LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 506

Search options

  1. Article ; Online: Guidelines on the hygienic management of wild meat in Japan.

    Takai, Shinji

    Meat science

    2022  Volume 191, Page(s) 108864

    Abstract: The density and distribution of wild ungulates, especially sika deer (Cervus nippon) and wild boar (Sus scrofa), have increased across the Japanese archipelago in the last two decades. The tradition of consuming wild game meat has been inherited in ... ...

    Abstract The density and distribution of wild ungulates, especially sika deer (Cervus nippon) and wild boar (Sus scrofa), have increased across the Japanese archipelago in the last two decades. The tradition of consuming wild game meat has been inherited in limited areas in Japan, but recently, the use of wild animals for food has increased. Game meat has become popular at local restaurants and retail meat shops. However, fundamental knowledge of game meat hygiene and health risks has not been fully established among hunters, meat processors, restaurant operators, and consumers. Moreover, game meat-borne illnesses have been reported occasionally. Unlike domesticated livestock, wild animals are not inspected for diseases when being butchered for food, and the meat obtained is at a high risk of being unhygienic. The Guidelines on the hygienic management of wild meat were established in 2014 to ensure the safety of wild meat in Japan. This study describes the situation regarding wild animals and game meat in Japan.
    MeSH term(s) Animals ; Animals, Wild ; Deer ; Hygiene ; Japan ; Meat/analysis ; Sus scrofa ; Swine
    Language English
    Publishing date 2022-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 753319-6
    ISSN 1873-4138 ; 0309-1740
    ISSN (online) 1873-4138
    ISSN 0309-1740
    DOI 10.1016/j.meatsci.2022.108864
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: Guidelines on the hygienic management of wild meat in Japan

    Takai, Shinji

    Meat science. 2022 May 18,

    2022  

    Abstract: The density and distribution of wild ungulates, especially sika deer (Cervus nippon) and wild boar (Sus scrofa), have increased across the Japanese archipelago in the last two decades. The tradition of consuming wild game meat has been inherited in ... ...

    Abstract The density and distribution of wild ungulates, especially sika deer (Cervus nippon) and wild boar (Sus scrofa), have increased across the Japanese archipelago in the last two decades. The tradition of consuming wild game meat has been inherited in limited areas in Japan, but recently, the use of wild animals for food has increased. Game meat has become popular at local restaurants and retail meat shops. However, fundamental knowledge of game meat hygiene and health risks has not been fully established among hunters, meat processors, restaurant operators, and consumers. Moreover, game meat-borne illnesses have been reported occasionally. Unlike domesticated livestock, wild animals are not inspected for diseases when being butchered for food, and the meat obtained is at a high risk of being unhygienic. The Guidelines on the hygienic management of wild meat were established in 2014 to ensure the safety of wild meat in Japan. This study describes the situation regarding wild animals and game meat in Japan.
    Keywords Cervus nippon ; Japan ; Sus scrofa ; game animals ; game meat ; hygiene ; livestock ; meat science ; restaurants ; risk ; wild boars
    Language English
    Dates of publication 2022-0518
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 753319-6
    ISSN 1873-4138 ; 0309-1740
    ISSN (online) 1873-4138
    ISSN 0309-1740
    DOI 10.1016/j.meatsci.2022.108864
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  3. Article: Pathophysiological Role of Chymase-Activated Matrix Metalloproteinase-9.

    Takai, Shinji / Jin, Denan

    Biomedicines

    2022  Volume 10, Issue 10

    Abstract: Chymase present in mast cells can directly form matrix metalloproteinase (MMP)-9 from proMMP-9. Chymase-activated MMP-9 has been reportedly closely related to the pathogenesis of various diseases, and inflammation-related diseases in particular. ... ...

    Abstract Chymase present in mast cells can directly form matrix metalloproteinase (MMP)-9 from proMMP-9. Chymase-activated MMP-9 has been reportedly closely related to the pathogenesis of various diseases, and inflammation-related diseases in particular. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of aortic aneurysm, inflammatory gastrointestinal and hepatic diseases, acute pancreatic failure, atopic dermatitis and rheumatoid arthritis. Chymase at these regions is only derived from mast cells, while MMP-9 is derived from macrophages and neutrophils in addition to mast cells. Chymase inhibitors attenuate MMP-9 formation from pro-MMP-9, and ameliorate the development and progression of these disorders, along with reduction in inflammatory cell numbers. MMP-9 activated by chymase might also be involved in angiogenesis in the tumor environment. Development of angiogenesis around several cancers is closely related to the expression of chymase and MMP-9, and postoperative survival curves have revealed that patients with a higher number of chymase positive cells have lower survival rates. In this review, we wanted to clarify the role of chymase-activated MMP-9, which might become an important therapeutic target for various inflammatory disorders.
    Language English
    Publishing date 2022-10-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10102499
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Tryptase-Positive Mast Cells Promote Adipose Fibrosis in Secondary Lymphedema through PDGF.

    Nuri, Takashi / Jin, Denan / Takai, Shinji / Ueda, Koichi

    Current issues in molecular biology

    2023  Volume 45, Issue 10, Page(s) 8027–8039

    Abstract: Lymphedema is a chronic and progressive condition that causes physical disfigurement and psychological trauma due to the accumulation of lymphatic fluid in the interstitial space. Once it develops, lymphedema is difficult to treat because it leads to the ...

    Abstract Lymphedema is a chronic and progressive condition that causes physical disfigurement and psychological trauma due to the accumulation of lymphatic fluid in the interstitial space. Once it develops, lymphedema is difficult to treat because it leads to the fibrosis of adipose tissue. However, the mechanism behind this remains unclear. The purpose of this study was to investigate the involvement of mast cells (MCs) in the adipose tissues of patients with lymphedema. We found that fibrosis spread through blood vessels in the adipose tissues of lymphedema patients, and the expression of the collagen I and III genes was significantly increased compared to that of those in normal adipose tissue. Immunostaining of vimentin and α-smooth muscle actin showed that fibroblasts were the main cellular components in severely fibrotic regions. Toluidine blue staining confirmed a significant increase in the number of MCs in the adipose tissues of lymphedema patients, and immunostaining of serial sections of adipose tissue showed a significant increase in the number of tryptase-positive cells in lymphedema tissues compared with those in normal adipose tissues. Linear regression analyses revealed significant positive correlations between tryptase and the expressions of the TNF-α, platelet-derived growth factor (PDGF)-A, and PDGFR-α genes. PDGF-A-positive staining was observed in both fibroblasts and granules of tryptase-positive MCs. These results suggest that MC-derived tryptase plays a role in the fibrosis of adipose tissue due to lymphedema directly or in cooperation with other mediators.
    Language English
    Publishing date 2023-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45100507
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Lenvatinib Exacerbates the Decrease in Skeletal Muscle Mass in Patients with Hepatocellular Carcinoma, Whereas Atezolizumab Plus Bevacizumab Does Not.

    Imai, Kenji / Takai, Koji / Unome, Shinji / Miwa, Takao / Hanai, Tatsunori / Suetsugu, Atsushi / Shimizu, Masahito

    Cancers

    2024  Volume 16, Issue 2

    Abstract: This study aimed to evaluate chronological changes in skeletal muscle index (SMI), subcutaneous and visceral adipose tissue indices (SATI and VATI), AFP, PIVKA-II, and ALBI scores during atezolizumab plus bevacizumab (AB) or lenvatinib (LEN) treatment ... ...

    Abstract This study aimed to evaluate chronological changes in skeletal muscle index (SMI), subcutaneous and visceral adipose tissue indices (SATI and VATI), AFP, PIVKA-II, and ALBI scores during atezolizumab plus bevacizumab (AB) or lenvatinib (LEN) treatment for hepatocellular carcinoma (HCC) and the effect of these changes on survival. A total of 94 patients with HCC (37 were on AB and 57 on LEN) were enrolled. SMI, SATI, VATI, AFP, PIVKA-II, and ALBI scores were analyzed at the time of the treatment introduction (Intro), 3 months after the introduction (3M), at drug discontinuation (End), and the last observational time (Last). The differences between chronological changes were analyzed using the Wilcoxon paired test. The independent predictors for survival and the changes in SMI during AB or LEN (c-SMI%) were analyzed using the Cox proportional hazards model treating all these factors as time-varying covariates and the analysis of covariance, respectively. SMI in the AB group was maintained over time (42.9-44.0-40.6-44.2 cm
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16020442
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: [Rhodococcus equi infections in humans: an emerging zoonotic pathogen].

    Takai, Shinji / Mizuno, Yasutaka / Suzuki, Yasunori / Sasaki, Yukako / Kakuda, Tsutomu / Kirikae, Teruo

    Nihon saikingaku zasshi. Japanese journal of bacteriology

    2024  Volume 79, Issue 1, Page(s) 15–24

    Abstract: Rhodococcus equi is a facultative intracellular gram-positive coccobacillus which is a well-known cause of foal pneumonia and/or enteritis in equine veterinary medicine. More than 300 cases of R. equi infection have been reported since the first ... ...

    Abstract Rhodococcus equi is a facultative intracellular gram-positive coccobacillus which is a well-known cause of foal pneumonia and/or enteritis in equine veterinary medicine. More than 300 cases of R. equi infection have been reported since the first description of human disease in 1968. Most patients who become infected with R equi are immunocompromised, such as those infected with human immunodeficiency virus (HIV), recipients of organ transplantation, and patients receiving cancer treatment. However, there are increasing reports of the immunocompetent hosts. The pathogenicity of R. equi has been attributed to the presence of plasmid-encoded virulence-associated proteins (Vap). To date, three host-associated virulence plasmid types of R. equi have been identified as follows: the circular pVAPA and pVAPB, related, respectively, to equine and porcine isolates in 1991 and 1995, and a recently described linear pVAPN plasmid associated with bovine and caprine strains in 2015. More recently, these three plasmid types have been re-found in the human isolates which were isolated during 1980s to 1990s. Not only horses, but also pigs, goats, cattle and their environment should be considered as a potential source of R. equi for humans. In this review, we shed light on the current understanding of R. equi as an emerging zoonotic pathogen.
    MeSH term(s) Humans ; Animals ; Horses ; Cattle ; Swine ; Virulence Factors/genetics ; Rhodococcus equi/genetics ; Goats ; Plasmids/genetics
    Chemical Substances Virulence Factors
    Language Japanese
    Publishing date 2024-02-20
    Publishing country Japan
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 604101-2
    ISSN 1882-4110 ; 0021-4930
    ISSN (online) 1882-4110
    ISSN 0021-4930
    DOI 10.3412/jsb.79.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Contamination and Antimicrobial Susceptibility Testing of

    Kanungpean, Doungjit / Takai, Shinji / Kakuda, Tsutomu

    Veterinary medicine international

    2021  Volume 2021, Page(s) 6646846

    Abstract: ... We ... ...

    Abstract We surveyed
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2536385-2
    ISSN 2042-0048 ; 2090-8113
    ISSN (online) 2042-0048
    ISSN 2090-8113
    DOI 10.1155/2021/6646846
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Involvement of Glycogen Synthase Kinase 3β (GSK3β) in Formation of Phosphorylated Tau and Death of Retinal Ganglion Cells of Rats Caused by Optic Nerve Crush.

    Fukiyama, Yurie / Hirokawa, Takahisa / Takai, Shinji / Kida, Teruyo / Oku, Hidehiro

    Current issues in molecular biology

    2023  Volume 45, Issue 9, Page(s) 6941–6957

    Abstract: Tauopathy is a neurodegenerative condition associated with oligomeric tau formation through abnormal phosphorylation. We previously showed that tauopathy is involved in death of retinal ganglion cells (RGCs) after optic nerve crush (ONC). It has been ... ...

    Abstract Tauopathy is a neurodegenerative condition associated with oligomeric tau formation through abnormal phosphorylation. We previously showed that tauopathy is involved in death of retinal ganglion cells (RGCs) after optic nerve crush (ONC). It has been proposed that glycogen synthase kinase 3β (GSK3β) is involved in the hyperphosphorylation of tau in Alzheimer's disease. To determine the roles of GSK3β in tauopathy-related death of RGCs, lithium chloride (LiCl), a GSK3β inhibitor, was injected intravitreally just after ONC. The neuroprotective effects of LiCl were determined by counting Tuj-1-stained RGCs on day 7. Changes of phosphorylated (ser 396) tau in the retina were determined by Simple Western analysis (WES) on day 3. Retinal GSK3β levels were determined by immunohistochemistry (IHC) and an ELISA. There was a 1.9- and 2.1-fold increase in the levels of phosphorylated tau monomers and dimers on day 3 after ONC. LiCl significantly suppressed the increase in the levels of phosphorylated tau induced by ONC. GSK3β was mainly present in somas of RGCs, and ELISA showed that retinal levels increased to 2.0-fold on day 7. IHC showed that the GSK3β expression increased over time and remained in RGCs that were poorly stained by Tuj-1. The GSK3β and tau expression was colocalized in RGCs. The number of RGCs decreased from 1881 ± 188 (sham control) to 1150 ± 192 cells/mm
    Language English
    Publishing date 2023-08-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45090438
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Zinc Acetate Hydrate Supplementation versus Polaprezinc Supplementation for Improving Hypozincemia in Hemodialysis Patients: A Randomized Clinical Trial.

    Kumagai, Etsuko / Furumachi, Kazuhiro / Kurihara, Akihiro / Hosokawa, Ken / Hosohata, Keiko / Takai, Shinji

    International journal of nephrology

    2023  Volume 2023, Page(s) 2403755

    Abstract: Zinc supplementation may ameliorate zinc deficiency in maintenance hemodialysis patients; however, no standard protocol has been established. This study aimed to investigate the effects of zinc acetate hydrate (ZAH) and polaprezinc (PPZ) as zinc ... ...

    Abstract Zinc supplementation may ameliorate zinc deficiency in maintenance hemodialysis patients; however, no standard protocol has been established. This study aimed to investigate the effects of zinc acetate hydrate (ZAH) and polaprezinc (PPZ) as zinc supplements in hemodialysis patients. We enrolled 75 hemodialysis patients with serum zinc levels <60
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573904-9
    ISSN 2090-2158 ; 2090-214X
    ISSN (online) 2090-2158
    ISSN 2090-214X
    DOI 10.1155/2023/2403755
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Chymase as a Possible Therapeutic Target for Amelioration of Non-Alcoholic Steatohepatitis.

    Takai, Shinji / Jin, Denan

    International journal of molecular sciences

    2020  Volume 21, Issue 20

    Abstract: The development and progression of non-alcoholic steatohepatitis (NASH) are linked to oxidative stress, inflammation, and fibrosis of the liver. Chymase, a chymotrypsin-like enzyme produced in mast cells, has various enzymatic actions. These actions ... ...

    Abstract The development and progression of non-alcoholic steatohepatitis (NASH) are linked to oxidative stress, inflammation, and fibrosis of the liver. Chymase, a chymotrypsin-like enzyme produced in mast cells, has various enzymatic actions. These actions include activation of angiotensin II, matrix metalloproteinase (MMP)-9, and transforming growth factor (TGF)-β, which are associated with oxidative stress, inflammation, and fibrosis, respectively. Augmentation of chymase activity in the liver has been reported in various NASH models. Generation of hepatic angiotensin II and related oxidative stress is upregulated in NASH but attenuated by treatment with a chymase inhibitor. Additionally, increases in MMP-9 and accumulation of inflammatory cells are observed in NASH but are decreased by chymase inhibitor administration. TGF-β and collagen I upregulation in NASH is also attenuated by chymase inhibition. These results in experimental NASH models demonstrate that a chymase inhibitor can effectively ameliorate NASH via the reduction of oxidative stress, inflammation, and fibrosis. Thus, chymase may be a therapeutic target for amelioration of NASH.
    MeSH term(s) Animals ; Chymases/antagonists & inhibitors ; Chymases/metabolism ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Humans ; Liver/drug effects ; Liver/enzymology ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism
    Chemical Substances Enzyme Inhibitors ; Chymases (EC 3.4.21.39)
    Language English
    Publishing date 2020-10-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21207543
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top