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  1. Article ; Online: Letter to the editor: A contemporary assessment of CFTR modulator use and eligibility.

    Rubin, Jaime L / Kreindler, James L

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2024  

    Language English
    Publishing date 2024-03-04
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2024.02.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Is the best offense a good D-fense? Should we use vitamin D as adjunctive therapy for asthma?

    Kreindler, James L

    American journal of respiratory and critical care medicine

    2012  Volume 186, Issue 6, Page(s) 470–472

    MeSH term(s) Asthma/drug therapy ; Budesonide/administration & dosage ; Female ; Humans ; Male ; Nedocromil/administration & dosage ; Vitamin D/blood ; Vitamin D Deficiency/blood
    Chemical Substances Nedocromil (0B535E0BN0) ; Vitamin D (1406-16-2) ; Budesonide (51333-22-3)
    Language English
    Publishing date 2012-09-15
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201207-1295ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Postbronchodilator lung function improvements with benralizumab for patients with severe asthma.

    Mathur, Sameer K / Modena, Brian D / Coumou, Hanneke / Barker, Peter / Kreindler, James L / Zangrilli, James G

    Allergy

    2020  Volume 75, Issue 6, Page(s) 1507–1510

    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/drug therapy ; Humans ; Lung
    Chemical Substances Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized ; benralizumab (71492GE1FX)
    Language English
    Publishing date 2020-02-05
    Publishing country Denmark
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evaluating direct costs and productivity losses of patients with asthma receiving GINA 4/5 therapy in the United States.

    Settipane, Russell A / Kreindler, James L / Chung, Yen / Tkacz, Joseph

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2019  Volume 123, Issue 6, Page(s) 564–572.e3

    Abstract: Background: Despite the low prevalence for all patients with asthma, those with severe disease account for a disproportionately large economic burden.: Objective: To evaluate current direct health care and productivity loss costs associated with ... ...

    Abstract Background: Despite the low prevalence for all patients with asthma, those with severe disease account for a disproportionately large economic burden.
    Objective: To evaluate current direct health care and productivity loss costs associated with patients with asthma receiving Global Initiative for Asthma Step 4/5 therapy ("G4/5 asthma") in the United States.
    Methods: Asthma patients aged 12 years or older were identified in the IBM MarketScan Research Databases between January 1, 2012 and December 31, 2015. Patients were indexed on their earliest medical claim for asthma and were required to have at last 2 years of continuous eligibility. The G4/5 asthma classification required 1 or more medium- or high-dosage inhaled corticosteroids (ICS)/long-acting beta-agonist (LABA) claims, 1 or more omalizumab claims, or systemic corticosteroids covering at least 50% of the 12-month baseline period. The European Respiratory Society/American Thoracic Society criteria for severe uncontrolled asthma were modified for claims data and used to identify patients with exacerbations or high rescue medication use ("Ex/R″). Direct health care costs and productivity loss costs attributable to workplace absence or short-term or long-term disability were measured during the 12-month post-index period.
    Results: A total of 605,614 patients with asthma were identified. Annual health care costs were $4,384 greater for G4/5 asthma vs non-G4/5 patients with asthma; asthma-related costs contributed $2,183 of this difference (P < .001). Differences were primarily driven by G4/5 patients with asthma with Ex/R, whose costs were $5,019 greater than G4/5 patients without Ex/R (P < .001). For patients with 1 or more absences or short-term disability claims, G4/5 patients missed 7.2 more work hours for absence and had 3.9 more days of work lost for short-term disability than non-G4/5 patients with asthma, respectively (P < .05).
    Conclusion: G4/5 patients with asthma incurred significantly greater direct and indirect costs than non-G4/5 patients with asthma. Differences were largely driven by those with Ex/R.
    MeSH term(s) Adolescent ; Adrenal Cortex Hormones/economics ; Adrenal Cortex Hormones/therapeutic use ; Adrenergic beta-2 Receptor Agonists/economics ; Adrenergic beta-2 Receptor Agonists/therapeutic use ; Adult ; Anti-Asthmatic Agents/economics ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Asthma/economics ; Child ; Efficiency ; Female ; Health Care Costs ; Health Resources/economics ; Hospitalization/economics ; Humans ; Male ; Middle Aged ; Omalizumab/economics ; Omalizumab/therapeutic use ; Severity of Illness Index ; Young Adult
    Chemical Substances Adrenal Cortex Hormones ; Adrenergic beta-2 Receptor Agonists ; Anti-Asthmatic Agents ; Omalizumab (2P471X1Z11)
    Language English
    Publishing date 2019-09-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2019.08.462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cystic fibrosis: exploiting its genetic basis in the hunt for new therapies.

    Kreindler, James L

    Pharmacology & therapeutics

    2009  Volume 125, Issue 2, Page(s) 219–229

    Abstract: Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel expressed in epithelial cells throughout the body. In the lungs, absence or dysfunction of CFTR results in ... ...

    Abstract Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel expressed in epithelial cells throughout the body. In the lungs, absence or dysfunction of CFTR results in altered epithelial salt and water transport eventuating in impaired mucociliary clearance, chronic infection and inflammation, and tissue damage. CF lung disease is the major cause of morbidity and mortality in CF despite the many therapies aimed at reducing it. However, recent technological advances combined with two decades of research driven by the discovery of the CFTR gene have resulted in the development and clinical testing of novel therapies aimed at the principal underlying defect in CF, thereby ushering in a new age of therapy for CF.
    MeSH term(s) Anti-Infective Agents/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; Cystic Fibrosis/genetics ; Cystic Fibrosis/therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Diet ; Genetic Therapy/methods ; Humans ; Mucociliary Clearance ; Mutation
    Chemical Substances Anti-Infective Agents ; Anti-Inflammatory Agents ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2009-11-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2009.10.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Blood eosinophil count group shifts and kinetics in severe eosinophilic asthma.

    Lugogo, Njira L / Kreindler, James L / Martin, Ubaldo J / Cook, Bill / Hirsch, Ian / Trudo, Frank J

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2020  Volume 125, Issue 2, Page(s) 171–176

    Abstract: Background: Blood eosinophil count (BEC) measurements are a noninvasive, relatively reliable surrogate marker for eosinophilic airway inflammation. Single measurements of peripheral BEC greater than or equal to 150 cells/μL predict the response to anti- ... ...

    Abstract Background: Blood eosinophil count (BEC) measurements are a noninvasive, relatively reliable surrogate marker for eosinophilic airway inflammation. Single measurements of peripheral BEC greater than or equal to 150 cells/μL predict the response to anti-eosinophil therapies for patients with characteristics of severe eosinophilic asthma.
    Objective: To describe how BECs shift over time for patients with severe, uncontrolled asthma receiving placebo in 2 large, randomized, placebo-controlled clinical trials of benralizumab (SIROCCO and CALIMA).
    Methods: Our analysis included all adult patients who were randomized to placebo in the SIROCCO and CALIMA phase III benralizumab studies. Patients were categorized into baseline BEC groups of less than 150 cells/μL, greater than or equal to 150 cells/μL but less than 300 cells/μL, and greater than or equal to 300 cells/μL. The timing of the initial shift from baseline to a different group was evaluated at weeks 4, 8, 24, and 40 and at the end of treatment. Baseline characteristics, including oral corticosteroid use, were described based on the presence or absence of a BEC group shift.
    Results: Of the 734 evaluable patients, 65% (n = 474) shifted BEC groups during the study, and most patients (86% [n = 410]) shifted by week 24. Patients who started in the less than 150 cells/μL group tended to shift groups earlier, with 59% shifting by week 4 compared with 38% to 55% for other groups in the same time frame. Patients who shifted BEC groups vs those who did not tend to have lower BECs, more oral corticosteroid use, and less incidence of nasal polyps or past polypectomy.
    Conclusion: A single BEC measurement, particularly when low, may be inadequate to help establish a phenotype of severe eosinophilic asthma.
    Trial registration: ClinicalTrials.gov Identifiers NCT01928771 (SIROCCO trial) and NCT01914757 (CALIMA trial).
    MeSH term(s) Administration, Oral ; Adolescent ; Adult ; Aged ; Anti-Asthmatic Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/diagnosis ; Asthma/drug therapy ; Child ; Disease Progression ; Double-Blind Method ; Drug Therapy, Combination ; Eosinophils/pathology ; Female ; Humans ; Leukocyte Count/methods ; Male ; Middle Aged ; Phenotype ; Placebo Effect ; Severity of Illness Index ; Treatment Outcome ; Young Adult
    Chemical Substances Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized ; benralizumab (71492GE1FX)
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2020.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: On preventing the extinction of the physician-scientist in pediatric pulmonology.

    Rubenstein, Ronald C / Kreindler, James L

    Frontiers in pediatrics

    2014  Volume 2, Page(s) 4

    Abstract: While the founders of Pediatric Pulmonology recognized the necessity of research as a vital part of the developing sub specialty, the field has struggled to develop and maintain physician-scientists and investigators. The clinical growth in Pediatric ... ...

    Abstract While the founders of Pediatric Pulmonology recognized the necessity of research as a vital part of the developing sub specialty, the field has struggled to develop and maintain physician-scientists and investigators. The clinical growth in Pediatric Pulmonology has resulted in significant challenges in career development faced by physician-scientists who aim to establish or maintain independent investigative programs. Such challenges may only be overcome with changes in how both trainees and established physician-scientists in Pediatric Pulmonology are supported.
    Language English
    Publishing date 2014-01-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2014.00004
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  8. Article ; Online: Systemic Corticosteroid-Related Complications and Costs in Adults with Persistent Asthma.

    Zeiger, Robert / Sullivan, Patrick / Chung, Yen / Kreindler, James L / Zimmerman, Nicole M / Tkacz, Joseph

    The journal of allergy and clinical immunology. In practice

    2020  Volume 8, Issue 10, Page(s) 3455–3465.e13

    Abstract: Background: Systemic corticosteroids (SCS) may cause complications for patients with asthma.: Objective: We sought to better understand the burden of SCS use in persistent asthma, including health care costs.: Methods: Adult patients with ... ...

    Abstract Background: Systemic corticosteroids (SCS) may cause complications for patients with asthma.
    Objective: We sought to better understand the burden of SCS use in persistent asthma, including health care costs.
    Methods: Adult patients with persistent asthma were identified in the IBM MarketScan Databases from January 2003 to July 2016. The index date was set as the first SCS prescription for SCS users or an algorithm-matched date for non-SCS users. Patients were required to have ≥1 year of data before and after the index date. Based on the number of SCS claims in the first year after index, patients were categorized into 3 SCS groups: 0 SCS claims, 1 to 3 claims, and 4+ claims. Inverse probability of treatment weights were applied to adjust for differences between SCS and non-SCS users. Analyses included weighted and multivariate modeling to assess SCS-related complications and costs during a 3-year follow-up.
    Results: A total of 86,786 SCS users (1-3 claims: 76,690; 4+ claims: 10,096) and 91,409 non-SCS users were included; 45% remained 3 years after index. In multivariate analysis, the 3-year risk of developing any chronic complication was 6% greater for those with 1 to 3 claims and 26% greater for those with 4+ claims compared with non-SCS users (P < .001). Multivariate-adjusted health care costs over 3 years were significantly greater as 4+ users incurred $22,311 greater total costs, $4627 greater asthma-related costs, and $2647 greater chronic complication-related costs than non-SCS users (P < .001).
    Conclusions: In this study, adults with persistent asthma receiving SCS treatment had greater odds of complications and greater associated costs over 3 years than matched non-SCS asthma patients.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Adult ; Asthma/drug therapy ; Asthma/epidemiology ; Health Care Costs ; Humans ; Retrospective Studies
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2020-07-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.06.055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Response to: Letter to the Editor Regarding "Clinical Remission in Severe Asthma: A Pooled Post Hoc Analysis of the Patient Journey with Benralizumab".

    Menzies-Gow, Andrew / Hoyte, Flavia L / Price, David B / Cohen, David / Barker, Peter / Kreindler, James / Jison, Maria / Brooks, Christopher L / Papeleu, Peggy / Katial, Rohit

    Advances in therapy

    2022  Volume 39, Issue 8, Page(s) 3862–3865

    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/drug therapy ; Disease Progression ; Humans
    Chemical Substances Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized ; benralizumab (71492GE1FX)
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-022-02214-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Real-World Assessment of Asthma Specialist Visits Among U.S. Patients with Severe Asthma.

    Most, Jessica F / Ambrose, Christopher S / Chung, Yen / Kreindler, James L / Near, Aimee / Brunton, Stephen / Cao, Yao / Huang, Huan / Zhao, Xiaohui

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 10, Page(s) 3662–3671.e1

    Abstract: Background: U.S. guidelines recommend that patients with severe asthma be referred to specialists (allergists/immunologists or pulmonologists) for systematic assessment or comanagement; however, contemporary, real-world data on the frequency and impact ... ...

    Abstract Background: U.S. guidelines recommend that patients with severe asthma be referred to specialists (allergists/immunologists or pulmonologists) for systematic assessment or comanagement; however, contemporary, real-world data on the frequency and impact of specialist care among U.S. severe asthma patients are lacking.
    Objectives: To quantify the frequency of asthma specialist visits among U.S. patients with severe asthma, identify patient demographic and clinical characteristics associated with specialist visits and describe health outcomes following specialist care.
    Methods: Severe asthma patients aged 6 years or older were identified between January 1, 2015, and December 31, 2017, in the IQVIA PharMetrics® Plus database of commercially insured individuals, based on Healthcare Effectiveness Data and Information Set (HEDIS) criteria and Global Initiative for Asthma (GINA) step 4 or 5 treatment regimens. The frequency of asthma specialist (allergist/immunologist or pulmonologist) visits was described over 2 years. Patient characteristics associated with having 1 or more specialist visits were analyzed using multivariate regressions. Asthma exacerbations and health care resource utilization before and after specialist visit were compared.
    Results: Of 54,332 patients identified, 38.2% had 1 or more specialist visits over 2 years. Patient characteristics predictive of specialist visits were asthma exacerbation frequency, younger age, and allergy/respiratory comorbidity burden (all P < .001). Among patients with 1 or more specialist visits, a lower prevalence of asthma exacerbations and rescue inhaler use was observed following the first observed specialist visit.
    Conclusions: Specialist care was observed in fewer than half of U.S. patients with severe asthma and was least frequent among older adult patients and those with more nonrespiratory comorbidities. Increased specialist involvement in managing severe asthma may help improve care and patient outcomes.
    MeSH term(s) Aged ; Asthma/epidemiology ; Asthma/therapy ; Databases, Factual ; Delivery of Health Care ; Humans ; Nebulizers and Vaporizers ; Patient Acceptance of Health Care
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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