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  1. Article ; Online: Expanding the applicability of multiphoton fluorescence recovery after photobleaching by incorporating shear stress in laminar flow.

    Elias, Tresa M / Brown, Edward B / Brown, Edward B

    Journal of biomedical optics

    2023  Volume 28, Issue 7, Page(s) 76502

    Abstract: Significance: Multi-photon fluorescence recovery after photobleaching (MPFRAP) is a nonlinear microscopy technique used to measure the diffusion coefficient of fluorescently tagged molecules in solution. Previous MPFRAP fitting models calculate the ... ...

    Abstract Significance: Multi-photon fluorescence recovery after photobleaching (MPFRAP) is a nonlinear microscopy technique used to measure the diffusion coefficient of fluorescently tagged molecules in solution. Previous MPFRAP fitting models calculate the diffusion coefficient in systems with diffusion or diffusion in laminar flow.
    Aim: We propose an MPFRAP fitting model that accounts for shear stress in laminar flow, making it a more applicable technique for
    Approach: Fluorescence recovery curves are generated using high-throughput molecular dynamics simulations and then fit to all three models (diffusion, diffusion and flow, and diffusion and shear flow) to define the limits within which accurate diffusion coefficients are produced. Diffusion is simulated as a random walk with a variable horizontal bias to account for shear flow.
    Results: Contour maps of the accuracy of the fitted diffusion coefficient as a function of scaled velocity and scaled shear rate show the parameter space within which each model produces accurate diffusion coefficients; the shear-flow model covers a larger area than the previous models.
    Conclusion: The shear-flow model allows MPFRAP to be a viable optical tool for studying more biophysical systems than previous models.
    MeSH term(s) Fluorescence Recovery After Photobleaching/methods ; Diffusion ; Photobleaching
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1309154-2
    ISSN 1560-2281 ; 1083-3668
    ISSN (online) 1560-2281
    ISSN 1083-3668
    DOI 10.1117/1.JBO.28.7.076502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Publisher Correction: A rigid body framework for multicellular modeling.

    Brown, Phillip J / Green, J Edward F / Binder, Benjamin J / Osborne, James M

    Nature computational science

    2024  Volume 2, Issue 1, Page(s) 59

    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Published Erratum
    ISSN 2662-8457
    ISSN (online) 2662-8457
    DOI 10.1038/s43588-021-00188-8
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  3. Article ; Online: Reply to Adelman et al.

    Hooper, Gabriel A / Stenehjem, Edward A / Bledsoe, Joseph R / Brown, Samuel M / Peltan, Ithan D

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 2, Page(s) 328–329

    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad244
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  4. Book ; Online ; E-Book: Gynecologic oncology handbook

    Benoit, Michelle F. / Williams-Brown, M. Yvette / Edwards, Creighton L.

    an evidence-based clinical guide

    2023  

    Author's details Michelle F. Benoit, M. Yvette Williams-Brown, Creighton L. Edwards
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxvi, 568 Seiten), Illustrationen
    Edition Third edition
    Publisher Springer Publishing Company, Incorporated ; Demos Medical
    Publishing place New York
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021701026
    ISBN 978-0-8261-5598-6 ; 9780826155979 ; 0-8261-5598-7 ; 0826155979
    DOI 10.1891/9780826155986
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Hospital Facility Prices Declined As A Result Of Oregon's Hospital Payment Cap.

    Murray, Roslyn C / Brown, Zach Y / Miller, Sarah / Norton, Edward C / Ryan, Andrew M

    Health affairs (Project Hope)

    2024  Volume 43, Issue 3, Page(s) 424–432

    Abstract: Hospital prices for commercially insured people are high and vary widely, prompting states to seek ways to control hospital price growth. In October 2019, the Oregon state employee health insurance plan instituted a cap on hospital payments. Using 2014- ... ...

    Abstract Hospital prices for commercially insured people are high and vary widely, prompting states to seek ways to control hospital price growth. In October 2019, the Oregon state employee health insurance plan instituted a cap on hospital payments. Using 2014-21 data from the Oregon All Payer All Claims Reporting Program database, we performed a difference-in-differences analysis to test the impact of the cap on hospital facility prices for Oregon's state employee plan enrollees. We found that the cap was not associated with a significant reduction in inpatient facility prices across the post period (-$901.9 per admission) but was associated with a significant reduction in the second year after implementation (-$2,774.20). The cap was associated with a significant reduction in outpatient facility prices over the course of the first twenty-seven months of the policy (-$130.50 per procedure). We estimated $107.5 million (or 4 percent of total plan spending) in savings to the state employee plan during the first two years. The hospital payment cap successfully reduced hospital prices for enrollees in that plan.
    MeSH term(s) Humans ; Oregon ; Hospitals ; Hospitalization ; Databases, Factual ; Income
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632712-6
    ISSN 1544-5208 ; 0278-2715
    ISSN (online) 1544-5208
    ISSN 0278-2715
    DOI 10.1377/hlthaff.2023.01021
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  6. Article ; Online: Acute Effects of Vibrating Insoles on Dynamic Balance and Gait Quality in Individuals With Diabetic Peripheral Neuropathy: A Randomized Crossover Study.

    Orlando, Giorgio / Brown, Steven / Jude, Edward / Bowling, Frank L / Boulton, Andrew J M / Reeves, Neil D

    Diabetes care

    2024  

    Abstract: ... during stair ascent and descent in Vc2 (Ctrl vs. Vc2 for ascent 0.447 ± 0.180 vs. 0.517 ± 0.127 m/s; P ... 0.037 and descent 0.394 ± 0.170 vs. 0.487 ± 0.125 m/s; P = 0.016), Vc4 (Ctrl vs. Vc4 for ascent 0 ... 447 ± 0.180 vs. 0.482 ± 0.197 m/s; P = 0.047 and descent 0.394 ± 0.170 vs. 0.438 ± 0.181 m/s; P = 0 ...

    Abstract Objective: This study investigated the effects of vibrating insoles on dynamic balance and gait quality during level and stair walking and explored the influence of vibration type and frequency in individuals with diabetic peripheral neuropathy (DPN).
    Research design and methods: Twenty-two men with DPN were assessed for gait quality and postural and dynamic balance during walking and stair negotiation using a motion capture system and force plates across seven vibratory insole conditions (Vcs) versus a control (Ctrl) condition (insole without vibration). Vibration was applied during standing and walking tasks, and 15-min rest-stop periods without vibration were interposed between conditions. Repeated measures test conditions were randomized. The primary outcomes were gait speed and dynamic balance.
    Results: Gait speed during walking significantly improved in all Vcs compared with Ctrl (P < 0.005), with Vc2, Vc4, and Vc6 identified as the most effective. Gait speed increased (reflecting faster walking) during stair ascent and descent in Vc2 (Ctrl vs. Vc2 for ascent 0.447 ± 0.180 vs. 0.517 ± 0.127 m/s; P = 0.037 and descent 0.394 ± 0.170 vs. 0.487 ± 0.125 m/s; P = 0.016), Vc4 (Ctrl vs. Vc4 for ascent 0.447 ± 0.180 vs. 0.482 ± 0.197 m/s; P = 0.047 and descent 0.394 ± 0.170 vs. 0.438 ± 0.181 m/s; P = 0.017), and Vc6 (Ctrl vs. Vc6 for ascent 0.447 ± 0.180 vs. 0.506 ± 0.179 m/s; P = 0.043 and descent 0.394 ± 0.170 vs. 0.463 ± 0.159 m/s; P = 0.026). Postural balance improved during quiet standing with eyes closed in Vc2, Vc4, Vc6, and Vc7 (P < 0.005).
    Conclusions: Vibrating insoles are an effective acute strategy for improving postural balance and gait quality during level walking and stair descent in individuals with DPN. These benefits are particularly evident when the entire plantar foot surface is stimulated.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc23-1858
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  7. Article: Second-Harmonic Generation Imaging Reveals Changes in Breast Tumor Collagen Induced by Neoadjuvant Chemotherapy.

    Desa, Danielle E / Wu, Wencheng / Brown, Robert M / Brown, Edward B / Hill, Robert L / Turner, Bradley M

    Cancers

    2022  Volume 14, Issue 4

    Abstract: Breast cancer is the most common invasive cancer in women, with most deaths attributed to metastases. Neoadjuvant chemotherapy (NACT) may be prescribed prior to surgical removal of the tumor for subsets of breast cancer patients but can have diverse ... ...

    Abstract Breast cancer is the most common invasive cancer in women, with most deaths attributed to metastases. Neoadjuvant chemotherapy (NACT) may be prescribed prior to surgical removal of the tumor for subsets of breast cancer patients but can have diverse undesired and off-target effects, including the increased appearance of the 'tumor microenvironment of metastasis', image-based multicellular signatures that are prognostic of breast tumor metastasis. To assess whether NACT can induce changes in two other image-based prognostic/predictive signatures derived from tumor collagen, we quantified second-harmonic generation (SHG) directionality and fiber alignment in formalin-fixed, paraffin-embedded sections of core needle biopsies and primary tumor excisions from 22 human epidermal growth factor receptor 2-overexpressing (HER2+) and 22 triple-negative breast cancers. In both subtypes, we found that SHG directionality (i.e., the forward-to-backward scattering ratio, or F/B) is increased by NACT in the bulk of the tumor, but not the adjacent tumor-stroma interface. Overall collagen fiber alignment is increased by NACT in triple-negative but not HER2+ breast tumors. These results suggest that NACT impacts the collagenous extracellular matrix in a complex and subtype-specific manner, with some prognostic features being unchanged while others are altered in a manner suggestive of a more metastatic phenotype.
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14040857
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  8. Article: François Leuret: the last moral therapist.

    Brown, Edward M

    History of psychiatry

    2017  Volume 29, Issue 1, Page(s) 38–48

    Abstract: By the 1840s French psychiatrists had abandoned Moral Treatment as an individual psychological therapy, as opposed to an institutional practice. One advocate of Moral Treatment, however, would not go along with this movement. In three books and several ... ...

    Abstract By the 1840s French psychiatrists had abandoned Moral Treatment as an individual psychological therapy, as opposed to an institutional practice. One advocate of Moral Treatment, however, would not go along with this movement. In three books and several papers published between 1834 and 1846, François Leuret (1797-1851) advocated aggressive psychological treatment. Recent commentators have understandably concentrated on the controversies surrounding Leuret's practices. What such an approach has failed to make clear, however, is that Leuret had a complex, systematic psychological theory supporting his clinical judgements. In addition to reviewing the controversies that surrounded Leuret, this paper spells out Leuret's psychological theory and shows how he used this theory to think about the individual psychotherapy he provided for his patients.
    MeSH term(s) France ; History, 19th Century ; Humans ; Mental Disorders/history ; Mental Disorders/therapy ; Morals ; Psychiatry/history ; Psychological Theory ; Psychotherapy/history
    Language English
    Publishing date 2017-10-26
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1028145-9
    ISSN 1740-2360 ; 0957-154X
    ISSN (online) 1740-2360
    ISSN 0957-154X
    DOI 10.1177/0957154X17735782
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  9. Article: Matching an immersion medium's refractive index to a cell's cytosol isolates organelle scattering.

    Dunn, Kaitlin J / Elias, Tresa M / Brown, Edward B / Berger, Andrew J

    Biomedical optics express

    2022  Volume 13, Issue 8, Page(s) 4236–4246

    Abstract: Angularly-resolved light scattering has been proven to be an early detector of subtle changes in organelle size due to its sensitivity to scatterer size and refractive index contrast. However, for cells immersed in media with a refractive index close to ... ...

    Abstract Angularly-resolved light scattering has been proven to be an early detector of subtle changes in organelle size due to its sensitivity to scatterer size and refractive index contrast. However, for cells immersed in media with a refractive index close to 1.33, the cell itself acts as a larger scatterer and contributes its own angular signature. This whole-cell scattering, highly dependent on the cell's shape and size, is challenging to distinguish from the desired organelle scattering signal. This degrades the accuracy with which organelle size information can be extracted from the angular scattering. To mitigate this effect, we manipulate the refractive index of the immersion medium by mixing it with a water-soluble, biocompatible, high-refractive-index liquid. This approach physically reduces the amount of whole-cell scattering by minimizing the refractive index contrast between the cytosol and the modified medium. We demonstrate this technique on live cells adherent on a coverslip, using Fourier transform light scattering to compute the angular scattering from complex field images. We show that scattering from the cell: media refractive index contrast contributes significant scattering at angles up to twenty degrees and that refractive index-matching reduces such low-angle scatter by factors of up to 4.5. This result indicates the potential of refractive index-matching for improving the estimates of organelle size distributions in single cells.
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.461874
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  10. Article ; Online: Paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2: It is not over until it's over.

    Haydar, Rania / Davis, Andrew M / Sheridan, Bennett / Buratto, Edward / Brown, Georgia / Jones, Bryn

    Journal of paediatrics and child health

    2022  Volume 58, Issue 11, Page(s) 2112–2115

    MeSH term(s) Child ; Humans ; SARS-CoV-2 ; COVID-19 ; Systemic Inflammatory Response Syndrome/diagnosis ; Intensive Care Units, Pediatric
    Language English
    Publishing date 2022-07-01
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.16097
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