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  1. Article ; Online: Efectos adversos de lopinavir/ritonavir en enfermedad grave por coronavirus (COVID-19).

    Vecchio, Gisela / Zapico, Valeria / Catanzariti, Alejandro / Carboni Bisso, Indalecio / Las Heras, Marcos

    Medicina

    2020  Volume 80, Issue 5, Page(s) 439–441

    Abstract: During the SARSCoV-2 pandemic many drugs have been used as potential treatments in order to improve the clinical outcome and reduce the mortality. But since it is a currently unknown disease, the evidence about efficacy and safety is built as the drugs ... ...

    Title translation Adverse effects of lopinavir/ritonavir in critically ill patients with COVID-19.
    Abstract During the SARSCoV-2 pandemic many drugs have been used as potential treatments in order to improve the clinical outcome and reduce the mortality. But since it is a currently unknown disease, the evidence about efficacy and safety is built as the drugs are prescribed. In this context, intensive pharmacovigilance allows early detection of adverse events, and thereby infer the safety profile of the indication. We conducted an observational, retrospective, single-center study involving adult patients with severe SARS-CoV-2 infection. All adverse events detected in 23 patients in the Intensive Care Unit between March 15 and June 15, 2020 were registered. We describe type and severity of the adverse events and if treatment suspension was needed. The results show a high rate of adverse events (10/23, 43%) in treatment with lopinavir/ritonavir. In most cases early treatment suspension was required. Even though the limitations of our study derived from the small sample size, these results could help in building evidence about the safety of using lopinavir/ritonavir for severe SARS-CoV-2 infection.
    MeSH term(s) Adult ; Aged ; Argentina/epidemiology ; Betacoronavirus ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Critical Illness ; Cytochrome P-450 CYP3A Inhibitors/adverse effects ; Cytochrome P-450 CYP3A Inhibitors/therapeutic use ; Female ; Humans ; Lopinavir/adverse effects ; Lopinavir/therapeutic use ; Male ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Retrospective Studies ; Ritonavir/adverse effects ; Ritonavir/therapeutic use ; Treatment Outcome
    Chemical Substances Cytochrome P-450 CYP3A Inhibitors ; Lopinavir (2494G1JF75) ; Ritonavir (O3J8G9O825)
    Keywords covid19
    Language Spanish
    Publishing date 2020-10-13
    Publishing country Argentina
    Document type Journal Article
    ZDB-ID 411586-7
    ISSN 1669-9106 ; 0025-7680 ; 0325-951X
    ISSN (online) 1669-9106
    ISSN 0025-7680 ; 0325-951X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Adverse effects of lopinavir/ritonavir in critically ill patients with COVID-19

    Gisela Vecchio / Valeria Zapico / Alejandro Catanzariti / Indalecio Carboni Bisso / Marcos Las Heras

    Medicina (Buenos Aires), Vol 80, Iss 5, Pp 439-

    2020  Volume 441

    Abstract: During the SARSCoV-2 pandemic many drugs have been used as potential treatments in order to improve the clinical outcome and reduce the mortality. But since it is a currently unknown disease, the evidence about efficacy and safety is built as the drugs ... ...

    Abstract During the SARSCoV-2 pandemic many drugs have been used as potential treatments in order to improve the clinical outcome and reduce the mortality. But since it is a currently unknown disease, the evidence about efficacy and safety is built as the drugs are prescribed. In this context, intensive pharmacovigilance allows early detection of adverse events, and thereby infer the safety profile of the indication. We conducted an observational, retrospective, single-center study involving adult patients with severe SARS-CoV-2 infection. All adverse events detected in 23 patients in the Intensive Care Unit between March 15 and June 15, 2020 were registered. We describe type and severity of the adverse events and if treatment suspension was needed. The results show a high rate of adverse events (10/23, 43%) in treatment with lopinavir/ritonavir. In most cases early treatment suspension was required. Even though the limitations of our study derived from the small sample size, these results could help in building evidence about the safety of using lopinavir/ritonavir for severe SARS-CoV-2 infection.
    Keywords critical care ; covid-19 ; argentina ; lopinavir ; ritonavir ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607 ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Fundación Revista Medicina
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book: El financiamiento de inversiones ecocompatibles

    Vecchio, Gisela C / Vento, Gianfranco A

    la experiencia global y de América Latina ; Kioto, Copenhague, Cancún

    2011  

    Author's details Gisela C. Vecchio; Gianfranco A. Vento
    Keywords Environmental protection/Finance ; Investments/Environmental aspects ; Internationale Klimapolitik ; Umweltschutzinvestition ; Nachhaltige Entwicklung ; Lateinamerika
    Language Spanish
    Size 182 S., Ill., 24 cm
    Edition 1ra ed.
    Publisher EDICON, Fondo Editorial Consejo, Consejo Profesional de Ciencias Económicas de la Ciudad Autónoma de Buenos Aires
    Publishing place Ciudad Autónoma de Buenos Aires
    Document type Book
    Note Includes bibliographical references (p. 155-158)
    ISBN 9789876600927 ; 9876600923
    Database ECONomics Information System

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  4. Article ; Online: Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study.

    Si, Shuqing / Bi, Anbreen / Yu, Zhaoying / See, Cheryl / Kelly, Sinead / Ambrogi, Sonia / Arango, Celso / Baeza, Inmaculada / Banaj, Nerisa / Berk, Michael / Castro-Fornieles, Josefina / Crespo-Facorro, Benedicto / Crouse, Jacob J / Díaz-Caneja, Covadonga M / Fett, Anne-Kathrin / Fortea, Adriana / Frangou, Sophia / Goldstein, Benjamin I / Hickie, Ian B /
    Janssen, Joost / Kennedy, Kody G / Krabbendam, Lydia / Kyriakopoulos, Marinos / MacIntosh, Bradley J / Morgado, Pedro / Nerland, Stener / Pascual-Diaz, Saül / Picó-Pérez, Maria / Piras, Fabrizio / Rund, Bjørn Rishovd / de la Serna, Elena / Spalletta, Gianfranco / Sugranyes, Gisela / Suo, Chao / Tordesillas-Gutiérrez, Diana / Vecchio, Daniela / Radua, Joaquim / McGuire, Philip / Thomopoulos, Sophia I / Jahanshad, Neda / Thompson, Paul M / Barth, Claudia / Agartz, Ingrid / James, Anthony / Kempton, Matthew J

    Molecular psychiatry

    2024  

    Abstract: Introduction: Regional gray matter (GM) alterations have been reported in early-onset psychosis (EOP, onset before age 18), but previous studies have yielded conflicting results, likely due to small sample sizes and the different brain regions examined. ...

    Abstract Introduction: Regional gray matter (GM) alterations have been reported in early-onset psychosis (EOP, onset before age 18), but previous studies have yielded conflicting results, likely due to small sample sizes and the different brain regions examined. In this study, we conducted a whole brain voxel-based morphometry (VBM) analysis in a large sample of individuals with EOP, using the newly developed ENIGMA-VBM tool.
    Methods: 15 independent cohorts from the ENIGMA-EOP working group participated in the study. The overall sample comprised T1-weighted MRI data from 482 individuals with EOP and 469 healthy controls. Each site performed the VBM analysis locally using the standardized ENIGMA-VBM tool. Statistical parametric T-maps were generated from each cohort and meta-analyzed to reveal voxel-wise differences between EOP and healthy controls as well as the individual-based association between GM volume and age of onset, chlorpromazine (CPZ) equivalent dose, and other clinical variables.
    Results: Compared with healthy controls, individuals with EOP showed widespread lower GM volume encompassing most of the cortex, with the most marked effect in the left median cingulate (Hedges' g = 0.55, p = 0.001 corrected), as well as small clusters of lower white matter (WM), whereas no regional GM or WM volumes were higher in EOP. Lower GM volume in the cerebellum, thalamus and left inferior parietal gyrus was associated with older age of onset. Deficits in GM in the left inferior frontal gyrus, right insula, right precentral gyrus and right superior frontal gyrus were also associated with higher CPZ equivalent doses.
    Conclusion: EOP is associated with widespread reductions in cortical GM volume, while WM is affected to a smaller extent. GM volume alterations are associated with age of onset and CPZ equivalent dose but these effects are small compared to case-control differences. Mapping anatomical abnormalities in EOP may lead to a better understanding of the role of psychosis in brain development during childhood and adolescence.
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02343-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis.

    Barth, Claudia / Kelly, Sinead / Nerland, Stener / Jahanshad, Neda / Alloza, Clara / Ambrogi, Sonia / Andreassen, Ole A / Andreou, Dimitrios / Arango, Celso / Baeza, Inmaculada / Banaj, Nerisa / Bearden, Carrie E / Berk, Michael / Bohman, Hannes / Castro-Fornieles, Josefina / Chye, Yann / Crespo-Facorro, Benedicto / de la Serna, Elena / Díaz-Caneja, Covadonga M /
    Gurholt, Tiril P / Hegarty, Catherine E / James, Anthony / Janssen, Joost / Johannessen, Cecilie / Jönsson, Erik G / Karlsgodt, Katherine H / Kochunov, Peter / Lois, Noemi G / Lundberg, Mathias / Myhre, Anne M / Pascual-Diaz, Saül / Piras, Fabrizio / Smelror, Runar E / Spalletta, Gianfranco / Stokkan, Therese S / Sugranyes, Gisela / Suo, Chao / Thomopoulos, Sophia I / Tordesillas-Gutiérrez, Diana / Vecchio, Daniela / Wedervang-Resell, Kirsten / Wortinger, Laura A / Thompson, Paul M / Agartz, Ingrid

    Molecular psychiatry

    2022  Volume 28, Issue 3, Page(s) 1159–1169

    Abstract: Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years). However, as neuroimaging methods vary and sample sizes are modest, results remain inconclusive. Using harmonized data ... ...

    Abstract Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years). However, as neuroimaging methods vary and sample sizes are modest, results remain inconclusive. Using harmonized data processing protocols and a mega-analytic approach, we compared white matter microstructure in EOP and healthy controls using diffusion tensor imaging (DTI). Our sample included 321 adolescents with EOP (median age = 16.6 years, interquartile range (IQR) = 2.14, 46.4% females) and 265 adolescent healthy controls (median age = 16.2 years, IQR = 2.43, 57.7% females) pooled from nine sites. All sites extracted mean fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) for 25 white matter regions of interest per participant. ComBat harmonization was performed for all DTI measures to adjust for scanner differences. Multiple linear regression models were fitted to investigate case-control differences and associations with clinical variables in regional DTI measures. We found widespread lower FA in EOP compared to healthy controls, with the largest effect sizes in the superior longitudinal fasciculus (Cohen's d = 0.37), posterior corona radiata (d = 0.32), and superior fronto-occipital fasciculus (d = 0.31). We also found widespread higher RD and more localized higher MD and AD. We detected significant effects of diagnostic subgroup, sex, and duration of illness, but not medication status. Using the largest EOP DTI sample to date, our findings suggest a profile of widespread white matter microstructure alterations in adolescents with EOP, most prominently in male individuals with early-onset schizophrenia and individuals with a shorter duration of illness.
    MeSH term(s) Female ; Humans ; Male ; Adolescent ; White Matter ; Diffusion Tensor Imaging/methods ; Brain ; Psychotic Disorders ; Schizophrenia/drug therapy ; Anisotropy
    Language English
    Publishing date 2022-12-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-022-01901-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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