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Article ; Online: Longitudinally Extensive Spinal Lesion of Subacute Combined Degeneration.

Sano, Terunori / Ohira, Masayuki / Sato, Wakiro / Takao, Masaki

2022 Volume 62, Issue 2, Page(s) 313–314

MeSH term(s)	Humans ; Subacute Combined Degeneration/diagnostic imaging ; Subacute Combined Degeneration/etiology ; Vitamin B 12 Deficiency ; Spinal Cord/diagnostic imaging ; Spinal Cord/pathology ; Vitamin B 12 ; Magnetic Resonance Imaging ; Spinal Cord Diseases/pathology
Chemical Substances	Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	2022-06-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.9497-22
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Article: Leiomyoma of the Prostate Treated via Holmium Laser Enucleation: A Case Report and Literature Review.

Sano, Masayuki / Narimoto, Kazutaka / Shimbo, Masaki / Hattori, Kazunori / Endo, Fumiyasu

Cureus

2023 Volume 15, Issue 9, Page(s) e45273

Abstract: Leiomyoma is a rare tumor that arises from mesenchymal cells, with few reported cases of treatment using holmium laser enucleation of the prostate. A 74-year-old man with dysuria had a mass near the bladder neck in magnetic resonance imaging; this entity ...

Abstract	Leiomyoma is a rare tumor that arises from mesenchymal cells, with few reported cases of treatment using holmium laser enucleation of the prostate. A 74-year-old man with dysuria had a mass near the bladder neck in magnetic resonance imaging; this entity was suspected to be a leiomyoma. The patient underwent holmium laser enucleation of the prostate and one lobe was removed. However, the mass was firm and morcellation was difficult to break into small pieces. Therefore, it was fragmented via trans-urethral resection and removed with a curette. The postoperative course was favorable, with a positive clinical outcome. This case highlights the efficacy of holmium laser enucleation of the prostate in the management of prostatic leiomyoma and emphasizes its importance as a viable treatment option.
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.45273
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Article: Functional Neurological Disorder Overlapping Paroxysmal Kinesigenic Dyskinesia Confirmed by Genetic Diagnosis.

Ohira, Masayuki / Osada, Takashi / Kimura, Hiroaki / Sano, Terunori / Takao, Masaki

Cureus

2023 Volume 15, Issue 7, Page(s) e42693

Abstract: Functional neurological disorder (FND) may mimic various kinds of neurologic diseases and may coexist with other neurologic disorders. In cases overlapped by FND, it might be challenging to distinguish symptoms induced by FND and those induced by other ... ...

Abstract	Functional neurological disorder (FND) may mimic various kinds of neurologic diseases and may coexist with other neurologic disorders. In cases overlapped by FND, it might be challenging to distinguish symptoms induced by FND and those induced by other underlying neurological disorders, especially when patients show no positive signs indicative of FND. Here, we present the case of a patient who was genetically diagnosed with paroxysmal kinesigenic dyskinesia (PKD). However, most of the patient's symptoms were considered to indicate FND. To our knowledge, there are no reports of FND overlapping PKD. This case illustrates the possibility that FND can coexist with and mimic symptoms of other diseases. It is necessary to rule out coexisting FND symptoms that may modify clinical presentations that cannot simply be explained by a recognized neurological disease.
Language	English
Publishing date	2023-07-30
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42693
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Article: The Role of Chorein Deficiency in Late Spermatogenesis.

Arai, Kaoru / Nishizawa, Yoshiaki / Nagata, Omi / Sakimoto, Hitoshi / Sasaki, Natsuki / Sano, Akira / Nakamura, Masayuki

Biomedicines

2024 Volume 12, Issue 1

Abstract: VPS13A, also known as chorein, whose loss of function causes chorea-acanthocytosis (ChAc), is characterized by Huntington's-disease-like neurodegeneration and neuropsychiatric symptoms in addition to acanthocytosis in red blood cells. We previously ... ...

Abstract	VPS13A, also known as chorein, whose loss of function causes chorea-acanthocytosis (ChAc), is characterized by Huntington's-disease-like neurodegeneration and neuropsychiatric symptoms in addition to acanthocytosis in red blood cells. We previously reported that ChAc-model mice with a loss of chorein function exhibited male infertility, with asthenozoospermia and mitochondrial dysmorphology in the spermatozoa. Here, we report a novel aspect of chorein dysfunction in male fertility, particularly its role in spermatogenesis and mitochondrial integrity. An increase in anti-malondialdehyde antibody immunoreaction within the testes, predominantly observed at the advanced stages of sperm formation in chorein-deficient mice, suggests oxidative stress as a contributing factor to mitochondrial dysfunction and impaired sperm maturation. The chorein immunoreactivity in spermatids of wild-type mice accentuates its significance in sperm development. ChAc-model mice exhibit mitochondrial ultrastructural abnormalities, specifically during the late stages of sperm maturation, suggesting a critical timeframe for chorein's action in spermiogenesis. We observed an increase in TOM20 protein levels, indicative of disrupted mitochondrial import mechanisms. The concurrent decrease in metabolic enzymes such as IDH3A, LDHC, PGK2, and ACAT1 suggests a complex chorein-mediated metabolic network that is essential for sperm vitality. Additionally, heightened separation of cytoplasmic droplets from sperm highlights the potential membrane instability in chorein-deficient spermatozoa. Metabolomic profiling further suggests a compensatory metabolic shift, with elevated glycolytic and TCA-cycle substrates. Our findings suggest that chorein is involved in anti-ferroptosis and the maturation of mitochondrial morphology in the late stages of spermatogenesis, and its deficiency leads to asthenozoospermia characterized by membrane instability, abnormal cytosolic glycolysis, abnormal mitochondrial function, and a disrupted TCA cycle. Further analyses are required to unravel the molecular mechanisms that directly link these findings and to elucidate the role of chorein in spermatogenesis as well as its broader implications.
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12010240
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Article ; Online: Clinical characteristics of motor functional neurological disorder manifesting as limb weakness after vaccination against coronavirus disease 2019: A case series.

Ohira, Masayuki / Osada, Takashi / Kimura, Hiroaki / Sano, Terunori / Takao, Masaki

eNeurologicalSci

2023 Volume 33, Page(s) 100487

Abstract: Background: The characteristics of functional limb weakness (FLW) as one of the manifestations of functional neurological disorder after vaccination against coronavirus disease 2019 (COVID-19) remain controversial.: Methods: In this descriptive case ... ...

Abstract	Background: The characteristics of functional limb weakness (FLW) as one of the manifestations of functional neurological disorder after vaccination against coronavirus disease 2019 (COVID-19) remain controversial. Methods: In this descriptive case series, we aimed to elucidate the characteristics of Japanese patients with FLW who claimed muscle weakness after COVID-19 vaccination among patients who visited our outpatient clinic between 1 June 2021 and 31 December 2022. Results: Nine patients were diagnosed with FLW (mean age: 30.8 years), including two men and seven women. Seven patients were vaccinated with the BioNTech/Pfizer vaccine and two with the mRNA-1273 Moderna vaccine. All patients demonstrated various positive signs for FLW. Magnetic resonance imaging or computed tomography indicated no abnormality that could explain their symptoms. At the time of the clinic visit, five patients were treated for psychiatric disorders, including depression, insomnia, attention-deficit hyperactivity disorder, and Asperger's syndrome. Muscle weakness spread to the limbs beyond the vaccinated arm in seven patients. Conclusions: We describe the basic characteristics of FLW in Japanese patients after COVID-19 vaccination. Further recognition of these characteristics could aid the diagnosis of FLW by physicians allowing them to support these patients effectively.
Language	English
Publishing date	2023-11-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2838045-9
ISSN	2405-6502 ; 2405-6502
ISSN (online)	2405-6502
ISSN	2405-6502
DOI	10.1016/j.ensci.2023.100487
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Article ; Online: Clinical features of patients who visited the outpatient clinic for long COVID in Japan.

Ohira, Masayuki / Sano, Terunori / Takao, Masaki

eNeurologicalSci

2022 Volume 28, Page(s) 100418

Abstract: Background: The clinical course, comorbidity, and management of symptoms after the acute phase of coronavirus disease 2019 (COVID-19) remain controversial.: Methods: This was a descriptive case series study, examining the characteristics of patients ... ...

Abstract	Background: The clinical course, comorbidity, and management of symptoms after the acute phase of coronavirus disease 2019 (COVID-19) remain controversial. Methods: This was a descriptive case series study, examining the characteristics of patients with longstanding symptoms related to COVID-19 who visited our outpatient clinic between 1 June and 31 December 2021. We analyzed patients' background, chief complaints, clinical course after COVID-19 onset, and clinical examination results. Results: A total of 90 patients with a mean age of 39.8 years were confirmed as having long COVID. The median time between diagnosis of COVID-19 and visiting our clinic was 66.8 days, and 89 patients (98.9%) were unvaccinated. Depression was the most common comorbidity (nine patients, 10.0%). The most common chief complaint was disturbance of smell and/or taste (35, 38.9%), followed by memory disturbance (22, 24.4%) and fatigue (29, 31.1%). Head MRI was performed for 42 (46.7%) patients, and the most common finding was sinusitis (four patients). Olfactory testing was conducted in 25 patients (27.8%) using a T&T olfactometer, and 14 patients (56%) had mild olfactory impairment. Of the five odors in the T&T, recognition of β-phenylethyl alcohol was most impaired. Conclusions: This study describes the basic characteristics of long COVID in Japan. It suggests that long COVID is complex because it results in a wide range of symptoms.
Language	English
Publishing date	2022-07-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2838045-9
ISSN	2405-6502 ; 2405-6502
ISSN (online)	2405-6502
ISSN	2405-6502
DOI	10.1016/j.ensci.2022.100418
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Article ; Online: Neuropathological studies of serotonergic and noradrenergic systems in Lewy body disease patients with delusion or depression.

Mizutani, Masashi / Sano, Terunori / Ohira, Masayuki / Takao, Masaki

Psychiatry and clinical neurosciences

2022 Volume 76, Issue 9, Page(s) 459–467

Abstract: Aim: The association between psychiatric symptoms in Lewy body disease (LBD) and the noradrenergic and serotonergic systems is still controversial. This study investigated the quantitative relationships of depression and delusion with these systems.: ... ...

Abstract	Aim: The association between psychiatric symptoms in Lewy body disease (LBD) and the noradrenergic and serotonergic systems is still controversial. This study investigated the quantitative relationships of depression and delusion with these systems. Methods: We studied 24 postmortem tissues from individuals with a pathological diagnosis of LBD with sufficient clinical history. The numbers of neurons and Lewy bodies (LBs) in the locus coeruleus (LC) and dorsal raphe nucleus (DRN) were counted, and the density of neurons in the DRN was analyzed. In addition, the densities of tryptophan hydroxylase-positive neurites and norepinephrine transporter-positive neurites in the amygdala and dorsal prefrontal cortex were measured. Finally, we divided the cases into two groups: with or without depressive mood, and with or without delusion. Quantitative histological data were compared between the groups. Results: The group with depressive mood had a significantly smaller number of neurons in the LC compared with the group without depressive mood. The group with delusion had a significantly larger number of LBs in the DRN compared with the group without delusion. The density of norepinephrine transporter-positive neurites in the dorsal prefrontal cortex was significantly correlated with the number of neurons in the LC. Conclusions: The accumulation of LBs in the DRN of individuals with LBD was associated with delusion, whereas a decrease in the number of neurons in the LC was associated with depressive mood. These neurodegenerative changes involved the serotonergic and noradrenergic systems and may be associated with the formation of delusion and depression, respectively, in LBD.
MeSH term(s)	Delusions ; Depression ; Dorsal Raphe Nucleus/pathology ; Dorsal Raphe Nucleus/physiology ; Humans ; Lewy Body Disease ; Norepinephrine ; Norepinephrine Plasma Membrane Transport Proteins
Chemical Substances	Norepinephrine Plasma Membrane Transport Proteins ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2022-06-28
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1292906-2
ISSN	1440-1819 ; 1323-1316
ISSN (online)	1440-1819
ISSN	1323-1316
DOI	10.1111/pcn.13436
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Article ; Online: Brainstem Infarction Presenting with Trigeminal Neuralgia and Bell's Palsy.

Sano, Terunori / Ohira, Masayuki / Mizutani, Masashi / Segawa, Kazuhiko / Takao, Masaki

The American journal of medicine

2022 Volume 136, Issue 1, Page(s) e9

MeSH term(s)	Humans ; Bell Palsy/diagnosis ; Bell Palsy/etiology ; Trigeminal Neuralgia/diagnosis ; Trigeminal Neuralgia/etiology ; Facial Paralysis ; Brain Stem Infarctions/diagnosis ; Brain Stem Infarctions/diagnostic imaging
Language	English
Publishing date	2022-09-23
Publishing country	United States
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2022.08.036
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Article ; Online: Chemical design of radioiodinated probes with a metabolizable linkage for target-selective imaging of systemic amyloidosis.

Haratake, Yoshie / Sano, Kohei / Fujioka, Chika / Oshima, Satsuki / Munekane, Masayuki / Yamasaki, Toshihide / Mukai, Takahiro

Bioorganic & medicinal chemistry

2023 Volume 92, Page(s) 117426

Abstract: Introduction: Systemic amyloidosis is a rare disease caused by the deposition of amyloid fibrils in various organs. Amyloid-targeted radiopharmaceuticals have been developed and applied to diagnose systemic amyloidosis peripherally; however, high- ... ...

Abstract	Introduction: Systemic amyloidosis is a rare disease caused by the deposition of amyloid fibrils in various organs. Amyloid-targeted radiopharmaceuticals have been developed and applied to diagnose systemic amyloidosis peripherally; however, high-contrast imaging has not been achieved because of the high background signals in normal organs. To overcome this problem, we designed an amyloid-targeted radioiodinated probe 1 with a metabolizable linkage (ester bond) to release of radiolabeled metabolites (m-iodohippuric acid) in normal organs that could be rapidly excreted in the urine. Methods: Compound 1 was synthesized by conjugating 2-(4-(methylamino)phenyl)benzo[d]thiazol-6-ol, an amyloid-targeting compound, with m-iodohippuric acid. [ Results: [ Conclusion: These results suggest that the interposition of a metabolizable linkage between an amyloid-targeting moiety and a radiolabeled hippuric acid would be useful in the design of radiopharmaceuticals for high-contrast imaging of systemic amyloidosis.
MeSH term(s)	Mice ; Animals ; Radiopharmaceuticals/chemistry ; Iodohippuric Acid ; Amyloidosis/diagnostic imaging ; Amyloid/metabolism
Chemical Substances	Iodine-125 (GVO776611R) ; Radiopharmaceuticals ; Iodohippuric Acid (147-58-0) ; Amyloid
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2023.117426
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Article: An engineered ligand-responsive Csy4 endoribonuclease controls transgene expression from Sendai virus vectors.

Kishimoto, Takumi / Nishimura, Ken / Morishita, Kana / Fukuda, Aya / Miyamae, Yusaku / Kumagai, Yutaro / Sumaru, Kimio / Nakanishi, Mahito / Hisatake, Koji / Sano, Masayuki

Journal of biological engineering

2024 Volume 18, Issue 1, Page(s) 9

Abstract: Background: Viral vectors are attractive gene delivery vehicles because of their broad tropism, high transduction efficiency, and durable expression. With no risk of integration into the host genome, the vectors developed from RNA viruses such as Sendai ...

Abstract	Background: Viral vectors are attractive gene delivery vehicles because of their broad tropism, high transduction efficiency, and durable expression. With no risk of integration into the host genome, the vectors developed from RNA viruses such as Sendai virus (SeV) are especially promising. However, RNA-based vectors have limited applicability because they lack a convenient method to control transgene expression by an external inducer. Results: We engineered a Csy4 switch in Sendai virus-based vectors by combining Csy4 endoribonuclease with mutant FKBP12 (DD: destabilizing domain) that becomes stabilized when a small chemical Shield1 is supplied. In this Shield1-responsive Csy4 (SrC) switch, Shield1 increases Csy4 fused with DD (DD-Csy4), which then cleaves and downregulates the transgene mRNA containing the Csy4 recognition sequence (Csy4RS). Moreover, when Csy4RS is inserted in the viral L gene, the SrC switch suppresses replication and transcription of the SeV vector in infected cells in a Shield1-dependent manner, thus enabling complete elimination of the vector from the cells. By temporally controlling BRN4 expression, a BRN4-expressing SeV vector equipped with the SrC switch achieves efficient, stepwise differentiation of embryonic stem cells into neural stem cells, and then into astrocytes. Conclusion: SeV-based vectors with the SrC switch should find wide applications in stem cell research, regenerative medicine, and gene therapy, especially when precise control of reprogramming factor expression is desirable.
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2391582-1
ISSN	1754-1611
ISSN	1754-1611
DOI	10.1186/s13036-024-00404-9
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