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Article ; Online: Vascular Aging and Atherosclerosis: A Perspective on Aging.

Ma, Shudong / Xie, Xuena / Yuan, Rong / Xin, Qiqi / Miao, Yu / Leng, Sean Xiao / Chen, Keji / Cong, Weihong

2024

Abstract: Vascular aging (VA) is recognized as a pivotal factor in the development and progression of atherosclerosis (AS). Although various epidemiological and clinical research has demonstrated an intimate connection between aging and AS, the candidate ... ...

Abstract	Vascular aging (VA) is recognized as a pivotal factor in the development and progression of atherosclerosis (AS). Although various epidemiological and clinical research has demonstrated an intimate connection between aging and AS, the candidate mechanisms still require thorough examination. This review adopts an aging-centric perspective to deepen the comprehension of the intricate relationship between biological aging, vascular cell senescence, and AS. Various aging-related physiological factors influence the physical system's reactions, including oxygen radicals, inflammation, lipids, angiotensin II, mechanical forces, glucose levels, and insulin resistance. These factors cause endothelial dysfunction, barrier damage, sclerosis, and inflammation for VA and promote AS via distinct or shared pathways. Furthermore, the increase of senescent cells inside the vascular tissues, caused by genetic damage, dysregulation, secretome changes, and epigenetic modifications, might be the primary cause of VA.
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625789-0
ISSN	2152-5250 ; 2152-5250
ISSN (online)	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2024.0201-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High-Yield Gold Nanohydrangeas on Three-Dimensional Carbon Nanotube Foams for Surface-Enhanced Raman Scattering Sensors.

Yang, Rong / Zhang, Zhen / Miao, Naiqian / Fang, Weichen / Xiao, Zuo / Shen, Xiaodong / Xin, Wenbo

ACS omega

2023 Volume 8, Issue 30, Page(s) 26973–26981

Abstract: Recently, carbon nanomaterial-supported plasmonic nanocrystals used as high-performance surface-enhanced Raman scattering (SERS) substrates have attracted increasing attention due to their ultra-high sensitivity of detection. However, most of the work ... ...

Abstract	Recently, carbon nanomaterial-supported plasmonic nanocrystals used as high-performance surface-enhanced Raman scattering (SERS) substrates have attracted increasing attention due to their ultra-high sensitivity of detection. However, most of the work focuses on the design of 2-D planar substrates with traditional plasmonic structures, such as nanoparticles, nanorods, nanowires, and so forth. Here, we report a novel strategy for the preparation of high-yield Au nanohydrangeas on three-dimensional porous polydopamine (PDA)/polyvinyl alcohol (PVA)/carbon nanotube (CNT) foams. The structures and growth mechanisms of these specific Au nanocrystals are systematically investigated. PDA plays the role of both a reducing agent as well as an anchoring site for Au nanohydrangeas' growth. We also show that the ratio of surfactant KBr to the gold precursor (HAuCl
Language	English
Publishing date	2023-07-21
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c01802
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pantao Pill Improves the Learning and Memory Abilities of APP/PS1 Mice by Multiple Mechanisms.

Xin, Qiqi / Shi, Weili / Wang, Yan / Yuan, Rong / Miao, Yu / Chen, Keji / Cong, Weihong

Frontiers in pharmacology

2022 Volume 13, Page(s) 729605

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-02-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.729605
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Article ; Online: Identification of a Novel Angiogenesis Signalling circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the Regulatory Effects of TMP-PF In Vitro.

Yuan, Rong / Xin, Qiqi / Ma, Xiaochang / Yu, Meng / Miao, Yu / Chen, Keji / Cong, Weihong

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 3

Abstract: Angiogenesis contributes to plaque instability in atherosclerosis and further increases cardio-cerebrovascular risk. Circular RNAs (circRNAs) are promising biomarkers and potential therapeutic targets for atherosclerosis. Previous studies have ... ...

Abstract	Angiogenesis contributes to plaque instability in atherosclerosis and further increases cardio-cerebrovascular risk. Circular RNAs (circRNAs) are promising biomarkers and potential therapeutic targets for atherosclerosis. Previous studies have demonstrated that tetramethylpyrazine (TMP) and paeoniflorin (PF) combination treatment (TMP-PF) inhibited oxidized low-density lipoprotein (ox-LDL)-induced angiogenesis in vitro. However, whether circRNAs regulate angiogenesis in atherosclerosis and whether TMP-PF can regulate angiogenesis-related target circRNAs in atherosclerosis are unknown. In this study, human RNA sequencing (RNA-seq) data were analysed to identify differentially expressed (DE) circRNAs in atherosclerosis and to obtain angiogenesis-associated circRNA-microRNA (miRNA)-messenger RNA (mRNA) networks. Target circRNA-related mechanisms in angiogenesis in atherosclerosis and the regulatory effects of TMP-PF on target circRNA signalling were studied in ox-LDL-induced human umbilical vein endothelial cells (HUVECs) by cell proliferation, migration, tube formation, and luciferase reporter assays, real-time quantitative polymerase chain reaction (RT-qPCR) and Western blotting. A novel circRNA (circular stimulator of chondrogenesis 1, circSCRG1) was initially identified associated with angiogenesis in atherosclerosis, and circSCRG1 silencing up-regulated miR-1268b expression, increased nuclear receptor subfamily 4 group A member 1 (NR4A1) expression and then promoted ox-LDL-induced angiogenesis. TMP-PF (1 μmol/L TMP combined with 10 μmol/L PF) up-regulated circSCRG1 expression, mediated miR-1268b to suppress NR4A1 expression and then inhibited ox-LDL-induced angiogenesis. However, circSCRG1 silencing abolished the inhibitory effects of TMP-PF on ox-LDL-induced angiogenesis, which were rescued by the miR-1268b inhibitor. In conclusion, circSCRG1 might serve as a new target regulating angiogenesis in atherosclerosis via the circSCRG1/miR-1268b/NR4A1 axis and TMP-PF could regulate the circSCRG1/miR-1268b/NR4A1 axis to inhibit angiogenesis in atherosclerosis in vitro, indicating a novel angiogenesis signalling circSCRG1/miR-1268b/NR4A1 pathway in atherosclerosis and the regulatory effects of TMP-PF, which might provide a new pharmaceutical strategy to combat atherosclerotic plaque instability.
MeSH term(s)	Humans ; Apoptosis ; Atherosclerosis/drug therapy ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Cell Proliferation ; Human Umbilical Vein Endothelial Cells/metabolism ; Lipoproteins, LDL/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Nuclear Receptor Subfamily 4, Group A, Member 1/genetics ; Plaque, Atherosclerotic ; RNA, Circular/genetics
Chemical Substances	Lipoproteins, LDL ; MicroRNAs ; NR4A1 protein, human ; Nuclear Receptor Subfamily 4, Group A, Member 1 ; peoniflorin (21AIQ4EV64) ; RNA, Circular ; tetramethylpyrazine (V80F4IA5XG) ; MIRN1268 microRNA, human ; SCRG1 protein, human
Language	English
Publishing date	2023-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28031271
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Article ; Online: One-pot Tandem Synthesis and Spontaneous Product Separation of N-heterocycles based on Bifunctional Small-molecule Photocatalyst.

Yao, Xin-Rong / Jia, Meng-Ze / Miao, Xiao-Li / Chen, Yun-Rui / Pan, Jia-Qi / Zhang, Jie

ChemSusChem

2024 Volume 17, Issue 7, Page(s) e202301495

Abstract: Homogeneous and heterogeneous reactions wherein the resulting products remain dissolved in solvents generally require complicated separation and purification process, despite the advantage of heterogeneous systems allowing retrieval of catalysts. Herein, ...

Abstract	Homogeneous and heterogeneous reactions wherein the resulting products remain dissolved in solvents generally require complicated separation and purification process, despite the advantage of heterogeneous systems allowing retrieval of catalysts. Herein, we have developed an efficient approach for the one-pot tandem synthesis of quinazolines, quinazolinones and benzothiadiazine 1,1-dioxides from alcohols and amines utilizing a bifunctional bipyridinium photocatalyst with redox and Lewis acid sites using air as an oxidant. Through solvent-modulation strategy, the photocatalytic system exhibits high performance and enables most products to separate spontaneously. Consequently, the homogeneous catalyst can be reused by direct centrifugation isolation of the products. Notably, the method is also applicable to the less active substrates, such as heterocyclic alcohols and aliphatic alcohols, and thus provides an efficient and environmentally friendly photocatalytic route with spontaneous separation of N-heterocycles to reduce production costs and meet the needs of atomic economy and green chemistry.
Language	English
Publishing date	2024-02-05
Publishing country	Germany
Document type	Journal Article
ISSN	1864-564X
ISSN (online)	1864-564X
DOI	10.1002/cssc.202301495
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Photocatalyzed Oxidative Tandem Reaction Mediated by Bipyridinium for Multifunctional Derivatization of Alcohols.

Yao, Xin-Rong / Jia, Meng-Ze / Miao, Xiao-Li / Yu, Shi-Kai / Chen, Yun-Rui / Pan, Jia-Qi / Zhang, Jie

ChemSusChem

2024 , Page(s) e202301911

Abstract: The multifunctional derivatization of alcohols has been achieved by the bipyridinium-based conjugated small molecule photocatalysts with redox center and Lewis acid site. Besides exhibiting high activity in the selective generation of aldehydes/ketones, ... ...

Abstract	The multifunctional derivatization of alcohols has been achieved by the bipyridinium-based conjugated small molecule photocatalysts with redox center and Lewis acid site. Besides exhibiting high activity in the selective generation of aldehydes/ketones, acids from alcohols through solvent modulation, this system renders the first selective synthesis of esters via an attractive cross-coupling pattern, whose reaction route is significantly different from the traditional condensation of alcohols and acids or esterification from hemiacetals. Following the oxidization of alcohol to aldehyde via bipyridinium-mediated electron and energy transfer, the Lewis acid site of bipyridinium then activates the aldehyde and methanol to obtain the acetal, which further reacts with methanol to generate ester. This method not only demonstrates a clear advantage of bipyridinium in diverse catalytic activities, but also paves the way for designing efficient multifunctional small molecule photocatalysts. This metal- and additive-free photocatalytic esterification reaction marks a significant advancement towards a more environmentally friendly, cost-effective and green sustainable approach, attributed to the utilization of renewable substrate alcohol and the abundant, low-cost air as the oxidant. The mildness of this esterification reaction condition provides a more suitable alternative for large-scale industrial production of esters.
Language	English
Publishing date	2024-03-13
Publishing country	Germany
Document type	Journal Article
ISSN	1864-564X
ISSN (online)	1864-564X
DOI	10.1002/cssc.202301911
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Weyl Anomaly Induced Current in Boundary Quantum Field Theories.

Chu, Chong-Sun / Miao, Rong-Xin

Physical review letters

2019 Volume 121, Issue 25, Page(s) 251602

Abstract: We show that when an external magnetic field parallel to the boundary is applied, the Weyl anomaly gives rises to a new anomalous current in the vicinity of the boundary. The induced current is a magnetization current in origin: the movement of the ... ...

Abstract	We show that when an external magnetic field parallel to the boundary is applied, the Weyl anomaly gives rises to a new anomalous current in the vicinity of the boundary. The induced current is a magnetization current in origin: the movement of the virtual charges near the boundary give rise to a nonuniform magnetization of the vacuum and hence a magnetization current. Unlike other previously studied anomalous current phenomena such as the chiral magnetic effect or the chiral vortical effect, this induced current does not rely on the presence of a material system and can occur in vacuum. Similar to the Casimir effect, our discovered phenomenon arises from the effect of the boundary on the quantum fluctuations of the vacuum. However this induced current is purely quantum mechanical and has no classical limit. We briefly comment on how this induced current may be observed experimentally.
Language	English
Publishing date	2019-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.121.251602
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Enhancement of Anomalous Boundary Current by High Temperature

Guo, Ruiping / Miao, Rong-Xin

2021

Abstract: Recently it is found that Weyl anomaly leads to novel anomalous currents in the spacetime with a boundary. However, the anomalous current is suppressed by the mass of charge carriers and the distance to the boundary, which makes it difficult to be ... ...

Abstract	Recently it is found that Weyl anomaly leads to novel anomalous currents in the spacetime with a boundary. However, the anomalous current is suppressed by the mass of charge carriers and the distance to the boundary, which makes it difficult to be measured. In this paper, we explore the possible mechanisms for the enhancement of anomalous currents. Interestingly, we find that the anomalous current can be significantly enhanced by the high temperature, which makes easier the experimental detection. For free theories, the anomalous current is proportional to the temperature in the high temperature limit. Note that the currents can be enhanced by thermal effects only at high temperatures. In general, this is not the case at low temperatures. For general temperatures, the absolute value of the current of Neumann boundary condition first decreases and then increases with the temperature, while the current of Dirichlet boundary condition always increases with the temperature. It should be mentioned that the enhancement does not have an anomalous nature. In fact, the so-called anomalous current in this paper is not always related to Weyl anomaly. Instead, it is an anomalous effect due to the boundary. Comment: 16 pages, 6 figures,references added, minor revision accepted for publication in EPJC
Keywords	High Energy Physics - Theory ; Condensed Matter - Other Condensed Matter
Subject code	539 ; 551
Publishing date	2021-02-01
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Interspecific root interaction enhances cadmium accumulation in Oryza sativa when intercropping with cadmium accumulator Artemisia argyi

Xin-sheng Chen / Ze Zhang / Xiang-rong Song / Zheng-miao Deng / Chao Xu / Dao-you Huang / Xian-yan Qin

Ecotoxicology and Environmental Safety, Vol 269, Iss , Pp 115788- (2024)

1481

Abstract: The contamination of arable land with heavy metals, such as Cd, is a serious concern worldwide. Intercropping with Cd accumulators can be used for efficient safe crop production and phytoremediation of Cd-contaminated soil. However, the effect of ... ...

Abstract	The contamination of arable land with heavy metals, such as Cd, is a serious concern worldwide. Intercropping with Cd accumulators can be used for efficient safe crop production and phytoremediation of Cd-contaminated soil. However, the effect of intercropping on Cd uptake by main crops and accumulators varies among plant combinations. Rhizosphere interaction may mediate Cd uptake by intercropped plants, but the mechanism is unclear. Thus, in the present study, we aimed to examine the effect of rhizosphere interaction on Cd uptake by intercropping rice (Oryza sativa L.) with mugwort (Artemisia argyi Levl. et Vant.) in Cd-contaminated paddy soil. We grew O. sativa and A. argyi in pots designed to allow different levels of interaction: complete root interaction (no barrier), partial root interaction (nylon mesh barrier), and no root interaction (plastic film barrier). Our results indicated that both complete and partial root interaction increased the shoot and root mass of A. argyi, but did not decrease the shoot, root, and grain mass of O. sativa. Interspecific root interaction significantly increased the Cd content in the shoots, roots, and grains of O. sativa and the shoots of A. argyi. Increased content of total organic acids in the rhizosphere, which increased the content of available Cd, was a possible mechanism of increased Cd uptake in both plants under interspecific root interaction. Our findings demonstrate that an intercropping system can extract more Cd from contaminated soil than a monocropping system of either A. argyi or O. sativa. However, the intercropping system did not facilitate safe crop production because it substantially increased grain Cd content in O. sativa.
Keywords	Intercropping system ; Phytoremediation ; Cadmium extraction ; Rhizosphere effect ; Organic acids ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	580
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of a Novel Angiogenesis Signalling circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the Regulatory Effects of TMP-PF In Vitro

Rong Yuan / Qiqi Xin / Xiaochang Ma / Meng Yu / Yu Miao / Keji Chen / Weihong Cong

Molecules, Vol 28, Iss 1271, p

2023 Volume 1271

Abstract	Angiogenesis contributes to plaque instability in atherosclerosis and further increases cardio-cerebrovascular risk. Circular RNAs (circRNAs) are promising biomarkers and potential therapeutic targets for atherosclerosis. Previous studies have demonstrated that tetramethylpyrazine (TMP) and paeoniflorin (PF) combination treatment (TMP-PF) inhibited oxidized low-density lipoprotein (ox-LDL)-induced angiogenesis in vitro. However, whether circRNAs regulate angiogenesis in atherosclerosis and whether TMP-PF can regulate angiogenesis-related target circRNAs in atherosclerosis are unknown. In this study, human RNA sequencing (RNA-seq) data were analysed to identify differentially expressed (DE) circRNAs in atherosclerosis and to obtain angiogenesis-associated circRNA-microRNA (miRNA)-messenger RNA (mRNA) networks. Target circRNA-related mechanisms in angiogenesis in atherosclerosis and the regulatory effects of TMP-PF on target circRNA signalling were studied in ox-LDL-induced human umbilical vein endothelial cells (HUVECs) by cell proliferation, migration, tube formation, and luciferase reporter assays, real-time quantitative polymerase chain reaction (RT-qPCR) and Western blotting. A novel circRNA (circular stimulator of chondrogenesis 1, circSCRG1) was initially identified associated with angiogenesis in atherosclerosis, and circSCRG1 silencing up-regulated miR-1268b expression, increased nuclear receptor subfamily 4 group A member 1 (NR4A1) expression and then promoted ox-LDL-induced angiogenesis. TMP-PF (1 μmol/L TMP combined with 10 μmol/L PF) up-regulated circSCRG1 expression, mediated miR-1268b to suppress NR4A1 expression and then inhibited ox-LDL-induced angiogenesis. However, circSCRG1 silencing abolished the inhibitory effects of TMP-PF on ox-LDL-induced angiogenesis, which were rescued by the miR-1268b inhibitor. In conclusion, circSCRG1 might serve as a new target regulating angiogenesis in atherosclerosis via the circSCRG1/miR-1268b/NR4A1 axis and TMP-PF could regulate the circSCRG1/miR-1268b/NR4A1 ...
Keywords	atherosclerosis ; plaque stability ; cardio-cerebrovascular disease ; neovascularization ; circRNA ; Chinese medicine ; Organic chemistry ; QD241-441
Subject code	616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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