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Article ; Online: Re: The Impact of Bleomycin on Retroperitoneal Histology at Post-Chemotherapy Retroperitoneal Lymph Node Dissection of Good Risk Germ Cell Tumors: K. C. Cary, J. A. Pedrosa, H. Z. Kaimakliotis, T. A. Masterson, L. H. Einhorn and R. S. Foster J Urol 2015;193:507-512.

Verma, Amit / Giri, Vikas / Priyadarshi, Shivam

2015 Volume 194, Issue 1, Page(s) 266; author reply 266

MeSH term(s)	Antibiotics, Antineoplastic/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bleomycin/therapeutic use ; Humans ; Lymph Node Excision ; Male ; Neoplasms, Germ Cell and Embryonal/drug therapy ; Neoplasms, Germ Cell and Embryonal/surgery ; Retroperitoneal Space/pathology ; Testicular Neoplasms/drug therapy ; Testicular Neoplasms/surgery
Chemical Substances	Antibiotics, Antineoplastic ; Bleomycin (11056-06-7)
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2015.01.103
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Article ; Online: Correlation of serum uric acid levels with certain anthropometric parameters in prediabetic and drug-naive diabetic subjects.

Tiwari, Ritu / Verma, Shivam / Verma, Narsingh / Verma, Dileep / Narayan, Jagdish

Annals of African medicine

2024 Volume 23, Issue 1, Page(s) 13–18

Abstract: Introduction: Uric acid is produced during the metabolism of nucleotide and adenosine triphosphate and contains the final product of human purine metabolism. It acts both as an antioxidant and pro-inflammatory marker and has a positive association with ... ...

Abstract	Introduction: Uric acid is produced during the metabolism of nucleotide and adenosine triphosphate and contains the final product of human purine metabolism. It acts both as an antioxidant and pro-inflammatory marker and has a positive association with visceral fat in overweight subjects. The aim of the present study is to find an association of uric acid level with certain anthropometric parameters in subjects having type 2 diabetes. Materials and methods: The study included 124 urban drug-naive diabetic Indian subjects above 18 years of age from the general population of the city of North India. Uric acid concentrations were estimated by the uricase method. Fasting plasma glucose (FPG) concentrations were estimated by the glucose oxidase-peroxidase method. Anthropometric measurements and information on lifestyle factors and disease history were collected through in-person meeting. Results: All participants of the study subjects had a body mass index (BMI) of more than 23.5. BMI, waist-to-hip ratio (WHR), waist-to-height ratio, waist circumference, neck circumference, weight, age, sagittal abdominal diameter (SAD), skinfold thickness, and body roundness index were positively correlated with the serum uric acid level. The correlation of weight, BMI, SAD, and WHR was statistically significant. Conclusion: We found that serum uric acid level increases as body fat content increases. Statistical data show remarkable results for a significant correlation of uric acid level with BMI, WHR, SAD, and FPG. Hypertrophy occurs as a result of inflammatory processes and oxidative stress when the supply of energy starts to exceed the storage capacity of adipocytes, as a result, adipokines such as interleukin (IL)-1, IL-6, and tumor-necrosis factor-alpha are released more frequently which lead to low-grade chronic inflammation. Uric acid levels are much lean toward visceral obesity than overall body fat content.
MeSH term(s)	Humans ; Uric Acid ; Diabetes Mellitus, Type 2/complications ; Prediabetic State/complications ; Anthropometry ; Overweight ; Body Mass Index ; Waist Circumference ; Waist-Hip Ratio
Chemical Substances	Uric Acid (268B43MJ25)
Language	English
Publishing date	2024-01-31
Publishing country	India
Document type	Journal Article
ZDB-ID	2165792-0
ISSN	0975-5764 ; 0975-5764
ISSN (online)	0975-5764
ISSN	0975-5764
DOI	10.4103/aam.aam_40_22
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Article ; Online: Multilocular cystic nephroma in an adult: a diagnostic quandary.

Verma, Ritu / Verma, Jyoti / Gupta, Neelima

CEN case reports

2024

Abstract: Multilocular cystic nephroma (MLCN) is an unusual, benign slow-growing renal cystic neoplasm which mimics other cystic renal lesions and has such clinical, radiological, and morphological features that causes diagnostic dilemma. MLCN lies in the spectrum ...

Abstract	Multilocular cystic nephroma (MLCN) is an unusual, benign slow-growing renal cystic neoplasm which mimics other cystic renal lesions and has such clinical, radiological, and morphological features that causes diagnostic dilemma. MLCN lies in the spectrum of mixed epithelial and stromal tumor (MEST) family of kidney. According to World Health Organization (WHO 2016 classification), MEST encompasses spectrum of tumors ranging from predominantly cystic tumors, adult cystic nephroma (ACN) to tumors that are variably solid (MEST), thus creating diagnostic dilemma. Moreover, it has several benign and malignant differentials due to its several overlapping histomorphological features which when not cautiously dealt with may result in misdiagnosing it as malignant lesion. We hereby present a case of a woman in late twenties who presented with left flank swelling and pain since 6 months which was misdiagnosed as renal cell carcinoma on radiology which turned out to be ACN on histology and further verified on immunohistochemistry.
Language	English
Publishing date	2024-02-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2660492-9
ISSN	2192-4449 ; 2192-4449
ISSN (online)	2192-4449
ISSN	2192-4449
DOI	10.1007/s13730-024-00852-8
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Article ; Online: Electro-optical behaviour of CuFe

Verma, Rahul / Singh, Kshitij Rb / Verma, Ranjana / Singh, Jay

Luminescence : the journal of biological and chemical luminescence

2023 Volume 38, Issue 7, Page(s) 1393–1404

Abstract: Uric acid (UA) is a blood and urine component obtained as a metabolic by-product of purine nucleotides. Abnormalities in UA metabolism cause crystal deposition as monosodium urate and lead to various diseases such as gout, hyperuricemia, Lesch-Nyhan ... ...

Abstract	Uric acid (UA) is a blood and urine component obtained as a metabolic by-product of purine nucleotides. Abnormalities in UA metabolism cause crystal deposition as monosodium urate and lead to various diseases such as gout, hyperuricemia, Lesch-Nyhan syndrome, etc. Monitoring these diseases requires a rapid, sensitive, selective, and portable detection approach. Therefore, this study demonstrates the hydrothermal synthesis of CuFe
MeSH term(s)	Uric Acid ; Kinetics ; Graphite/chemistry ; Electrochemical Techniques/methods ; Nanocomposites/chemistry ; Electrodes
Chemical Substances	graphene oxide ; Uric Acid (268B43MJ25) ; Graphite (7782-42-5)
Language	English
Publishing date	2023-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1470995-8
ISSN	1522-7243 ; 1522-7235 ; 1099-1271
ISSN (online)	1522-7243
ISSN	1522-7235 ; 1099-1271
DOI	10.1002/bio.4479
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Article: Cardiometabolic Risk Factors Associated With Type 2 Diabetes Mellitus: A Mechanistic Insight.

Chakraborty, Snigdha / Verma, Anjali / Garg, Rajeev / Singh, Jyoti / Verma, Hitesh

Clinical medicine insights. Endocrinology and diabetes

2023 Volume 16, Page(s) 11795514231220780

Abstract: A complex metabolic condition referred to as Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR) and decreased insulin production. Obesity, dyslipidemia, hypertension, and chronic inflammation are just a few of the cardiometabolic ...

Abstract	A complex metabolic condition referred to as Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR) and decreased insulin production. Obesity, dyslipidemia, hypertension, and chronic inflammation are just a few of the cardiometabolic illnesses that people with T2DM are more likely to acquire and results in cardiovascular issues. It is essential to comprehend the mechanistic insights into these risk variables in order to prevent and manage cardiovascular problems in T2DM effectively. Impaired glycemic control leads to upregulation of De novo lipogenesis (DNL), promote hepatic triglyceride (TG) synthesis, worsening dyslipidemia that is accompanied by low levels of high density lipoprotein cholesterol (HDL-C) and high amounts of small, dense low-density lipoprotein cholesterol (LDL-C) further developing atherosclerosis. By causing endothelial dysfunction, oxidative stress, and chronic inflammation, chronic hyperglycemia worsens already existing cardiometabolic risk factors. Vasoconstriction, inflammation, and platelet aggregation are caused by endothelial dysfunction, which is characterized by decreased nitric oxide production, increased release of vasoconstrictors, proinflammatory cytokines, and adhesion molecules. The loop of IR and endothelial dysfunction is sustained by chronic inflammation fueled by inflammatory mediators produced in adipose tissue. Infiltrating inflammatory cells exacerbate inflammation and the development of plaque in the artery wall. In addition, the combination of chronic inflammation, dyslipidemia, and IR contributes to the emergence of hypertension, a prevalent comorbidity in T2DM. The ability to target therapies and management techniques is made possible by improvements in our knowledge of these mechanistic insights. Aim of present review is to enhance our current understanding of the mechanistic insights into the cardiometabolic risk factors related to T2DM provides important details into the interaction of pathophysiological processes resulting in cardiovascular problems. Understanding these pathways will enable us to create efficient plans for the prevention, detection, and treatment of cardiovascular problems in T2DM patients, ultimately leading to better overall health outcomes.
Language	English
Publishing date	2023-12-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2628990-8
ISSN	1179-5514
ISSN	1179-5514
DOI	10.1177/11795514231220780
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Article ; Online: Factor XI inhibitors: what should clinicians know.

Pandey, Arjun / Verma, Raj / Eikelboom, John / Verma, Subodh

Current opinion in cardiology

2022 Volume 38, Issue 2, Page(s) 88–93

Abstract: Purpose of review: Factor XI (FXI) inhibitors were developed to address unmet needs and limitations of current anticoagulants and are currently being studied in several indications. In this paper, we review the rationale for the development of these ... ...

Abstract	Purpose of review: Factor XI (FXI) inhibitors were developed to address unmet needs and limitations of current anticoagulants and are currently being studied in several indications. In this paper, we review the rationale for the development of these agents and summarize what clinicians should know about drugs that target FXI. Recent findings: Patients with FXI deficiency may have a lower risk of venous thromboembolism and cardiovascular events and have a variable but generally mild bleeding diathesis. FXI has been proposed as a target for anticoagulants due to the potential for reduction in thrombosis with a lower risk of bleeding than current anticoagulant agents. Several classes of drugs that target FXI are under development, of which three classes (small molecule inhibitors, antisense oligonucleotides and monoclonal antibodies) have been studied in Phase II trials. At least three large Phase III trial programs are planned or are underway, and will study the efficacy and safety of FXI inhibitors in tens of thousands of patients across a variety of indications including atrial fibrillation, stroke and cancer-associated venous thromboembolism. Summary: FXI inhibitors were developed with the hope of attenuating thrombosis with reduced bleeding/impairment of haemostasis. These agents have shown promise in preliminary trials with a low rate of bleeding. Ongoing Phase III investigations will inform the utility of these agents in clinical practice.
MeSH term(s)	Humans ; Factor XI ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control ; Thrombosis ; Anticoagulants/adverse effects ; Hemorrhage/chemically induced ; Hemorrhage/prevention & control
Chemical Substances	Factor XI (9013-55-2) ; Anticoagulants
Language	English
Publishing date	2022-01-30
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	645186-x
ISSN	1531-7080 ; 0268-4705
ISSN (online)	1531-7080
ISSN	0268-4705
DOI	10.1097/HCO.0000000000001015
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Article: Development and Evaluation of an Eco-Friendly Hand Sanitizer Formulation Valorized from Fruit Peels.

Verma, J / Mishra, R / Mazumdar, A / Singh, R / El-Gendy, N Sh

International journal of biomaterials

2023 Volume 2023, Page(s) 2516233

Abstract: Hand sanitizer usage has proven to be a common and practical method for reducing the spread of infectious diseases which can be caused by many harmful pathogens. There is a need for alcohol-free hand sanitizers because most hand sanitizers on the market ... ...

Abstract	Hand sanitizer usage has proven to be a common and practical method for reducing the spread of infectious diseases which can be caused by many harmful pathogens. There is a need for alcohol-free hand sanitizers because most hand sanitizers on the market are alcohol-based, and regular use of them can damage the skin and can be hazardous. India is the world's largest producer of fruits and one of the major problems after fruit consumption is their peels, causing waste management problems and contributing to the formation of greenhouse gases leading to air pollution and adding to the problem of climate change. Valorization of such wastes into other value-added products and their incorporation into formulations of eco-friendly alcohol-free hand sanitizers would solve these issues, save the environment, benefit the society, and help in achieving the sustainable development goals. Thus, this research focuses on formulating an effective natural alcohol-free hand sanitizer that harnesses the antimicrobial properties of the various types of bioactive components found in fruit peels of pomegranate, sweet lime, and lemon. The peel extracts and the formulated sanitizer proved considerable antimicrobial activity against the pathogenic
Language	English
Publishing date	2023-12-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2494344-7
ISSN	1687-8795 ; 1687-8787
ISSN (online)	1687-8795
ISSN	1687-8787
DOI	10.1155/2023/2516233
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Article ; Online: Can Quantitative Electroencephalography and Functional Near-Infrared Spectroscopy be a Good Guide in Kleine-Levin Syndrome?

Singh, Swarndeep / Singh, Jawahar / Shrivastava, Neha P / Verma, Rohit

Neurology India

2024 Volume 71, Issue 6, Page(s) 1250–1253

Abstract: There is scarce literature on functional neuroimaging data in Kleine-Levin syndrome. The current case report presents the electrical and metabolic status of cortical activity utilizing functional near-infrared spectroscopy (fNIRS) and quantitative ... ...

Abstract	There is scarce literature on functional neuroimaging data in Kleine-Levin syndrome. The current case report presents the electrical and metabolic status of cortical activity utilizing functional near-infrared spectroscopy (fNIRS) and quantitative electroencephalography (qEEG) before and after treatment of symptomatic phase of illness with modafinil.
MeSH term(s)	Humans ; Kleine-Levin Syndrome/diagnostic imaging ; Kleine-Levin Syndrome/drug therapy ; Spectroscopy, Near-Infrared ; Electroencephalography ; Modafinil
Chemical Substances	Modafinil (R3UK8X3U3D)
Language	English
Publishing date	2024-01-04
Publishing country	India
Document type	Case Reports
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.391382
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Article ; Online: Laccase-Conjugated Nanostructured ZnFe

Verma, Rahul / Yadav, Surendra K / Singh, Kshitij Rb / Verma, Ranjana / Kumar, Deepak / Singh, Jay

ACS applied bio materials

2023 Volume 6, Issue 12, Page(s) 5842–5853

Abstract: A propitious biosensor for adrenaline (AD) detection in bovine serum albumin (BSA) real samples, which can be used for diagnosis and treatment of neurodegenerative disorders, is reported here. The biosensor consists of a La/ZF/rGO/ITO bioelectrode, which ...

Abstract	A propitious biosensor for adrenaline (AD) detection in bovine serum albumin (BSA) real samples, which can be used for diagnosis and treatment of neurodegenerative disorders, is reported here. The biosensor consists of a La/ZF/rGO/ITO bioelectrode, which is fabricated by electrophoretic deposition of zinc ferrite/reduced graphene oxide (ZF/rGO) nanohybrid followed by drop casting of laccase (La) enzymes. The material characterization and electrochemical studies revealed that the ZF/rGO nanohybrid enhanced the electroactive surface and facilitated direct electron transfer between the electrode and electrolyte interface, resulting in enhanced electrocatalytic performance. The cyclic voltammetry and electrochemical impedance spectroscopy results asserted that the ZF/rGO nanohybrid decreased the charge-transfer resistance (
MeSH term(s)	Humans ; Laccase ; Electrochemical Techniques/methods ; Epinephrine ; Electric Impedance ; Biosensing Techniques/methods ; Electrodes ; Neurodegenerative Diseases
Chemical Substances	Laccase (EC 1.10.3.2) ; Epinephrine (YKH834O4BH) ; graphene oxide
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.3c00968
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Article ; Online: An 18-Year-Old Female Athlete Presenting with Knee Pain Following a Basketball Game and Diagnosed with Bilateral Patellar Stress Fractures.

Dhillon, Nireet K / Jackson, Garrett R / Kaplan, Daniel J / Verma, Nikhil N

The American journal of case reports

2023 Volume 24, Page(s) e938420

Abstract: BACKGROUND Stress fractures of the patella are rare, may result from overuse, and can be difficult to detect on imaging. Furthermore, the differential diagnosis of the anterior knee pain associated with most patellar stress fractures is broad, making it ... ...

Abstract	BACKGROUND Stress fractures of the patella are rare, may result from overuse, and can be difficult to detect on imaging. Furthermore, the differential diagnosis of the anterior knee pain associated with most patellar stress fractures is broad, making it difficult to quickly reach the diagnosis. This report is of an 18-year-old female athlete presenting with knee pain after playing basketball and diagnosed with bilateral patellar stress fractures. CASE REPORT An 18-year-old female athlete with a history of bilateral anterior knee pain presented with left knee pain and swelling following a basketball game. X-ray images and magnetic resonance imaging (MRI) revealed a displaced inferior pole fracture of the left patella. The patient underwent surgical fixation of the patella. Approximately 4 months following surgical fixation of the left patella, right anterior knee pain persisted, and imaging demonstrated a stress reaction in the inferior pole of the right patella. The patient was ultimately treated with surgical fixation of the right patella as well. CONCLUSIONS This report demonstrates that, although stress fractures of the patella are rare, and bilateral stress fractures of the patella are even more rare, this condition may present with pain and usually with a history of high-impact exercise. Challenges remain in identifying patellar stress fractures early in their progression and determining the best course of treatment.
MeSH term(s)	Female ; Humans ; Adolescent ; Patella/diagnostic imaging ; Patella/surgery ; Fractures, Stress/diagnostic imaging ; Fractures, Stress/etiology ; Basketball ; Pain ; Athletes
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.938420
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