomarker of neurodegeneration in certain HLA class I carriers.
MeSH term(s)	Humans ; Animals ; Mice ; Aged ; HLA-A24 Antigen ; Serogroup ; Alleles ; Histocompatibility Antigens Class I/genetics ; Dementia/genetics
Chemical Substances	HLA-A*23 antigen ; HLA-A24 Antigen ; Histocompatibility Antigens Class I
Language	English
Publishing date	2023-07-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.15149
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Choroid Plexus Is an Alternative Source of Prolactin to the Rat Brain.

Costa-Brito, Ana R / Quintela, Telma / Gonçalves, Isabel / Duarte, Ana C / Costa, Ana R / Arosa, Fernando A / Cavaco, José E / Lemos, Manuel C / Santos, Cecília R A

Molecular neurobiology

2021 Volume 58, Issue 4, Page(s) 1846–1858

Abstract: Among the more than 300 functions attributed to prolactin (PRL), this hormone has been associated with the induction of neurogenesis and differentiation of olfactory neurons especially during pregnancy, which are essential for maternal behavior. Despite ... ...

Abstract	Among the more than 300 functions attributed to prolactin (PRL), this hormone has been associated with the induction of neurogenesis and differentiation of olfactory neurons especially during pregnancy, which are essential for maternal behavior. Despite the original hypothesis that PRL enters the central nervous system through a process mediated by PRL receptors (PRLR) at the choroid plexus (CP), recent data suggested that PRL transport into the brain is independent of its receptors. Based on transcriptomic data suggesting that PRL could be expressed in the CP, this work aimed to confirm PRL synthesis and secretion by CP epithelial cells (CPEC). The secretion of PRL and the distribution of PRLR in CPEC were further characterized using an in vitro model of the rat blood-cerebrospinal fluid barrier. RT-PCR analysis of PRL transcripts showed its presence in pregnant rat CP, in CPEC, and in the rat immortalized CP cell line, Z310. These observations were reinforced by immunocytochemistry staining of PRL in CPEC and Z310 cell cytoplasm. A 63-kDa immunoreactive PRL protein was detected by Western blot in CP protein extracts as well as in culture medium incubated with rat pituitary and samples of rat cerebrospinal fluid and serum. Positive immunocytochemistry staining of PRLR was present throughout the CPEC cytoplasm and in the apical and basal membrane of these cells. Altogether, our evidences suggest that CP is an alternative source of PRL to the brain, which might impact neurogenesis of olfactory neurons at the subventricular zone, given its proximity to the CP.
MeSH term(s)	Animals ; Choroid Plexus/cytology ; Choroid Plexus/metabolism ; Epithelial Cells/metabolism ; Female ; Gene Expression Regulation ; Models, Biological ; Peptides/metabolism ; Pregnancy ; Prolactin/genetics ; Prolactin/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Wistar ; Receptors, Prolactin/metabolism ; Rats
Chemical Substances	Peptides ; RNA, Messenger ; Receptors, Prolactin ; Prolactin (9002-62-4)
Language	English
Publishing date	2021-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-020-02267-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Open MHC Class I Conformers

Fernando A. Arosa / André J. Esgalhado / Débora Reste-Ferreira / Elsa M. Cardoso

International Journal of Molecular Sciences, Vol 22, Iss 9738, p

A Look through the Looking Glass

2021 Volume 9738

Abstract: Studies carried out during the last few decades have consistently shown that cell surface MHC class I (MHC-I) molecules are endowed with functions unrelated with antigen presentation. These include cis–trans-interactions with inhibitory and activating ... ...

Abstract	Studies carried out during the last few decades have consistently shown that cell surface MHC class I (MHC-I) molecules are endowed with functions unrelated with antigen presentation. These include cis–trans-interactions with inhibitory and activating KIR and LILR, and cis-interactions with receptors for hormones, growth factors, cytokines, and neurotransmitters. The mounting body of evidence indicates that these non-immunological MHC-I functions impact clinical and biomedical settings, including autoimmune responses, tumor escape, transplantation, and neuronal development. Notably, most of these functions appear to rely on the presence in hematopoietic and non-hematopoietic cells of heavy chains not associated with β2m and the peptide at the plasma membrane; these are known as open MHC-I conformers. Nowadays, open conformers are viewed as functional cis-trans structures capable of establishing physical associations with themselves, with other surface receptors, and being shed into the extracellular milieu. We review past and recent developments, strengthening the view that open conformers are multifunctional structures capable of fine-tuning cell signaling, growth, differentiation, and cell communication.
Keywords	HLA-ABC ; open conformers ; soluble HLA-I ; cis-trans ; associations ; signaling ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Antibodies to cryptic epitopes on HLA class I and class II heavy chains bound to single antigen beads: Clinically relevant?

Ravindranath, Mepur H / Filippone, Edward J / Amato-Menker, Carly J / Arosa, Fernando A / Das, Ballabh / Ou, Yijun / Norin, Allen J

Transplant immunology

2021 Volume 69, Page(s) 101482

Abstract: Cell surface HLA class I consists of trimers, i.e., alpha - heavy chain, beta - 2 - microglobulin, and a peptide, termed closed conformers (CC) on non-activated lymphocytes. HLA class I and class II may also exist, respectively, as alpha-chain only or ... ...

Abstract	Cell surface HLA class I consists of trimers, i.e., alpha - heavy chain, beta - 2 - microglobulin, and a peptide, termed closed conformers (CC) on non-activated lymphocytes. HLA class I and class II may also exist, respectively, as alpha-chain only or alpha and beta - chain only on activated cells termed open conformers (OC). We extend previous studies using an OC-specific monoclonal antibody that demonstrate LABScreen HLA class I and II single antigen beads (SABs) contain a mixture of open and closed conformers. LIFECODES SABs have bound CC only. More HLA class I and class II LABScreen SABs were reactive than LIFECODES SABs due to the presence of OC on LABScreen SABs. We hypothesized that antibody against OC on HLA B antigens would not be detected in cell based cross matches (XMs) with typical lymphocyte targets since anti-HLA OC antibodies would not react with native HLA CC on the cell surface. To test this hypothesis, we performed flow cytometry XM (FCXM) assays with sera of sufficient strength that most laboratories would likely predict positive FCXMs. Sera that reacted strongly with LABScreen SABs (>13,000 MFI) but weakly or not at all with LIFECODES SABs (<1000 MFI) gave negative T and B cell FCXMs. In contrast, sera that reacted with LIFECODES SABs (>13,000 MFI) but weakly with LABScreen SABs (<2100 MFI) exhibited positive FCXMs. Detection of antibodies directed against OC in SAB assays, may lead to inappropriate listing of unacceptable antigens, a decision not to XM or pre-or post - transplant desensitization procedures.
MeSH term(s)	Antibodies, Monoclonal ; Blood Grouping and Crossmatching ; Epitopes ; HLA Antigens ; Histocompatibility Testing ; Isoantibodies ; Kidney Transplantation
Chemical Substances	Antibodies, Monoclonal ; Epitopes ; HLA Antigens ; Isoantibodies
Language	English
Publishing date	2021-10-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1160846-8
ISSN	1878-5492 ; 0966-3274
ISSN (online)	1878-5492
ISSN	0966-3274
DOI	10.1016/j.trim.2021.101482
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