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  1. Book ; Thesis: Clinical and genetic findings after therapy of head and neck paragangliomas

    Luths, Charlotte / Gudziol, Volker / Eisenhofer, Graeme

    = Klinische und genetische Befunde nach Therapie von Kopf-Hals-Paragangliomen

    2021  

    Title variant Klinische und genetische Befunde nach Therapie von Kopf-Hals-Paragangliomen
    Institution Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde
    Author's details von Charlotte Luths aus Lüneburg ; Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde [Dresden]
    Language English
    Size 95 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2022
    HBZ-ID HT030032040
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 866 order for loan Magazin

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  2. Article ; Online: New Way Forward for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Tumors with an LC-MS/MS Panel of Indole Biomarkers.

    Eisenhofer, Graeme

    Clinical chemistry

    2019  Volume 65, Issue 11, Page(s) 1346–1347

    MeSH term(s) Biomarkers ; Chromatography, Liquid ; Humans ; Indoles ; Neuroendocrine Tumors ; Pancreatic Neoplasms ; Platelet-Rich Plasma ; Tandem Mass Spectrometry
    Chemical Substances Biomarkers ; Indoles
    Language English
    Publishing date 2019-09-30
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2019.311456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; Thesis: Catecholamine metabolism in pheochromocytomas/paragangliomas due to pathogenic variants in HRAS and its association with clinical practice

    Li, Minghao [Verfasser] / Eisenhofer, Graeme [Gutachter] / Poitz, David [Gutachter]

    2024  

    Author's details Minghao Li ; Gutachter: Graeme Eisenhofer, David Poitz
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Technische Universität Dresden
    Publishing place Dresden
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article ; Online: Is predicting metastatic phaeochromocytoma and paraganglioma still effective without methoxytyramine? - Authors' reply.

    Pamporaki, Christina / Filippatos, Angelos / Eisenhofer, Graeme

    The Lancet. Digital health

    2023  Volume 6, Issue 3, Page(s) e155

    MeSH term(s) Humans ; Pheochromocytoma/pathology ; Pheochromocytoma/secondary ; Paraganglioma/pathology ; Dopamine/analogs & derivatives ; Adrenal Gland Neoplasms/pathology
    Chemical Substances 3-methoxytyramine (JCH2767EDP) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Letter
    ISSN 2589-7500
    ISSN (online) 2589-7500
    DOI 10.1016/S2589-7500(24)00018-9
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  5. Article: HIF and MYC signaling in adrenal neoplasms of the neural crest: implications for pediatrics.

    Bechmann, Nicole / Westermann, Frank / Eisenhofer, Graeme

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1022192

    Abstract: Pediatric neural crest-derived adrenal neoplasms include neuroblastoma and pheochromocytoma. Both entities are associated with a high degree of clinical heterogeneity, varying from spontaneous regression to malignant disease with poor outcome. Increased ... ...

    Abstract Pediatric neural crest-derived adrenal neoplasms include neuroblastoma and pheochromocytoma. Both entities are associated with a high degree of clinical heterogeneity, varying from spontaneous regression to malignant disease with poor outcome. Increased expression and stabilization of HIF2α appears to contribute to a more aggressive and undifferentiated phenotype in both adrenal neoplasms, whereas
    MeSH term(s) Humans ; Child ; Proto-Oncogene Proteins c-myc/metabolism ; Neural Crest/metabolism ; Neural Crest/pathology ; Signal Transduction/genetics ; Adrenal Gland Neoplasms/metabolism ; Neuroblastoma/metabolism ; Carcinogenesis/metabolism
    Chemical Substances Proto-Oncogene Proteins c-myc
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1022192
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  6. Article ; Online: Norepinephrine reuptake blockade to treat neurogenic orthostatic hypotension.

    Eisenhofer, Graeme / Goldstein, David S

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2021  Volume 31, Issue 3, Page(s) 351–353

    MeSH term(s) Blood Pressure ; Droxidopa/therapeutic use ; Humans ; Hypotension, Orthostatic/drug therapy
    Chemical Substances Droxidopa (J7A92W69L7)
    Language English
    Publishing date 2021-05-11
    Publishing country Germany
    Document type Editorial ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-021-00808-3
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    Zs.A 3270: Show issues Location:
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  7. Article ; Online: Biochemical Assessment of Pheochromocytoma and Paraganglioma.

    Eisenhofer, Graeme / Pamporaki, Christina / Lenders, Jacques W M

    Endocrine reviews

    2023  Volume 44, Issue 5, Page(s) 862–909

    Abstract: Pheochromocytoma and paraganglioma (PPGL) require prompt consideration and efficient diagnosis and treatment to minimize associated morbidity and mortality. Once considered, appropriate biochemical testing is key to diagnosis. Advances in understanding ... ...

    Abstract Pheochromocytoma and paraganglioma (PPGL) require prompt consideration and efficient diagnosis and treatment to minimize associated morbidity and mortality. Once considered, appropriate biochemical testing is key to diagnosis. Advances in understanding catecholamine metabolism have clarified why measurements of the O-methylated catecholamine metabolites rather than the catecholamines themselves are important for effective diagnosis. These metabolites, normetanephrine and metanephrine, produced respectively from norepinephrine and epinephrine, can be measured in plasma or urine, with choice according to available methods or presentation of patients. For patients with signs and symptoms of catecholamine excess, either test will invariably establish the diagnosis, whereas the plasma test provides higher sensitivity than urinary metanephrines for patients screened due to an incidentaloma or genetic predisposition, particularly for small tumors or in patients with an asymptomatic presentation. Additional measurements of plasma methoxytyramine can be important for some tumors, such as paragangliomas, and for surveillance of patients at risk of metastatic disease. Avoidance of false-positive test results is best achieved by plasma measurements with appropriate reference intervals and preanalytical precautions, including sampling blood in the fully supine position. Follow-up of positive results, including optimization of preanalytics for repeat tests or whether to proceed directly to anatomic imaging or confirmatory clonidine tests, depends on the test results, which can also suggest likely size, adrenal vs extra-adrenal location, underlying biology, or even metastatic involvement of a suspected tumor. Modern biochemical testing now makes diagnosis of PPGL relatively simple. Integration of artificial intelligence into the process should make it possible to fine-tune these advances.
    MeSH term(s) Humans ; Pheochromocytoma/diagnosis ; Pheochromocytoma/pathology ; Artificial Intelligence ; Paraganglioma/diagnosis ; Paraganglioma/pathology ; Metanephrine/urine ; Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/pathology
    Chemical Substances Metanephrine (5001-33-2)
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603096-8
    ISSN 1945-7189 ; 0163-769X
    ISSN (online) 1945-7189
    ISSN 0163-769X
    DOI 10.1210/endrev/bnad011
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    Zs.A 1562: Show issues Location:
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  8. Article ; Online: Hypoxia-inducible Factor 2α: A Key Player in Tumorigenesis and Metastasis of Pheochromocytoma and Paraganglioma?

    Bechmann, Nicole / Eisenhofer, Graeme

    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

    2021  Volume 130, Issue 5, Page(s) 282–289

    Abstract: Germline or somatic driver mutations linked to specific phenotypic features are identified in approximately 70% of all catecholamine-producing pheochromocytomas and paragangliomas (PPGLs). Mutations leading to stabilization of hypoxia-inducible factor 2α ...

    Abstract Germline or somatic driver mutations linked to specific phenotypic features are identified in approximately 70% of all catecholamine-producing pheochromocytomas and paragangliomas (PPGLs). Mutations leading to stabilization of hypoxia-inducible factor 2α (HIF2α) and downstream pseudohypoxic signaling are associated with a higher risk of metastatic disease. Patients with metastatic PPGLs have a variable prognosis and treatment options are limited. In most patients with PPGLs, germline mutations lead to the stabilization of HIF2α. Mutations in
    MeSH term(s) Adrenal Gland Neoplasms/metabolism ; Carcinogenesis ; Catecholamines/metabolism ; Catecholamines/therapeutic use ; Humans ; Hypoxia ; Paraganglioma/genetics ; Paraganglioma/metabolism ; Paraganglioma/pathology ; Pheochromocytoma/metabolism
    Chemical Substances Catecholamines
    Language English
    Publishing date 2021-07-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1225416-2
    ISSN 1439-3646 ; 0947-7349
    ISSN (online) 1439-3646
    ISSN 0947-7349
    DOI 10.1055/a-1526-5263
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  9. Article ; Online: Commentary on Cryptogenic Cushing Syndrome Due to a White Lie.

    Eisenhofer, Graeme / Constantinescu, Georgiana

    Clinical chemistry

    2020  Volume 66, Issue 5, Page(s) 661–662

    MeSH term(s) Cushing Syndrome/complications ; Cushing Syndrome/diagnosis ; Humans
    Language English
    Publishing date 2020-04-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvaa036
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  10. Article ; Online: Blood sampling for metanephrines: to stick or stick and wait?

    Eisenhofer, Graeme / Pamporaki, Christina

    Clinical chemistry and laboratory medicine

    2020  Volume 58, Issue 10, Page(s) 1609–1610

    MeSH term(s) Blood Specimen Collection ; Cannula ; Healthy Volunteers ; Humans ; Metanephrine ; Phlebotomy
    Chemical Substances Metanephrine (5001-33-2)
    Language English
    Publishing date 2020-04-28
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2020-0326
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