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  1. Article ; Online: Requirement for further validation on the seroconversion of hepatitis B surface antigen in successful vaccinees.

    Zeng, Qing-Lei / Zhou, Yi-Hua

    Human vaccines & immunotherapeutics

    2021  Volume 17, Issue 8, Page(s) 2773–2774

    Abstract: Hepatitis B vaccination can provide long-term protection against transmission of hepatitis B virus (HBV). An article recently published in Human Vaccine & Immunotherapeutics reported that 3.5% (5/143) of the individuals who had been successfully ... ...

    Abstract Hepatitis B vaccination can provide long-term protection against transmission of hepatitis B virus (HBV). An article recently published in Human Vaccine & Immunotherapeutics reported that 3.5% (5/143) of the individuals who had been successfully vaccinated against hepatitis B at infancy became positive for hepatitis B surface antigen (HBsAg) at their young adulthood during a period of four years, indicating that hepatitis B vaccination appears to have no long-term protection. We concern on the exceptional results in that article since the critical data are lacking, questionable, or very implausible. We consider that any exceptional data should be validated as far as possible before the data are used to obtain a conclusion.
    MeSH term(s) Adult ; Hepatitis B/prevention & control ; Hepatitis B Antibodies ; Hepatitis B Surface Antigens ; Hepatitis B Vaccines ; Hepatitis B virus ; Humans ; Seroconversion ; Vaccination ; Young Adult
    Chemical Substances Hepatitis B Antibodies ; Hepatitis B Surface Antigens ; Hepatitis B Vaccines
    Language English
    Publishing date 2021-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2021.1889258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply letter regarding seroconversion of hepatitis B surface antigen in a successful long-term immune cohort.

    Zheng, Zhigang / Zeng, Qing-Lei / Zhou, Yi-Hua

    Human vaccines & immunotherapeutics

    2021  Volume 17, Issue 8, Page(s) 2775–2776

    MeSH term(s) Cohort Studies ; Hepatitis B Surface Antigens ; Hepatitis B e Antigens ; Hepatitis B, Chronic/therapy ; Humans ; Seroconversion
    Chemical Substances Hepatitis B Surface Antigens ; Hepatitis B e Antigens
    Language English
    Publishing date 2021-04-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2021.1897488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genomic Epidemiology of SARS-CoV-2 From Mainland China With Newly Obtained Genomes From Henan Province.

    Song, Ning / Cui, Guang-Lin / Zeng, Qing-Lei

    Frontiers in microbiology

    2021  Volume 12, Page(s) 673855

    Abstract: Even though the COVID-19 epidemic in China has been successfully put under control within a few months, it is still very important to infer the origin time and genetic diversity from the perspective of the whole genome sequence of its agent, SARS-CoV-2. ... ...

    Abstract Even though the COVID-19 epidemic in China has been successfully put under control within a few months, it is still very important to infer the origin time and genetic diversity from the perspective of the whole genome sequence of its agent, SARS-CoV-2. Yet, the sequence of the entire virus genome from China in the current public database is very unevenly distributed with reference to time and place of collection. In particular, only one sequence was obtained in Henan province, adjacent to China's worst-case province, Hubei Province. Herein, we used high-throughput sequencing techniques to get 19 whole-genome sequences of SARS-CoV-2 from 18 severe patients admitted to the First Affiliated Hospital of Zhengzhou University, a provincial designated hospital for the treatment of severe COVID-19 cases in Henan province. The demographic, baseline, and clinical characteristics of these patients were described. To investigate the molecular epidemiology of SARS-CoV-2 of the current COVID-19 outbreak in China, 729 genome sequences (including 19 sequences from this study) sampled from Mainland China were analyzed with state-of-the-art comprehensive methods, including likelihood-mapping, split network, ML phylogenetic, and Bayesian time-scaled phylogenetic analyses. We estimated that the evolutionary rate and the time to the most recent common ancestor (TMRCA) of SARS-CoV-2 from Mainland China were 9.25 × 10
    Language English
    Publishing date 2021-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.673855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply to Rabelo-da-Ponte et al.

    Zeng, Qing-Lei / Yu, Zu-Jiang / Ji, Fanpu

    The Journal of infectious diseases

    2020  Volume 222, Issue 9, Page(s) 1578

    MeSH term(s) COVID-19/therapy ; Humans ; Immunization, Passive ; Plasma ; SARS-CoV-2 ; Virus Shedding
    Keywords covid19
    Language English
    Publishing date 2020-08-09
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiaa510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Response to Malkovsky.

    Zeng, Qing-Lei / Ji, Fanpu / Zhang, Ji-Yuan

    The Journal of infectious diseases

    2020  Volume 222, Issue 3, Page(s) 510–511

    MeSH term(s) Antibodies, Neutralizing ; Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Plasma Exchange ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Antibodies, Neutralizing
    Keywords covid19
    Language English
    Publishing date 2020-05-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiaa313
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  7. Article ; Online: Neurological manifestations and risk factors associated with poor prognosis in hospitalized children with Omicron variant infection.

    Tang, Li / Guo, Yuxin / Shu, Chang / Peng, Xiaokang / Qiu, Sikai / Li, Ruina / Liu, Pan / Wei, Huijing / Liao, Shan / Du, Yali / Guo, Dandan / Gao, Ning / Zeng, Qing-Lei / Liu, Xiaoguai / Ji, Fanpu

    European journal of pediatrics

    2024  Volume 183, Issue 5, Page(s) 2353–2363

    Abstract: There are increasing reports of neurological manifestation in children with coronavirus disease 2019 (COVID-19). However, the frequency and clinical outcomes of in hospitalized children infected with the Omicron variant are unknown. The aim of this study ...

    Abstract There are increasing reports of neurological manifestation in children with coronavirus disease 2019 (COVID-19). However, the frequency and clinical outcomes of in hospitalized children infected with the Omicron variant are unknown. The aim of this study was to describe the clinical characteristics, neurological manifestations, and risk factor associated with poor prognosis of hospitalized children suffering from COVID-19 due to the Omicron variant. Participants included children older than 28 days and younger than 18 years. Patients were recruited from December 10, 2022 through January 5, 2023. They were followed up for 30 days. A total of 509 pediatric patients hospitalized with the Omicron variant infection were recruited into the study. Among them, 167 (32.81%) patients had neurological manifestations. The most common manifestations were febrile convulsions (n = 90, 53.89%), viral encephalitis (n = 34, 20.36%), epilepsy (n = 23, 13.77%), hypoxic-ischemic encephalopathy (n = 9, 5.39%), and acute necrotizing encephalopathy (n = 6, 3.59%). At discharge, 92.81% of patients had a good prognosis according to the Glasgow Outcome Scale (scores ≥ 4). However, 7.19% had a poor prognosis. Eight patients died during the follow-up period with a cumulative 30-day mortality rate of 4.8% (95% confidence interval (CI) 1.5-8.1). Multivariate analysis revealed that albumin (odds ratio 0.711, 95% CI 0.556-0.910) and creatine kinase MB (CK-MB) levels (odds ratio 1.033, 95% CI 1.004-1.063) were independent risk factors of poor prognosis due to neurological manifestations. The area under the curve for the prediction of poor prognosis with albumin and CK-MB was 0.915 (95%CI 0.799-1.000), indicating that these factors can accurately predict a poor prognosis.          Conclusion: In this study, 32.8% of hospitalized children suffering from COVID-19 due to the Omicron variant infection experienced neurological manifestations. Baseline albumin and CK-MB levels could accurately predict poor prognosis in this patient population. What is Known: • Neurological injury has been reported in SARS-CoV-2 infection; compared with other strains, the Omicron strain is more likely to cause neurological manifestations in adults. • Neurologic injury in adults such as cerebral hemorrhage and epilepsy has been reported in patients with Omicron variant infection. What is New: • One-third hospitalized children with Omicron infection experience neurological manifestations, including central nervous system manifestations and peripheral nervous system manifestations. • Albumin and CK-MB combined can accurately predict poor prognosis (AUC 0.915), and the 30-day mortality rate of children with Omicron variant infection and neurological manifestations was 4.8%.
    MeSH term(s) Humans ; COVID-19/mortality ; COVID-19/complications ; COVID-19/diagnosis ; Male ; Female ; Child ; Prognosis ; Risk Factors ; Child, Preschool ; Infant ; SARS-CoV-2 ; Adolescent ; Nervous System Diseases/etiology ; Nervous System Diseases/virology ; Hospitalization/statistics & numerical data ; Infant, Newborn ; China/epidemiology ; Child, Hospitalized/statistics & numerical data
    Language English
    Publishing date 2024-03-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-024-05495-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Iodine-131 intervention in hyperthyroidism with hepatic insufficiency: Metabolomic evaluation.

    Luo, Zhaoxia / Lei, Yangyang / Zeng, Lingpeng / Chen, Xuezhong / Liu, Shaozheng / Zhang, Qing

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 173, Page(s) 116300

    Abstract: Hyperthyroidism, often accompanied by hepatic insufficiency (HI), poses significant clinical challenges, highlighting the necessity for identifying optimal treatment strategies and early diagnostic biomarkers to improve patient outcomes. This study aimed ...

    Abstract Hyperthyroidism, often accompanied by hepatic insufficiency (HI), poses significant clinical challenges, highlighting the necessity for identifying optimal treatment strategies and early diagnostic biomarkers to improve patient outcomes. This study aimed to determine the optimal iodine-131 (
    MeSH term(s) Mice ; Animals ; Humans ; Chromatography, High Pressure Liquid ; Mass Spectrometry ; Metabolomics ; Liver Failure ; Hepatic Insufficiency ; Biomarkers/metabolism ; Hyperthyroidism/radiotherapy ; Iodine Radioisotopes
    Chemical Substances Iodine-131 ; Biomarkers ; Iodine Radioisotopes
    Language English
    Publishing date 2024-03-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model.

    Liu, Chun-Jie / Li, Hua-Yi / Gao, Yue / Xie, Gui-Yan / Chi, Jian-Hua / Li, Gui-Ling / Zeng, Shao-Qing / Xiong, Xiao-Ming / Liu, Jia-Hao / Shi, Lin-Li / Li, Xiong / Cheng, Xiao-Dong / Song, Kun / Ma, Ding / Guo, An-Yuan / Gao, Qing-Lei

    Protein & cell

    2023  Volume 14, Issue 8, Page(s) 618–622

    MeSH term(s) Humans ; Female ; Deep Learning ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/genetics ; Carcinoma, Ovarian Epithelial/genetics ; Neural Networks, Computer ; RNA
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2023-08-01
    Publishing country Germany
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2543451-2
    ISSN 1674-8018 ; 1674-8018
    ISSN (online) 1674-8018
    ISSN 1674-8018
    DOI 10.1093/procel/pwac053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Computed Tomography Images of Spontaneous Portosystemic Shunt in Liver Cirrhosis.

    Yi, Fangfang / Guo, Xiaozhong / Zeng, Qing-Lei / Yang, Benqiang / He, Yanglan / Yuan, Shanshan / Arora, Ankur / Qi, Xingshun

    Canadian journal of gastroenterology & hepatology

    2022  Volume 2022, Page(s) 3231144

    Abstract: Spontaneous portosystemic shunt (SPSS) refers to collateral vessels that communicate between the portal vein system and systemic circulation. SPSS mainly includes esophageal varices, gastric varices, left gastric vein, recanalized paraumbilical vein, ... ...

    Abstract Spontaneous portosystemic shunt (SPSS) refers to collateral vessels that communicate between the portal vein system and systemic circulation. SPSS mainly includes esophageal varices, gastric varices, left gastric vein, recanalized paraumbilical vein, abdominal wall varices, and spontaneous splenorenal shunt. SPSS contributes to the development of hepatic encephalopathy caused by portal vein inflow bypassing and carries a higher risk of death in liver cirrhosis. Abdominal contrast-enhanced computed tomography is a major imaging approach to establish a diagnosis of SPSS and evaluate its location and feature. This review primarily describes the main contrast-enhanced CT features of SPSS in liver cirrhosis.
    MeSH term(s) Esophageal and Gastric Varices/complications ; Esophageal and Gastric Varices/etiology ; Hepatic Encephalopathy/diagnostic imaging ; Hepatic Encephalopathy/etiology ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnostic imaging ; Portasystemic Shunt, Transjugular Intrahepatic/adverse effects ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2022-06-08
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2762182-0
    ISSN 2291-2797 ; 1916-7237 ; 0835-7900
    ISSN (online) 2291-2797 ; 1916-7237
    ISSN 0835-7900
    DOI 10.1155/2022/3231144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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