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  1. Book ; Online: Environmental pollution and chronic arsenicosis in South Calcutta / D. N. Guha Mazumder . [et al.]

    Guha Mazumder, D. N / Das Gupta, J / Chakraborty, A. K / Chatterjee, A / Das, D / Chakraborti, D

    1992  

    Keywords Arsenic ; Industrial waste ; Water pollutants ; Chemical ; India ; Environment and Public Health ; toxicity
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: Environmental pollution and chronic arsenicosis in South Calcutta / D. N. Guha Mazumder . [et al.]

    Guha Mazumder, D. N / Das Gupta, J / Chakraborty, A. K / Chatterjee, A / Das, D / Chakraborti, D

    1992  

    Keywords Arsenic ; Industrial waste ; Water pollutants ; Chemical ; India ; Environment and Public Health ; toxicity
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Online: Chronic arsenic toxicity from drinking tubewell water in rural West Bengal / D. N. Guha Mazumder . [et al.]

    Guha Mazumder, D. N / Chakraborty, A. K / Ghose, A / Gupta, J. D / Chakraborty, D. P / Dey, S. B / Chattopadhyay, N

    1988  

    Keywords Water pollution ; Arsenic ; Liver diseases ; India ; Community Health and Primary Health Care ; toxicity ; chemically induced
    Document type Book ; Online
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  4. Book ; Online: Chronic arsenic toxicity from drinking tubewell water in rural West Bengal / D. N. Guha Mazumder . [et al.]

    Guha Mazumder, D. N / Chakraborty, A. K / Ghose, A / Gupta, J. D / Chakraborty, D. P / Dey, S. B / Chattopadhyay, N

    1988  

    Keywords Water pollution ; Arsenic ; Liver diseases ; India ; Community Health and Primary Health Care ; toxicity ; chemically induced
    Document type Book ; Online
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  5. Article ; Online: Skin score correlates with global DNA methylation and GSTO1 A140D polymorphism in arsenic-affected population of Eastern India.

    Majumder, Moumita / Dasgupta, Uma B / Guha Mazumder, D N / Das, Nilansu

    Toxicology mechanisms and methods

    2017  Volume 27, Issue 6, Page(s) 467–475

    Abstract: Arsenic is a potent environmental toxicant causing serious public health concerns in India, Bangladesh and other parts of the world. Gene- and promoter-specific hypermethylation has been reported in different arsenic-exposed cell lines, whereas whole ... ...

    Abstract Arsenic is a potent environmental toxicant causing serious public health concerns in India, Bangladesh and other parts of the world. Gene- and promoter-specific hypermethylation has been reported in different arsenic-exposed cell lines, whereas whole genome DNA methylation study suggested genomic hypo- and hypermethylation after arsenic exposure in in vitro and in vivo studies. Along with other characteristic biomarkers, arsenic toxicity leads to typical skin lesions. The present study demonstrates significant correlation between severities of skin manifestations with their whole genome DNA methylation status as well as with a particular polymorphism (Ala 140 Asp) status in arsenic metabolizing enzyme Glutathione S-transferase Omega-1 (GSTO1) in arsenic-exposed population of the district of Nadia, West Bengal, India.
    Language English
    Publishing date 2017-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081252-8
    ISSN 1537-6524 ; 1537-6516 ; 1051-7235
    ISSN (online) 1537-6524
    ISSN 1537-6516 ; 1051-7235
    DOI 10.1080/15376516.2017.1323255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3215: Show issues Location:
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  6. Article: Hepatology in Kolkata.

    Guha Mazumder, D N

    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

    2007  Volume 26 Suppl 1, Page(s) S18–23

    MeSH term(s) Animals ; Gastroenterology/history ; Gastroenterology/trends ; History, 20th Century ; Humans ; India ; Liver Diseases/history
    Language English
    Publishing date 2007-07-17
    Publishing country India
    Document type Historical Article ; Journal Article
    ZDB-ID 632595-6
    ISSN 0254-8860
    ISSN 0254-8860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Chronic arsenic toxicity & human health.

    Guha Mazumder, D N

    The Indian journal of medical research

    2008  Volume 128, Issue 4, Page(s) 436–447

    Abstract: Chronic arsenic toxicity (arsenicosis) due to drinking of arsenic contaminated ground water is a major environmental health hazard throughout the world including India. A lot of new information is emerging from extensive research on health effects of ... ...

    Abstract Chronic arsenic toxicity (arsenicosis) due to drinking of arsenic contaminated ground water is a major environmental health hazard throughout the world including India. A lot of new information is emerging from extensive research on health effects of chronic arsenic toxicity (CAT) in humans during the last two decades. Available literature has been reviewed to highlight the problem including its malignancies. Pigmentation and keratosis are the specific skin lesions characteristics of CAT. CAT also produces various systemic manifestations over and above skin lesions, important ones being chronic lung disease like chronic bronchitis, chronic obstructive pulmonary disease and bronchiectasis, liver disease like non-cirrhotic portal fibrosis and other diseases like polyneuropathy, peripheral vascular disease, hypertension and ischeamic heart disease, diabetes mellitus, non-pitting oedema of feet/hands, weakness and anaemia. Cancer of skin, lung and urinary bladder are important cancers associated with chronic arsenic toxicity. Stoppage of drinking of arsenic contaminated water is the main stay in the management of arsenicosis as specific chelation therapy has limited value. Early skin cancer, detectable by regular active surveillance, is curable. In addition to dermatological features, CAT produces protean clinical manifestations. Treatment of arsenicosis is unsatisfactory and is mostly symtomatic.
    MeSH term(s) Arsenic/toxicity ; Environmental Exposure ; Humans ; Water Pollutants, Chemical/toxicity ; Water Supply
    Chemical Substances Water Pollutants, Chemical ; Arsenic (N712M78A8G)
    Language English
    Publishing date 2008-10
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article: Arsenic and non-malignant lung disease.

    Guha Mazumder, D N

    Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

    2007  Volume 42, Issue 12, Page(s) 1859–1867

    Abstract: Many aquifers in various parts of the world have been found to be contaminated with arsenic at concentration above 0.05 mg/L. However reports of large number of affected people in India and Bangladesh are unprecedented. Characteristic skin lesions ( ... ...

    Abstract Many aquifers in various parts of the world have been found to be contaminated with arsenic at concentration above 0.05 mg/L. However reports of large number of affected people in India and Bangladesh are unprecedented. Characteristic skin lesions (pigmentation, depigmentation and keratosis) are the hallmark signs of chronic arsenic toxicity. Emerging evidences show that ingestion of arsenic through drinking water may also lead to non-malignant respiratory effects. Early report of non-malignant pulmonary effect of chronic ingestion of arsenic was available from studies in children in Chile as early as 1970. However on the basis of case studies, respiratory effect of chronic arsenic toxicity in adults following drinking of arsenic contaminated water in West Bengal was first reported in 1997. Epidemiological studies carried out in West Bengal on a population of 7683 showed that the prevalence odds ratio (POR) estimates were markedly increased for participants with arsenic induced skin lesions who also had high levels of arsenic in their current drinking water source (> or = 0.5 mg/L) compared with individuals who had normal skin and were exposed to low levels of arsenic (< 0.05 mg/L). In participants with skin lesions, age-adjusted POR estimates for chronic cough were 7.8 for females (95% CI:3.1-19.5) and 5.0 for males (95% CI:2.6-9.9). In Bangladesh, similar study carried out on a population of 218 showed that the crude prevalence ratio for chronic bronchitis was found to be 10.3 (95% CI:2.4-43.1) for females and 1.6 (95% CI:0.8-3.1) for males. Reports of lung function tests were available from both hospital and population based studies. Results show evidences of restrictive, obstructive and combined obstructive and restrictive lung disease in different people having chronic lung disease associated with chronic arsenic toxicity. On the basis of clinical study, chest X-ray and HRCT done in Arsenicosis patients with features of chronic lung disease, the abnormalities observed were varied. Evidences of obstructive pulmonary disease (COPD), interstitial lung disease (ILD) and bronchiectasis were found in some of the cases. Results of studies carried out on people showing features of Arsenicosis due to drinking arsenic contaminated water provide evidence that arsenic is a potent respiratory toxicant, even following ingestion.
    MeSH term(s) Adult ; Arsenic/analysis ; Arsenic Poisoning/epidemiology ; Arsenic Poisoning/etiology ; Arsenic Poisoning/pathology ; Bangladesh/epidemiology ; Bronchiectasis/chemically induced ; Bronchiectasis/epidemiology ; Bronchiectasis/pathology ; Bronchitis, Chronic/chemically induced ; Bronchitis, Chronic/epidemiology ; Bronchitis, Chronic/pathology ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Female ; Humans ; India/epidemiology ; Lung Diseases/chemically induced ; Lung Diseases/epidemiology ; Lung Diseases/pathology ; Lung Diseases, Interstitial/chemically induced ; Lung Diseases, Interstitial/epidemiology ; Lung Diseases, Interstitial/pathology ; Male ; Middle Aged ; Odds Ratio ; Prevalence ; Pulmonary Disease, Chronic Obstructive/chemically induced ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/pathology ; Skin Diseases/chemically induced ; Skin Diseases/epidemiology ; Skin Diseases/pathology ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/poisoning ; Water Supply/analysis
    Chemical Substances Water Pollutants, Chemical ; Arsenic (N712M78A8G)
    Language English
    Publishing date 2007-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 196584-0
    ISSN 1532-4117 ; 1093-4529 ; 0360-1226 ; 1077-1204
    ISSN (online) 1532-4117
    ISSN 1093-4529 ; 0360-1226 ; 1077-1204
    DOI 10.1080/10934520701566926
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1217: Show issues Location:
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  9. Article: Baseline characteristics of HIV & hepatitis B virus (HIV/HBV) co-infected patients from Kolkata, India.

    Sarkar, Jayeeta / Saha, Debraj / Bandyopadhyay, Bhaswati / Saha, Bibhuti / Kedia, Deepika / Guha Mazumder, D N / Chakravarty, Runu / Guha, Subhasish Kamal

    The Indian journal of medical research

    2016  Volume 143, Issue 5, Page(s) 636–642

    Abstract: ... HBV/D was the predominant genotype (73.2%) and D2 (43.7%) was the commonest subgenotype ...

    Abstract Background & objectives: Hepatitis B virus (HBV) and HIV co-infection has variable prevalence worldwide. In comparison to HBV mono-infection, the course of chronic HBV infection is accelerated in HIV/HBV co-infected patients. the present study was carried out to analyse the baseline characteristics (clinical, biochemical, serological and virological) of treatment naïve HIV/HBV co-infected and HIV mono-infected patients.
    Methods: Between July 2011 and January 2013, a total number of 1331 HIV-seropositive treatment naïve individuals, enrolled in the ART Centre of Calcutta School of Tropical Medicine, Kolkata, India, were screened for hepatitis B surface antigen (HBsAg). A total of 1253 HIV mono-infected and 78 HIV/HBV co-infected patients were characterized. The co-infected patients were evaluated for HBeAg and anti-HBe antibody by ELISA. HIV RNA was quantified for all co-infected patients. HBV DNA was detected and quantified by real time-PCR amplification followed by HBV genotype determination.
    Results: HIV/HBV co-infected patients had proportionately more advanced HIV disease (WHO clinical stage 3 and 4) than HIV mono-infected individuals (37.1 vs. 19.9%). The co-infected patients had significantly higher serum bilirubin, alanine aminotransferase (ALT), alkaline phosphatase and ALT/platelet ratio index (APRI). CD4 count was non-significantly lower in co-infected patients. Majority (61.5%) were HBeAg positive with higher HIV RNA (P<0.05), HBV DNA (p<0.001) and APRI (p<0.05) compared to those who were HBeAg negative. HBV/D was the predominant genotype (73.2%) and D2 (43.7%) was the commonest subgenotype.
    Interpretation & conclusions: HIV/HBV co-infected patients had significantly higher serum bilirubin, ALT, alkaline phosphatase and lower platelet count. HBeAg positive co-infected patients had higher HIV RNA and HBV DNA compared to HBeAg negative co-infected patients. Prior to initiation of antiretroviral treatment (ART) all patients should be screened for HBsAg to initiate appropriate ART regimen.
    MeSH term(s) Adolescent ; Adult ; Aged ; Coinfection/physiopathology ; Female ; HIV/pathogenicity ; HIV Infections/blood ; HIV Infections/physiopathology ; HIV Infections/virology ; Hepatitis B/blood ; Hepatitis B/physiopathology ; Hepatitis B/virology ; Hepatitis B Surface Antigens/blood ; Hepatitis B virus/isolation & purification ; Hepatitis B virus/pathogenicity ; Humans ; Male ; Middle Aged
    Chemical Substances Hepatitis B Surface Antigens
    Language English
    Publishing date 2016-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/0971-5916.187113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Arsenic exposure and health effects.

    Guha Mazumder, D N

    Journal of toxicology. Clinical toxicology

    2002  Volume 40, Issue 4, Page(s) 527–8; author reply 529–30

    MeSH term(s) Arsenic Poisoning/complications ; Humans ; Laryngitis/chemically induced ; Muscular Diseases/chemically induced
    Language English
    Publishing date 2002
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0731-3810 ; 0009-9309 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0731-3810 ; 0009-9309 ; 1556-3650
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