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  1. Article ; Online: Bilateral Panuveitis Associated with Morvan Syndrome: A Case Report and Review of the Literature.

    Kryshtalskyj, Michael T / Devenyi, Robert G / Roy, Mili

    Ocular immunology and inflammation

    2022  Volume 31, Issue 4, Page(s) 851–855

    Abstract: Purpose: Morvan syndrome (MoS) is a neurologic disorder belonging to a spectrum of autoimmune encephalitis, Contactin-associated protein-like 2 (Caspr2) antibody syndrome. We report a case of bilateral panuveitis associated with MoS.: Methods: Case ... ...

    Abstract Purpose: Morvan syndrome (MoS) is a neurologic disorder belonging to a spectrum of autoimmune encephalitis, Contactin-associated protein-like 2 (Caspr2) antibody syndrome. We report a case of bilateral panuveitis associated with MoS.
    Methods: Case report and review of the literature.
    Results: A 57-year-old male with Morvan syndrome presented with painless vision loss and floaters. Initial visual acuities were 20/50 and 20/60. Hallmarks of this uveitis included persistently active vitritis, and nonhemorrhagic retinitis with nonperfusion and neovascularization. Uveitis consistently flared with attempted immunosuppressive tapers. Vision deteriorated to count fingers (2 ft) OU over 2.5 years despite corticosteroids, mycophenolate mofetil, intravenous immunoglobulin, adalimumab, and rituximab. Explanations for reduced final visual acuity included macular atrophy, disruption of retinal architecture, epiretinal membrane, vitritis, and cataract.
    Conclusions: This case constitutes the first report of uveitis associated with MoS and Caspr2 antibody syndrome, raising the question of autoimmunity targeting the retinal inner and/or outer plexiform layers.
    MeSH term(s) Male ; Humans ; Middle Aged ; Panuveitis/complications ; Panuveitis/diagnosis ; Panuveitis/drug therapy ; Uveitis/etiology ; Adrenal Cortex Hormones ; Retina ; Encephalitis/complications ; Syndrome ; Vision Disorders
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2022-04-11
    Publishing country England
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2022.2054823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: MAIA microperimeter for short-duration fixation stability measurements in central vision loss: Repeatability and comparison with the Nidek MP1.

    Pyatova, Yulia / Markowitz, Samuel N / Devenyi, Robert G / Tarita-Nistor, Luminita

    Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

    2022  Volume 42, Issue 3, Page(s) 633–643

    Abstract: Purpose: This study reports the repeatability of 20 s-duration fixation stability measurements recorded with the Macular Integrity Assessment (MAIA) microperimeter in patients with central vision loss, in contrast to the Nidek MP1 microperimeter.: ... ...

    Abstract Purpose: This study reports the repeatability of 20 s-duration fixation stability measurements recorded with the Macular Integrity Assessment (MAIA) microperimeter in patients with central vision loss, in contrast to the Nidek MP1 microperimeter.
    Methods: Fixation stability was recorded in 39 eyes of 25 patients with macular disease using MAIA and the MP1 for 20 s intervals, twice for each eye, with each instrument. Twenty eyes were identified as the better eye (BE) and 19 eyes as the worse eye (WE). Fixation stability was quantified with the 95% bivariate contour ellipse area (BCEA), logarithmically transformed. Bland-Altman plots were used to determine the 95% limits of agreement.
    Results: For MAIA, the 95% limits of agreement were ±0.84 log deg
    Conclusions: Repeatability of 20 s-duration fixation stability examination in patients with central vision loss is specific to the instrument used. We recommend that only data from same type of microperimeter with the same fixation duration should be compared when using fixation stability as an outcome measure to monitor disease progression, effect of treatment or in clinical trials.
    MeSH term(s) Fixation, Ocular ; Humans ; Retina ; Visual Acuity ; Visual Field Tests ; Visual Fields
    Language English
    Publishing date 2022-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 604564-9
    ISSN 1475-1313 ; 0275-5408
    ISSN (online) 1475-1313
    ISSN 0275-5408
    DOI 10.1111/opo.12960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: update on the modern management of wet age-related macular degeneration.

    Devenyi, Robert G

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2006  Volume 41, Issue 2, Page(s) 133–138

    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Choroidal Neovascularization/drug therapy ; Choroidal Neovascularization/etiology ; Humans ; Macular Degeneration/complications ; Macular Degeneration/drug therapy ; Vascular Endothelial Growth Factor A/antagonists & inhibitors
    Chemical Substances Angiogenesis Inhibitors ; VEGFA protein, human ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2006-04
    Publishing country England
    Document type Editorial
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1139/i06-901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: High school math helps explain observations during 25-gauge vitrectomy surgery.

    Devenyi, Robert G

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2004  Volume 39, Issue 5, Page(s) 488

    MeSH term(s) Drainage/instrumentation ; Humans ; Mathematics ; Sclerostomy ; Vitrectomy/instrumentation
    Language English
    Publishing date 2004-09-01
    Publishing country England
    Document type Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/s0008-4182(04)80137-6
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  5. Article ; Online: Reading with central vision loss: binocular summation and inhibition.

    Silvestri, Valeria / Sasso, Paola / Piscopo, Paola / Amore, Filippo / Rizzo, Stanislao / Devenyi, Robert G / Tarita-Nistor, Luminita

    Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

    2020  Volume 40, Issue 6, Page(s) 778–789

    Abstract: Purpose: There are conflicting reports as to whether there is a binocular advantage or disadvantage when reading with central vision loss. This study examined binocular reading summation in patients with macular degeneration.: Methods: Seventy-one ... ...

    Abstract Purpose: There are conflicting reports as to whether there is a binocular advantage or disadvantage when reading with central vision loss. This study examined binocular reading summation in patients with macular degeneration.
    Methods: Seventy-one patients with bilateral central vision loss [mean age: 63 (S.D. = 21) years] participated. Reading performances during binocular and monocular viewing with the better eye (i.e., the eye with the best monocular visual acuity) were evaluated using different versions of the Italian MNREAD reading chart (www.precision-vision.com). Fixation stability and preferred retinal loci (PRLs) were recorded monocularly for each eye. The overall sample was split into inhibition, equality, and summation groups based on the binocular ratio (i.e., binocular/monocular) of the maximum reading speed.
    Results: 41% of patients experienced binocular inhibition, 42% summation, and 17% equality. Binocular reading speed of the inhibition group was approximately 30 words per minute slower than those of the equality and summation groups, although the inhibition group had the best visual acuity. These patients generally had monocular PRLs in non-corresponding locations temporal or nasal to the scotoma, had the largest interocular acuity difference and lacked residual stereopsis. The three groups did not differ in fixational control, contrast sensitivity or critical print size.
    Conclusions: Equal proportions of patients with central vision loss show binocular reading summation and inhibition. Patients with binocular reading inhibition have poorer reading performance and different clinical characteristics than those with binocular reading summation and equality.
    MeSH term(s) Contrast Sensitivity/physiology ; Female ; Fixation, Ocular ; Humans ; Male ; Middle Aged ; Prospective Studies ; Reading ; Scotoma/physiopathology ; Vision, Binocular/physiology ; Vision, Monocular/physiology ; Visual Acuity
    Language English
    Publishing date 2020-09-04
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 604564-9
    ISSN 1475-1313 ; 0275-5408
    ISSN (online) 1475-1313
    ISSN 0275-5408
    DOI 10.1111/opo.12726
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  6. Article ; Online: Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age-related macular degeneration.

    Merry, Graham F / Munk, Marion R / Dotson, Robert S / Walker, Michael G / Devenyi, Robert G

    Acta ophthalmologica

    2017  Volume 95, Issue 4, Page(s) e270–e277

    Abstract: Purpose: To evaluate the efficacy of photobiomodulation (PBM) treatment for patients with dry age-related macular degeneration (AMD).: Methods: Assessments on 42 eyes with dry AMD (age related eye disease study (AREDS) 2-4) were conducted. ... ...

    Abstract Purpose: To evaluate the efficacy of photobiomodulation (PBM) treatment for patients with dry age-related macular degeneration (AMD).
    Methods: Assessments on 42 eyes with dry AMD (age related eye disease study (AREDS) 2-4) were conducted. Multiwavelength light emitting diode (LED) light comprising of yellow (590 nm), red (670 nm) and near-infrared (790 nm) bandwidths was applied to subjects' eyes for a treatment course of 3 weeks. Outcome measures were changes in best-corrected visual acuity (BCVA), contrast sensitivity (CS), drusen volume and central drusen thickness.
    Results: Significant improvement in mean BCVA of 5.90 letters (p < 0.001) was seen on completion of the 3-week treatment and 5.14 letters (p < 0.001) after 3 months. Contrast sensitivity improved significantly (log unit improvement of 0.11 (p = 0.02) at 3 weeks and 3 months (log unit improvement of 0.16 (p = 0.02) at three cycles per degree. Drusen volume decreased by 0.024 mm
    Conclusion: This is the first study demonstrating improvements in functional and anatomical outcomes in dry AMD subjects with PBM therapy. These findings corroborate an earlier pilot study that looked at functional outcome measures. The addition of anatomical evidence contributes to the basis for further development of a non-invasive PBM treatment for dry AMD.
    MeSH term(s) Aged ; Aged, 80 and over ; Contrast Sensitivity ; Female ; Follow-Up Studies ; Humans ; Laser Therapy/methods ; Macular Degeneration/complications ; Macular Degeneration/diagnosis ; Macular Degeneration/physiopathology ; Male ; Pilot Projects ; Retina/physiopathology ; Retinal Drusen/diagnosis ; Retinal Drusen/etiology ; Retinal Drusen/surgery ; Retrospective Studies ; Tomography, Optical Coherence ; Treatment Outcome ; Visual Acuity
    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.13354
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  7. Article ; Online: The Toronto experience with the Argus II retinal prosthesis: new technology, new hope for patients.

    Devenyi, Robert G / Manusow, Joshua / Patino, Beatrice E / Mongy, Mohamed / Markowitz, Michelle / Markowitz, Samuel N

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2017  Volume 53, Issue 1, Page(s) 9–13

    Abstract: Surgical restoration of vision with retinal prostheses is a new and developing technology currently available in a select group of countries, Canada among them. The Argus II retinal prosthesis is the first commercially available device for restoration of ...

    Abstract Surgical restoration of vision with retinal prostheses is a new and developing technology currently available in a select group of countries, Canada among them. The Argus II retinal prosthesis is the first commercially available device for restoration of vision in patients with Retinitis Pigmentosa or with similar retinal pathology who still have minimal residual native vision. The surgery is complex and requires training however it is within the abilities of any experienced retina surgeon. Surgical experience builds up with each case and in our patients length of surgery constantly went down. Complications occurred however we experienced no catastrophic events. Most notable is that in our implanted cases the Argus II technology proved to be beneficial to most patients. In order to obtain optimal results with this surgical intervention it is absolutely required that the surgical work is complemented simultaneously with the work of a specialized rehabilitation team. A review of the technology, of our experience, comments and concerns is presented in this paper.
    MeSH term(s) Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Ontario ; Prosthesis Design ; Prosthesis Implantation/trends ; Retina/diagnostic imaging ; Retina/physiology ; Retina/surgery ; Retinitis Pigmentosa/physiopathology ; Retinitis Pigmentosa/surgery ; Retrospective Studies ; Treatment Outcome ; Visual Acuity/physiology ; Visual Prosthesis
    Language English
    Publishing date 2017-12-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2017.10.043
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  8. Article ; Online: Real-world utilization of ranibizumab in wet age-related macular degeneration patients from Canada.

    Devenyi, Robert / Maberley, David / Sheidow, Tom G / Tourville, Eric / Brunck, Lynne / Berger, Alan R

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2016  Volume 51, Issue 2, Page(s) 55–57

    MeSH term(s) Aged ; Aged, 80 and over ; Angiogenesis Inhibitors/therapeutic use ; Canada ; European Union ; Female ; Humans ; Male ; Practice Patterns, Physicians'/statistics & numerical data ; Ranibizumab/therapeutic use ; Retreatment ; Retrospective Studies ; Tomography, Optical Coherence ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity/drug effects ; Wet Macular Degeneration/drug therapy
    Chemical Substances Angiogenesis Inhibitors ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Comparative Study ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2015.11.008
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  9. Article ; Online: Stable oxime-crosslinked hyaluronan-based hydrogel as a biomimetic vitreous substitute.

    Baker, Alexander E G / Cui, Hong / Ballios, Brian G / Ing, Sonja / Yan, Peng / Wolfer, Joe / Wright, Thomas / Dang, Mickael / Gan, Nicola Y / Cooke, Michael J / Ortín-Martínez, Arturo / Wallace, Valerie A / van der Kooy, Derek / Devenyi, Robert / Shoichet, Molly S

    Biomaterials

    2021  Volume 271, Page(s) 120750

    Abstract: Vitreous substitutes are clinically used to maintain retinal apposition and preserve retinal function; yet the most used substitutes are gases and oils which have disadvantages including strict face-down positioning post-surgery and the need for ... ...

    Abstract Vitreous substitutes are clinically used to maintain retinal apposition and preserve retinal function; yet the most used substitutes are gases and oils which have disadvantages including strict face-down positioning post-surgery and the need for subsequent surgical removal, respectively. We have engineered a vitreous substitute comprised of a novel hyaluronan-oxime crosslinked hydrogel. Hyaluronan, which is naturally abundant in the vitreous of the eye, is chemically modified to crosslink with poly(ethylene glycol)-tetraoxyamine via oxime chemistry to produce a vitreous substitute that has similar physical properties to the native vitreous including refractive index, density and transparency. The oxime hydrogel is cytocompatible in vitro with photoreceptors from mouse retinal explants and biocompatible in rabbit eyes as determined by histology of the inner nuclear layer and photoreceptors in the outer nuclear layer. The ocular pressure in the rabbit eyes was consistent over 56 d, demonstrating limited to no swelling. Our vitreous substitute was stable in vivo over 28 d after which it began to degrade, with approximately 50% loss by day 56. We confirmed that the implanted hydrogel did not impact retina function using electroretinography over 90 days versus eyes injected with balanced saline solution. This new oxime hydrogel provides a significant improvement over the status quo as a vitreous substitute.
    MeSH term(s) Animals ; Biomimetics ; Hyaluronic Acid ; Hydrogels ; Mice ; Oximes ; Rabbits ; Retina ; Vitreous Body
    Chemical Substances Hydrogels ; Oximes ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2021-03-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2021.120750
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  10. Article ; Online: Evaluating the safety of air travel for patients with scleral buckles and small volumes of intraocular gas.

    Noble, Jason / Kanchanaranya, Navapol / Devenyi, Robert G / Lam, Wai-Ching

    The British journal of ophthalmology

    2014  Volume 98, Issue 9, Page(s) 1226–1229

    Abstract: Aim: To evaluate the effect of scleral buckling on intraocular pressure (IOP) change during atmospheric decompression for eyes with small volumes of intravitreal gas.: Methods: 12 eyes of 12 patients, including 6 with and 6 without scleral buckles, ... ...

    Abstract Aim: To evaluate the effect of scleral buckling on intraocular pressure (IOP) change during atmospheric decompression for eyes with small volumes of intravitreal gas.
    Methods: 12 eyes of 12 patients, including 6 with and 6 without scleral buckles, were evaluated in a hypobaric chamber simulating air travel approximately 1 month post pars plana vitrectomy with 15% C3F8 gas fluid exchange. The chamber was decompressed with an ascent rate of 300 feet/min to a peak altitude of 8000 feet. After 15 min of cruising, descent was undertaken at 300 feet/min. IOP was measured at baseline and then every 5 min using slit-lamp mounted Goldmann applanation tonometry. The data were entered onto a spreadsheet and comparative statistics were done.
    Results: During ascent, IOP steadily rose from an average of 13±3 mm Hg to a peak of 26±9 mm Hg at 8000 feet. Patients with scleral buckles had significantly lower peak IOPs compared with those without buckles (20±5 mm Hg vs 32±8 mm Hg, p=0.013, t test) representing lower absolute increases in IOP (7±1 mm Hg vs 19±7 mm Hg, p=0.001, t test) and lower percentage increases in IOP from baseline (62±25% vs 140±40%, respectively).
    Conclusions: Eyes with small volumes of intravitreal gas demonstrate significant IOP changes during atmospheric decompression in simulated flight. The presence of a scleral buckle significantly limits the magnitude of IOP change, suggesting that such patients can likely tolerate typical air travel without undue risk of dangerous IOP elevation.
    MeSH term(s) Adult ; Aerospace Medicine ; Aged ; Aircraft ; Altitude ; Environment, Controlled ; Female ; Fluorocarbons ; Humans ; Intraocular Pressure/physiology ; Male ; Middle Aged ; Retinal Detachment/surgery ; Scleral Buckling ; Tonometry, Ocular ; Vitrectomy
    Chemical Substances Fluorocarbons ; perflutren (CK0N3WH0SR)
    Language English
    Publishing date 2014-09
    Publishing country England
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjophthalmol-2014-304923
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