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  1. Article ; Online: An Endodontic Forecasting Model Based on the Analysis of Preoperative Dental Radiographs: A Pilot Study on an Endodontic Predictive Deep Neural Network.

    Lee, Junghoon / Seo, Hyunseok / Choi, Yoon Jeong / Lee, Chena / Kim, Sunil / Lee, Ye Sel / Lee, Sukjoon / Kim, Euiseong

    Journal of endodontics

    2023  Volume 49, Issue 6, Page(s) 710–719

    Abstract: Introduction: This study aimed to evaluate the use of deep convolutional neural network (DCNN) algorithms to detect clinical features and predict the three-year outcome of endodontic treatment on preoperative periapical radiographs.: Methods: A ... ...

    Abstract Introduction: This study aimed to evaluate the use of deep convolutional neural network (DCNN) algorithms to detect clinical features and predict the three-year outcome of endodontic treatment on preoperative periapical radiographs.
    Methods: A database of single-root premolars that received endodontic treatment or retreatment by endodontists with presence of three-year outcome was prepared (n = 598). We constructed a 17-layered DCNN with a self-attention layer (Periapical Radiograph Explanatory System with Self-Attention Network [PRESSAN-17]), and the model was trained, validated, and tested to 1) detect 7 clinical features, that is, full coverage restoration, presence of proximal teeth, coronal defect, root rest, canal visibility, previous root filling, and periapical radiolucency and 2) predict the three-year endodontic prognosis by analyzing preoperative periapical radiographs as an input. During the prognostication test, a conventional DCNN without a self-attention layer (residual neural network [RESNET]-18) was tested for comparison. Accuracy and area under the receiver-operating-characteristic curve were mainly evaluated for performance comparison. Gradient-weighted class activation mapping was used to visualize weighted heatmaps.
    Results: PRESSAN-17 detected full coverage restoration (area under the receiver-operating-characteristic curve = 0.975), presence of proximal teeth (0.866), coronal defect (0.672), root rest (0.989), previous root filling (0.879), and periapical radiolucency (0.690) significantly, compared to the no-information rate (P < .05). Comparing the mean accuracy of 5-fold validation of 2 models, PRESSAN-17 (67.0%) showed a significant difference to RESNET-18 (63.4%, P < .05). Also, the area under average receiver-operating-characteristic of PRESSAN-17 was 0.638, which was significantly different compared to the no-information rate. Gradient-weighted class activation mapping demonstrated that PRESSAN-17 correctly identified clinical features.
    Conclusions: Deep convolutional neural networks can detect several clinical features in periapical radiographs accurately. Based on our findings, well-developed artificial intelligence can support clinical decisions related to endodontic treatments in dentists.
    MeSH term(s) Root Canal Therapy ; Pilot Projects ; Artificial Intelligence ; Radiography ; Neural Networks, Computer
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752412-2
    ISSN 1878-3554 ; 0099-2399
    ISSN (online) 1878-3554
    ISSN 0099-2399
    DOI 10.1016/j.joen.2023.03.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical and MRI correlates of autonomic dysfunction in neuromyelitis optica spectrum disorder.

    Kwon, Soonwook / Kim, Ye Sel / Kim, Juhyeon / Kim, Byoung Joon / Min, Ju-Hong

    Multiple sclerosis and related disorders

    2020  Volume 43, Page(s) 102215

    Abstract: Background: The aim of this study was to investigate the relationship of autonomic dysfunction and clinical findings in patients with neuromyelitis optica spectrum disorder (NMOSD).: Methods: For the assessment of autonomic dysfunction, heart rate ... ...

    Abstract Background: The aim of this study was to investigate the relationship of autonomic dysfunction and clinical findings in patients with neuromyelitis optica spectrum disorder (NMOSD).
    Methods: For the assessment of autonomic dysfunction, heart rate variability (HRV) and blood pressure (BP) measurement to deep breathing, Valsalva maneuver or head tilt-table test, with quantitative sudomotor axon reflex test (QSART) were used and interpreted in the form of the composite autonomic scoring scale (CASS). Clinical and radiological correlates with autonomic profiles were analyzed.
    Results: A total of 27 patients (mean age, 44.4 ± 12.26 years; female: male=22:5) were enrolled in this study and 74.1% of them showed autonomic dysfunction, involving the adrenergic, cardiovagal, or sudomotor domains. Eighteen patients were during remission, in whom, demographics and MRI findings were associated with an index or a total score of CASS. The presence of cervical cord lesion showed the association with cardiovagal index (B = 0.750, S.E. 0.242, 95% CI 0.237-1.263, p = 0.007), male gender with sudomotor index (B = 1.600, S.E. 0.653, 95% CI 0.199-3.001, p = 0.028) and the involvement of brain and/or spinal cord with a total CASS score (B = 1.500, S.E. 0.655, 95% CI 0.096-2.904, p = 0.038). In multivariable analysis, delayed pressure recovery time showed a significant positive association with EDSS score (B = 0.103, S.E. 0.031, 95% CI 0.037-0.168, p = 0.004).
    Discussion: Cardiovascular and sudomotor autonomic dysfunction are common in NMOSD. Several clinical and MRI characteristics of patients may warrant the investigation of autonomic dysfunction and its proper management.
    MeSH term(s) Adult ; Autonomic Nervous System ; Autonomic Nervous System Diseases/diagnostic imaging ; Autonomic Nervous System Diseases/etiology ; Female ; Heart Rate ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuromyelitis Optica/complications ; Neuromyelitis Optica/diagnostic imaging ; Valsalva Maneuver
    Language English
    Publishing date 2020-05-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2020.102215
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  3. Article ; Online: Role of the

    Kim, Hyung Jun / Choi, Eun-Hyeok / Chung, Jong-Won / Kim, Jae-Hwan / Kim, Ye Sel / Seo, Woo-Keun / Kim, Gyeong-Moon / Bang, Oh Young

    Journal of the American Heart Association

    2020  Volume 10, Issue 1, Page(s) e017660

    Abstract: Background ... ...

    Abstract Background The
    MeSH term(s) Adenosine Triphosphatases/genetics ; Far East/epidemiology ; Female ; Genetic Predisposition to Disease ; Humans ; Intracranial Arteriosclerosis/ethnology ; Intracranial Arteriosclerosis/genetics ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Moyamoya Disease/ethnology ; Moyamoya Disease/genetics ; Mutation ; Plaque, Atherosclerotic/diagnostic imaging ; Polymorphism, Single Nucleotide ; Recurrence ; Republic of Korea/epidemiology ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/genetics ; Ubiquitin-Protein Ligases/genetics
    Chemical Substances RNF213 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Adenosine Triphosphatases (EC 3.6.1.-)
    Language English
    Publishing date 2020-12-25
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.120.017660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association of Antiplatelet Therapy, Including Cilostazol, With Improved Survival in Patients With Moyamoya Disease in a Nationwide Study.

    Seo, Woo-Keun / Kim, Jae-Young / Choi, Eun-Hyeok / Kim, Ye-Sel / Chung, Jong-Won / Saver, Jeffrey L / Bang, Oh Young / Kim, Gyeong-Moon

    Journal of the American Heart Association

    2021  Volume 10, Issue 5, Page(s) e017701

    Abstract: Background Although antiplatelet agents are frequently prescribed in moyamoya disease in routine clinical practice, there are no large-scale epidemiologic trials or randomized trial evidence to support their use in patients with moyamoya disease. Methods ...

    Abstract Background Although antiplatelet agents are frequently prescribed in moyamoya disease in routine clinical practice, there are no large-scale epidemiologic trials or randomized trial evidence to support their use in patients with moyamoya disease. Methods and Results Using the Korean National Health Insurance Service database, patients diagnosed with moyamoya disease between 2002 and 2016 were followed up for up to 14 years to assess, using time-dependent Cox regression in all patients and in a propensity score-matched cohort, the association of antiplatelet therapy and individual antiplatelet agents with survival. Among 25 978 patients with newly diagnosed moyamoya disease, mean age was 37.6±19.9 years, 61.6% were women, and total follow-up was 163 347 person-years. Among 9154 patients who were prescribed antiplatelet agents at least once during the follow-up period, the proportion prescribed cilostazol gradually increased from 5.5% in 2002 to 56.0% in 2016. Any antiplatelet use was associated with reduced risk of death (hazard ratio, 0.77; 95% CI, 0.70-0.84) in a multivariate model. Among individual antiplatelet agents, cilostazol was associated with greater reduction in mortality than the 5 other antiplatelet regimens. Subgroup analysis, according to the age group and history of ischemic stroke, and sensitivity analysis, using propensity score-matched analysis, revealed consistent results. Conclusions Antiplatelet therapy is associated with substantial improvement in survival in patients with moyamoya disease, and cilostazol is associated with greater survival benefit compared with other antiplatelet regimens. These results provisionally support the use of antiplatelet therapy in patients with moyamoya disease and the conduct of confirmatory randomized controlled trials.
    MeSH term(s) Adult ; Cilostazol/therapeutic use ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Moyamoya Disease/drug therapy ; Moyamoya Disease/mortality ; Platelet Aggregation Inhibitors/therapeutic use ; Population Surveillance ; Republic of Korea/epidemiology ; Retrospective Studies ; Survival Rate/trends ; Young Adult
    Chemical Substances Platelet Aggregation Inhibitors ; Cilostazol (N7Z035406B)
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.120.017701
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  5. Article ; Online: Luminal and Wall Changes in Intracranial Arterial Lesions for Predicting Stroke Occurrence.

    Kim, Hyung Jun / Choi, Eun-Hyeok / Chung, Jong-Won / Kim, Jae-Hwan / Kim, Ye Sel / Seo, Woo-Keun / Kim, Gyeong-Moon / Bang, Oh Young

    Stroke

    2020  Volume 51, Issue 8, Page(s) 2495–2504

    Abstract: Background and purpose: Luminal imaging (degree of stenosis) currently serves as the gold standard to predict stroke recurrence and guide therapeutic strategies in patients with intracranial large artery diseases (ILADs). We comparatively evaluated the ... ...

    Abstract Background and purpose: Luminal imaging (degree of stenosis) currently serves as the gold standard to predict stroke recurrence and guide therapeutic strategies in patients with intracranial large artery diseases (ILADs). We comparatively evaluated the importance of vessel wall and luminal changes in predicting stroke occurrence.
    Methods: Consecutive patients with ILAD in the proximal middle cerebral artery or distal internal carotid artery without proximal sources of embolism from the carotid and heart underwent time-of-flight magnetic resonance angiography, high-resolution magnetic resonance imaging, and the ring finger protein 213 (
    Results: Of the 675 patients, 241 (35.7%) had atherosclerotic ILAD and 434 (64.3%) showed nonatherosclerotic ILAD (315 [46.7%] moyamoya disease cases and 119 [17.6%] dissection cases). The
    Conclusions: This study demonstrates the prevalence of nonatherosclerotic ILAD in East Asian patients with ILAD. Unlike luminal changes, wall changes determined by high-resolution magnetic resonance imaging and presence of the
    MeSH term(s) Adult ; Endothelium, Vascular/diagnostic imaging ; Far East/epidemiology ; Female ; Humans ; Intracranial Arterial Diseases/diagnostic imaging ; Intracranial Arterial Diseases/epidemiology ; Magnetic Resonance Imaging/trends ; Male ; Middle Aged ; Moyamoya Disease/diagnostic imaging ; Predictive Value of Tests ; Prospective Studies ; Stroke/diagnostic imaging ; Stroke/epidemiology
    Language English
    Publishing date 2020-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.120.030012
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  6. Article: How Cerebral Vessel Tortuosity Affects Development and Recurrence of Aneurysm: Outer Curvature versus Bifurcation Type.

    Kim, Hyung Jun / Song, Ha-Na / Lee, Ji-Eun / Kim, Yoon-Chul / Baek, In-Young / Kim, Ye-Sel / Chung, Jong-Won / Jee, Tae Keun / Yeon, Je Young / Bang, Oh Young / Kim, Gyeong-Moon / Kim, Keon-Ha / Kim, Jong-Soo / Hong, Seung-Chyul / Seo, Woo-Keun / Jeon, Pyeong

    Journal of stroke

    2021  Volume 23, Issue 2, Page(s) 213–222

    Abstract: Background and purpose: Previous studies have assessed the relationship between cerebral vessel tortuosity and intracranial aneurysm (IA) based on two-dimensional brain image analysis. We evaluated the relationship between cerebral vessel tortuosity and ...

    Abstract Background and purpose: Previous studies have assessed the relationship between cerebral vessel tortuosity and intracranial aneurysm (IA) based on two-dimensional brain image analysis. We evaluated the relationship between cerebral vessel tortuosity and IA according to the hemodynamic location using three-dimensional (3D) analysis and studied the effect of tortuosity on the recurrence of treated IA.
    Methods: We collected clinical and imaging data from patients with IA and disease-free controls. IAs were categorized into outer curvature and bifurcation types. Computerized analysis of the images provided information on the length of the arterial segment and tortuosity of the cerebral arteries in 3D space.
    Results: Data from 95 patients with IA and 95 controls were analyzed. Regarding parent vessel tortuosity index (TI; P<0.01), average TI (P<0.01), basilar artery (BA; P=0.02), left posterior cerebral artery (P=0.03), both vertebral arteries (VAs; P<0.01), and right internal carotid artery (P<0.01), there was a significant difference only in the outer curvature type compared with the control group. The outer curvature type was analyzed, and the occurrence of an IA was associated with increased TI of the parent vessel, average, BA, right middle cerebral artery, and both VAs in the logistic regression analysis. However, in all aneurysm cases, recanalization of the treated aneurysm was inversely associated with increased TI of the parent vessels.
    Conclusions: TIs of intracranial arteries are associated with the occurrence of IA, especially in the outer curvature type. IAs with a high TI in the parent vessel showed good outcomes with endovascular treatment.
    Language English
    Publishing date 2021-05-31
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2814366-8
    ISSN 2287-6405 ; 2287-6391
    ISSN (online) 2287-6405
    ISSN 2287-6391
    DOI 10.5853/jos.2020.04399
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  7. Article ; Online: Changes in intracranial volume and cranial shape in modern Koreans over four decades.

    Kim, Ye Sel / Park, In Sung / Kim, Hyun Jung / Kim, Dasom / Lee, Nam Joon / Rhyu, Im Joo

    American journal of physical anthropology

    2018  Volume 166, Issue 3, Page(s) 753–759

    Abstract: Objectives: This study investigated whether there was any secular change in cranial vault morphology among Koreans born between the 1930s and 1970s, a period of dramatic shift in Korea's socioeconomic conditions.: Materials and methods: Using three- ... ...

    Abstract Objectives: This study investigated whether there was any secular change in cranial vault morphology among Koreans born between the 1930s and 1970s, a period of dramatic shift in Korea's socioeconomic conditions.
    Materials and methods: Using three-dimensional MRI volumetry, we obtained the intracranial volume (ICV) and craniometric measurements of 115 healthy Koreans: 58 individuals (32 males and 26 females) born in the 1930s (1926-1936) and 57 (28 males and 29 females) born in the 1970s (1972-1979).
    Results: The intracranial volume of males was 1502.3 ± 110.3 cm
    Discussion: From the 1930s to 1970s, the Korean Peninsula experienced important historical shifts, and we speculate that the consequent shift in socioeconomic status is the most likely factor responsible for Koreans' cranial vault remodeling.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Anthropology, Physical ; Asian Continental Ancestry Group/statistics & numerical data ; Cephalometry ; Female ; Humans ; Industrial Development ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Organ Size ; Republic of Korea ; Skull/anatomy & histology ; Skull/diagnostic imaging ; Skull/physiology
    Language English
    Publishing date 2018-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219376-0
    ISSN 1096-8644 ; 0002-9483
    ISSN (online) 1096-8644
    ISSN 0002-9483
    DOI 10.1002/ajpa.23464
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  8. Article: Severe Hemifacial Spasm is a Predictor of Severe Indentation and Facial Palsy after Microdecompression Surgery.

    Na, Boo Suk / Cho, Jin Whan / Park, Kwan / Kwon, Soonwook / Kim, Ye Sel / Kim, Ji Sun / Youn, Jinyoung

    Journal of clinical neurology (Seoul, Korea)

    2018  Volume 14, Issue 3, Page(s) 303–309

    Abstract: Background and purpose: Hemifacial spasm (HFS) is mostly caused by the compression of the facial nerve by cerebral vessels, but the significance of spasm severity remains unclear. We investigated the clinical significance of spasm severity in patients ... ...

    Abstract Background and purpose: Hemifacial spasm (HFS) is mostly caused by the compression of the facial nerve by cerebral vessels, but the significance of spasm severity remains unclear. We investigated the clinical significance of spasm severity in patients with HFS who underwent microvascular decompression (MVD).
    Methods: We enrolled 636 patients with HFS who underwent MVD between May 2010 and December 2013 at Samsung Medical Center (SMC), Seoul, Korea. Subjects were divided into two groups based on spasm severity: severe (SMC grade 3 or 4) and mild (SMC grade 1 or 2). We compared demographic, clinical, and surgical data between these two groups.
    Results: The severe-spasm group was older and had a longer disease duration at the time of MVD compared to the mild-spasm group. Additionally, hypertension and diabetes mellitus were more common in the severe-spasm group than in the mild-spasm group. Regarding surgical findings, there were more patients with multiple offending vessels and more-severe indentations in the severe-spasm group than in the mild-spasm group. Even though the surgical outcomes did not differ, the incidence of delayed facial palsy after MVD was higher in the severe-spasm group than in the mild-spasm group. Logistic regression analysis showed that severe-spasm was correlated with longer disease duration, hypertension, severe indentation, multiple offending vessels, and delayed facial palsy after MVD.
    Conclusions: Spasm severity does not predict surgical outcomes, but it can be used as a marker of pathologic compression in MVD for HFS, and be considered as a predictor of delayed facial palsy after MVD.
    Language English
    Publishing date 2018-04-27
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2018.14.3.303
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  9. Article ; Online: Perfusion recovery on TTP maps after endovascular stroke treatment might predict favorable neurological outcomes.

    Shin, Jaewon / Kim, Ye Sel / Jang, Hyun-Soon / Kim, Keon Ha / Jeon, Pyoung / Chung, Jong-Won / Seo, Woo-Keun / Bang, Oh Young / Kim, Gyeong-Moon

    European radiology

    2020  Volume 30, Issue 12, Page(s) 6421–6431

    Abstract: Objectives: Early recanalization and adequate collateral blood flow are surrogates for functional recovery in endovascular stroke treatment (EVT). We evaluated the prognostic value of pre- and immediate post-thrombectomy perfusion-weighted magnetic ... ...

    Abstract Objectives: Early recanalization and adequate collateral blood flow are surrogates for functional recovery in endovascular stroke treatment (EVT). We evaluated the prognostic value of pre- and immediate post-thrombectomy perfusion-weighted magnetic resonance imaging (PWI) parameters.
    Methods: Consecutive patients with acute ischemic stroke who underwent EVT were enrolled. Lesion volumes and their corresponding changes on diffusion-weighted (DWI) and PWI were assessed. Outcome was measured with modified Rankin Scale (mRS) at 90 days, and early neurological improvement (> 8 points improvement on National Institutes of Health Stroke Scale [NIHSS] or 0 to 1) at 7 days.
    Results: Fifty-two patients were enrolled. After control of initial NIHSS and recanalization status, post-thrombectomy time-to-peak (TTP) hypoperfused volume and TTP hypoperfused volume change remained independent predictors of favorable functional outcome (odds ratio [OR] = 0.13, 95% confidence interval [CI] = 0.03-0.54, p = 0.005; OR = 1.018, 95% CI = 1.00-1.03, p = 0.017), and early neurological improvement (OR = 0.20, 95% CI 0.07-0.58, p = 0.003; OR = 1.02, 95% CI = 1.00-1.03, p = 0.010). The areas under the curve of post-thrombectomy TTP hypoperfused volume and TTP hypoperfused volume change were 0.90 and 0.82 (cutoff 68 mL and 56 mL) for favorable outcome and 0.86 and 0.82 (cutoff 76 mL and 58 mL) for early neurological improvement, which had better prognostic values than other MR parameters and recanalization grades.
    Conclusions: These results suggest a large amount of perfusion recovery on TTP is associated with favorable outcome as well as early neurological improvement after EVT, and may be a useful prognostic marker.
    Key points: • A large amount of perfusion recovery on TTP map is associated with favorable outcome and early neurological improvement after EVT. • The best cutoff value for favorable functional outcome was 68 mL for post-EVT TTP hypoperfused volume and 56 mL decrease for TTP hypoperfused volume. • Amount of perfusion recovery on TTP map has better performance on the prediction of favorable functional recovery and early neurological improvement than other diffusion- and perfusion-weighted MRI parameters and recanalization grades.
    MeSH term(s) Aged ; Endovascular Procedures/methods ; Female ; Humans ; Magnetic Resonance Angiography/methods ; Male ; Middle Aged ; Prospective Studies ; Stroke/physiopathology ; Stroke/surgery ; Thrombectomy ; Treatment Outcome
    Language English
    Publishing date 2020-07-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-020-07066-3
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  10. Article: Intracranial Cortical Calcifications in a Focal Epilepsy Patient with Pseudohypoparathyroidism.

    Kim, Ye Sel / Park, Jihyung / Park, Yoonkyung / Hwang, KyoungJin / Koo, Dae Lim / Kim, Daeyoung / Seo, Dae-Won

    Journal of epilepsy research

    2016  Volume 6, Issue 1, Page(s) 31–35

    Abstract: Patients with chronic parathyroid dysfunction often have intracranial calcification in deep gray matter (GM) and subcortical white matter (WM) of their brain. Some of them are also epilepsy patients. Although cortical etiologies are main cause of ... ...

    Abstract Patients with chronic parathyroid dysfunction often have intracranial calcification in deep gray matter (GM) and subcortical white matter (WM) of their brain. Some of them are also epilepsy patients. Although cortical etiologies are main cause of epileptic seizure, cortical calcification has not been reported in these patients. We report a newly diagnosed focal epilepsy patient whose brain magnetic resonance imaging revealed intracranial calcifications in cortical as well as subcortical areas. Blood lab revealed that he had hypocalcemia due to pseudohypoparathyroidism. Video EEG monitoring revealed the ictal EEG mainly consist of polymorphic delta to theta waves with maximum at right temporal area followed by background attenuation and muscle artifacts. The interictal EEG showed multiple focal spike-wave discharges. After given oral calcium and calcitriol supplement, his calcium and phosphorous level normalized and he remains seizure free. This is the first case to show cortical calcification in a patient with pseudohypoparathyroidism. Cortical calcification could be an important measure of seizure burden in these patients and thus sophisticated imaging protocols should be used to visualize the extent of calcium deposits.
    Language English
    Publishing date 2016-06-30
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 2771719-7
    ISSN 2233-6257 ; 2233-6249
    ISSN (online) 2233-6257
    ISSN 2233-6249
    DOI 10.14581/jer.16006
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