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  1. Article ; Online: Nuclear Quantum Effects on Nonadiabatic Dynamics of a Green Fluorescent Protein Chromophore Analogue: Ring-Polymer Surface-Hopping Simulation.

    Liu, Xiang-Yang / Wang, Sheng-Rui / Fang, Wei-Hai / Cui, Ganglong

    Journal of chemical theory and computation

    2024  

    Abstract: Herein, we have used the "on-the-fly" ring-polymer surface-hopping simulation method with the centroid approximation (RPSH-CA), in combination with the multireference OM2/MRCI electronic structure calculations to study the photoinduced dynamics of a ... ...

    Abstract Herein, we have used the "on-the-fly" ring-polymer surface-hopping simulation method with the centroid approximation (RPSH-CA), in combination with the multireference OM2/MRCI electronic structure calculations to study the photoinduced dynamics of a green fluorescent protein (GFP) chromophore analogue in the gas phase,
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.4c00068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Photoinduced Dynamics of a Single-Walled Carbon Nanotube with a sp

    Zhang, Yang / Jia, Meng-Ru / Liu, Xiang-Yang / Fang, Wei-Hai / Cui, Ganglong

    The journal of physical chemistry. A

    2024  

    Abstract: Herein, we employed linear-response time-dependent functional theory nonadiabatic dynamic simulations to explore the photoinduced exciton dynamics of a chiral single-walled carbon nanotube CNT(6,5) covalently doped with a 4-nitrobenzyl group (CNT65-NO2). ...

    Abstract Herein, we employed linear-response time-dependent functional theory nonadiabatic dynamic simulations to explore the photoinduced exciton dynamics of a chiral single-walled carbon nanotube CNT(6,5) covalently doped with a 4-nitrobenzyl group (CNT65-NO2). The results indicate that the introduction of a sp
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.4c00803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Studies on the Proteinaceous Structure Present on the Surface of the

    Yang, Yan / Yang, Ganglong / Li, Zi-Jie / Liu, Yi-Shi / Gao, Xiao-Dong / Nakanishi, Hideki

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 4

    Abstract: The surface of ... ...

    Abstract The surface of the
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9040392
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  4. Article: Editorial: Protein Glycosylation-Advances in Identification, Characterization and Biological Function Elucidation Using Mass Spectrometry.

    Yang, Ganglong / Zhang, Hui / Yi, Wen / Yan, Shi / Cao, Liwei

    Frontiers in chemistry

    2022  Volume 10, Page(s) 847242

    Language English
    Publishing date 2022-02-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2022.847242
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  5. Article ; Online: Thermally Activated Long Persistent Luminescence of Organic Inorganic Metal Halides.

    Gong, Hao / Yu, Heng / Zhang, Yang / Feng, Letong / Tian, Yang / Cui, Ganglong / Fu, Hongbing

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 14, Page(s) e202219085

    Abstract: Long persistent luminescence (LPL) materials of ... ...

    Abstract Long persistent luminescence (LPL) materials of SrAl
    Language English
    Publishing date 2023-02-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202219085
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  6. Article ; Online: Sialylation

    Xiaoman Zhou / Kaijun Chi / Chairui Zhang / Quan Liu / Ganglong Yang

    Biology, Vol 12, Iss 832, p

    A Cloak for Tumors to Trick the Immune System in the Microenvironment

    2023  Volume 832

    Abstract: The tumor microenvironment (TME), where the tumor cells incite the surrounding normal cells to create an immune suppressive environment, reduces the effectiveness of immune responses during cancer development. Sialylation, a type of glycosylation that ... ...

    Abstract The tumor microenvironment (TME), where the tumor cells incite the surrounding normal cells to create an immune suppressive environment, reduces the effectiveness of immune responses during cancer development. Sialylation, a type of glycosylation that occurs on cell surface proteins, lipids, and glycoRNAs, is known to accumulate in tumors and acts as a “cloak” to help tumor cells evade immunological surveillance. In the last few years, the role of sialylation in tumor proliferation and metastasis has become increasingly evident. With the advent of single-cell and spatial sequencing technologies, more research is being conducted to understand the effects of sialylation on immunity regulation. This review provides updated insights into recent research on the function of sialylation in tumor biology and summarizes the latest developments in sialylation-targeted tumor therapeutics, including antibody-mediated and metabolic-based sialylation inhibition, as well as interference with sialic acid–Siglec interaction.
    Keywords sialylation ; Siglecs ; immune checkpoint ; tumors ; tumor microenvironment ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Production of CA125 with Tn-antigens using a glycosylphosphatidylinositol anchoring system.

    Tang, Yu-He / Leng, Ji-Xiong / Yang, Ganglong / Gao, Xiao-Dong / Liu, Yi-Shi / Fujita, Morihisa

    Journal of biochemistry

    2024  

    Abstract: Cancer antigen 125 (CA125) is a serum marker associated with ovarian cancer. Despite its widespread use, CA125 levels can also be elevated in benign conditions. Recent reports suggest that detecting serum CA125 that carries the Tn-antigen, a truncated O- ... ...

    Abstract Cancer antigen 125 (CA125) is a serum marker associated with ovarian cancer. Despite its widespread use, CA125 levels can also be elevated in benign conditions. Recent reports suggest that detecting serum CA125 that carries the Tn-antigen, a truncated O-glycan containing only N-acetylgalactosamine on serine or threonine residues, can improve the specificity of ovarian cancer diagnosis. In this study, we engineered cells to express CA125 with a Tn-antigen. To achieve this, we knocked out C1GALT1 and SLC35A1, genes encoding Core1 synthase and a transporter for cytidine-5'-monophospho-sialic acid respectively, in human embryonic kidney 293 (HEK293) cells. In ClGALT1-SLC35A1-knockout (KO) cells, the expression of the Tn-antigen showed a significant increase, whereas the expression of the T-antigen (galactose-β1,3-N-acetylgalactosamine on serine or threonine residues) was decreased. Due to the inefficient secretion of soluble CA125, we employed a glycosylphosphatidylinositol (GPI) anchoring system. This allowed for the expression of GPI-anchored CA125 on the cell surface of ClGALT1-SLC35A1-KO cells. Cells expressing high levels of GPI-anchored CA125 were then enriched through cell sorting. By knocking out the PGAP2 gene, the GPI-anchored form of CA125 was converted to a secretory form. Through the engineering of O-glycans and the use of a GPI-anchoring system, we successfully produced CA125 with Tn-antigen modification.
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 218073-x
    ISSN 1756-2651 ; 0021-924X
    ISSN (online) 1756-2651
    ISSN 0021-924X
    DOI 10.1093/jb/mvae019
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    Uc I Zs.202: Show issues Location:
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  8. Article ; Online: Editorial

    Ganglong Yang / Hui Zhang / Wen Yi / Shi Yan / Liwei Cao

    Frontiers in Chemistry, Vol

    Protein Glycosylation—Advances in Identification, Characterization and Biological Function Elucidation Using Mass Spectrometry

    2022  Volume 10

    Keywords protein glycosylation ; mass spectrometry ; glycoproteomics ; glycomics ; SARS-CoV-2 ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Sialylation: A Cloak for Tumors to Trick the Immune System in the Microenvironment.

    Zhou, Xiaoman / Chi, Kaijun / Zhang, Chairui / Liu, Quan / Yang, Ganglong

    Biology

    2023  Volume 12, Issue 6

    Abstract: The tumor microenvironment (TME), where the tumor cells incite the surrounding normal cells to create an immune suppressive environment, reduces the effectiveness of immune responses during cancer development. Sialylation, a type of glycosylation that ... ...

    Abstract The tumor microenvironment (TME), where the tumor cells incite the surrounding normal cells to create an immune suppressive environment, reduces the effectiveness of immune responses during cancer development. Sialylation, a type of glycosylation that occurs on cell surface proteins, lipids, and glycoRNAs, is known to accumulate in tumors and acts as a "cloak" to help tumor cells evade immunological surveillance. In the last few years, the role of sialylation in tumor proliferation and metastasis has become increasingly evident. With the advent of single-cell and spatial sequencing technologies, more research is being conducted to understand the effects of sialylation on immunity regulation. This review provides updated insights into recent research on the function of sialylation in tumor biology and summarizes the latest developments in sialylation-targeted tumor therapeutics, including antibody-mediated and metabolic-based sialylation inhibition, as well as interference with sialic acid-Siglec interaction.
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12060832
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  10. Article ; Online: Theoretical insights into the photophysics of an unnatural base Z: A MS-CASPT2 investigation.

    Chen, Xin-Rui / Jiang, Wen-Jun / Guo, Qian-Hong / Liu, Xiang-Yang / Cui, Ganglong / Li, Laicai

    Photochemistry and photobiology

    2023  Volume 100, Issue 2, Page(s) 380–392

    Abstract: We have employed the highly accurate multistate complete active space second-order perturbation theory (MS-CASPT2) method to investigate the photoinduced excited state relaxation properties of one unnatural base, namely Z. Upon excitation to the ... ...

    Abstract We have employed the highly accurate multistate complete active space second-order perturbation theory (MS-CASPT2) method to investigate the photoinduced excited state relaxation properties of one unnatural base, namely Z. Upon excitation to the S
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123540-0
    ISSN 1751-1097 ; 0031-8655
    ISSN (online) 1751-1097
    ISSN 0031-8655
    DOI 10.1111/php.13884
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1686: Show issues Location:
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