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Article ; Online: DNA barcoding of Notopterygii Rhizoma et Radix (Qiang-huo) and identification of adulteration in its medicinal services.

Liu, Zhen-Wen / Zhou, Jing

2024 Volume 14, Issue 1, Page(s) 2879

Abstract: ... from the Apiaceae family, commonly known as "Qiang-huo", is a widely used herbal medicine. The recent surge ... may become a universal mini-barcode for the quality control of "Qiang-huo", thereby ensuring the safety ...

Abstract	Safety concerns, stemming from the presence of complex and unpredictable adulterants, permeate the entire industrial chain of traditional Chinese medicines (TCMs). The Notopterygii Rhizoma et Radix (NReR) from the Apiaceae family, commonly known as "Qiang-huo", is a widely used herbal medicine. The recent surge in its demand has given rise to a proliferation of counterfeit and substituted products in the market. Traditional identification presents inherent limitations, while DNA mini-barcoding, reliant on sequencing a short-standardized region, has received considerable attention as a new potential means to identify processed medicinal materials. In this study, we constructed a comprehensive Internal Transcribed Spacer 2 (ITS2) matrix encompassing genuine NReR and their commonly found adulterants for the first time. Leveraging this matrix, we conducted a thorough assessment of the genetic profiles and sources of NReR available in the Chinese herbal medicine market. Following established DNA barcoding protocols, the intra-specific genetic divergences within NReR species were found to be lower than the inter-specific genetic divergences from other species. Among the 120 samples that were successfully amplified, ITS2 exhibits an outstanding species-level identification efficiency of 100% when evaluated using both the BLASTN and neighbor-joining (NJ) tree methods. We concluded that ITS2 is a mini-barcode that has shown its potential and may become a universal mini-barcode for the quality control of "Qiang-huo", thereby ensuring the safety of clinical medication.
MeSH term(s)	Drugs, Chinese Herbal ; DNA Barcoding, Taxonomic/methods ; DNA, Plant/genetics ; DNA, Ribosomal Spacer/genetics ; Phylogeny
Chemical Substances	qiang-huo ; Drugs, Chinese Herbal ; DNA, Plant ; DNA, Ribosomal Spacer
Language	English
Publishing date	2024-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53008-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tibetan medicine Si-Wei-Qiang-Wei Powder ameliorates cholecystitis via inhibiting the production of pro-inflammatory cytokines and regulating the MAPK signaling pathway.

Zheng, Zhe / Xiong, Hui / Zhao, Zhongqiu / Zhou, Keli / Fu, Miao / Liu, Xinqiao / Mei, Zhinan

Journal of ethnopharmacology

2022 Volume 303, Page(s) 116026

Abstract: Ethnopharmacological relevance: Si-Wei-Qiang-Wei Powder (SWQ) is a formulated ...

Abstract	Ethnopharmacological relevance: Si-Wei-Qiang-Wei Powder (SWQ) is a formulated traditional Tibetan medicine preparation that has been used clinically to treat liver and gallbladder diseases for centuries. Previous work has confirmed its clinical effectiveness, however, the specific mechanism of SWQ is still unknown. Aim of the study: This study aims to explore the anti-inflammatory effect of SWQ on cholecystitis and its possible mechanism. Materials and methods: The main chemical components of SWQ were analyzed by HPLC. The network pharmacology database was used to screen and construct the network of the main components and molecular targets of SWQ, and to predict the molecular pathways of its core targets. Cholecystitis guinea pig model and LPS stimulated cultured human gallbladder epithelial cells (HGBEC) were used, as in vivo and in vitro methods respectively, to study the anti-cholecystitis activity of SWQ. Specifically, gallbladder wall thickness, hematoxylin-eosin (H&E) staining, and liver function indexes were used to evaluate the anti-inflammatory activities of SWQ in cholecystitis; qRT-PCR and ELISA were used to detect the changes of the production of inflammatory cytokines; Western blot analysis was used to analyze the effects of SWQ on phosphorylation of P38, ERK1/2, JNK and AKT. Results: SWQ decreased the indexes of ALT, AST, TBA, CHOL, DBIL in serum and TBIL, TC and Ca Conclusion: In summary, our research showed that SWQ relieves gallbladder inflammation by inhibiting the MAPK pathway.
Language	English
Publishing date	2022-12-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.116026
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Uncovering the Molecular Mechanism of the Qiang-Xin 1 Formula on Sepsis-Induced Cardiac Dysfunction Based on Systems Pharmacology.

He, Shasha / Zhao, Jingxia / Xu, Xiaolong / Cui, Xuran / Wang, Ning / Han, Xuyang / Guo, Yuhong / Liu, Qingquan

Oxidative medicine and cellular longevity

2020 Volume 2020, Page(s) 3815185

Abstract: ... Qiang-Xin 1 (QX1), ameliorates cardiac tissue damage in septic mice; however, the underlying ...

Abstract	Cardiac dysfunction is a critical manifestation of sepsis-induced multiorgan failure and results in the high mortality of sepsis. Our previous study demonstrated that a traditional Chinese medicine formula, Qiang-Xin 1 (QX1), ameliorates cardiac tissue damage in septic mice; however, the underlying pharmacology mechanism remains to be elucidated. The present study was aimed at clarifying the protective mechanism of the QX1 formula on sepsis-induced cardiac dysfunction. The moderate sepsis model of mice was established by cecal ligation and puncture surgery. Treatment with the QX1 formula improved the 7-day survival outcome, attenuated cardiac dysfunction, and ameliorated the disruption of myocardial structure in septic mice. Subsequent systems pharmacology analysis found that 63 bioactive compounds and the related 79 candidate target proteins were screened from the QX1 formula. The network analysis showed that the QX1 active components quercetin, formononetin, kaempferol, taxifolin, cryptotanshinone, and tanshinone IIA had a good binding activity with screened targets. The integrating pathway analysis indicated the calcium, PI3K/AKT, MAPK, and Toll-like receptor signaling pathways may be involved in the protective effect of the QX1 formula on sepsis-induced cardiac dysfunction. Further, experimental validation showed that the QX1 formula inhibited the activity of calcium/calmodulin-dependent protein kinase II (CaMKII), MAPK (P38, ERK1/2, and JNK), and TLR4/NF-
MeSH term(s)	Animals ; Cytokines/blood ; Disease Models, Animal ; Drug Delivery Systems ; Drug Evaluation, Preclinical ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Heart/drug effects ; Heart/physiopathology ; Heart Diseases/blood ; Heart Diseases/drug therapy ; Heart Diseases/pathology ; Heart Diseases/physiopathology ; Male ; Mice, Inbred BALB C ; Sepsis/complications ; Tissue Distribution/drug effects
Chemical Substances	Cytokines ; Drugs, Chinese Herbal
Language	English
Publishing date	2020-08-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2020/3815185
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prevalence and risk factors associated with hypertension in the Chinese Qiang population.

Huang, Xiao-Bo / Chen, Fei / Dai, Wen / Song, Lei / Tu, Jiao / Xu, Jun-Bo / Liu, Jian-Xiong / Yi, Yan-Jing / Liu, Ya / Chen, Yong / Wang, Tzung-Dau / Zhao, Shui-Ping

Clinical and experimental hypertension (New York, N.Y. : 1993)

2017 Volume 40, Issue 5, Page(s) 427–433

Abstract: ... among the Chinese Qiang population. From September 2012 to March 2013, a cross-sectional study was conducted ... in urban and rural communities of the Qiang population using multistage cluster sampling. A total of 2676 ... overweight and obesity, family history of hypertension. The prevalence of hypertension in Chinese Qiang ...

Abstract	Our aim is to investigate the prevalence and risk factors associated with hypertension among the Chinese Qiang population. From September 2012 to March 2013, a cross-sectional study was conducted in urban and rural communities of the Qiang population using multistage cluster sampling. A total of 2676 people aged above 20 years were enrolled in the analysis. Standardized mercury sphygmomanometer was used to measure the blood pressure twice after a 10-minute seated rest, and the average blood pressure was obtained. The hypertension prevalence among the population aged above 20 years was 13.9%, and age-standardized prevalence was 12.3%. Male and female prevalence of hypertension, as well as the prevalence in urban and rural areas, all increased with age. There were no significant differences between males and females and between urban and rural residents. Among hypertensive patients, 44.2% were aware of their hypertension, 38.0% were undergoing antihypertensive treatment, but only 10.5% achieved blood pressure control. Multivariate logistic regression analysis showed that the risk factors of hypertension included age, low income, overweight and obesity, family history of hypertension. The prevalence of hypertension in Chinese Qiang adults is significantly lower than the national level. Awareness, treatment, and control rates of hypertension were low in the Qiang population. Thus, hypertension-related health knowledge should be more aggressively delivered to improve public awareness and the capacity of community health services should be strengthened.
MeSH term(s)	Adult ; Age Factors ; Aged ; Antihypertensive Agents/therapeutic use ; Asian Continental Ancestry Group/statistics & numerical data ; Blood Pressure ; China/epidemiology ; Cross-Sectional Studies ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Hypertension/drug therapy ; Hypertension/ethnology ; Hypertension/genetics ; Income ; Male ; Middle Aged ; Obesity/epidemiology ; Prevalence ; Risk Factors ; Rural Population/statistics & numerical data ; Urban Population/statistics & numerical data ; Young Adult
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2017-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	604757-9
ISSN	1525-6006 ; 0730-0077
ISSN (online)	1525-6006
ISSN	0730-0077
DOI	10.1080/10641963.2017.1392553
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1429: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Qiang Xin 1 Formula Suppresses Excessive Pro-Inflammatory Cytokine Responses and Microglia Activation to Prevent Cognitive Impairment and Emotional Dysfunctions in Experimental Sepsis.

Wang, Xuerui / Xu, Xiaolong / Guo, Yuhong / Huang, Po / Ha, Yanxiang / Zhang, Rui / Bai, Yunjing / Cui, Xuran / He, Shasha / Liu, Qingquan

Frontiers in pharmacology

2020 Volume 11, Page(s) 579

Abstract: ... reported that the administration of a traditional Chinese herbal Qiang Xin 1 (QX1) formula improves ...

Abstract	Sepsis commonly leads to acute and long-term cognitive and affective impairments which are associated with increased mortality in patients. Neuroinflammation characterized by excessive cytokine release and immune cell activation underlies the behavioral changes associated with sepsis. We previously reported that the administration of a traditional Chinese herbal Qiang Xin 1 (QX1) formula improves survival in septic mice. This study was performed to better understand the effects and the mechanisms of QX1 formula treatment on behavioral changes in a preclinical septic model induced by cecal ligation and puncture. Oral administration of QX1 formula significantly improved survival, alleviated overall cognitive impairment and emotional dysfunction as assessed by the Morris water maze, novel object recognition testing, elevated plus maze and open field testing in septic mice. QX1 formula administration dramatically inhibited short and long-term excessive pro-inflammatory cytokine production both peripherally and centrally, and was accompanied by diminished microglial activation in septic mice. Biological processes including synaptic transmission, microglia cell activation, cytokine production, microglia cell polarization, as well as inflammatory responses related to signaling pathways including the MAPK signaling pathway and the NF-κB signaling pathway were altered prominently by QX1 formula treatment in the hippocampus of septic mice. In addition, QX1 formula administration decreased the expression of the M1 phenotype microglia gene markers such as
Language	English
Publishing date	2020-05-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.00579
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Qiang-Xin 1 Formula Prevents Sepsis-Induced Apoptosis in Murine Cardiomyocytes by Suppressing Endoplasmic Reticulum- and Mitochondria-Associated Pathways.

Xu, Xiaolong / Liu, Qingquan / He, Shasha / Zhao, Jingxia / Wang, Ning / Han, Xuyang / Guo, Yuhong

Frontiers in pharmacology

2018 Volume 9, Page(s) 818

Abstract: ... The present study aimed to investigate the effect of Qiang-Xin 1 (QX1) formula, a traditional Chinese ...

Abstract	Sepsis is reported to be an unusual systemic reaction to infection, accompanied by multiple-organ failure. Sepsis-induced cardiomyopathy (SIC), defined as damages and dysfunction of the heart, is essential in the pathogenesis of sepsis. Traditional Chinese formula, which has long been used to improve the situation of patients through multitarget regulation, is now gradually being used as complementary therapy. The present study aimed to investigate the effect of Qiang-Xin 1 (QX1) formula, a traditional Chinese herbal medicine designed for cardiac dysfunction, on cecal ligation puncture (CLP)-induced heart damage and its underlying mechanisms in mice. Survival test first showed that an oral administration of QX1 formula significantly increased the 7-days survival of septic mice from 22 to 40%. By estimating the secretion of serum cytokines, QX1 treatment dramatically inhibited the excessive production of interleukin-1β and tumor necrosis factor-α. Immunohistochemical staining illustrated that the expression of c-Jun N-terminal kinase, caspase-12, and high-mobility group box 1 was downregulated in cardiomyocytes of the QX1-treated group compared with that of the CLP surgery group. Western blotting confirmed that the activation of essential caspase family members, such as caspase-3, caspase-9, and caspase-12, was prohibited by treatment with QX1. Moreover, the abnormal expression of key regulators of endoplasmic reticulum (ER) and mitochondria-associated apoptosis in cardiomyocytes of septic mice, including CHOP, GRP78, Cyt-c, Bcl-2, Bcl-X
Language	English
Publishing date	2018-07-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.00818
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Pen qiang ji bing ying xiang tu pu

Liu, Bo

2016

Title variant	Imaging atlas of pelvic diseases
Author's details	zhu bian Liu Bo, Liu Yupin
MeSH term(s)	Pelvic Floor Disorders/pathology
Language	Chinese
Size	6, 330 pages :, illustrations, portraits
Edition	Di 1 ban.
Document type	Book
ISBN	9787117222082 ; 7117222085
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Qiang Xin 1 Formula Suppresses Excessive Pro-Inflammatory Cytokine Responses and Microglia Activation to Prevent Cognitive Impairment and Emotional Dysfunctions in Experimental Sepsis

Xuerui Wang / Xiaolong Xu / Yuhong Guo / Po Huang / Yanxiang Ha / Rui Zhang / Yunjing Bai / Xuran Cui / Shasha He / Qingquan Liu

Frontiers in Pharmacology, Vol

2020 Volume 11

Abstract: ... reported that the administration of a traditional Chinese herbal Qiang Xin 1 (QX1) formula improves ...

Abstract	Sepsis commonly leads to acute and long-term cognitive and affective impairments which are associated with increased mortality in patients. Neuroinflammation characterized by excessive cytokine release and immune cell activation underlies the behavioral changes associated with sepsis. We previously reported that the administration of a traditional Chinese herbal Qiang Xin 1 (QX1) formula improves survival in septic mice. This study was performed to better understand the effects and the mechanisms of QX1 formula treatment on behavioral changes in a preclinical septic model induced by cecal ligation and puncture. Oral administration of QX1 formula significantly improved survival, alleviated overall cognitive impairment and emotional dysfunction as assessed by the Morris water maze, novel object recognition testing, elevated plus maze and open field testing in septic mice. QX1 formula administration dramatically inhibited short and long-term excessive pro-inflammatory cytokine production both peripherally and centrally, and was accompanied by diminished microglial activation in septic mice. Biological processes including synaptic transmission, microglia cell activation, cytokine production, microglia cell polarization, as well as inflammatory responses related to signaling pathways including the MAPK signaling pathway and the NF-κB signaling pathway were altered prominently by QX1 formula treatment in the hippocampus of septic mice. In addition, QX1 formula administration decreased the expression of the M1 phenotype microglia gene markers such as Cd32, Socs3, and Cd68, while up-regulated M2 phenotype marker genes including Myc, Arg-1, and Cd206 as revealed by microarray analysis and Real-time PCR. In conclusion, QX1 formula administration attenuates cognitive deficits, emotional dysfunction, and reduces neuroinflammatory responses to improve survival in septic mice. Diminished microglial activation and altered microglial polarization are involved in the neuroprotective mechanism of QX1 formula.
Keywords	sepsis ; cognitive impairment ; emotional dysfunctions ; traditional Chinese medicine ; neuroinflammation ; microglia ; Therapeutics. Pharmacology ; RM1-950
Subject code	616
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Audio / Video: Xin HSK su cheng qiang hua jiao cheng. Wu ji

Liu, Chaoying / Long, Qingtao

2013

Author's details	Liu Chaoying ; Long Qingtao
Language	Chinese
Size	4, 4, 295 S., 1 CD-ROM
Edition	1. Auflage
Publisher	Beijing language and culture university press
Publishing place	Beijing
Document type	Book ; Audio / Video
ISBN	9787561934913 ; 7561934912
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Qiang-Xin 1 Formula Prevents Sepsis-Induced Apoptosis in Murine Cardiomyocytes by Suppressing Endoplasmic Reticulum- and Mitochondria-Associated Pathways

Xiaolong Xu / Qingquan Liu / Shasha He / Jingxia Zhao / Ning Wang / Xuyang Han / Yuhong Guo

Frontiers in Pharmacology, Vol

2018 Volume 9

Abstract: ... The present study aimed to investigate the effect of Qiang-Xin 1 (QX1) formula, a traditional Chinese ...

Abstract	Sepsis is reported to be an unusual systemic reaction to infection, accompanied by multiple-organ failure. Sepsis-induced cardiomyopathy (SIC), defined as damages and dysfunction of the heart, is essential in the pathogenesis of sepsis. Traditional Chinese formula, which has long been used to improve the situation of patients through multitarget regulation, is now gradually being used as complementary therapy. The present study aimed to investigate the effect of Qiang-Xin 1 (QX1) formula, a traditional Chinese herbal medicine designed for cardiac dysfunction, on cecal ligation puncture (CLP)-induced heart damage and its underlying mechanisms in mice. Survival test first showed that an oral administration of QX1 formula significantly increased the 7-days survival of septic mice from 22 to 40%. By estimating the secretion of serum cytokines, QX1 treatment dramatically inhibited the excessive production of interleukin-1β and tumor necrosis factor-α. Immunohistochemical staining illustrated that the expression of c-Jun N-terminal kinase, caspase-12, and high-mobility group box 1 was downregulated in cardiomyocytes of the QX1-treated group compared with that of the CLP surgery group. Western blotting confirmed that the activation of essential caspase family members, such as caspase-3, caspase-9, and caspase-12, was prohibited by treatment with QX1. Moreover, the abnormal expression of key regulators of endoplasmic reticulum (ER) and mitochondria-associated apoptosis in cardiomyocytes of septic mice, including CHOP, GRP78, Cyt-c, Bcl-2, Bcl-XL, and Bax, was effectively reversed by treatment with QX1 formula. This study provided a new insight into the role of QX1 formula in heart damage and potential complementary therapeutic effect of traditional Chinese medicine on sepsis.
Keywords	apoptosis ; ER stress ; mitochondria ; murine ; sepsis ; traditional Chinese medicine ; Therapeutics. Pharmacology ; RM1-950
Subject code	570 ; 610
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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