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  1. Article ; Online: Deterioração sócioeconômica e ambiental na sub-bacia hidrográfica do arroio Inhamandá, São Pedro do Sul (RS) / Socioeconomic and environmental deterioration in arroio Inhamandá subbasin, São Pedro do Sul (RS)

    Fábio Charão Kurtz / José Sales Mariano da Rocha / Silvia Margareti de Juli Morais Kurtz / Sandra Maria Garcia / Alessandro Herbert de Oliveira Santos / Paulo Roberto Jaques Dill / Fabrina Bolzan Martins / Maria Simone de Juli Morais

    Ambiência, Vol 1, Iss 2, Pp 207-

    2005  Volume 212

    Abstract: ... da Sub-Bacia Hidrográfica do Arroio Inhamandá, no município de São Pedro do Sul (RS). Os resultados ...

    Abstract Os Diagnósticos Sócioeconômicos e Ambientais fazem parte de um conjunto de projetos ambientais que visam contribuir para a utilização racional e sustentável dos recursos naturais, bem como avaliar as relações entre o homem e a ambiência dentro das unidades naturais, ou seja, as bacias hidrográficas. A utilização deste diagnóstico específico permite analisar as deteriorações sociais, econômicas, tecnológicas, sócio-econômicas e ambientais, com o intuito de fornecer subsídios para programas de Educação Ambiental Técnica. Visa também a disseminação de conhecimentos e conseqüentemente a busca de alternativas para a melhoria da qualidade e do nível de vida da população. O referido diagnóstico foi realizado na área rural da Sub-Bacia Hidrográfica do Arroio Inhamandá, no município de São Pedro do Sul (RS). Os resultados obtidos apresentam um elevado índice de deterioração nas cinco linhas abordadas pelo diagnóstico, demonstrando a real necessidade de programas que visem a ações para a melhor utilização dos recursos naturais, além da melhoria da qualidade de vida da comunidade rural.
    Keywords arroio Inhamandá ; deterioração ; recuperação ambiental ; Environmental sciences ; GE1-350
    Language English
    Publishing date 2005-08-01T00:00:00Z
    Publisher Editora Unicentro
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book: The play of allegory in the Autos sacramentales of Pedro Calderón de la Barca

    Kurtz, Barbara Ellen

    (Contexts and literature ; 2)

    1991  

    Author's details Barbara E. Kurtz
    Series title Contexts and literature ; 2
    Language English
    Size V, 250 S
    Publisher Catholic Univ. of America Pr
    Publishing place Washington, D.C
    Document type Book
    Note Text teilw. span
    ISBN 0813207339 ; 9780813207339
    Database Former special subject collection: coastal and deep sea fishing

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  3. Article ; Online: Acute encephalopathy in the ICU: a practical approach.

    Kurtz, Pedro / van den Boogaard, Mark / Girard, Timothy D / Hermann, Bertrand

    Current opinion in critical care

    2024  Volume 30, Issue 2, Page(s) 106–120

    Abstract: Purpose of review: Acute encephalopathy (AE) - which frequently develops in critically ill patients with and without primary brain injury - is defined as an acute process that evolves rapidly and leads to changes in baseline cognitive status, ranging ... ...

    Abstract Purpose of review: Acute encephalopathy (AE) - which frequently develops in critically ill patients with and without primary brain injury - is defined as an acute process that evolves rapidly and leads to changes in baseline cognitive status, ranging from delirium to coma. The diagnosis, monitoring, and management of AE is challenging. Here, we discuss advances in definitions, diagnostic approaches, therapeutic options, and implications to outcomes of the clinical spectrum of AE in ICU patients without primary brain injury.
    Recent findings: Understanding and definitions of delirium and coma have evolved. Delirium is a neurocognitive disorder involving impairment of attention and cognition, usually fluctuating, and developing over hours to days. Coma is a state of unresponsiveness, with absence of command following, intelligible speech, or visual pursuit, with no imaging or neurophysiological evidence of cognitive motor dissociation. The CAM-ICU(-7) and the ICDSC are validated, guideline-recommended tools for clinical delirium assessment, with identification of clinical subtypes and stratification of severity. In comatose patients, the roles of continuous EEG monitoring and neuroimaging have grown for the early detection of secondary brain injury and treatment of reversible causes.
    Summary: Evidence-based pharmacologic treatments for delirium are limited. Dexmedetomidine is effective for mechanically ventilated patients with delirium, while haloperidol has minimal effect of delirium but may have other benefits. Specific treatments for coma in nonprimary brain injury are still lacking.
    MeSH term(s) Humans ; Delirium/diagnosis ; Delirium/therapy ; Coma/diagnosis ; Coma/therapy ; Intensive Care Units ; Haloperidol/therapeutic use ; Critical Illness/psychology ; Brain Injuries/complications
    Chemical Substances Haloperidol (J6292F8L3D)
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001144
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  4. Article: Nutrition Therapy, Glucose Control, and Brain Metabolism in Traumatic Brain Injury: A Multimodal Monitoring Approach.

    Kurtz, Pedro / Rocha, Eduardo E M

    Frontiers in neuroscience

    2020  Volume 14, Page(s) 190

    Abstract: The goal of neurocritical care in patients with traumatic brain injury (TBI) is to prevent secondary brain damage. Pathophysiological mechanisms lead to loss of body mass, negative nitrogen balance, dysglycemia, and cerebral metabolic dysfunction. All of ...

    Abstract The goal of neurocritical care in patients with traumatic brain injury (TBI) is to prevent secondary brain damage. Pathophysiological mechanisms lead to loss of body mass, negative nitrogen balance, dysglycemia, and cerebral metabolic dysfunction. All of these complications have been shown to impact outcomes. Therapeutic options are available that prevent or mitigate their negative impact. Nutrition therapy, glucose control, and multimodality monitoring with cerebral microdialysis (CMD) can be applied as an integrated approach to optimize systemic immune and organ function as well as adequate substrate delivery to the brain. CMD allows real-time bedside monitoring of aspects of brain energy metabolism, by measuring specific metabolites in the extracellular fluid of brain tissue. Sequential monitoring of brain glucose and lactate/pyruvate ratio may reveal pathologic processes that lead to imbalances in supply and demand. Early recognition of these patterns may help individualize cerebral perfusion targets and systemic glucose control following TBI. In this direction, recent consensus statements have provided guidelines and recommendations for CMD applications in neurocritical care. In this review, we summarize data from clinical research on patients with severe TBI focused on a multimodal approach to evaluate aspects of nutrition therapy, such as timing and route; aspects of systemic glucose management, such as intensive vs. moderate control; and finally, aspects of cerebral metabolism. Research and clinical applications of CMD to better understand the interplay between substrate supply, glycemic variations, insulin therapy, and their effects on the brain metabolic profile were also reviewed. Novel mechanistic hypotheses in the interpretation of brain biomarkers were also discussed. Finally, we offer an integrated approach that includes nutritional and brain metabolic monitoring to manage severe TBI patients.
    Language English
    Publishing date 2020-03-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2020.00190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction: Effects of Tranexamic Acid in Patients with Subarachnoid Hemorrhage in Brazil: A Prospective Observational Study with Propensity Score Analysis.

    Rynkowski, Carla B / Hegele, Vanessa / Soares, Pedro Henrique Rigotti / Tonello, Monica Lopes / Petterson, Letícia / Gomes, Frederico Klein / Rabinstein, Alejandro A / Bastos, Leonardo S L / Turon, Ricardo / Gonçalves, Bruno / Righy, Cassia / Bozza, Fernando A / Kurtz, Pedro

    Neurocritical care

    2023  Volume 39, Issue 3, Page(s) 754

    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-023-01866-3
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  6. Article ; Online: A microfluidic approach for label-free identification of small-sized microplastics in seawater.

    Gong, Liyuan / Martinez, Omar / Mesquita, Pedro / Kurtz, Kayla / Xu, Yang / Lin, Yang

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11011

    Abstract: Marine microplastics are emerging as a growing environmental concern due to their potential harm to marine biota. The substantial variations in their physical and chemical properties pose a significant challenge when it comes to sampling and ... ...

    Abstract Marine microplastics are emerging as a growing environmental concern due to their potential harm to marine biota. The substantial variations in their physical and chemical properties pose a significant challenge when it comes to sampling and characterizing small-sized microplastics. In this study, we introduce a novel microfluidic approach that simplifies the trapping and identification process of microplastics in surface seawater, eliminating the need for labeling. We examine various models, including support vector machine, random forest, convolutional neural network (CNN), and residual neural network (ResNet34), to assess their performance in identifying 11 common plastics. Our findings reveal that the CNN method outperforms the other models, achieving an impressive accuracy of 93% and a mean area under the curve of 98 ± 0.02%. Furthermore, we demonstrate that miniaturized devices can effectively trap and identify microplastics smaller than 50 µm. Overall, this proposed approach facilitates efficient sampling and identification of small-sized microplastics, potentially contributing to crucial long-term monitoring and treatment efforts.
    MeSH term(s) Microfluidic Analytical Techniques/instrumentation ; Microfluidic Analytical Techniques/methods ; Seawater/chemistry ; Plastics/chemistry ; Machine Learning ; Water Pollutants, Chemical/chemistry
    Chemical Substances Plastics ; Water Pollutants, Chemical
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-37900-9
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  7. Article ; Online: Critical care management of infectious meningitis and encephalitis.

    Meyfroidt, Geert / Kurtz, Pedro / Sonneville, Romain

    Intensive care medicine

    2020  Volume 46, Issue 2, Page(s) 192–201

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Cerebrospinal Fluid/chemistry ; Cerebrospinal Fluid/microbiology ; Critical Care/methods ; Critical Care/trends ; Cross Infection ; Encephalitis/epidemiology ; Encephalitis/therapy ; Humans ; Meningitis, Bacterial/epidemiology ; Meningitis, Bacterial/therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-019-05901-w
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  8. Article ; Online: A microfluidic approach for label-free identification of small-sized microplastics in seawater

    Liyuan Gong / Omar Martinez / Pedro Mesquita / Kayla Kurtz / Yang Xu / Yang Lin

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 14

    Abstract: Abstract Marine microplastics are emerging as a growing environmental concern due to their potential harm to marine biota. The substantial variations in their physical and chemical properties pose a significant challenge when it comes to sampling and ... ...

    Abstract Abstract Marine microplastics are emerging as a growing environmental concern due to their potential harm to marine biota. The substantial variations in their physical and chemical properties pose a significant challenge when it comes to sampling and characterizing small-sized microplastics. In this study, we introduce a novel microfluidic approach that simplifies the trapping and identification process of microplastics in surface seawater, eliminating the need for labeling. We examine various models, including support vector machine, random forest, convolutional neural network (CNN), and residual neural network (ResNet34), to assess their performance in identifying 11 common plastics. Our findings reveal that the CNN method outperforms the other models, achieving an impressive accuracy of 93% and a mean area under the curve of 98 ± 0.02%. Furthermore, we demonstrate that miniaturized devices can effectively trap and identify microplastics smaller than 50 µm. Overall, this proposed approach facilitates efficient sampling and identification of small-sized microplastics, potentially contributing to crucial long-term monitoring and treatment efforts.
    Keywords Medicine ; R ; Science ; Q
    Subject code 333
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Thrombotic and Hemorrhagic Neurological Complications in Critically Ill COVID-19 Patients.

    Gonçalves, Bruno / Righy, Cassia / Kurtz, Pedro

    Neurocritical care

    2020  Volume 33, Issue 2, Page(s) 587–590

    MeSH term(s) Adult ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/therapy ; Cerebral Hemorrhage/virology ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/therapy ; Fatal Outcome ; Female ; Humans ; Intracranial Thrombosis/diagnostic imaging ; Intracranial Thrombosis/therapy ; Intracranial Thrombosis/virology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-020-01078-z
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  10. Article ; Online: Antimicrobial consumption and drug utilization patterns among COVID-19 and non-COVID-19 patients.

    Antunes, Bianca B P / Silva, Amanda A B / Nunes, Patricia H C / Martin-Loeches, Ignacio / Kurtz, Pedro / Hamacher, Silvio / Bozza, Fernando A

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 3, Page(s) 840–849

    Abstract: Objectives: To understand differences in antimicrobial use between COVID-19 and non-COVID-19 patients. To compare two metrics commonly used for antimicrobial use: Defined Daily Dose (DDD) and Days of Therapy (DOT). To analyse the order in which ... ...

    Abstract Objectives: To understand differences in antimicrobial use between COVID-19 and non-COVID-19 patients. To compare two metrics commonly used for antimicrobial use: Defined Daily Dose (DDD) and Days of Therapy (DOT). To analyse the order in which antimicrobials were prescribed to COVID-19 patients using process mining techniques.
    Methods: We analysed data regarding all ICU admissions from 1 January 2018 to 14 September 2020, in 17 Brazilian hospitals. Our main outcome was the antimicrobial use estimated by the DDD and DOT (Days of Therapy). We compared clinical characteristics and antimicrobial consumption between COVID-19 and non-COVID-19 patients. We used process mining to evaluate the order in which the antimicrobial schemes were prescribed to each COVID-19 patient.
    Results: We analysed 68 405 patients admitted before the pandemic, 12 319 non-COVID-19 patients and 3240 COVID-19 patients. Comparing those admitted during the pandemic, the COVID-19 patients required advanced respiratory support more often (42% versus 12%). They also had longer ICU length of stay (6 versus 3 days), higher ICU mortality (18% versus 5.4%) and greater use of antimicrobials (70% versus 39%). Most of the COVID-19 treatments started with penicillins with ß-lactamase inhibitors (30%), third-generation cephalosporins (22%), or macrolides in combination with penicillins (19%).
    Conclusions: Antimicrobial prescription increased in Brazilian ICUs during the COVID-19 pandemic, especially during the first months of the epidemic. We identified greater use of broad-spectrum antimicrobials by COVID-19 patients. Overall, the DDD metric overestimated antimicrobial use compared with the DOT metric.
    MeSH term(s) Humans ; Pandemics ; COVID-19 ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Drug Utilization ; Penicillins
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Penicillins
    Language English
    Publishing date 2023-02-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad025
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