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  1. AU=Albensi Benedict C.
  2. AU=McRae Simon
  3. AU="Shorubalko, Ivan"
  4. AU="Stewart, Rodney A"
  5. AU="Bakthavatsalu, Maheshwar"
  6. AU="Fussner, Steven"
  7. AU="Dolsten, Mikael"
  8. AU="Sarnyai, Zoltán"
  9. AU=Dongaonkar Ranjeet M
  10. AU="Singh, Leher"
  11. AU="Sevilla Porras, Marta"
  12. AU="Fuller, Chris K"
  13. AU="Vandeloo, Judith"
  14. AU="Meyers, Amanda"
  15. AU="Jiménez-Bambague, Eliana M"
  16. AU="Turner, J C"
  17. AU="Moore, C J" AU="Moore, C J"
  18. AU="Leresche, Téa"
  19. AU=Astrom Siv AU=Astrom Siv
  20. AU="Di Meglio, Florent"
  21. AU=Simon H U
  22. AU=Croucher P I
  23. AU="Jasti, Madhu"

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  1. Artikel ; Online: Editorial: Are Mitochondrial Therapeutics the Next Disruptor in Molecular Healthcare?

    Albensi, Benedict C

    Molecular neurobiology

    2023  

    Sprache Englisch
    Erscheinungsdatum 2023-09-29
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03653-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Buch ; Online: The Transcriptional Regulation of Memory

    Albensi, Benedict C. / Djordjevic, Jelena

    2016  

    Abstract: ... binding protein (C/EBP), and early growth response factor (Egr). In recent years, numerous studies have implicated ...

    Abstract The formation of various forms of memory involves a series of distinct cellular and molecular mechanisms, many of which are not fully understood. There are highly conserved pathways that are involved in learning, memory, and synaptic plasticity, which is the primary substrate for memory storage. The formation of short-term (across minutes) memory is mediated by local changes in synapses, while long-term (across hours to days) memory storage is associated with activation of transcription and synthesis of proteins that modify synaptic function. Transcription factors, which can either repress or activate transcription, play a vital role in driving protein synthesis underlying synaptic plasticity and memory, whereby protein synthesis provides the necessary building blocks to accommodate structural changes at the synapse that foster memory formation. Recent data implicate several families of transcription factors that appear critically important in the regulation of memory.In this Topic we will focus on the families of transcription factors thus far found to be critically involved in synaptic plasticity and memory formation. These include cAMP response element binding protein (CREB), Rel/nuclear factor B (Rel/NFB), CCAAT enhancer binding protein (C/EBP), and early growth response factor (Egr). In recent years, numerous studies have implicated epigenetic mechanisms, changes in gene activity and expression that occur without alteration in gene sequence, in the memory consolidation process. DNA methylation and chromatin remodeling are critically involved in learning and memory, supporting a role of epigenetic mechanisms. Here we provide more evidence of the importance of DNA methylation, histone posttranslational modifications and the role of histone acetylation and HDAC inhibitors in above mentioned processes
    Schlagwörter Neurosciences. Biological psychiatry. Neuropsychiatry ; Science (General)
    Umfang 1 electronic resource (116 p.)
    Verlag Frontiers Media SA
    Dokumenttyp Buch ; Online
    Anmerkung English ; Open Access
    HBZ-ID HT020090586
    ISBN 9782889198658 ; 2889198650
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  3. Artikel: Should artificial intelligence be used in conjunction with Neuroimaging in the diagnosis of Alzheimer's disease?

    Mirkin, Sophia / Albensi, Benedict C

    Frontiers in aging neuroscience

    2023  Band 15, Seite(n) 1094233

    Abstract: Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that affects memory, thinking, behavior, and other cognitive functions. Although there is no cure, detecting AD early is important for the development of a therapeutic plan and a care ... ...

    Abstract Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that affects memory, thinking, behavior, and other cognitive functions. Although there is no cure, detecting AD early is important for the development of a therapeutic plan and a care plan that may preserve cognitive function and prevent irreversible damage. Neuroimaging, such as magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET), has served as a critical tool in establishing diagnostic indicators of AD during the preclinical stage. However, as neuroimaging technology quickly advances, there is a challenge in analyzing and interpreting vast amounts of brain imaging data. Given these limitations, there is great interest in using artificial Intelligence (AI) to assist in this process. AI introduces limitless possibilities in the future diagnosis of AD, yet there is still resistance from the healthcare community to incorporate AI in the clinical setting. The goal of this review is to answer the question of whether AI should be used in conjunction with neuroimaging in the diagnosis of AD. To answer the question, the possible benefits and disadvantages of AI are discussed. The main advantages of AI are its potential to improve diagnostic accuracy, improve the efficiency in analyzing radiographic data, reduce physician burnout, and advance precision medicine. The disadvantages include generalization and data shortage, lack of
    Sprache Englisch
    Erscheinungsdatum 2023-04-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1094233
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Loss of cholinergic receptor muscarinic 1 impairs cortical mitochondrial structure and function: implications in Alzheimer's disease.

    Sabbir, Mohammad Golam / Swanson, Mamiko / Albensi, Benedict C

    Frontiers in cell and developmental biology

    2023  Band 11, Seite(n) 1158604

    Abstract: Introduction: ...

    Abstract Introduction:
    Sprache Englisch
    Erscheinungsdatum 2023-05-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1158604
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?

    Albensi, Benedict C

    Frontiers in cell and developmental biology

    2019  Band 7, Seite(n) 154

    Abstract: A large body of literature supports the idea that nuclear factor kappa B (NF-κB) signaling contributes to not only immunity, but also inflammation, cancer, and nervous system function. However, studies on NF-κB activity in mitochondrial function are much ...

    Abstract A large body of literature supports the idea that nuclear factor kappa B (NF-κB) signaling contributes to not only immunity, but also inflammation, cancer, and nervous system function. However, studies on NF-κB activity in mitochondrial function are much more limited and scattered throughout the literature. For example, in 2001 it was first published that NF-κB subunits were found
    Sprache Englisch
    Erscheinungsdatum 2019-08-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2019.00154
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Dysfunction of mitochondria: Implications for Alzheimer's disease.

    Albensi, Benedict C

    International review of neurobiology

    2019  Band 145, Seite(n) 13–27

    Abstract: Alzheimer's disease (AD), the most common form of dementia, is thought to be associated with multiple factors, where the greatest risk factor is aging. Several traditional views attribute the cause of AD to genetic heritability, reduced synthesis of the ... ...

    Abstract Alzheimer's disease (AD), the most common form of dementia, is thought to be associated with multiple factors, where the greatest risk factor is aging. Several traditional views attribute the cause of AD to genetic heritability, reduced synthesis of the neurotransmitter acetylcholine, the accumulation of a toxic protein known as amyloid β (Aβ) peptide, and/or neurofibrillary tangles of hyperphosphorylated tau-protein, which affect microtubule stability. However, with several recent clinical trial failures involving billions of dollars of revenue, traditional views are being questioned more each day. New theories involving metabolic activity and mitochondrial dysfunction, which proposes that altered mitochondria are the driving force for the development of AD, are being examined and investigated more critically. Understanding mitochondrial dysfunction and therapeutically targeting mitochondrial bioenergetics in AD could be a novel treatment approach holding great promise for preventing and/or slowing the onset of AD.
    Mesh-Begriff(e) Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Animals ; Energy Metabolism ; Humans ; Mitochondria/pathology ; Models, Biological
    Sprache Englisch
    Erscheinungsdatum 2019-03-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 209876-3
    ISSN 2162-5514 ; 0074-7742
    ISSN (online) 2162-5514
    ISSN 0074-7742
    DOI 10.1016/bs.irn.2019.03.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Hippocampal versus cortical deletion of cholinergic receptor muscarinic 1 in mice differentially affects post-translational modifications and supramolecular assembly of respiratory chain-associated proteins, mitochondrial ultrastructure, and respiration: implications in Alzheimer's disease.

    Sabbir, Mohammad Golam / Swanson, Mamiko / Speth, Robert C / Albensi, Benedict C

    Frontiers in cell and developmental biology

    2023  Band 11, Seite(n) 1179252

    Abstract: Introduction: ...

    Abstract Introduction:
    Sprache Englisch
    Erscheinungsdatum 2023-05-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1179252
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Loss of cholinergic receptor muscarinic 1 impairs cortical mitochondrial structure and function

    Mohammad Golam Sabbir / Mamiko Swanson / Benedict C. Albensi

    Frontiers in Cell and Developmental Biology, Vol

    implications in Alzheimer’s disease

    2023  Band 11

    Abstract: Introduction: Cholinergic Receptor Muscarinic 1 (CHRM1) is a G protein-coupled acetylcholine (ACh) receptor predominantly expressed in the cerebral cortex. In a retrospective postmortem brain tissues-based study, we demonstrated that severely (≥50% ... ...

    Abstract Introduction: Cholinergic Receptor Muscarinic 1 (CHRM1) is a G protein-coupled acetylcholine (ACh) receptor predominantly expressed in the cerebral cortex. In a retrospective postmortem brain tissues-based study, we demonstrated that severely (≥50% decrease) reduced CHRM1 proteins in the temporal cortex of Alzheimer’s patients significantly correlated with poor patient outcomes. The G protein-mediated CHRM1 signal transduction cannot sufficiently explain the mechanistic link between cortical CHRM1 loss and the appearance of hallmark Alzheimer’s pathophysiologies, particularly mitochondrial structural and functional abnormalities. Therefore, the objective of this study was to analyze the molecular, ultrastructural, and functional properties of cortical mitochondria using CHRM1 knockout (Chrm1-/-) and wild-type mice to identify mitochondrial abnormalities.Methods: Isolated and enriched cortical mitochondrial fractions derived from wild-type and Chrm1-/- mice were assessed for respiratory deficits (oxygen consumption) following the addition of different substrates. The supramolecular assembly of mitochondrial oxidative phosphorylation (OXPHOS)-associated protein complexes (complex I-V) and cortical mitochondrial ultrastructure were investigated by blue native polyacrylamide gel electrophoresis and transmission electron microscopy (TEM), respectively. A cocktail of antibodies, specific to Ndufb8, Sdhb, Uqcrc2, Mtco1, and Atp5a proteins representing different subunits of complexes I-V, respectively was used to characterize different OXPHOS-associated protein complexes.Results: Loss of Chrm1 led to a significant reduction in cortical mitochondrial respiration (oxygen consumption) concomitantly associated with reduced oligomerization of ATP synthase (complex V) and supramolecular assembly of complexes I-IV (Respirasome). Overexpression of Chrm1 in transformed cells (lacking native Chrm1) significantly increased complex V oligomerization and respirasome assembly leading to enhanced respiration. TEM analysis revealed ...
    Schlagwörter cholinergic receptor muscarinic 1 ; mitochondria ; pyramidal neuron ; oligomerization ; Alzheimer’s disease ; respiration ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Neurocovid, Neuroinflammation, and Nuclear Factor-κB: The Role for Micronutrients.

    Adlimoghaddam, Aida / Albensi, Benedict C / Eiser, Arnold R

    Journal of integrative and complementary medicine

    2022  Band 28, Heft 12, Seite(n) 916–918

    Mesh-Begriff(e) Humans ; Micronutrients ; NF-kappa B/genetics ; Neuroinflammatory Diseases ; Research
    Chemische Substanzen Micronutrients ; NF-kappa B
    Sprache Englisch
    Erscheinungsdatum 2022-10-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2768-3613
    ISSN (online) 2768-3613
    DOI 10.1089/jicm.2022.0736
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  10. Artikel ; Online: Dementia-Friendly "Design": Impact on COVID-19 Death Rates in Long-Term Care Facilities Around the World.

    Olson, Nancy L / Albensi, Benedict C

    Journal of Alzheimer's disease : JAD

    2021  Band 81, Heft 2, Seite(n) 427–450

    Abstract: Persons with dementia (PWD) make up a large portion of the long-term care (LTC) population the world over. Before a global pandemic swept the world, governments and healthcare providers struggled with how to best care for this unique population. One of ... ...

    Abstract Persons with dementia (PWD) make up a large portion of the long-term care (LTC) population the world over. Before a global pandemic swept the world, governments and healthcare providers struggled with how to best care for this unique population. One of the greatest challenges is a PWD's tendency to "walk with purpose" and exhibit unsafe wayfinding and elopement, which places them at risk of falls and injury. Past solutions included increased use of restraints and pharmacological interventions, but these have fallen out of favor over the years and are not optimal. These challenges put enormous strain on staff and caregivers, who are often poorly trained in dementia care, underpaid, overworked, and overstressed. PWD are impacted by these stresses, and unmet needs in LTC places an even greater stress on them and increases their risks of morbidity and mortality. The physical design of their environments contributes to the problem. Old, institutionalized buildings have poor lighting, poor ventilation, long dead-end hallways, poor visual cues, lack of home-like décor, shared bedrooms and bathrooms, and are often dense and overcrowded. These design elements contribute to the four 'A's' of dementia: apathy, anxiety, agitation, and aggression, and they also contributed to the rapid spread of COVID-19 in these facilities the world over. In this review, we present current "dementia friendly" design models in the home, community, and LTC, and argue how they could have saved lives during the pandemic and reduced the stresses on both the dementia resident and the caregiver/staff.
    Mesh-Begriff(e) COVID-19 ; Dementia/therapy ; Environment Design ; Health Services Needs and Demand ; Humans ; Long-Term Care ; Pandemics ; Quality of Life
    Sprache Englisch
    Erscheinungsdatum 2021-04-02
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-210017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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