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Article ; Online: Fluvoxamine for the treatment of COVID-19 - Author's reply.

Reis, Gilmar / Mills, Edward

2022 Volume 10, Issue 3, Page(s) e333

MeSH term(s)	COVID-19/drug therapy ; Fluvoxamine/therapeutic use ; Humans ; SARS-CoV-2
Chemical Substances	Fluvoxamine (O4L1XPO44W)
Language	English
Publishing date	2022-02-18
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2723488-5
ISSN	2214-109X ; 2214-109X
ISSN (online)	2214-109X
ISSN	2214-109X
DOI	10.1016/S2214-109X(21)00588-X
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Article ; Online: Ivermectin Treatment for Covid-19. Reply.

Reis, Gilmar / Mills, Edward J

The New England journal of medicine

2022 Volume 387, Issue 24, Page(s) e66

MeSH term(s)	Humans ; Ivermectin/therapeutic use ; COVID-19 ; Patients
Chemical Substances	Ivermectin (70288-86-7)
Language	English
Publishing date	2022-11-22
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2207995
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Article ; Online: Evaluating COVID-19 vaccines in the real world.

Mills, Edward J / Reis, Gilmar

Lancet (London, England)

2022 Volume 399, Issue 10331, Page(s) 1205–1206

MeSH term(s)	COVID-19/prevention & control ; COVID-19 Vaccines ; Evidence-Based Medicine ; Humans
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-03-15
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(22)00194-5
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Article ; Online: Pegylated Interferon Lambda for Covid-19. Reply.

Reis, Gilmar / Mills, Edward J / Glenn, Jeffrey S

The New England journal of medicine

2023 Volume 388, Issue 22, Page(s) 2108

MeSH term(s)	Humans ; Interferon Lambda ; COVID-19 ; Antiviral Agents/therapeutic use ; Interferons/therapeutic use ; Polyethylene Glycols/therapeutic use
Chemical Substances	Interferon Lambda ; Antiviral Agents ; Interferons (9008-11-1) ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2303519
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Article ; Online: PROJETO DE EXTENSÃO “CINECLUBE CAFÉ COM LEITE” PARA O TRABALHO COM A DIVERSIDADE

Carlos Roberto Campos / Maria de Louldes Virgínio / Gilmar Virgínio / Edmar Reis Thiengo

Revista Extensão & Cidadania, Vol 9, Iss

2021 Volume 15

Abstract: O cinema configura-se como uma forma criativa de estabelecer o diálogo entre temas curriculares e o cotidiano da escola, além de ser uma maneira agradável de trabalhar questões polêmicas, contribuindo para a formação de criticidade. O artigo apresenta os ...

Abstract	O cinema configura-se como uma forma criativa de estabelecer o diálogo entre temas curriculares e o cotidiano da escola, além de ser uma maneira agradável de trabalhar questões polêmicas, contribuindo para a formação de criticidade. O artigo apresenta os resultados de um projeto de extensão escolar chamado Cineclube Café com Leite, realizado em uma escola pública estadual do Espírito Santo, buscando a promoção de debates sobre questões relativas à diversidade de gênero, ao preconceito e à intolerância. Trata-se de uma intervenção pedagógica participativa, apoiada por observações anotadas em diário de campo, colhidas em rodas de debates. Os dados foram abordados à luz dos pressupostos da teoria queer. O projeto cineclube favoreceu aos alunos a leitura crítica do mundo e a compreensão de que as questões relacionadas à diversidade, no campo dos Direitos Humanos, são sempre acompanhadas de lutas e desafios.
Keywords	Diversidade Sexual ; Intolerância ; Cine clube escolar ; Teoria Queer ; Education (General) ; L7-991 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Universidade Estadual do Sudoeste da Bahia (UESB)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Early Treatment with Fluvoxamine among Patients with COVID-19: A Cost-Consequence Model.

Mills, Fergal P / Reis, Gilmar / Wilson, Lindsay A / Thorlund, Kristian / Forrest, Jamie I / Guo, Christina M / Boulware, David R / Mills, Edward J

The American journal of tropical medicine and hygiene

2022 Volume 108, Issue 1, Page(s) 101–106

Abstract: To date, two published randomized trials have indicated a clinical benefit of early treatment with fluvoxamine versus placebo for adults with symptomatic COVID-19. Using the results of the largest of these trials, the TOGETHER trial, we conducted a cost- ... ...

Abstract	To date, two published randomized trials have indicated a clinical benefit of early treatment with fluvoxamine versus placebo for adults with symptomatic COVID-19. Using the results of the largest of these trials, the TOGETHER trial, we conducted a cost-consequence analysis to assess the health system benefits of preventing progression to severe COVID-19 in outpatient populations in the United States. A decision-analytic model in the form of a decision tree was constructed to evaluate two treatment strategies for high-risk patients with confirmed, symptomatic COVID-19 in the primary analysis: treatment with a 10-day course of fluvoxamine (100 mg twice daily) and current standard-of-care. A secondary analysis comparing a 5-day course of nirmatrelvir-ritonavir was also conducted. We used a time horizon of 28 days. Reported outcomes included cost-savings and hospitalization days avoided. The results of our analysis indicated that administration of fluvoxamine to symptomatic outpatients at high risk of progressing to severe COVID-19 was substantially cost-saving, in the amount of $232 per eligible patient and prevented an average of 0.15 hospital days per patient treated, compared with standard of care. Nirmatrelvir-ritonavir was also shown to be cost-saving despite its higher acquisition cost and provided savings to the healthcare system of $625 per patient treated. These findings suggest that fluvoxamine is likely to be a cost-effective addition to frontline COVID-19 mitigation strategies in many settings, particularly where access to nirmaltrevir-ritonavir or monoclonal antibodies is limited.
MeSH term(s)	Adult ; Humans ; COVID-19 ; Ritonavir/therapeutic use ; Fluvoxamine/therapeutic use ; Treatment Outcome ; COVID-19 Drug Treatment
Chemical Substances	Ritonavir (O3J8G9O825) ; nirmatrelvir (7R9A5P7H32) ; Fluvoxamine (O4L1XPO44W)
Language	English
Publishing date	2022-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.22-0106
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Article ; Online: Resilient Clinical Trial Infrastructure in Response to the COVID-19 Pandemic: Lessons Learned from the TOGETHER Randomized Platform Clinical Trial.

Forrest, Jamie I / Rawat, Angeli / Duailibe, Felipe / Guo, Christina M / Sprague, Sheila / McKay, Paula / Reis, Gilmar / Mills, Edward J

The American journal of tropical medicine and hygiene

2022 Volume 106, Issue 2, Page(s) 389–393

Abstract: In response to the COVID-19 pandemic, clinical research groups across the world developed trial protocols to evaluate the safety and efficacy of treatments for COVID-19. Despite this initial enthusiasm, only a small portion of these protocols were ... ...

Abstract	In response to the COVID-19 pandemic, clinical research groups across the world developed trial protocols to evaluate the safety and efficacy of treatments for COVID-19. Despite this initial enthusiasm, only a small portion of these protocols were implemented. Of those implemented, a fraction successfully recruited their target sample size to analyze and disseminate findings. More than a year and a half into the COVID-19 pandemic, only a few clinical trials evaluating treatments for COVID-19 have generated new evidence. Productive randomized platform clinical trials evaluating COVID-19 treatments may attribute their success to intentional investments in developing resilient clinical trial infrastructures. Health system resiliency discourse provides a conceptual framework for characterizing attributes for withstanding shocks. This framework may also be useful for contextualizing the attributes of productive clinical trials evaluating COVID-19 therapies. We characterize the successful attributes and lessons learned in developing the TOGETHER Trial infrastructure using a health system resiliency framework. This framework may be considered by clinical trialists aiming to build resilient trial infrastructures capable of responding rapidly and efficiently to global health threats.
MeSH term(s)	COVID-19/drug therapy ; COVID-19/therapy ; Delivery of Health Care/organization & administration ; Efficiency, Organizational ; Humans ; Randomized Controlled Trials as Topic ; Research Design ; SARS-CoV-2
Language	English
Publishing date	2022-01-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.21-1202
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Article ; Online: IgG Isotypes Targeting a Recombinant Chimeric Protein of Trypanosoma cruzi in Different Clinical Presentations of Chronic Chagas Disease.

Serrano, Isabela Machado / Ribeiro, Gilmar / Santos, Ronnei Silva / Cruz, Jaqueline Silva / Lanza, Fernanda Cardoso / Santos, Emily Ferreira Dos / Almeida, Márcio Cerqueira de / Soares, Jorgana Fernanda de Souza / Luquetti, Alejandro Ostermayer / Celedon, Paola Alejandra Fiorani / Zanchin, Nilson Ivo Tonin / Santos, Fred Luciano Neves / Reis, Mitermayer Galvão Dos

The American journal of tropical medicine and hygiene

2024 Volume 110, Issue 4, Page(s) 669–676

Abstract: Chagas disease (CD) is caused by the protozoan Trypanosoma cruzi, which leads to a spectrum of clinical presentations that range from asymptomatic to severe cardiac involvement. The host immune response plays a pivotal role in disease progression. Ig ... ...

Abstract	Chagas disease (CD) is caused by the protozoan Trypanosoma cruzi, which leads to a spectrum of clinical presentations that range from asymptomatic to severe cardiac involvement. The host immune response plays a pivotal role in disease progression. Ig isotypes may contribute to disease pathogenesis. Investigating these components can provide insights into the immunopathogenic mechanisms underlying CD. This cross-sectional study aims to establish a correlation between the Ig profile of individuals infected with T. cruzi with the clinical forms of chronic CD. Serum samples were collected from partner institutions in different states of Brazil. Individuals diagnosed with chronic CD were categorized based on the clinical form of the disease. The indirect ELISA method using the recombinant chimeric Molecular Biology Institute of Paraná membrane protein 8.4 as the antigen was used to determine the Ig profile, including total IgG, IgG1, IgG2, IgG3, and IgG4. Ninety-seven serum samples from patients classified as negative (NEG, n = 38), indeterminate (IND, n = 24), mild cardiac (MC, n = 20), and severe cardiac (SC, n = 15) forms were analyzed. IgG1 exhibited greater levels compared with the other isotypes, showing a significant difference between the MC and IND groups. IgG3 levels were greater in individuals from the MC group compared with the SC group. IgG1 and IgG3 isotypes can serve as biomarkers to evaluate the progression of CD because they exhibit variations across clinical groups. Additional longitudinal studies are necessary to explore the relationship between antibody kinetics and the development of tissue damage.
MeSH term(s)	Humans ; Trypanosoma cruzi/genetics ; Recombinant Fusion Proteins ; Cross-Sectional Studies ; Antigens, Protozoan ; Chagas Disease/diagnosis ; Immunoglobulin G ; Antibodies, Protozoan
Chemical Substances	Recombinant Fusion Proteins ; Antigens, Protozoan ; Immunoglobulin G ; Antibodies, Protozoan
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.23-0652
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Article ; Online: Epidemiological indicators of Chagas disease in the metropolitan region of Salvador, Bahia, Brazil.

Lanza, Fernanda Cardoso / Ribeiro-Jr, Gilmar / Miranda, Diego Lopes Paim / Santos, Fred Luciano Neves / Carvalho, Cristiane Medeiros Moraes de / Cunha, Gabriel Muricy / Carneiro, Ianei de Oliveira / Reis, Renato Barbosa / Cunha, José Maurício Albuquerque / Cardoso, Cristiane Wanderley / Soares, Jorgana Fernanda de Souza / Araújo, Fernando Luiz Vieira de / Reis, Mitermayer Galvão

Revista da Sociedade Brasileira de Medicina Tropical

2023 Volume 56, Page(s) e0185

Abstract: Background: Chagas disease (CD) is caused by Trypanosoma cruzi and transmitted by triatomines. Historical information from the 20th century demonstrates T. cruzi records in the metropolitan region of Salvador (MRS), the third largest urban agglomeration ...

Abstract	Background: Chagas disease (CD) is caused by Trypanosoma cruzi and transmitted by triatomines. Historical information from the 20th century demonstrates T. cruzi records in the metropolitan region of Salvador (MRS), the third largest urban agglomeration in the Brazilian Northeast and the eighth largest in Brazil, an area with intense migratory activity from CD-endemic regions. Therefore, this study aimed to evaluate CD indicators (prevalence and mortality) in the MRS. Methods: A mixed ecological and descriptive study was conducted using secondary data. We analyzed data from 2008 to 2015: deaths due to CD, self-reported cases of CD, and blood donors that were non-negative for T. cruzi infection. Results: São Francisco do Conde was one of the municipalities with the highest mortality rates due to CD. The seroprevalence rates varied by year and municipality; those with the highest values were 2008: Vera Cruz, 2009: Mata de São João, 2010: Dias D'Ávila, 2011 and 2015: São Francisco do Conde, 2012: São Sebastião do Passé, and 2013 and 2014: Pojuca. Spatial correlations between the municipalities were not detected. Conclusions: We conclude that CD is present in the MRS. The indicators analyzed in the MRS are below-state-level data. Given the importance of indicator analysis for the surveillance and control of CD at the state and national levels, it is important to strengthen the surveillance program at the municipal level, including the regions classified as low risk for T. cruzi vector transmission.
MeSH term(s)	Humans ; Brazil/epidemiology ; Seroepidemiologic Studies ; Chagas Disease/epidemiology ; Trypanosoma cruzi ; Cities
Language	English
Publishing date	2023-02-20
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/0037-8682-0185-2022
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Article ; Online: Polycaprolactone/chlorinated bioglass scaffolds doped with Mg and Li ions: Morphological, physicochemical, and biological analysis.

Kukulka, Elisa Camargo / de Souza, Joyce Rodrigues / de Araújo, Juliani Carolini Ribeiro / de Vasconcellos, Luana Marotta Reis / Campos, Tiago Moreira Bastos / Thim, Gilmar Patricínio / Borges, Alexandre Luiz Souto

Journal of biomedical materials research. Part B, Applied biomaterials

2022 Volume 111, Issue 1, Page(s) 140–150

Abstract: The objective was to synthesize and characterize fine polycaprolactone (PCL) fibers associated with a new 58S bioglass obtained by the precipitated sol-gel route, produced by the electrospinning process in order to incorporate therapeutic ions (Mg and Li) ...

Abstract	The objective was to synthesize and characterize fine polycaprolactone (PCL) fibers associated with a new 58S bioglass obtained by the precipitated sol-gel route, produced by the electrospinning process in order to incorporate therapeutic ions (Mg and Li). In PCL/acetone solutions were added 7% pure bioglass, bioglass doped with Mg(NO
MeSH term(s)	Tissue Scaffolds/chemistry ; Polyesters/chemistry ; Ceramics/chemistry ; Biocompatible Materials/chemistry ; Ions ; Tissue Engineering/methods
Chemical Substances	polycaprolactone (24980-41-4) ; Bioglass ; Polyesters ; Biocompatible Materials ; Ions
Language	English
Publishing date	2022-07-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.35140
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