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  1. Article ; Online: Does the money matter? Disparities in total joint replacement outcomes by income.

    Singh, Jasvinder A

    Osteoarthritis and cartilage

    2023  Volume 32, Issue 2, Page(s) 121–123

    MeSH term(s) Arthroplasty, Replacement ; Income
    Language English
    Publishing date 2023-11-07
    Publishing country England
    Document type Editorial
    ZDB-ID 1167809-4
    ISSN 1522-9653 ; 1063-4584
    ISSN (online) 1522-9653
    ISSN 1063-4584
    DOI 10.1016/j.joca.2023.11.001
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    Zs.A 3828: Show issues Location:
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  2. Article ; Online: The Emerging Safety Profile of JAK Inhibitors in Rheumatic Diseases.

    Singh, Jasvinder A

    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

    2023  Volume 37, Issue 5, Page(s) 625–635

    Abstract: Janus kinase inhibitor (JAKi) medications are small-molecule drugs that affect intracellular signal transduction. They are highly effective oral medications that have been approved for the treatment of various rheumatic diseases, with rheumatoid ... ...

    Abstract Janus kinase inhibitor (JAKi) medications are small-molecule drugs that affect intracellular signal transduction. They are highly effective oral medications that have been approved for the treatment of various rheumatic diseases, with rheumatoid arthritis being a key example of an autoimmune rheumatic disease. JAKi are oral-route medications that are alternatives to injectable biologic therapies, launched in the late 1990s. While most safety concerns with JAKi are similar to the biologics, there are many differences. New data on comparative safety of JAKi versus tumor necrosis factor inhibitors (TNFi) were recently published that led to new black box warnings by the US Food and Drug Administration (FDA) about cardiovascular and cancer risks and a label change for JAKi. This review summarizes the current published data with regards to the safety of JAKi, focused on rheumatic diseases. Specifically, any risk differences between agents or across different indications are discussed, as well as the risk factors for these adverse outcomes.
    MeSH term(s) Humans ; Janus Kinase Inhibitors/adverse effects ; Rheumatic Diseases/drug therapy ; Rheumatic Diseases/chemically induced ; Arthritis, Rheumatoid/drug therapy ; Biological Products/therapeutic use ; Administration, Oral ; Antirheumatic Agents/adverse effects
    Chemical Substances Janus Kinase Inhibitors ; Biological Products ; Antirheumatic Agents
    Language English
    Publishing date 2023-06-23
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1364202-9
    ISSN 1179-190X ; 1173-8804
    ISSN (online) 1179-190X
    ISSN 1173-8804
    DOI 10.1007/s40259-023-00612-7
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  3. Article ; Online: Making the current non-surgical treatments for knee osteoarthritis more effective: Solutions from a diverse patient group.

    Singh, Jasvinder A

    Joint bone spine

    2023  Volume 90, Issue 3, Page(s) 105535

    Abstract: Objective: To examine patient perceived solutions to barriers to effective non-surgical knee osteoarthritis (OA) treatments in a diverse racial/ethnic group.: Methods: Nominal groups were conducted with consecutive patients with knee OA at a medical ... ...

    Abstract Objective: To examine patient perceived solutions to barriers to effective non-surgical knee osteoarthritis (OA) treatments in a diverse racial/ethnic group.
    Methods: Nominal groups were conducted with consecutive patients with knee OA at a medical center clinic, oversampling for African Americans with knee OA. Participants discussed potential solutions and rank-ordered their concerns.
    Results: Thirteen nominal groups with 46 knee OA patients were conducted with mean age, 60.8 years (standard deviation [sd], 10.0) and knee OA duration, 8.1 years (sd, 5.4); 22% were men, and 56% were African American. The following solutions were in the top three ranked solutions in 13 NGTs: (A) more research, effective and/or safer new medications/treatments, and joint cartilage restoration (8 groups; 15% votes [43/276]); (B) early diagnosis (2 groups; 7% votes [20/276]); (C) better and more effective communication (5 groups; 10% votes [29/276]); (D) public and patient education (4 groups; 8% votes [22/276]); (E) motivation and behavioral modification (4 groups; 9% votes [26/276]); (F) team approach (1 group; 1% votes [2/276]); (G) personalized medicine (6 groups; 8% votes [24/276]); (H) cheaper and more affordable medications and treatments (3 groups; 5% votes [15/276]).
    Conclusions: A diverse group of participants with knee OA identified several solutions to barriers to the effectiveness of current knee OA treatments. This new knowledge can inform the development and implementation of future interventions to improve the outcomes of people with knee OA.
    MeSH term(s) Male ; Humans ; Middle Aged ; Female ; Osteoarthritis, Knee/diagnosis ; Osteoarthritis, Knee/therapy ; Exercise Therapy ; Treatment Outcome
    Language English
    Publishing date 2023-01-25
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2023.105535
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  4. Article ; Online: Risks and Benefits of Janus Kinase Inhibitors in Rheumatoid Arthritis - Past, Present, and Future.

    Singh, Jasvinder A

    The New England journal of medicine

    2022  Volume 386, Issue 4, Page(s) 387–389

    MeSH term(s) Antirheumatic Agents/adverse effects ; Arthritis, Rheumatoid/drug therapy ; Humans ; Janus Kinase Inhibitors/adverse effects ; Risk Assessment
    Chemical Substances Antirheumatic Agents ; Janus Kinase Inhibitors
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2117663
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  5. Article ; Online: Treatment Guidelines in Rheumatoid Arthritis.

    Singh, Jasvinder A

    Rheumatic diseases clinics of North America

    2022  Volume 48, Issue 3, Page(s) 679–689

    Abstract: Rheumatoid arthritis is the most common autoimmune, destructive, inflammatory arthritis in adults. Effective treatments include oral conventional synthetic disease-modifying antirheumatic drugs (DMARDs; eg, methotrexate), injectable biologic DMARDs, and ... ...

    Abstract Rheumatoid arthritis is the most common autoimmune, destructive, inflammatory arthritis in adults. Effective treatments include oral conventional synthetic disease-modifying antirheumatic drugs (DMARDs; eg, methotrexate), injectable biologic DMARDs, and targeted synthetic DMARDs (oral). Key recommendations are to start effective treatment immediately with DMARDs to reduce disability; use effective doses of methotrexate (oral or subcutaneous) with folic acid as the initial treatment; rapidly escalate treatment with various DMARDs, if methotrexate alone is not effective in controlling rheumatoid arthritis; and aim for a treat-to-target strategy with a goal of low disease activity or remission by frequently monitoring disease activity and escalating treatment.
    MeSH term(s) Adult ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Drug Therapy, Combination ; Humans ; Methotrexate/therapeutic use ; Treatment Outcome
    Chemical Substances Antirheumatic Agents ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2022.03.005
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  6. Article ; Online: Cardiovascular safety of febuxostat.

    Singh, Jasvinder A

    Lancet (London, England)

    2021  Volume 398, Issue 10304, Page(s) 955

    MeSH term(s) Febuxostat/adverse effects ; Gout/drug therapy ; Gout Suppressants/adverse effects ; Humans
    Chemical Substances Gout Suppressants ; Febuxostat (101V0R1N2E)
    Language English
    Publishing date 2021-09-03
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)01386-6
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  7. Article ; Online: Driving Impairment Following Vaporization of Cannabis.

    Singh, Jasvinder A

    JAMA

    2021  Volume 325, Issue 12, Page(s) 1226

    MeSH term(s) Automobile Driving ; Cannabidiol ; Cannabis/adverse effects ; Dronabinol ; Marijuana Smoking ; Volatilization
    Chemical Substances Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S)
    Language English
    Publishing date 2021-03-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.0445
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  8. Article ; Online: In-hospital mortality reduction in systemic lupus erythematosus over 2 decades varied by patient sex and age.

    Singh, Jasvinder A

    Clinical rheumatology

    2021  Volume 40, Issue 3, Page(s) 1201–1203

    MeSH term(s) Hospital Mortality ; Humans ; Lupus Erythematosus, Systemic
    Language English
    Publishing date 2021-01-04
    Publishing country Germany
    Document type Letter
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-020-05563-w
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  9. Article ; Online: Disease modification in gout: a qualitative study of gout expert rheumatologists.

    Singh, Jasvinder A

    Rheumatology advances in practice

    2022  Volume 6, Issue 1, Page(s) rkab107

    Abstract: Objective: The aim was to examine the views of health-care providers regarding disease modification in gout, with the potential to derive a provisional set of domains for disease modification in gout.: Methods: A qualitative nominal group study was ... ...

    Abstract Objective: The aim was to examine the views of health-care providers regarding disease modification in gout, with the potential to derive a provisional set of domains for disease modification in gout.
    Methods: A qualitative nominal group study was performed with 20 gout experts (15 expert/expert panel members of the 2012 and/or 2020 ACR gout guidelines and/or 2015 ACR/EULAR gout classification criteria) about what constitutes disease modification in gout: 'What sorts of things do you think constitute a change in the course of disease in gout? (positive); what are all the ways in which gout as a disease can be modified?'
    Results: Decrease in gout flares was rated number one rank in all six nominal groups as indicative of disease modification in gout, followed by serum urate lowering, which was rated number one rank in one of the six nominal groups (tied score with flares in one nominal group). Other components of gout disease modification were to improve quality of life/productivity; restore function; reduce/eliminate pain; reduce tophi burden; and joint preservation or resolution of joint damage. Potential additional components that were not ranked in the top three votes within each nominal group were: decreasing health-care cost/utilization; reducing cardiovascular/renal morbidity/mortality; and stopping formation of urate crystals.
    Conclusion: This qualitative study provides a provisional set of domains for disease modification in gout. Future studies for the development of thresholds for disease modification domains and wider consensus on this definition are needed.
    Language English
    Publishing date 2022-01-03
    Publishing country England
    Document type Journal Article
    ISSN 2514-1775
    ISSN (online) 2514-1775
    DOI 10.1093/rap/rkab107
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  10. Article ; Online: Letter to the editor: Cocaine use and cocaine use disorder: Revisiting epidemiology and clinical impact.

    Singh, Jasvinder A

    Journal of psychiatric research

    2021  Volume 143, Page(s) 467–468

    MeSH term(s) Cocaine/adverse effects ; Cocaine-Related Disorders/epidemiology ; Humans ; Substance-Related Disorders
    Chemical Substances Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2021-06-02
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2021.05.083
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