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  1. Article ; Online: Ibrutinib-Associated Leukocytoclastic Vasculitis in a Patient with Chronic Lymphocytic Leukemia.

    Kaya, Ayşe / Aras, İbrahim / Özkan Kurtgöz, Pervin / Çakıroğlu, Umut

    Turkish journal of haematology : official journal of Turkish Society of Haematology

    2024  Volume 41, Issue 1, Page(s) 57–58

    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Vasculitis, Leukocytoclastic, Cutaneous/chemically induced ; Vasculitis, Leukocytoclastic, Cutaneous/diagnosis ; Piperidines/adverse effects ; Adenine/analogs & derivatives
    Chemical Substances ibrutinib (1X70OSD4VX) ; Piperidines ; Adenine (JAC85A2161)
    Language English
    Publishing date 2024-03-04
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2185903-6
    ISSN 1308-5263 ; 1300-7777
    ISSN (online) 1308-5263
    ISSN 1300-7777
    DOI 10.4274/tjh.galenos.2023.2023.0368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The impact of COVID-19 pandemic on anxiety levels among patients who have to go to the hospital due to chronic illnesses: A prospective study.

    Ozkan Kurtgoz, Pervin / Sackan, Fatih / Oner, Irem / Bilgin, Ozlem / Ozdemir, Deniz / Karakose, Suleyman / Eryılmaz, Mehmet Ali / Guney, Ibrahim / Kızılarslanoglu, Muhammet Cemal

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

    2023  Volume 27, Issue 4, Page(s) 711–719

    Abstract: Introduction: Cancer and hemodialysis (HD) patients are at high risk for COVID-19. In our study, we aimed to evaluate the effect of pandemic on anxiety in these patients.: Methods: One hundred and six oncology and 97 HD patients participated in the ... ...

    Abstract Introduction: Cancer and hemodialysis (HD) patients are at high risk for COVID-19. In our study, we aimed to evaluate the effect of pandemic on anxiety in these patients.
    Methods: One hundred and six oncology and 97 HD patients participated in the study. Anxiety levels were assessed by using the Beck Anxiety Inventory (BAI) and State-Trait Anxiety Inventory (STAI). At the end of 8-month follow-up, these questionnaires were re-administered.
    Results: During this period, 38 patients (38/203; 18.7%) had COVID-19 infection. Twenty-three patients (23/203; 11.3%) died due to COVID-19 and/or other causes. One hundred and thirteen of the remaining patients were participated in the second questionnaire. Having COVID-19 was not the independent factor for changes in STAI, and BAI scores in any regression models.
    Conclusion: Having COVID-19 does not affect the increased anxiety levels in HD and oncology patients. The effect of the pandemic may have remained in the background, as these patients have more concerns about their own diseases.
    MeSH term(s) Humans ; COVID-19 ; Prospective Studies ; Pandemics ; Anxiety/epidemiology ; Hospitals ; Chronic Disease
    Language English
    Publishing date 2023-02-07
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2119809-3
    ISSN 1744-9987 ; 1091-6660 ; 1744-9979
    ISSN (online) 1744-9987
    ISSN 1091-6660 ; 1744-9979
    DOI 10.1111/1744-9987.13971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease.

    Ozkan Kurtgoz, Pervin / Karakose, Suleyman / Cetinkaya, Cigdem Damla / Erkus, Edip / Guney, Ibrahim

    International urology and nephrology

    2021  Volume 54, Issue 1, Page(s) 131–135

    Abstract: Purpose: Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease and the majority of patients have a PKD-1 or PKD-2 mutation. Sirtuin 1 (SIRT1) has roles in cellular aging, antioxidant activity, cellular ... ...

    Abstract Purpose: Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease and the majority of patients have a PKD-1 or PKD-2 mutation. Sirtuin 1 (SIRT1) has roles in cellular aging, antioxidant activity, cellular proliferation. In an experimental study, inhibition of SIRT1 was found to delay renal cyst development in ADPKD. The purpose of this study is to determine the SIRT1 levels in ADPKD patients. To our knowledge, this is the first study that investigating blood and urine SIRT1 levels in ADPKD patients.
    Methods: Sixty-seven patients with ADPKD and 34 control cases with normal renal functions and without renal cysts were included in this study. Serum and urine SIRT1 concentrations were determined by human enzyme-linked immunosorbent assay (ELISA) kit. 24-h urine samples were used for urine SIRT1 measurements.
    Results: The urine SIRT1 levels were statistically significantly lower in ADPKD patients group (p < 0.001). Although blood SIRT1 levels of ADPKD patients were higher than control cases but there were no statistically significant difference between the groups in terms of blood SIRT1 levels. Urine SIRT1 levels (β = 2.452, CI 95% 1.419-4.239, p = 0.001) were found an independent factor in multivariate regression analysis for ADPKD.
    Conclusions: Urine SIRT1 levels were lower in ADPKD patients than control group. The low urinary SIRT1 levels despite the similar blood SIRT1 levels might be due to the impaired metabolism of SIRT1 in ADPKD patients; this state might has a role in cyst development.
    MeSH term(s) Adult ; Aged ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Polycystic Kidney, Autosomal Dominant/blood ; Polycystic Kidney, Autosomal Dominant/urine ; Sirtuin 1/blood ; Sirtuin 1/urine
    Chemical Substances Sirtuin 1 (EC 3.5.1.-)
    Language English
    Publishing date 2021-04-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-021-02862-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of anxiety on COVID-19 infection in hemodialysis patients.

    Ozkan Kurtgoz, Pervin / Sackan, Fatih / Kızılarslanoglu, Muhammet Cemal / Bilgin, Ozlem / Guney, Ibrahim

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

    2021  Volume 26, Issue 4, Page(s) 775–780

    Abstract: Some evidence suggests that anxiety deteriorate the immune system. We aimed to determine the effect of anxiety on COVID-19 infection in hemodialysis (HD) patients. Our study was conducted with 80 HD patients. State-Trait Anxiety Inventory (STAI), and ... ...

    Abstract Some evidence suggests that anxiety deteriorate the immune system. We aimed to determine the effect of anxiety on COVID-19 infection in hemodialysis (HD) patients. Our study was conducted with 80 HD patients. State-Trait Anxiety Inventory (STAI), and Beck Anxiety Inventory (BAI) questionnaires were administered between April 15 and May 1, 2020. These patients were followed up for about 8 months and COVID-19 infection, hospitalization, and death rates were recorded. Twenty-one (26%) of the patients were diagnosed with COVID-19 infection. Fourteen out of twenty one (66.6%) of the patients were hospitalized, and 8/21 (38%) of them died due to COVID-19. STAI-S (p= 0.006) and BAI (p= 0.021) scores were found to be higher and STAI-T (p= 0.040) score was found to be lower in HD patients who were infected with COVID-19 compared to without, at the follow-up period. It might be concluded in this study that COVID-19 was more common in anxious HD patients.
    MeSH term(s) Anxiety/diagnosis ; Anxiety/epidemiology ; Anxiety Disorders ; COVID-19 ; Humans ; Renal Dialysis ; Surveys and Questionnaires
    Language English
    Publishing date 2021-11-26
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2119809-3
    ISSN 1744-9987 ; 1091-6660 ; 1744-9979
    ISSN (online) 1744-9987
    ISSN 1091-6660 ; 1744-9979
    DOI 10.1111/1744-9987.13759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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