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Article ; Online: Substratos e fungos micorrízicos arbusculares no desenvolvimento vegetativo de Citrange Troyer

Paulo Vitor Dutra de Souza / Edgar Carniel / José Antônio Kröeff Schmitz / Samar Velho da Silveira

Agropecuária Catarinense, Vol 16, Iss

2021 Volume 3

Abstract: ... radicular por FMA em Citrange Troyer (Poncirus trifoliata L. RAF. x Citrus sinensis L. Osb.). Os tratamentos ... de substâncias de reserva às plantas de Citrange Troyer em relação ao substrato solo + areia. A eficiência ...

Abstract	O presente estudo teve por objetivos avaliar o efeito da composição do substrato e da inoculação de duas espécies de fungos micorrízicos arbusculares (FMA) (Glomus clarum e Acaulospora scrobiculata) sobre o desenvolvimento vegetativo, o conteúdo em substâncias de reserva nos tecidos e a porcentagem de colonização radicular por FMA em Citrange Troyer (Poncirus trifoliata L. RAF. x Citrus sinensis L. Osb.). Os tratamentos consistiram de dois substratos: S1 = solo + areia (1:1, v:v) e S2 = solo + areia + resíduo decomposto de casca de acácia-negra (2:2:1, v:v:v) ambos com e sem inoculação isolada de duas espécies de FMA (G. clarum e A. scrobiculata). Constatou-se que a adição de resíduo decomposto de casca de acácia-negra melhorou as características químicas e físicas do substrato, permitindo um maior desenvolvimento vegetativo e acúmulo de substâncias de reserva às plantas de Citrange Troyer em relação ao substrato solo + areia. A eficiência da simbiose foi variável com o substrato e com a espécie de FMA, em que o efeito positivo dos FMA foi observado apenas no substrato solo + areia, mais pobre nutricionalmente, sendo A. scrobiculata a espécie mais eficiente.
Keywords	Citrus sp ; porta-enxerto ; endomicorrizas ; cultivo protegido ; Agriculture (General) ; S1-972
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.

Kretzschmar, Kai / Boonekamp, Kim E / Bleijs, Margit / Asra, Priyanca / Koomen, Mandy / Chuva de Sousa Lopes, Susana M / Giovannone, Barbara / Clevers, Hans

Stem cell reports

2021 Volume 16, Issue 9, Page(s) 2379–2394

Abstract: ... to the IFE. Here, we identify Troy as a marker of IFE and HF infundibulum basal layer cells in developing and ... adult human and mouse epidermis. Genetic lineage-tracing experiments demonstrate that Troy-expressing ... transcriptomics and organoid assays of Troy-expressing cells, as well as their progeny, confirmed stem cell ...

Abstract	The skin epidermis is a highly compartmentalized tissue consisting of a cornifying epithelium called the interfollicular epidermis (IFE) and associated hair follicles (HFs). Several stem cell populations have been described that mark specific compartments in the skin but none of them is specific to the IFE. Here, we identify Troy as a marker of IFE and HF infundibulum basal layer cells in developing and adult human and mouse epidermis. Genetic lineage-tracing experiments demonstrate that Troy-expressing basal cells contribute to long-term renewal of all layers of the cornifying epithelium. Single-cell transcriptomics and organoid assays of Troy-expressing cells, as well as their progeny, confirmed stem cell identity as well as the ability to generate differentiating daughter cells. In conclusion, we define Troy as a marker of epidermal basal cells that govern interfollicular epidermal renewal and cornification.
MeSH term(s)	Animals ; Cell Differentiation/genetics ; Cell Proliferation ; Cells, Cultured ; Epidermal Cells/cytology ; Epidermal Cells/metabolism ; Fluorescent Antibody Technique ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Hair Follicle/embryology ; Hair Follicle/metabolism ; Immunohistochemistry ; Immunophenotyping ; Mice ; Organogenesis/genetics ; Organoids ; Receptors, Tumor Necrosis Factor/genetics ; Receptors, Tumor Necrosis Factor/metabolism ; Single-Cell Analysis/methods
Chemical Substances	Receptors, Tumor Necrosis Factor ; TNFRSF19 protein, human
Language	English
Publishing date	2021-08-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2720528-9
ISSN	2213-6711 ; 2213-6711
ISSN (online)	2213-6711
ISSN	2213-6711
DOI	10.1016/j.stemcr.2021.07.007
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Article ; Online: A molecular portrait of maternal sepsis from Byzantine Troy.

eLife

2017 Volume 6

Abstract: ... their importance in contemporary and ancient societies. While excavating a Byzantine cemetery in Troy ...

Abstract	Pregnancy complications are poorly represented in the archeological record, despite their importance in contemporary and ancient societies. While excavating a Byzantine cemetery in Troy, we discovered calcified abscesses among a woman's remains. Scanning electron microscopy of the tissue revealed 'ghost cells', resulting from dystrophic calcification, which preserved ancient maternal, fetal and bacterial DNA of a severe infection, likely chorioamnionitis.
MeSH term(s)	Abscess/microbiology ; Abscess/pathology ; DNA, Bacterial/genetics ; DNA, Bacterial/isolation & purification ; Female ; Fossils ; Gardnerella vaginalis/classification ; Gardnerella vaginalis/genetics ; Gram-Positive Bacterial Infections/microbiology ; Gram-Positive Bacterial Infections/pathology ; Humans ; Microscopy, Electron, Scanning ; Pregnancy ; Pregnancy Complications, Infectious/pathology ; Staphylococcus saprophyticus/classification ; Staphylococcus saprophyticus/genetics
Chemical Substances	DNA, Bacterial
Language	English
Publishing date	2017-01-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.20983
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Article: Presencia de líneas de exocortis en mandarina Clementina sobre citrange Troyer

Pérez, R., Estación Experimental de Cítricos, Jagüey Grande, Matanzas Cuba / González, A., Estación Experimental de Cítricos, Jagüey Grande, Matanzas Cuba / Izquierdo, R., Estación Experimental de Cítricos, Jagüey Grande, Matanzas Cuba / Álvarez, G., Estación Experimental de Cítricos, Jagüey Grande, Matanzas Cuba

Centro Agrícola

(Sep-Dic 1984) Volume v. 11, Issue (3), Page(s) p. 65–72

Abstract: ... Clementina injertada sobre Citrange Troyer en Jagüey Grande, mediante la indicadora Cidra Etrog Arizona 861 ...

Abstract	Líneas leves, moderadas y severas del viroide de la exocortis han sido detectadas en mandarina Clementina injertada sobre Citrange Troyer en Jagüey Grande, mediante la indicadora Cidra Etrog Arizona 861 mantenida en condiciones de aislador con temperaturas medias entre 32,1 y 21,8 °C. Las características de los árboles en condiciones de campo, los síntomas externos de la enfermedad así como el comportamiento de las indicadoras inoculadas con cada una de las fuentes, son objeto de análisis y discusión en el presente trabajo.
Keywords	CITRUS ; CITRUS CROSSES ; PLANT DISEASES ; VIROIDS ; CITRUS ; AGRUME HYBRIDE ; MALADIE DES PLANTES ; VIROIDE ; CITRUS ; HIBRIDOS DE CITRICOS ; ENFERMEDADES DE LAS PLANTAS ; VIROIDES ; http://www.fao.org/aos/agrovoc#c_1637 ; http://www.fao.org/aos/agrovoc#c_1640 ; http://www.fao.org/aos/agrovoc#c_5962 ; http://www.fao.org/aos/agrovoc#c_15856
Language	Spanish
Document type	Article
ISSN	0253-5785
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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Article ; Online: Propentofylline targets TROY, a novel microglial signaling pathway.

Jacobs, Valerie L / Liu, Yingna / De Leo, Joyce A

PloS one

2012 Volume 7, Issue 5, Page(s) e37955

Abstract: ... TROY, a novel signaling molecule up-regulated in infiltrating microglia, and not macrophages ... in response to CNS-1 cells. We identify Pyk2, Rac1 and pJNK as the downstream signaling molecules of TROY ... through western blot analysis and siRNA transfection. We demonstrate that inhibition of TROY expression in microglia by siRNA ...

Abstract	Glioblastoma multiforme (GBM) is the most common and aggressive primary brain cancer, with a median survival of less than 2 years after diagnosis with current available therapies. The tumor microenvironment serves a critical role in tumor invasion and progression, with microglia as a critical player. Our laboratory has previously demonstrated that propentofylline, an atypical methylxanthine with central nervous system glial modulating and anti-inflammatory actions, significantly decreases tumor growth in a GBM rodent model by preferentially targeting microglia. In the present study, we used the CNS-1 rat glioma model to elucidate the mechanisms of propentofylline. Here we demonstrate that propentofylline targets TROY, a novel signaling molecule up-regulated in infiltrating microglia, and not macrophages, in response to CNS-1 cells. We identify Pyk2, Rac1 and pJNK as the downstream signaling molecules of TROY through western blot analysis and siRNA transfection. We demonstrate that inhibition of TROY expression in microglia by siRNA transfection significantly inhibits microglial migration towards CNS-1 cells similar to 10 µM propentofylline treatment. These results identify TROY as a novel molecule expressed in microglia, involved in their migration and targeted by propentofylline. Furthermore, these results describe a signaling molecule that is differentially expressed between microglia and macrophages in the tumor microenvironment.
MeSH term(s)	Animals ; Blotting, Western ; Cell Movement/drug effects ; Cell Movement/physiology ; Flow Cytometry ; Focal Adhesion Kinase 2/metabolism ; Glioblastoma/drug therapy ; Glioblastoma/physiopathology ; Immunohistochemistry ; Microglia/drug effects ; Microglia/metabolism ; Microglia/physiology ; Neuropeptides/metabolism ; RNA Interference ; RNA, Small Interfering/genetics ; Rats ; Receptors, Tumor Necrosis Factor/metabolism ; Signal Transduction/genetics ; Signal Transduction/physiology ; Xanthines/pharmacology ; Xanthines/therapeutic use ; rac GTP-Binding Proteins/metabolism ; rac1 GTP-Binding Protein
Chemical Substances	Neuropeptides ; RNA, Small Interfering ; Rac1 protein, mouse ; Receptors, Tumor Necrosis Factor ; Tnfrsf19 protein, mouse ; Xanthines ; propentofylline (5RTA398U4H) ; Focal Adhesion Kinase 2 (EC 2.7.10.2) ; Ptk2b protein, mouse (EC 2.7.10.2) ; rac GTP-Binding Proteins (EC 3.6.5.2) ; rac1 GTP-Binding Protein (EC 3.6.5.2)
Language	English
Publishing date	2012-05-23
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0037955
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Replanting problems in citrus. A case of Washington navel on Troyer citrange

De Barreda, D.G / Tarancon, J / Lorenzo, E / Legaz, F

Citriculture : proceedings of the Sixth International Citrus Congress : Middle-East, Tel Aviv, Israel, March 6-11, 1988 / scientific editors, R. Goren and K. Mendel, editor, N. Goren.

1988

Keywords	Citrus sinensis ; rootstocks ; Citroncirus webberi ; plant parasitic nematodes ; Tylenchulus semipenetrans ; nematicides ; nematode control
Language	English
Size	p. 977-981.
Publisher	Balaban, c1989.
Publishing place	Rehovot, Israel
Document type	Article
ISBN	3823611364 ; 9783823611363
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Clinical effectiveness of coronavirus disease 2019 vaccination in patients with multiple sclerosis stratified by disease-modifying treatment.

De Troyer, Marijke / Van Remoortel, Ann / Van Schependom, Jeroen / Faille, Laetitia Della / D'hooghe, Marie B / Peeters, Gertjan / Nagels, Guy / D'haeseleer, Miguel

European journal of neurology

2024 , Page(s) e16300

Abstract: Background and purpose: Coronavirus disease 2019 (COVID-19) vaccination has been associated with a dampened humoral and/or cellular immune response in patients with multiple sclerosis (MS) who were concurrently on disease-modifying treatment (DMT) with ... ...

Abstract	Background and purpose: Coronavirus disease 2019 (COVID-19) vaccination has been associated with a dampened humoral and/or cellular immune response in patients with multiple sclerosis (MS) who were concurrently on disease-modifying treatment (DMT) with B-cell depleting agents or sphingosine-1-phosphate receptor modulators (S1PRMs). Our main goal was to investigate the impact of these DMT classes on the clinical effectiveness of COVID-19 vaccination. Methods: Since March 2020, demographics and clinical data of patients with MS who developed COVID-19 have been collected at the Belgian National MS Centre in Melsbroek. Patients were considered to be 'protected by vaccination' if they were (i) fully vaccinated and (ii) tested positive for COVID-19 in the period ranging from 14 days to 6 months after the last administered vaccine. Results: On 19 December 2022, 418 COVID-19 cases were retrospectively identified in 389 individual patients. Hospitalization and mortality rates resulting from the infection were 10.8% and 2.4%, respectively. Being 'unprotected by vaccination' was significantly associated with a worse COVID-19 outcome (i.e., hospitalization and/or death) in the total cohort (N = 418, odds ratio [OR] 3.96), in patients on ongoing DMT other than anti-CD20 agents or S1PRMs (N = 123, OR 31.75) and in patients without DMT (N = 182, OR 5.60), but not in those receiving anti-CD20 agents (N = 91, OR 0.39); the S1PRMs subgroup was considered too small (22 infections) for any meaningful analysis. Conclusions: Coronavirus disease 2019 vaccination protects against severe infection in patients with MS but it was not possible to confirm this effect in those on DMT with B-cell depleting agents.
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.16300
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Article ; Online: Propentofylline targets TROY, a novel microglial signaling pathway.

Valerie L Jacobs / Yingna Liu / Joyce A De Leo

PLoS ONE, Vol 7, Iss 5, p e

2012 Volume 37955

Abstract	Glioblastoma multiforme (GBM) is the most common and aggressive primary brain cancer, with a median survival of less than 2 years after diagnosis with current available therapies. The tumor microenvironment serves a critical role in tumor invasion and progression, with microglia as a critical player. Our laboratory has previously demonstrated that propentofylline, an atypical methylxanthine with central nervous system glial modulating and anti-inflammatory actions, significantly decreases tumor growth in a GBM rodent model by preferentially targeting microglia. In the present study, we used the CNS-1 rat glioma model to elucidate the mechanisms of propentofylline. Here we demonstrate that propentofylline targets TROY, a novel signaling molecule up-regulated in infiltrating microglia, and not macrophages, in response to CNS-1 cells. We identify Pyk2, Rac1 and pJNK as the downstream signaling molecules of TROY through western blot analysis and siRNA transfection. We demonstrate that inhibition of TROY expression in microglia by siRNA transfection significantly inhibits microglial migration towards CNS-1 cells similar to 10 µM propentofylline treatment. These results identify TROY as a novel molecule expressed in microglia, involved in their migration and targeted by propentofylline. Furthermore, these results describe a signaling molecule that is differentially expressed between microglia and macrophages in the tumor microenvironment.
Keywords	Medicine ; R ; Science ; Q
Subject code	572
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Widespread triazole pesticide use affects infection dynamics of a global amphibian pathogen.

Barbi, Andrea / Goessens, Tess / Strubbe, Diederik / Deknock, Arne / Van Leeuwenberg, Robby / De Troyer, Niels / Verbrugghe, Elin / Greener, Mark / De Baere, Siegrid / Lens, Luc / Goethals, Peter / Martel, An / Croubels, Siska / Pasmans, Frank

Ecology letters

2023 Volume 26, Issue 2, Page(s) 313–322

Abstract: The sixth mass extinction is a consequence of complex interplay between multiple stressors with negative impact on biodiversity. We here examine the interaction between two globally widespread anthropogenic drivers of amphibian declines: the fungal ... ...

Abstract	The sixth mass extinction is a consequence of complex interplay between multiple stressors with negative impact on biodiversity. We here examine the interaction between two globally widespread anthropogenic drivers of amphibian declines: the fungal disease chytridiomycosis and antifungal use in agriculture. Field monitoring of 26 amphibian ponds in an agricultural landscape shows widespread occurrence of triazole fungicides in the water column throughout the amphibian breeding season, together with a negative correlation between early season application of epoxiconazole and the prevalence of chytrid infections in aquatic newts. While triazole concentrations in the ponds remained below those that inhibit growth of Batrachochytrium dendrobatidis, they bioaccumulated in the newts' skin up to tenfold, resulting in cutaneous growth-suppressing concentrations. As such, a concentration of epoxiconazole, 10 times below that needed to inhibit fungal growth, prevented chytrid infection in anuran tadpoles. The widespread presence of triazoles may thus alter chytrid dynamics in agricultural landscapes.
MeSH term(s)	Animals ; Pesticides ; Chytridiomycota ; Plant Breeding ; Mycoses/epidemiology ; Mycoses/veterinary ; Amphibians/microbiology ; Triazoles/pharmacology
Chemical Substances	epoxiconazole (U80T84L776) ; Pesticides ; Triazoles
Language	English
Publishing date	2023-01-02
Publishing country	England
Document type	Letter
ZDB-ID	1441608-6
ISSN	1461-0248 ; 1461-023X
ISSN (online)	1461-0248
ISSN	1461-023X
DOI	10.1111/ele.14154
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Article ; Online: Action of the diaphragm on the rib cage.

Troyer, André De / Wilson, Theodore A

Journal of applied physiology (Bethesda, Md. : 1985)

2016 Volume 121, Issue 2, Page(s) 391–400

Abstract: When the diaphragm contracts, pleural pressure falls, exerting a caudal and inward force on the entire rib cage. However, the diaphragm also exerts forces in the cranial and outward direction on the lower ribs. One of these forces, the "insertional force, ...

Abstract	When the diaphragm contracts, pleural pressure falls, exerting a caudal and inward force on the entire rib cage. However, the diaphragm also exerts forces in the cranial and outward direction on the lower ribs. One of these forces, the "insertional force," is applied by the muscle at its attachments to the lower ribs. The second, the "appositional force," is due to the transmission of abdominal pressure to the lower rib cage in the zone of apposition. In the control condition at functional residual capacity, the effects of these two forces on the lower ribs are nearly equal and outweigh the effect of pleural pressure, whereas for the upper ribs, the effect of pleural pressure is greater. The balance between these effects, however, may be altered. When the abdomen is given a mechanical support, the insertional and appositional forces are increased, so that the muscle produces a larger expansion of the lower rib cage and, with it, a smaller retraction of the upper rib cage. In contrast, at higher lung volumes the zone of apposition is decreased, and pleural pressure is the dominant force on the lower ribs as well. Consequently, although the force exerted by the diaphragm on these ribs remains inspiratory, rib displacement is reversed into a caudal-inward displacement. This mechanism likely explains the inspiratory retraction of the lateral walls of the lower rib cage observed in many subjects with chronic obstructive pulmonary disease (Hoover's sign). These observations support the use of a three-compartment, rather than a two-compartment, model to describe chest wall mechanics.
MeSH term(s)	Computer Simulation ; Diaphragm/physiology ; Humans ; Models, Biological ; Muscle Contraction/physiology ; Pleural Cavity/physiology ; Respiratory Mechanics/physiology ; Rib Cage/physiology ; Stress, Mechanical ; Thoracic Wall/physiology
Language	English
Publishing date	2016-06-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	219139-8
ISSN	1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
ISSN (online)	1522-1601
ISSN	0021-8987 ; 0161-7567 ; 8750-7587
DOI	10.1152/japplphysiol.00268.2016
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