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  1. Book: Oxford desk reference critical care

    Waldmann, Carl / Rhodes, Andy / Soni, Neil / Handy, Jonathan M.

    (Oxford desk reference)

    2019  

    Title variant Critical care
    Author's details edited by Carl Waldmann, Andrew Rhodes, Neil Soni
    Series title Oxford desk reference
    Keywords Critical care medicine
    Language English
    Size 704 Seiten
    Edition Second edition
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    Note Zugang zur Online-Ausgabe über Code
    HBZ-ID HT020254180
    ISBN 978-0-19-872356-1 ; 0-19-872356-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 1563 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Article ; Online: Nutrition and gut health: the impact of specific dietary components - it's not just five-a-day.

    Rhodes, Jonathan M

    The Proceedings of the Nutrition Society

    2020  Volume 80, Issue 1, Page(s) 9–18

    Abstract: The health benefits of fruit, vegetables and dietary fibre have been promoted for many years. Much of the supporting evidence is circumstantial or even contradictory and mechanisms underlying health benefits of specific foods are poorly understood. ... ...

    Abstract The health benefits of fruit, vegetables and dietary fibre have been promoted for many years. Much of the supporting evidence is circumstantial or even contradictory and mechanisms underlying health benefits of specific foods are poorly understood. Colorectal cancer shows marked geographical differences in incidence, probably linked with diet, and explanations for this require knowledge of the complex interactions between diet, microbiota and the gut epithelium. Dietary fibres can act as prebiotics, encouraging growth of saccharolytic bacteria, but other mechanisms are also important. Some but not all soluble fibres have a 'contrabiotic' effect inhibiting bacterial adherence to the epithelium. This is particularly a property of pectins (galacturonans) whereas dietary fructans, previously regarded as beneficial prebiotics, can have a proinflammatory effect mediated via toxic effects of high butyrate concentrations. This also suggests that ulcerative colitis could in part result from potentially toxic faecal butyrate concentrations in the presence of a damaged mucus layer. Epithelial adherence of lectins, either dietary lectins as found in legumes, or bacterial lectins such as the galactose-binding lectin expressed by colon cancer-associated Fusobacterium nucleatum, may also be important and could be inhibitable by specific dietary glycans. Conversely, emulsifiers in processed foods may increase bacterial translocation and alter the microbiota thus promoting inflammation or cancer. Focusing on one condition is of limited value although in developing public health messages and growing evidence for impacts of dietary components on all-cause mortality is gaining more attention. We are only just starting to understand the complex interactions between food, the microbiota and health.
    MeSH term(s) Diet/methods ; Diet, Healthy/methods ; Dietary Fiber/analysis ; Gastrointestinal Microbiome ; Humans ; Prebiotics/analysis
    Chemical Substances Dietary Fiber ; Prebiotics
    Language English
    Publishing date 2020-01-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391142-1
    ISSN 1475-2719 ; 0029-6651
    ISSN (online) 1475-2719
    ISSN 0029-6651
    DOI 10.1017/S0029665120000026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Message from the Editors.

    Rhodes, Jonathan M / Howden, Colin W

    Alimentary pharmacology & therapeutics

    2020  Volume 53, Issue 1, Page(s) 4–5

    Language English
    Publishing date 2020-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.16188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
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  4. Article ; Online: Common framework mutations impact antibody interfacial dynamics and flexibility.

    Rhodes, Emily R / Faris, Jonathan G / Petersen, Brian M / Sprenger, Kayla G

    Frontiers in immunology

    2023  Volume 14, Page(s) 1120582

    Abstract: Introduction: With the flood of engineered antibodies, there is a heightened need to elucidate the structural features of antibodies that contribute to specificity, stability, and breadth. While antibody flexibility and interface angle have begun to be ... ...

    Abstract Introduction: With the flood of engineered antibodies, there is a heightened need to elucidate the structural features of antibodies that contribute to specificity, stability, and breadth. While antibody flexibility and interface angle have begun to be explored, design rules have yet to emerge, as their impact on the metrics above remains unclear. Furthermore, the purpose of framework mutations in mature antibodies is highly convoluted.
    Methods: To this end, a case study utilizing molecular dynamics simulations was undertaken to determine the impact framework mutations have on the VH-VL interface. We further sought to elucidate the governing mechanisms by which changes in the VH-VL interface angle impact structural elements of mature antibodies by looking at root mean squared deviations, root mean squared fluctuations, and solvent accessible surface area.
    Results and discussion: Overall, our results suggest framework mutations can significantly shift the distribution of VH-VL interface angles, which leads to local changes in antibody flexibility through local changes in the solvent accessible surface area. The data presented herein highlights the need to reject the dogma of static antibody crystal structures and exemplifies the dynamic nature of these proteins in solution. Findings from this work further demonstrate the importance of framework mutations on antibody structure and lay the foundation for establishing design principles to create antibodies with increased specificity, stability, and breadth.
    MeSH term(s) Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Light Chains/genetics ; Mutation ; Antibodies/genetics ; Solvents
    Chemical Substances Immunoglobulin Heavy Chains ; Immunoglobulin Light Chains ; Antibodies ; Solvents
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1120582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Guts UK 50 years old: onwards and upwards.

    Harrington, Julie / McLaughlin, John / Rhodes, Jonathan M

    Gut

    2021  Volume 70, Issue 11, Page(s) 2217–2218

    MeSH term(s) Biomedical Research/history ; Charities/history ; Gastroenterology/history ; History, 20th Century ; History, 21st Century ; Research Support as Topic/history ; Societies, Medical/history ; United Kingdom
    Language English
    Publishing date 2021-06-16
    Publishing country England
    Document type Historical Article ; Letter
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2021-325324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Machine-Learning Model for Prediction of Cefepime Susceptibility in Escherichia coli from Whole-Genome Sequencing Data.

    Humphries, Romney M / Bragin, Eugene / Parkhill, Julian / Morales, Grace / Schmitz, Jonathan E / Rhodes, Paul A

    Journal of clinical microbiology

    2023  Volume 61, Issue 3, Page(s) e0143122

    Abstract: The declining cost of performing bacterial whole-genome sequencing (WGS) coupled with the availability of large libraries of sequence data for well-characterized isolates have enabled the application of machine-learning (ML) methods to the development of ...

    Abstract The declining cost of performing bacterial whole-genome sequencing (WGS) coupled with the availability of large libraries of sequence data for well-characterized isolates have enabled the application of machine-learning (ML) methods to the development of nonlinear sequence-based predictive models. We tested the ML-based model developed by Next Gen Diagnostics for prediction of cefepime phenotypic susceptibility results in Escherichia coli. A cohort of 100 isolates of E. coli recovered from urine (
    MeSH term(s) Humans ; Cefepime/pharmacology ; Anti-Bacterial Agents/pharmacology ; Escherichia coli/genetics ; Cephalosporins/pharmacology ; Microbial Sensitivity Tests
    Chemical Substances Cefepime (807PW4VQE3) ; Anti-Bacterial Agents ; Cephalosporins
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.01431-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Message from the Editors.

    Rhodes, Jonathan M / Howden, Colin W

    Alimentary pharmacology & therapeutics

    2018  Volume 49, Issue 1, Page(s) 4–5

    Language English
    Publishing date 2018-12-11
    Publishing country England
    Document type Editorial
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.15067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Unnecessary Cervical Discectomy - A simple test to differentiate between Cervical and Shoulder Pathology: A Case Report.

    Ampat, George / Sims, Jonathan M G / Rhodes, Samantha J / Ali, Mohammed

    Journal of orthopaedic case reports

    2022  Volume 12, Issue 4, Page(s) 31–34

    Abstract: Background: Diagnostic dilemma exists in differentiating between neck and shoulder pathology, as both can give a rise to shoulder and arm symptoms. In addition, the hypersensitivity of magnetic resonance imaging (MRI) scans may wrongly highlight non- ... ...

    Abstract Background: Diagnostic dilemma exists in differentiating between neck and shoulder pathology, as both can give a rise to shoulder and arm symptoms. In addition, the hypersensitivity of magnetic resonance imaging (MRI) scans may wrongly highlight non-clinically significant changes as potential targets for surgical intervention. The arm- squeeze test is a recognised recognized method used to help differentiate pathology arising from the shoulder or the neck. Performing this test preoperatively may prevent needless surgical intervention when diagnostic difficulties exist, even when MRI scans are not helpful.
    Case presentation: We report the case of a 41-year-old male who initially presented with numbness and pins and needles in both arms. Following clinical review and an MRI scan of the cervical spine, the patient underwent an Anterior Cervical Discectomy and Fusion. Unfortunately, there was no relief of symptoms following surgery. A post- operative clinical review identified the shoulder as a potential cause of the symptoms.
    Conclusion: The arm- squeeze test is not popular and is not routinely used in shoulder and cervical spine examinations. However, it is recommended by National Institute for health and care excellence to help differentiate between neck and shoulder pathology, and, hence, dissemination of this information is vital.
    Language English
    Publishing date 2022-11-11
    Publishing country India
    Document type Case Reports
    ZDB-ID 2658169-3
    ISSN 2250-0685
    ISSN 2250-0685
    DOI 10.13107/jocr.2022.v12.i04.2754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Targeted Metabolite Fingerprints of Thirteen

    Murray, J Sam / Passfield, Emillie M F / Rhodes, Lesley L / Puddick, Jonathan / Finch, Sarah C / Smith, Kirsty F / van Ginkel, Roel / Mudge, Elizabeth M / Nishimura, Tomohiro / Funaki, Hiroshi / Adachi, Masao / Prinsep, Michèle R / Harwood, D Tim

    Marine drugs

    2024  Volume 22, Issue 3

    Abstract: ... The ... ...

    Abstract The genus
    MeSH term(s) Dinoflagellida ; Ciguatoxins ; Ethers ; Serogroup
    Chemical Substances gambierone ; Ciguatoxins (11050-21-8) ; Ethers
    Language English
    Publishing date 2024-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md22030119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Lectin methods and protocols

    Rhodes, Jonathan M.

    (Methods in molecular medicine ; 9)

    1998  

    Author's details ed. by Jonathan M. Rhodes
    Series title Methods in molecular medicine ; 9
    Collection
    Keywords Lectins / analysis ; Lectins / chemistry ; Lectine ; Molekularbiologie ; Analyse
    Subject Analytik ; Analysen ; Molekulare Biologie ; Lektine ; Phytagglutinine
    Language English
    Size XVIII, 616 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT008083323
    ISBN 0-89603-396-1 ; 978-0-89603-396-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 817 order for loan Magazin

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