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  1. Article ; Online: Photons for Photography: A First Diagnostic Approach to Polaroid Emulsion Transfer on Paper in Paolo Gioli's Artworks.

    Alp, Zeynep / Ciccola, Alessandro / Serafini, Ilaria / Nucara, Alessandro / Postorino, Paolo / Gentili, Alessandra / Curini, Roberta / Favero, Gabriele

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 20

    Abstract: ... in the contemporary artist Paolo Gioli's artworks to provide preliminary knowledge about the materials of his artworks ... present in the mock-up sample which was obtained from Polacolor Type 88 and from Paolo Gioli's original ...

    Abstract The aim of this research is to study and diagnose for the first time the Polaroid emulsion transfer in the contemporary artist Paolo Gioli's artworks to provide preliminary knowledge about the materials of his artworks and the appropriate protocols which can be applied for future studies. The spectral analysis performed followed a multi-technical approach first on the mock-up samples created following Gioli's technique and on one original artwork of Gioli, composed by: FORS (Fiber Optics Reflectance), Raman, and FTIR (Fourier-Transform InfraRed) spectroscopies. These techniques were chosen according to their completely non-invasiveness and no requirement for sample collection. The obtained spectra from FTIR were not sufficient to assign the dyes found in the transferred Polaroid emulsion. However, they provided significant information about the cellulose-based materials. The most diagnostic results were obtained from FORS for the determination of the dye developers present in the mock-up sample which was obtained from Polacolor Type 88 and from Paolo Gioli's original artwork created with Polacolor type 89.
    MeSH term(s) Emulsions ; Photography ; Spectroscopy, Fourier Transform Infrared/methods ; Coloring Agents/analysis ; Cellulose
    Chemical Substances Emulsions ; Coloring Agents ; Cellulose (9004-34-6)
    Language English
    Publishing date 2022-10-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27207023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: CCR1 and CCR5 mediate cancer-induced myelopoiesis and differentiation of myeloid cells in the tumor.

    Zilio, Serena / Bicciato, Silvio / Weed, Donald / Serafini, Paolo

    Journal for immunotherapy of cancer

    2022  Volume 10, Issue 1

    Abstract: Background: Cancer-induced 'emergency' myelopoiesis plays a key role in tumor progression by inducing the accumulation of myeloid cells with a suppressive phenotype peripherally and in the tumor. Chemokine receptors (CCRs) and, in particular, CCR1, CCR2, ...

    Abstract Background: Cancer-induced 'emergency' myelopoiesis plays a key role in tumor progression by inducing the accumulation of myeloid cells with a suppressive phenotype peripherally and in the tumor. Chemokine receptors (CCRs) and, in particular, CCR1, CCR2, CCR5, and CCR7 are emerging as key regulators of myeloid cell trafficking and function but their precise role has not been completely clarified yet because of the signal redundancy, integration, and promiscuity of chemokines and of the expression of these CCRs on other leukocyte subsets.
    Methods: We used the 4PD nanoparticle for the in vivo targeted silencing of CCR1, CCR2, CCR5, and/or CCR7 in the myeloid cells of tumor bearing mice to evaluate the effect of treatments on tumor growth, myeloid cell trafficking and polarization. We used flow and image cytometry and functional assays to monitor changes in the tumor microenvironment and depletion experiments and immune deficient mice to determine the role of Ly6G
    Results: 4PD-mediated in vivo silencing of CCR1 and CCR5 on myeloid cells and myeloid precursors was necessary and sufficient to inhibit tumor progression. Functional studies indicated that this antitumor effect was not mediated by alteration of myeloid cell chemotaxes but rather by the repolarization of polymorphonuclear myeloid-derived suppressor cells (MDSCs) into tumoricidal neutrophils. Transcriptome functional and cytokine analysis indicated that tumor derived factors induced CCL3 and CCL4 in HSPCs that, through the autocrine engagement of CCR1 and CCR5, induced HSPCs differentiation in MDSCs. These finding were confirmed across mice with different genetic backgrounds and using HSPCs from umbilical cord blood and peripheral blood of patients with cancer.
    Conclusions: Our data support the notion that CCR1 and CCR5 and their ligands are a master immunological hub activated by several tumor derived factors. Activation of this pathway is necessary for the differentiation of MDSCs and protumoral macrophages.
    MeSH term(s) Animals ; Cell Differentiation ; Humans ; Immunomodulation/immunology ; Mice ; Myeloid-Derived Suppressor Cells/metabolism ; Myelopoiesis/immunology ; Nanoparticles/metabolism ; Receptors, CCR1/metabolism ; Receptors, CCR5/metabolism ; Tumor Microenvironment
    Chemical Substances CCR5 protein, mouse ; Ccr1 protein, mouse ; Receptors, CCR1 ; Receptors, CCR5
    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2021-003131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Computational Complexity and ILP Models for Pattern Problems in the Logical Analysis of Data

    Giuseppe Lancia / Paolo Serafini

    Algorithms, Vol 14, Iss 235, p

    2021  Volume 235

    Abstract: Logical Analysis of Data is a procedure aimed at identifying relevant features in data sets with both positive and negative samples. The goal is to build Boolean formulas, represented by strings over {0,1,-} called patterns , which can be used to ... ...

    Abstract Logical Analysis of Data is a procedure aimed at identifying relevant features in data sets with both positive and negative samples. The goal is to build Boolean formulas, represented by strings over {0,1,-} called patterns , which can be used to classify new samples as positive or negative. Since a data set can be explained in alternative ways, many computational problems arise related to the choice of a particular set of patterns. In this paper we study the computational complexity of several of these pattern problems (showing that they are, in general, computationally hard) and we propose some integer programming models that appear to be effective. We describe an ILP model for finding the minimum-size set of patterns explaining a given set of samples and another one for the problem of determining whether two sets of patterns are equivalent, i.e., they explain exactly the same samples. We base our first model on a polynomial procedure that computes all patterns compatible with a given set of samples. Computational experiments substantiate the effectiveness of our models on fairly large instances. Finally, we conjecture that the existence of an effective ILP model for finding a minimum-size set of patterns equivalent to a given set of patterns is unlikely, due to the problem being NP-hard and co-NP-hard at the same time.
    Keywords logical analysis of data ; pattern problems ; data mining ; computational complexity ; integer linear programming models ; Industrial engineering. Management engineering ; T55.4-60.8 ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 006 ; 511
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Myeloid derived suppressor cells in physiological and pathological conditions: the good, the bad, and the ugly.

    Serafini, Paolo

    Immunologic research

    2013  Volume 57, Issue 1-3, Page(s) 172–184

    Abstract: Myeloid derived suppressor cells (MDSCs), a heterogeneous population of myeloid progenitors, are recognized as a key element in tumor escape and progression. The importance of MDSCs in human malignancies has been demonstrated in recent years, and new ... ...

    Abstract Myeloid derived suppressor cells (MDSCs), a heterogeneous population of myeloid progenitors, are recognized as a key element in tumor escape and progression. The importance of MDSCs in human malignancies has been demonstrated in recent years, and new approaches targeting their suppressive/tolerogenic action are currently being tested in both preclinical model and clinical trials. However, emerging evidence suggests that MDSCs may play a prominent role as regulator of the physiologic, the chronic, and the pathologic immune responses. This review will focus on the biology of MDSC in light of these new findings and the possible role of this myeloid population not only in the progression of the tumor but also in its initiation.
    MeSH term(s) Animals ; Antigen-Presenting Cells/immunology ; Antigen-Presenting Cells/metabolism ; Humans ; Immune Tolerance ; Immunosuppression Therapy ; Inflammation/immunology ; Inflammation/metabolism ; Myeloid Cells/immunology ; Myeloid Cells/metabolism ; Neoplasms/immunology ; Neoplasms/metabolism ; Phenotype
    Language English
    Publishing date 2013-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-013-8455-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1755: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Editorial: Roles of Tumor-Recruited Myeloid Cells in Immune Evasion in Cancer.

    Kusmartsev, Sergei / Serafini, Paolo / Bharadwaj, Srinivas Nagaraj / Kortylewski, Marcin

    Frontiers in immunology

    2021  Volume 12, Page(s) 749605

    MeSH term(s) Animals ; Biomarkers ; Humans ; Immune Tolerance ; Myeloid-Derived Suppressor Cells/immunology ; Neoplasms/immunology ; Tumor Escape ; Tumor-Associated Macrophages/immunology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-08-27
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.749605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Certificates of optimality for minimum norm biproportional apportionments

    Serafini, Paolo

    Social choice and welfare Vol. 44, No. 1 , p. 1-12

    2015  Volume 44, Issue 1, Page(s) 1–12

    Author's details Paolo Serafini
    Keywords Biproportional apportionment ; Minimum quota deviation ; Linear complementarity conditions
    Language English
    Publisher Springer
    Publishing place Berlin ; Heidelberg
    Document type Article
    ZDB-ID 855101-7 ; 1463157-x
    ISSN 1432-217X ; 0176-1714
    ISSN (online) 1432-217X
    ISSN 0176-1714
    Database ECONomics Information System

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  7. Article: Biodistribution Assessment of a Novel

    Pavone, Anna Maria / Benfante, Viviana / Giaccone, Paolo / Stefano, Alessandro / Torrisi, Filippo / Russo, Vincenzo / Serafini, Davide / Richiusa, Selene / Pometti, Marco / Scopelliti, Fabrizio / Ippolito, Massimo / Giannone, Antonino Giulio / Cabibi, Daniela / Asti, Mattia / Vettorato, Elisa / Morselli, Luca / Merone, Mario / Lunardon, Marcello / Andrighetto, Alberto /
    Tuttolomondo, Antonino / Cammarata, Francesco Paolo / Verona, Marco / Marzaro, Giovanni / Mastrotto, Francesca / Parenti, Rosalba / Russo, Giorgio / Comelli, Albert

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 3

    Abstract: The aim of the present study consists of the evaluation of the biodistribution of a ... ...

    Abstract The aim of the present study consists of the evaluation of the biodistribution of a novel
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14030409
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  8. Article ; Online: The Relation between Persistent Post-Traumatic Headache and PTSD: Similarities and Possible Differences.

    Guglielmetti, Martina / Serafini, Gianluca / Amore, Mario / Martelletti, Paolo

    International journal of environmental research and public health

    2020  Volume 17, Issue 11

    Abstract: Post-traumatic headache (PTH) may be considered a secondary headache, which is linked to severe disability and psychosocial impairment. Interestingly, nearly 30% of subjects with persistent post-traumatic headache (PPTH) also suffer from post-traumatic ... ...

    Abstract Post-traumatic headache (PTH) may be considered a secondary headache, which is linked to severe disability and psychosocial impairment. Interestingly, nearly 30% of subjects with persistent post-traumatic headache (PPTH) also suffer from post-traumatic stress disorder (PTSD). Although existing studies demonstrated the existence of common pathophysiological characteristics in subjects with migraine and PPTH, the differences and similarities between these complex diseases are currently poorly understood and are yet to be comprehensively elucidated. Thus, the present review aimed to systematically investigate the nature of PPTH in the effort to better identify both the neurobiological and clinical aspects underlying this condition. Overall, the included studies reported that: (1) the predictors for persistent acute traumatic injury to the head were female gender, persistent symptoms related to mild post-traumatic brain injury (mTBI), PTSD, elevated inflammatory markers, prior mild traumatic brain injury, being injured while suffering from alcohol abuse; (2) static/dynamic functional connectivity differences, white matter tract abnormalities, and morphology changes were found between PPTH and migraine in brain regions involved in pain processing; and (3) clinical differences which were most prominent at early time points when they were linked to the increased risk of PPTH. Based on the selected reports, the relation between migraine and PPTH needs to be considered bidirectionally, but PTSD may play a critical role in this relation. The main implications of these findings, with a specific focus on PTSD, are discussed. Further longitudinal studies are needed to reveal the exact nature of this relation, as well as to clarify the distinct clinical characteristics of migraine, PPTH, and PTSD.
    MeSH term(s) Brain Concussion ; Female ; Headache ; Humans ; Migraine Disorders ; Post-Traumatic Headache ; Stress Disorders, Post-Traumatic
    Language English
    Publishing date 2020-06-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph17114024
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  9. Article ; Online: New Advances in Dye Analyses: In Situ Gel-Supported Liquid Extraction from Paint Layers and Textiles for SERS and HPLC-MS/MS Identification.

    Bosi, Adele / Peruzzi, Greta / Ciccola, Alessandro / Serafini, Ilaria / Vincenti, Flaminia / Montesano, Camilla / Postorino, Paolo / Sergi, Manuel / Favero, Gabriele / Curini, Roberta

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 14

    Abstract: To date, it is still not possible to obtain exhaustive information about organic materials in cultural heritage without sampling. Nonetheless, when studying unique objects with invaluable artistic or historical significance, preserving their integrity is ...

    Abstract To date, it is still not possible to obtain exhaustive information about organic materials in cultural heritage without sampling. Nonetheless, when studying unique objects with invaluable artistic or historical significance, preserving their integrity is a priority. In particular, organic dye identification is of significant interest for history and conservation research, but it is still hindered by analytes' low concentration and poor fastness. In this work, a minimally invasive approach for dye identification is presented. The procedure is designed to accompany noninvasive analyses of inorganic substances for comprehensive studies of complex cultural heritage matrices, in compliance with their soundness. Liquid extraction of madder, turmeric, and indigo dyes was performed directly from paint layers and textiles. The extraction was supported by hydrogels, which themselves can undergo multitechnique analyses in the place of samples. After extraction, Ag colloid pastes were applied on the gels for SERS analyses, allowing for the identification of the three dyes. For the HPLC-MS/MS analyses, re-extraction of the dyes was followed by a clean-up step that was successfully applied on madder and turmeric. The colour change perceptivity after extraction was measured with colorimetry. The results showed ΔE values mostly below the upper limit of rigorous colour change, confirming the gentleness of the procedure.
    Language English
    Publishing date 2023-07-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28145290
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    Zs.MO 81: Show issues

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  10. Article ; Online: Editorial: PGE2-producing MDSC: a role in tumor progression?

    Serafini, Paolo

    Journal of leukocyte biology

    2010  Volume 88, Issue 5, Page(s) 827–829

    MeSH term(s) Antigen-Presenting Cells/immunology ; Antigen-Presenting Cells/physiology ; CD4-Positive T-Lymphocytes/immunology ; Cell Differentiation ; Cell Division ; Dinoprostone/physiology ; Disease Progression ; Granulocyte-Macrophage Colony-Stimulating Factor/physiology ; Granulocyte-Macrophage Colony-Stimulating Factor/secretion ; Humans ; Leukemia, Myeloid/pathology ; Leukemia, Myeloid/physiopathology ; Vascular Endothelial Growth Factor A/physiology ; Vascular Endothelial Growth Factor A/secretion
    Chemical Substances Vascular Endothelial Growth Factor A ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2010-11
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1189/jlb.0510303
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    Zs.A 603: Show issues Location:
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