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Article ; Online: Editorial: increasing IBD prevalence and its complications in the context of the COVID-19 pandemic. Authors' reply.

King, Dominic Stephen / Trudgill, Nigel John / Adderley, Nicola J

2020 Volume 51, Issue 12, Page(s) 1442–1443

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Inflammatory Bowel Diseases ; Pandemics ; Pneumonia, Viral ; Prevalence ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-14
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.15769
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Article: Editorial: increasing IBD prevalence and its complications in the context of the COVID-19 pandemic. Authors' reply

King, Dominic Stephen / Trudgill, Nigel John / Adderley, Nicola J

Aliment Pharmacol Ther

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #260367
Database	COVID19

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Article ; Online: Editorial

King, Dominic Stephen / Trudgill, Nigel John / Adderley, Nicola J.

Alimentary Pharmacology & Therapeutics

increasing IBD prevalence and its complications in the context of the COVID-19 pandemic. Authors' reply

2020 Volume 51, Issue 12, Page(s) 1442–1443

Keywords	Pharmacology (medical) ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.15769
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The risk of subsequent surgery following bowel resection for Crohn's disease in a national cohort of 19 207 patients.

King, Dominic / Coupland, Benjamin / Dosanjh, Amandeep / Cole, Andrew / Ward, Stephen / Reulen, Raoul C / Adderley, Nicola J / Patel, Prashant / Trudgill, Nigel

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2022 Volume 25, Issue 1, Page(s) 83–94

Abstract: Aim: Surgery is required for most patients with Crohn's disease (CD) and further surgery may be necessary if medical treatment fails to control disease activity. The aim of this study was to characterize the risk of, and factors associated with, further ...

Abstract	Aim: Surgery is required for most patients with Crohn's disease (CD) and further surgery may be necessary if medical treatment fails to control disease activity. The aim of this study was to characterize the risk of, and factors associated with, further surgery following a first resection for Crohn's disease. Methods: Hospital Episode Statistics from England were examined to identify patients with CD and a first recorded bowel resection between 2007 and 2016. Multivariable logistic regression was used to examine risk factors for further resectional surgery within 5 years. Prevalence-adjusted surgical rates for index CD surgery over the study period were calculated. Results: In total, 19 207 patients (median age 39 years, interquartile range 27-53 years; 55% women) with CD underwent a first recorded resection during the study period. 3141 (16%) underwent a further operation during the study period. The median time to further surgery was 2.4 (interquartile range 1.2-4.6) years. 3% of CD patients had further surgery within 1 year, 14% by 5 years and 23% by 10 years. Older age (≥58), index laparoscopic surgery and index elective surgery (adjusted OR 0.65, 95% CI 0.54-0.77; 0.77, 0.67-0.88; and 0.77, 0.69-0.85; respectively) were associated with a reduced risk of further surgery by 5 years. Prior surgery for perianal disease (1.60, 1.37-1.87), an extraintestinal manifestation of CD (1.51, 1.22-1.86) and index surgery in a high-volume centre for CD surgery (1.20, 1.02-1.40) were associated with an increased risk of further surgery by 5 years. A 25% relative and 0.3% absolute reduction in prevalence-adjusted index surgery rates for CD was observed over the study period. Conclusions: Further surgery following an index operation is common in CD. This risk was particularly seen in patients with perianal disease, extraintestinal manifestations and those who underwent index surgery in a high-volume centre.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Male ; Crohn Disease/epidemiology ; Crohn Disease/surgery ; Crohn Disease/complications ; Digestive System Surgical Procedures/adverse effects ; Risk Factors ; Laparoscopy/adverse effects ; England/epidemiology
Language	English
Publishing date	2022-10-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.16331
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Article ; Online: Effectiveness of laparoscopic removal of isolated superficial peritoneal endometriosis for the management of chronic pelvic pain in women (ESPriT2): protocol for a multi-centre randomised controlled trial.

Mackenzie, Scott C / Stephen, Jacqueline / Williams, Linda / Daniels, Jane / Norrie, John / Becker, Christian M / Byrne, Dominic / Cheong, Ying / Clark, T Justin / Cooper, Kevin G / Cox, Emma / Doust, Ann M / Fernandez, Priscilla / Hawe, Jeremy / Holland, Tom / Hummelshoj, Lone / Jackson, Louise J / King, Kathleen / Maheshwari, Abha /

Martin, Dan C / Sutherland, Lauren / Thornton, Jim / Vincent, Katy / Vyas, Sanjay / Horne, Andrew W / Whitaker, Lucy H R

Trials

2023 Volume 24, Issue 1, Page(s) 425

Abstract: Background: Endometriosis affects 190 million women and those assigned female at birth worldwide. For some, it is associated with debilitating chronic pelvic pain. Diagnosis of endometriosis is often achieved through diagnostic laparoscopy. However, ... ...

Abstract	Background: Endometriosis affects 190 million women and those assigned female at birth worldwide. For some, it is associated with debilitating chronic pelvic pain. Diagnosis of endometriosis is often achieved through diagnostic laparoscopy. However, when isolated superficial peritoneal endometriosis (SPE), the most common endometriosis subtype, is identified during laparoscopy, limited evidence exists to support the common decision to surgically remove it via excision or ablation. Improved understanding of the impact of surgical removal of isolated SPE for the management of chronic pelvic pain in women is required. Here, we describe our protocol for a multi-centre trial to determine the effectiveness of surgical removal of isolated SPE for the management of endometriosis-associated pain. Methods: We plan to undertake a multi-centre participant-blind parallel-group randomised controlled clinical and cost-effectiveness trial with internal pilot. We plan to randomise 400 participants from up to 70 National Health Service Hospitals in the UK. Participants with chronic pelvic pain awaiting diagnostic laparoscopy for suspected endometriosis will be consented by the clinical research team. If isolated SPE is identified at laparoscopy, and deep or ovarian endometriosis is not seen, participants will be randomised intraoperatively (1:1) to surgical removal (by excision or ablation or both, according to surgeons' preference) versus diagnostic laparoscopy alone. Randomisation with block-stratification will be used. Participants will be given a diagnosis but will not be informed of the procedure they received until 12 months post-randomisation, unless required. Post-operative medical treatment will be according to participants' preference. Participants will be asked to complete validated pain and quality of life questionnaires at 3, 6 and 12 months after randomisation. Our primary outcome is the pain domain of the Endometriosis Health Profile-30 (EHP-30), via a between randomised group comparison of adjusted means at 12 months. Assuming a standard deviation of 22 points around the pain score, 90% power, 5% significance and 20% missing data, 400 participants are required to be randomised to detect an 8-point pain score difference. Discussion: This trial aims to provide high quality evidence of the clinical and cost-effectiveness of surgical removal of isolated SPE. Trial registration: ISRCTN registry ISRCTN27244948. Registered 6 April 2021.
MeSH term(s)	Female ; Humans ; Chronic Pain/diagnosis ; Chronic Pain/etiology ; Chronic Pain/surgery ; Endometriosis/complications ; Endometriosis/diagnosis ; Endometriosis/surgery ; Laparoscopy/methods ; Multicenter Studies as Topic ; Pelvic Pain/diagnosis ; Pelvic Pain/etiology ; Pelvic Pain/surgery ; Quality of Life ; Randomized Controlled Trials as Topic ; State Medicine
Language	English
Publishing date	2023-06-22
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-023-07386-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The daily association between affect and alcohol use: A meta-analysis of individual participant data.

Dora, Jonas / Piccirillo, Marilyn / Foster, Katherine T / Arbeau, Kelly / Armeli, Stephen / Auriacombe, Marc / Bartholow, Bruce / Beltz, Adriene M / Blumenstock, Shari M / Bold, Krysten / Bonar, Erin E / Braitman, Abby / Carpenter, Ryan W / Creswell, Kasey G / De Hart, Tracy / Dvorak, Robert D / Emery, Noah / Enkema, Matthew / Fairbairn, Catharine /

Fairlie, Anne M / Ferguson, Stuart G / Freire, Teresa / Goodman, Fallon / Gottfredson, Nisha / Halvorson, Max / Haroon, Maleeha / Howard, Andrea L / Hussong, Andrea / Jackson, Kristina M / Jenzer, Tiffany / Kelly, Dominic P / Kuczynski, Adam M / Kuerbis, Alexis / Lee, Christine M / Lewis, Melissa / Linden-Carmichael, Ashley N / Littlefield, Andrew / Lydon-Staley, David M / Merrill, Jennifer E / Miranda, Robert / Mohr, Cynthia / Read, Jennifer P / Richardson, Clarissa / O'Connor, Roisin / O'Malley, Stephanie S / Papp, Lauren / Piasecki, Thomas M / Sacco, Paul / Scaglione, Nichole / Serre, Fuschia / Shadur, Julia / Sher, Kenneth J / Shoda, Yuichi / Simpson, Tracy L / Smith, Michele R / Stevens, Angela / Stevenson, Brittany / Tennen, Howard / Todd, Michael / Treloar Padovano, Hayley / Trull, Timothy / Waddell, Jack / Walukevich-Dienst, Katherine / Witkiewitz, Katie / Wray, Tyler / Wright, Aidan G C / Wycoff, Andrea M / King, Kevin M

Psychological bulletin

2024 Volume 149, Issue 1-2, Page(s) 1–24

Abstract: Influential psychological theories hypothesize that people consume alcohol in response to the experience of both negative and positive emotions. Despite two decades of daily diary and ecological momentary assessment research, it remains unclear whether ... ...

Abstract	Influential psychological theories hypothesize that people consume alcohol in response to the experience of both negative and positive emotions. Despite two decades of daily diary and ecological momentary assessment research, it remains unclear whether people consume more alcohol on days they experience higher negative and positive affect in everyday life. In this preregistered meta-analysis, we synthesized the evidence for these daily associations between affect and alcohol use. We included individual participant data from 69 studies (
MeSH term(s)	Humans ; Affect/physiology ; Alcohol Drinking/epidemiology ; Alcohol Drinking/psychology ; Motivation ; Ecological Momentary Assessment ; Surveys and Questionnaires
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	1321-3
ISSN	1939-1455 ; 0033-2909
ISSN (online)	1939-1455
ISSN	0033-2909
DOI	10.1037/bul0000387
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Zs.A 1403: Show issues

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Article ; Online: Transformation from a traditional model to a virtual model of care in orthopaedic surgery: COVID-19 experience and beyond.

King, Dominic / Emara, Ahmed K / Ng, Mitchell K / Evans, Peter J / Estes, Kelly / Spindler, Kurt P / Mroz, Thomas / Patterson, Brendan M / Krebs, Viktor E / Pinney, Stephen / Piuzzi, Nicolas S / Schaffer, Jonathan L

Bone & joint open

2020 Volume 1, Issue 6, Page(s) 272–280

Abstract: Virtual encounters have experienced an exponential rise amid the current COVID-19 crisis. This abrupt change, seen in response to unprecedented medical and environmental challenges, has been forced upon the orthopaedic community. However, such changes to ...

Abstract	Virtual encounters have experienced an exponential rise amid the current COVID-19 crisis. This abrupt change, seen in response to unprecedented medical and environmental challenges, has been forced upon the orthopaedic community. However, such changes to adopting virtual care and technology were already in the evolution forecast, albeit in an unpredictable timetable impeded by regulatory and financial barriers. This adoption is not meant to replace, but rather augment established, traditional models of care while ensuring patient/provider safety, especially during the pandemic. While our department, like those of other institutions, has performed virtual care for several years, it represented a small fraction of daily care. The pandemic required an accelerated and comprehensive approach to the new reality. Contemporary literature has already shown equivalent safety and patient satisfaction, as well as superior efficiency and reduced expenses with musculoskeletal virtual care (MSKVC) versus traditional models. Nevertheless, current literature detailing operational models of MSKVC is scarce. The current review describes our pre-pandemic MSKVC model and the shift to a MSKVC pandemic workflow that enumerates the conceptual workflow organization (patient triage, from timely care provision based on symptom acuity/severity to a continuum that includes future follow-up). Furthermore, specific setup requirements (both resource/personnel requirements such as hardware, software, and network connectivity requirements, and patient/provider characteristics respectively), and professional expectations are outlined. MSKVC has already become a pivotal element of musculoskeletal care, due to COVID-19, and these changes are confidently here to stay. Readiness to adapt and evolve will be required of individual musculoskeletal clinical teams as well as organizations, as established paradigms evolve. Cite this article:
Keywords	covid19
Language	English
Publishing date	2020-11-01
Publishing country	England
Document type	Journal Article
ISSN	2633-1462
ISSN (online)	2633-1462
DOI	10.1302/2046-3758.16.BJO-2020-0063.R1
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Article ; Online: Effectiveness of laparoscopic removal of isolated superficial peritoneal endometriosis for the management of chronic pelvic pain in women (ESPriT2)

Scott C. Mackenzie / Jacqueline Stephen / Linda Williams / Jane Daniels / John Norrie / Christian M. Becker / Dominic Byrne / Ying Cheong / T. Justin Clark / Kevin G. Cooper / Emma Cox / Ann M. Doust / Priscilla Fernandez / Jeremy Hawe / Tom Holland / Lone Hummelshoj / Louise J. Jackson / Kathleen King / Abha Maheshwari /

Dan C. Martin / Lauren Sutherland / Jim Thornton / Katy Vincent / Sanjay Vyas / Andrew W. Horne / Lucy H. R. Whitaker

Trials, Vol 24, Iss 1, Pp 1-

protocol for a multi-centre randomised controlled trial

2023 Volume 15

Abstract: Abstract Background Endometriosis affects 190 million women and those assigned female at birth worldwide. For some, it is associated with debilitating chronic pelvic pain. Diagnosis of endometriosis is often achieved through diagnostic laparoscopy. ... ...

Abstract	Abstract Background Endometriosis affects 190 million women and those assigned female at birth worldwide. For some, it is associated with debilitating chronic pelvic pain. Diagnosis of endometriosis is often achieved through diagnostic laparoscopy. However, when isolated superficial peritoneal endometriosis (SPE), the most common endometriosis subtype, is identified during laparoscopy, limited evidence exists to support the common decision to surgically remove it via excision or ablation. Improved understanding of the impact of surgical removal of isolated SPE for the management of chronic pelvic pain in women is required. Here, we describe our protocol for a multi-centre trial to determine the effectiveness of surgical removal of isolated SPE for the management of endometriosis-associated pain. Methods We plan to undertake a multi-centre participant-blind parallel-group randomised controlled clinical and cost-effectiveness trial with internal pilot. We plan to randomise 400 participants from up to 70 National Health Service Hospitals in the UK. Participants with chronic pelvic pain awaiting diagnostic laparoscopy for suspected endometriosis will be consented by the clinical research team. If isolated SPE is identified at laparoscopy, and deep or ovarian endometriosis is not seen, participants will be randomised intraoperatively (1:1) to surgical removal (by excision or ablation or both, according to surgeons’ preference) versus diagnostic laparoscopy alone. Randomisation with block-stratification will be used. Participants will be given a diagnosis but will not be informed of the procedure they received until 12 months post-randomisation, unless required. Post-operative medical treatment will be according to participants’ preference. Participants will be asked to complete validated pain and quality of life questionnaires at 3, 6 and 12 months after randomisation. Our primary outcome is the pain domain of the Endometriosis Health Profile-30 (EHP-30), via a between randomised group comparison of adjusted means at ...
Keywords	Endometriosis ; Pelvic pain ; Laparoscopy ; Surgical ablation ; Surgical excision ; Randomised controlled trial ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Implementation of a Digitally Enabled Care Pathway (Part 1): Impact on Clinical Outcomes and Associated Health Care Costs.

Journal of medical Internet research

2019 Volume 21, Issue 7, Page(s) e13147

Abstract: Background: The development of acute kidney injury (AKI) in hospitalized patients is associated with adverse outcomes and increased health care costs. Simple automated e-alerts indicating its presence do not appear to improve outcomes, perhaps because ... ...

Abstract	Background: The development of acute kidney injury (AKI) in hospitalized patients is associated with adverse outcomes and increased health care costs. Simple automated e-alerts indicating its presence do not appear to improve outcomes, perhaps because of a lack of explicitly defined integration with a clinical response. Objective: We sought to test this hypothesis by evaluating the impact of a digitally enabled intervention on clinical outcomes and health care costs associated with AKI in hospitalized patients. Methods: We developed a care pathway comprising automated AKI detection, mobile clinician notification, in-app triage, and a protocolized specialist clinical response. We evaluated its impact by comparing data from pre- and postimplementation phases (May 2016 to January 2017 and May to September 2017, respectively) at the intervention site and another site not receiving the intervention. Clinical outcomes were analyzed using segmented regression analysis. The primary outcome was recovery of renal function to ≤120% of baseline by hospital discharge. Secondary clinical outcomes were mortality within 30 days of alert, progression of AKI stage, transfer to renal/intensive care units, hospital re-admission within 30 days of discharge, dependence on renal replacement therapy 30 days after discharge, and hospital-wide cardiac arrest rate. Time taken for specialist review of AKI alerts was measured. Impact on health care costs as defined by Patient-Level Information and Costing System data was evaluated using difference-in-differences (DID) analysis. Results: The median time to AKI alert review by a specialist was 14.0 min (interquartile range 1.0-60.0 min). There was no impact on the primary outcome (estimated odds ratio [OR] 1.00, 95% CI 0.58-1.71; P=.99). Although the hospital-wide cardiac arrest rate fell significantly at the intervention site (OR 0.55, 95% CI 0.38-0.76; P<.001), DID analysis with the comparator site was not significant (OR 1.13, 95% CI 0.63-1.99; P=.69). There was no impact on other secondary clinical outcomes. Mean health care costs per patient were reduced by £2123 (95% CI -£4024 to -£222; P=.03), not including costs of providing the technology. Conclusions: The digitally enabled clinical intervention to detect and treat AKI in hospitalized patients reduced health care costs and possibly reduced cardiac arrest rates. Its impact on other clinical outcomes and identification of the active components of the pathway requires clarification through evaluation across multiple sites.
MeSH term(s)	Delivery of Health Care/economics ; Female ; Humans ; Male ; Telemedicine/methods ; Treatment Outcome
Language	English
Publishing date	2019-07-15
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1438-8871
ISSN (online)	1438-8871
ISSN	1438-8871
DOI	10.2196/13147
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Article: Service evaluation of the implementation of a digitally-enabled care pathway for the recognition and management of acute kidney injury.

Connell, Alistair / Montgomery, Hugh / Morris, Stephen / Nightingale, Claire / Stanley, Sarah / Emerson, Mary / Jones, Gareth / Sadeghi-Alavijeh, Omid / Merrick, Charles / King, Dominic / Karthikesalingam, Alan / Hughes, Cian / Ledsam, Joseph / Back, Trevor / Rees, Geraint / Raine, Rosalind / Laing, Christopher

F1000Research

2017 Volume 6, Page(s) 1033

Abstract: Acute Kidney Injury (AKI), an abrupt deterioration in kidney function, is defined by changes in urine output or serum creatinine. AKI is common (affecting up to 20% of acute hospital admissions in the United Kingdom), associated with significant ... ...

Abstract	Acute Kidney Injury (AKI), an abrupt deterioration in kidney function, is defined by changes in urine output or serum creatinine. AKI is common (affecting up to 20% of acute hospital admissions in the United Kingdom), associated with significant morbidity and mortality, and expensive (excess costs to the National Health Service in England alone may exceed £1 billion per year). NHS England has mandated the implementation of an automated algorithm to detect AKI based on changes in serum creatinine, and to alert clinicians. It is uncertain, however, whether 'alerting' alone improves care quality. We have thus developed a digitally-enabled care pathway as a clinical service to inpatients in the Royal Free Hospital (RFH), a large London hospital. This pathway incorporates a mobile software application - the "Streams-AKI" app, developed by DeepMind Health - that applies the NHS AKI algorithm to routinely collected serum creatinine data in hospital inpatients. Streams-AKI alerts clinicians to potential AKI cases, furnishing them with a trend view of kidney function alongside other relevant data, in real-time, on a mobile device. A clinical response team comprising nephrologists and critical care nurses responds to these AKI alerts by reviewing individual patients and administering interventions according to existing clinical practice guidelines. We propose a mixed methods service evaluation of the implementation of this care pathway. This evaluation will assess how the care pathway meets the health and care needs of service users (RFH inpatients), in terms of clinical outcome, processes of care, and NHS costs. It will also seek to assess acceptance of the pathway by members of the response team and wider hospital community. All analyses will be undertaken by the service evaluation team from UCL (Department of Applied Health Research) and St George's, University of London (Population Health Research Institute).
Language	English
Publishing date	2017
Publishing country	England
Document type	Journal Article
ZDB-ID	2699932-8
ISSN	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.11637.2
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