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Article ; Online: 7,8-Dihydroxyflavone Attenuates Inflammatory Response and Insulin Resistance Induced by the Paracrine Interaction between Adipocytes and Macrophages.

Shin, Ye-Eun / Choi, Ji Won / Park, Yong Il / Kim, Hye-Kyeong

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: ... tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) and FFA secretion but suppressed the production ...

Abstract	Obesity-induced inflammation and insulin resistance are mediated by macrophage infiltration into adipose tissue. We investigated the effects of 7,8-dihydroxyflavone (7,8-DHF), a flavone found in plants, on the inflammatory response and insulin resistance induced by the interaction between adipocytes and macrophages. Hypertrophied 3T3-L1 adipocytes were cocultured with RAW 264.7 macrophages and treated with 7,8-DHF (3.12, 12.5, and 50 μM). The inflammatory cytokines and free fatty acid (FFA) release were evaluated by assay kits, and signaling pathways were determined by immunoblotting. Coculture of adipocytes and macrophages increased inflammatory mediators, such as nitric oxide (NO), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) and FFA secretion but suppressed the production of anti-inflammatory adiponectin. 7,8-DHF counteracted the coculture-induced changes (
MeSH term(s)	Animals ; Mice ; 3T3-L1 Cells ; Adipocytes/metabolism ; Coculture Techniques ; Inflammation/metabolism ; Insulin/metabolism ; Insulin Resistance ; Macrophages/metabolism ; Obesity/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Flavones/metabolism ; Flavones/pharmacology ; Paracrine Communication
Chemical Substances	6,7-dihydroxyflavone ; Insulin ; Tumor Necrosis Factor-alpha ; Flavones
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043520
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Article: Correction: Chloroquine inhibits vasodilation induced by ATP-sensitive potassium channels in isolated rat aorta.

Park, Kyeong-Eon / Lee, Soo Hee / Bae, Sung Il / Hwang, Yeran / Ok, Seong-Ho / Kang, Dawon / Ahn, Seung Hyun / Sim, Gyujin / Park, Jin Kyeong / Sohn, Ju-Tae

General physiology and biophysics

2023 Volume 42, Issue 4, Page(s) 383

Abstract: ... University College of Medicine, Jinju-si, Gyeongsangnam-do, Republic of Korea was added for the author Kyeong ... Eon Park at his own request. ...

Abstract	Another affiliation: 2 Department of Anesthesiology and Pain Medicine, Gyeongsang National University College of Medicine, Jinju-si, Gyeongsangnam-do, Republic of Korea was added for the author Kyeong-Eon Park at his own request.
Language	English
Publishing date	2023-06-17
Publishing country	Slovakia
Document type	Published Erratum
ZDB-ID	791184-1
ISSN	0231-5882
ISSN	0231-5882
DOI	10.4149/gpb_2023014
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Article ; Online: CD1b glycoprotein, a crucial marker of thymocyte development during T cell maturation in cynomolgus monkeys.

Choi, Sung Min / Park, Hi Jung / Choi, Eun A / Jung, Kyeong Cheon / Lee, Jae Il

Scientific reports

2023 Volume 13, Issue 1, Page(s) 14388

Abstract: Phenotypic markers that denote different developmental stages of thymocytes are important for understanding T cell development in the thymus. Here, we show that CD1b is a critical discriminator of thymocyte maturation stage in cynomolgus monkeys. CD1b ... ...

Abstract	Phenotypic markers that denote different developmental stages of thymocytes are important for understanding T cell development in the thymus. Here, we show that CD1b is a critical discriminator of thymocyte maturation stage in cynomolgus monkeys. CD1b was expressed by immature thymocytes prior to β-selection, and its expression decreased as cells became fully mature in the thymus. MHC-I expression was lowest at the CD3
MeSH term(s)	Animals ; Macaca fascicularis ; Thymocytes ; Cell Differentiation ; Thymus Gland ; Glycoproteins
Chemical Substances	Glycoproteins
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41708-y
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Article ; Online: Increased Apolipoprotein B/Apolipoprotein A-I Ratio Is Associated With Decline in Lung Function in Healthy Individuals: The Kangbuk Samsung Health Study.

Lee, Jonghoo / Park, Hye Kyeong / Kwon, Min-Jung / Ham, Soo-Youn / Gil, Hyun-Il / Lim, Si-Young / Song, Jae-Uk

Journal of Korean medical science

2024 Volume 39, Issue 6, Page(s) e51

Abstract: Background: Lung dysfunction and high apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio are both recognized risk factors for cardiovascular disease. However, few studies have examined the association between the apoB/ApoA-I ratio and lung function. ...

Abstract	Background: Lung dysfunction and high apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio are both recognized risk factors for cardiovascular disease. However, few studies have examined the association between the apoB/ApoA-I ratio and lung function. Therefore, we investigated whether this ratio is associated with decreased lung function in a large healthy cohort. Methods: We performed a cohort study on 68,418 healthy Koreans (34,797 males, mean age: 38.1 years) who underwent a health examination in 2019. ApoB/apoA-I ratio was categorized into quartiles. Spirometric values at the fifth percentile in our population were considered the lower limit of normal (LLN), which was used to define lung function impairment. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs), using the lowest quartile as the reference, were estimated to determine lung function impairment. Results: Mean apoB/apoA-I ratio was 0.67 ± 0.21. Subjects with the highest quartile of this ratio had the lowest predicted forced expiratory volume in one second (FEV Conclusion: High apoB/apoA-I ratio was associated with decreased lung function. However, longitudinal follow-up studies are required to validate our findings.
MeSH term(s)	Adult ; Humans ; Male ; Apolipoprotein A-I ; Apolipoproteins B ; Cohort Studies ; Forced Expiratory Volume ; Lung/pathology ; Spirometry ; Vital Capacity ; Lung Diseases/blood ; Lung Diseases/diagnosis
Chemical Substances	Apolipoprotein A-I ; Apolipoproteins B
Language	English
Publishing date	2024-02-19
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2024.39.e51
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Article ; Online: Anti-Tumor Efficacy of Oleuropein-Loaded ZnO/Au Mesoporous Silica Nanoparticle in 5-FU-Resistant Colorectal Cancer Cells.

Park, Sang Mi / Kim, Da Yeon / Lee, Kyeong Hyeon / Shin, Yong-Il / Han, Sang-Cheol / Kwon, Sang-Mo

International journal of nanomedicine

2024 Volume 19, Page(s) 2675–2690

Abstract: Purpose: 5-fluorouracil (5-FU) is a first-line chemotherapeutic agent used to treat colorectal cancer (CRC). However, 5-FU induces drug resistance and activation of cancer stem cells (CSCs). In the present study, we designed a novel biocompatible ... ...

Abstract	Purpose: 5-fluorouracil (5-FU) is a first-line chemotherapeutic agent used to treat colorectal cancer (CRC). However, 5-FU induces drug resistance and activation of cancer stem cells (CSCs). In the present study, we designed a novel biocompatible nanomedicine system with high efficacy and biocompatibility by synthesizing mesoporous silica nanoparticle (MSN)-structured ZnO and gold ions. Oleuropein (OLP) is a phenolic compound derived from olive leaves that exerts anti-cancer effects. Therefore, we synthesized OLP-loaded ZnO/Au MSNs (ZnO/Au/OLP MSNs) and examined their anti-cancer effects on 5-FU-resistant CRC cells. Methods: ZnO/Au MSNs were synthesized and functionalized, and their physical and chemical compositions were characterized using UV-visible spectroscopy, dynamic light scattering, and transmission electron microscopy (TEM). Their effects were assessed in terms of cellular proliferation capacity, migration and invasion ability, colony-forming ability, spheroid-forming ability, reactive oxygen species (ROS) production, and mitochondrial membrane depolarization. Results: ZnO/Au MSNs were mostly composed of various ions containing ZnO and gold ions, had a spheroid phenotype, and exhibited no cytotoxicity. ZnO/Au/OLP MSNs reduced cell viability and CSC formation and induced apoptosis of 5-FU-resistant CRC cells via necrosis via ROS accumulation and DNA fragmentation. Conclusion: ZnO/Au/OLP MSNs exhibited anti-cancer activity by upregulating necrosis. These results revealed that ZnO/Au/OLP MSNs are a novel drug delivery system for 5-FU CRC therapy.
MeSH term(s)	Humans ; Zinc Oxide ; Silicon Dioxide/chemistry ; Reactive Oxygen Species ; Nanoparticles/chemistry ; Fluorouracil/pharmacology ; Necrosis ; Gold/chemistry ; Ions ; Colorectal Neoplasms/drug therapy ; Porosity ; Iridoid Glucosides
Chemical Substances	Zinc Oxide (SOI2LOH54Z) ; oleuropein (2O4553545L) ; Silicon Dioxide (7631-86-9) ; Reactive Oxygen Species ; Fluorouracil (U3P01618RT) ; Gold (7440-57-5) ; Ions ; Iridoid Glucosides
Language	English
Publishing date	2024-03-14
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S439392
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Article ; Online: Neuroprotective Effects of Aucubin against Cerebral Ischemia and Ischemia Injury through the Inhibition of the TLR4/NF-κB Inflammatory Signaling Pathway in Gerbils.

Park, Joon Ha / Lee, Tae-Kyeong / Kim, Dae Won / Ahn, Ji Hyeon / Shin, Myoung Cheol / Cho, Jun Hwi / Won, Moo-Ho / Kang, Il Jun

International journal of molecular sciences

2024 Volume 25, Issue 6

Abstract: Aucubin, an iridoid glycoside, possesses beneficial bioactivities in many diseases, but little is known about its neuroprotective effects and mechanisms in brain ischemia and reperfusion (IR) injury. This study evaluated whether aucubin exhibited ... ...

Abstract	Aucubin, an iridoid glycoside, possesses beneficial bioactivities in many diseases, but little is known about its neuroprotective effects and mechanisms in brain ischemia and reperfusion (IR) injury. This study evaluated whether aucubin exhibited neuroprotective effects against IR injury in the hippocampal CA1 region through anti-inflammatory activity in gerbils. Aucubin (10 mg/kg) was administered intraperitoneally once a day for one week prior to IR. Neuroprotective effects of aucubin were assessed by neuronal nuclei (NeuN) immunofluorescence and Floro-Jade C (FJC) histofluorescence. Microgliosis and astrogliosis were evaluated using immunohistochemistry with anti-ionized calcium binding adapter protein 1 (Iba1) and glial fibrillary acidic protein (GFAP). Protein levels of proinflammatory cytokines interleukin1 beta (IL1β) and tumor necrosis factor alpha (TNFα) were assayed using enzyme-linked immunosorbent assay and Western blot. Changes in toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling pathway were assessed by measuring levels of TLR4, inhibitor of NF-κB alpha (IκBα), and NF-κB p65 using Western blot. Aucubin treatment protected pyramidal neurons from IR injury. IR-induced microgliosis and astrogliosis were suppressed by aucubin treatment. IR-induced increases in IL1β and TNFα levels were significantly alleviated by the treatment. IR-induced upregulation of TLR4 and downregulation of IκBα were significantly prevented by aucubin treatment, and IR-induced nuclear translocation of NF-κB was reversed by aucubin treatment. Briefly, aucubin exhibited neuroprotective effects against brain IR injury, which might be related to the attenuation of neuroinflammation through inhibiting the TLR-4/NF-κB signaling pathway. These results suggest that aucubin pretreatment may be a potential approach for the protection of brain IR injury.
MeSH term(s)	Animals ; NF-kappa B/metabolism ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; NF-KappaB Inhibitor alpha/metabolism ; Gerbillinae/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Toll-Like Receptor 4/metabolism ; Gliosis ; Signal Transduction ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Ischemia ; Cerebral Infarction ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Iridoid Glucosides
Chemical Substances	NF-kappa B ; Neuroprotective Agents ; aucubin (2G52GS8UML) ; NF-KappaB Inhibitor alpha (139874-52-5) ; Tumor Necrosis Factor-alpha ; Toll-Like Receptor 4 ; Iridoid Glucosides
Language	English
Publishing date	2024-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25063461
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Article: Prevention of severe lung immunopathology associated with influenza infection through adeno-associated virus vector administration.

Choi, Eun Ah / Park, Hi Jung / Choi, Sung Min / Lee, Jae Il / Jung, Kyeong Cheon

Laboratory animal research

2023 Volume 39, Issue 1, Page(s) 26

Abstract: Background: Influenza A viruses (IAVs) have long posed a threat to humans, occasionally causing significant morbidity and mortality. The initial immune response is triggered by infected epithelial cells, alveolar macrophages and dendritic cells. However, ...

Abstract	Background: Influenza A viruses (IAVs) have long posed a threat to humans, occasionally causing significant morbidity and mortality. The initial immune response is triggered by infected epithelial cells, alveolar macrophages and dendritic cells. However, an exaggerated innate immune response can result in severe lung injury and even host mortality. One notable pathology observed in hosts succumbing to severe influenza is the excessive influx of neutrophils and monocytes into the lung. In this study, we investigated a strategy for controlling lung immunopathology following severe influenza infection. Results: To evaluate the impact of innate immunity on influenza-associated lung injury, we employed CB17.SCID and NOD.SCID mice. NOD.SCID mice exhibited slower weight loss and longer survival than CB17.SCID mice following influenza infection. Lung inflammation was reduced in NOD.SCID mice compared to CB17.SCID mice. Bulk RNA sequencing analysis of lung tissue showed significant downregulation of 827 genes, and differentially expressed gene analysis indicated that the cytokine-cytokine receptor interaction pathway was predominantly downregulated in NOD.SCID mice. Interestingly, the expression of the Cxcl14 gene was higher in the lungs of influenza-infected NOD.SCID mice than in CB17.SCID mice. Therefore, we induced overexpression of the Cxcl14 gene in the lung using the adeno-associated virus 9 (AAV9)-vector system for target gene delivery. However, when we administered the AAV9 vector carrying the Cxcl14 gene or a control AAV9 vector to BALB/c mice from both groups, the morbidity and mortality rates remained similar. Both groups exhibited lower morbidity and mortality than the naive group that did not receive the AAV9 vector prior to IAV infection, suggesting that the pre-administration of the AAV9 vector conferred protection against lethal influenza infection, irrespective of Cxcl14 overexpression. Furthermore, we found that pre-inoculation of BALB/c mice with AAV9 attenuated the infiltration of trans-macrophages, neutrophils and monocytes in the lungs following IAV infection. Although there was no difference in lung viral titers between the naive group and the AAV9 pre-inoculated group, pre-inoculation with AAV9 conferred lung injury protection against lethal influenza infection in mice. Conclusions: Our study demonstrated that pre-inoculation with AAV9 prior to IAV infection protected mouse lungs from immunopathology by reducing the recruitment of inflammatory cells.
Language	English
Publishing date	2023-10-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2623220-0
ISSN	2233-7660 ; 1738-6055
ISSN (online)	2233-7660
ISSN	1738-6055
DOI	10.1186/s42826-023-00177-0
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Article ; Online: Heterogeneity of circulating CD4

Choi, Sung Min / Park, Hi Jung / Choi, Eun A / Jung, Kyeong Cheon / Lee, Jae Il

Scientific reports

2022 Volume 12, Issue 1, Page(s) 14111

Abstract: The frequency of ... ...

Abstract	The frequency of CD4
MeSH term(s)	Animals ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Lymphocyte Count ; Macaca fascicularis ; Macaca mulatta ; Single-Cell Analysis ; T-Lymphocyte Subsets
Language	English
Publishing date	2022-08-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-18340-3
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Article: Chloroquine inhibits vasodilation induced by ATP-sensitive potassium channels in isolated rat aorta.

Park, Kyeong-Eon / Lee, Soo Hee / Bae, Sung Il / Hwang, Yeran / Ok, Seong-Ho / Kang, Dawon / Ahn, Seung Hyun / Sim, Gyujin / Park, Jin Kyeong / Sohn, Ju-Tae

General physiology and biophysics

2023 Volume 42, Issue 3, Page(s) 297–306

Abstract: This study examined the effect of chloroquine on vasodilation induced by levcromakalim in isolated endothelium-denuded rat aortas and clarified the underlying mechanisms. We examined the effects of chloroquine, hydroxychloroquine, lipid emulsion, ... ...

Abstract	This study examined the effect of chloroquine on vasodilation induced by levcromakalim in isolated endothelium-denuded rat aortas and clarified the underlying mechanisms. We examined the effects of chloroquine, hydroxychloroquine, lipid emulsion, reactive oxygen species (ROS) scavenger N-acetyl-ʟ-cysteine (NAC), and KATP channel inhibitor glibenclamide on levcromakaliminduced vasodilation. The effects of chloroquine, hydroxychloroquine, NAC, and levcromakalim on membrane hyperpolarization and ROS production were examined in aortic vascular smooth muscle cells (VSMCs). Chloroquine inhibited levcromakalim-induced vasodilation more than hydroxychloroquine. NAC attenuated chloroquine-mediated inhibition of levcromakalim-induced vasodilation, while lipid emulsion had no effect. Glibenclamide eliminated levcromakalim-induced vasodilation in aortas pretreated with chloroquine. Chloroquine and hydroxychloroquine inhibited levcromakalim-induced membrane hyperpolarization in VSMCs. Chloroquine and hydroxychloroquine both produced ROS, but chloroquine produced more. NAC inhibited chloroquine-induced ROS production in VSMCs. Collectively, these results suggest that, partially through ROS production, chloroquine inhibits levcromakalim-induced vasodilation. In addition, chloroquine-induced KATP channel-induced vasodilation impairment was not restored by lipid emulsion.
MeSH term(s)	Rats ; Animals ; Vasodilation ; Cromakalim/pharmacology ; Vasodilator Agents/pharmacology ; KATP Channels ; Glyburide/pharmacology ; Reactive Oxygen Species ; Hydroxychloroquine/pharmacology ; Chloroquine/pharmacology ; Emulsions/pharmacology ; Potassium Channels ; Aorta ; Lipids
Chemical Substances	Cromakalim (0G4X367WA3) ; Vasodilator Agents ; KATP Channels ; Glyburide (SX6K58TVWC) ; Reactive Oxygen Species ; Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF) ; Emulsions ; Potassium Channels ; Lipids
Language	English
Publishing date	2023-04-26
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	791184-1
ISSN	0231-5882
ISSN	0231-5882
DOI	10.4149/gpb_2023008
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Article ; Online: Response.

Choi, Joon Young / Kim, Ki Uk / Kim, Deog Kyeom / Kim, Yu-Il / Kim, Tae-Hyung / Lee, Won-Yeon / Park, Seong Ju / Park, Yong Bum / Song, Jin Woo / Shin, Kyeong-Cheol / Um, Soo-Jung / Yoo, Kwang Ha / Yoon, Hyoung Kyu / Lee, Chang Youl / Lee, Ho Sung / Leem, Ah Young / Choi, Won-Il / Lim, Seong Yong / Rhee, Chin Kook

Chest

2024 Volume 165, Issue 4, Page(s) e126–e128

Language	English
Publishing date	2024-03-16
Publishing country	United States
Document type	Letter
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2023.11.003
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