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  1. AU=Shikata Chihiro
  2. AU="Jordan P. Metcalf"
  3. AU=Peri?i? Nanut Milica AU=Peri?i? Nanut Milica
  4. AU="Pramod, Ganapathiraju"
  5. AU="Fu, Chu-Jun"
  6. AU="Nejad, Harry G."
  7. AU="Zhang, Q E"
  8. AU="Oppenheim, Madeline"

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  1. Artikel ; Online: Pressure difference between radial and femoral artery pressure in minimally invasive cardiac surgery using retrograde perfusion.

    Nakamura, Yoshitsugu / Emmanuel, Sam / Shikata, Fumiaki / Shirai, Chihiro / Ito, Yujiro / Kuroda, Miho

    The International journal of artificial organs

    2018  Band 41, Heft 10, Seite(n) 635–643

    Abstract: Objective: To investigate whether radial artery pressure is a reliable surrogate measure of central arterial pressure as approximated by femoral artery pressure in minimally invasive cardiac surgery with retrograde perfusion via femoral cannulation.: ... ...

    Abstract Objective: To investigate whether radial artery pressure is a reliable surrogate measure of central arterial pressure as approximated by femoral artery pressure in minimally invasive cardiac surgery with retrograde perfusion via femoral cannulation.
    Method: Fifty-two consecutive patients undergoing minimally invasive cardiac surgery were prospectively included in this study. Cardiopulmonary bypass was established via a femoral artery cannulation and femoral vein. Radial and femoral arterial pressures were recorded continuously, and the pressure differential between them was calculated for both systolic and mean arterial pressures. The agreement between measurements from the two arteries was compared using Bland-Altman plots. An interval of 95% limits of agreement of less than 20 mm Hg was set as satisfactory agreement.
    Results: Average age was 65 ± 14 years. With respect to systolic arterial pressure, 28 patients (54%) had a peak pressure differential between radial and femoral arteries ⩾20 mm Hg. With respect to mean arterial pressure, only five patients (9%) had a peak pressure differential ⩾20 mm Hg. The pressure differential changed with time. Pressure differential in systolic arterial pressure was 5 ± 8 mm Hg until aortic declamping, then increased to a peak of 23 ± 16 mm Hg when cardiopulmonary bypass was turned off. The femoral systolic arterial pressures were significantly greater than radial systolic arterial pressures from time of aortic declamping to 20 min after cardiopulmonary bypass. The Bland-Altman plots revealed large biases and poor agreement in this period.
    Conclusion: Radial and femoral systolic artery pressure readings can differ significantly in minimally invasive cardiac surgery with retrograde perfusion. Intraoperative arterial pressure management based solely on radial systolic arterial pressure readings should be avoided.
    Mesh-Begriff(e) Aged ; Arterial Pressure/physiology ; Blood Pressure/physiology ; Cardiopulmonary Bypass ; Female ; Femoral Artery/physiology ; Humans ; Male ; Monitoring, Intraoperative ; Prospective Studies ; Radial Artery/physiology
    Sprache Englisch
    Erscheinungsdatum 2018-07-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80456-3
    ISSN 1724-6040 ; 0391-3988
    ISSN (online) 1724-6040
    ISSN 0391-3988
    DOI 10.1177/0391398818784791
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Effect of sarpogrelate on cardiovascular disorders.

    Shikata, Chihiro / Nemoto, Masami / Ebisawa, Takanori / Nishiyama, Akihiro / Takeda, Nobuakira

    Experimental and clinical cardiology

    2011  Band 16, Heft 3, Seite(n) 75–76

    Abstract: The present article, dedicated to Dr NS Dhalla on the occasion of the jubilee of his life's work, is a brief review of articles based on the authors' studies of sarpogrelate conducted in collaboration with Dr NS Dhalla. These studies on the effects of ... ...

    Abstract The present article, dedicated to Dr NS Dhalla on the occasion of the jubilee of his life's work, is a brief review of articles based on the authors' studies of sarpogrelate conducted in collaboration with Dr NS Dhalla. These studies on the effects of sarpogrelate on cardiovascular disorders have been ongoing for more than 10 years, and 10 articles have been published to date.
    Sprache Englisch
    Erscheinungsdatum 2011-10-26
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 2061162-6
    ISSN 1918-1515 ; 1205-6626
    ISSN (online) 1918-1515
    ISSN 1205-6626
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Cardiovascular disorders in patients with diabetes mellitus.

    Takeda, Nobuakira / Shikata, Chihiro / Sekikawa, Tetsuaki / Kimura, Nobuaki / Nishiyama, Akihiro

    Experimental and clinical cardiology

    2008  Band 11, Heft 3, Seite(n) 237–238

    Abstract: Diabetes mellitus is a disease with multiorgan involvement. Besides retinopathy, nephropathy and peripheral neuropathy induced by microangiopathy, both cardiovascular and cerebrovascular complications are significant. Both cardiomyopathy and coronary ... ...

    Abstract Diabetes mellitus is a disease with multiorgan involvement. Besides retinopathy, nephropathy and peripheral neuropathy induced by microangiopathy, both cardiovascular and cerebrovascular complications are significant. Both cardiomyopathy and coronary artery disease are observed in patients with diabetes, and the latter is clinically more important because of its high incidence and seriousness.
    Sprache Englisch
    Erscheinungsdatum 2008-07-18
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 2061162-6
    ISSN 1205-6626
    ISSN 1205-6626
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Risk factors for coronary artery sclerosis in patients with diabetes.

    Nishiyama, Akihiro / Shikata, Chihiro / Kimura, Nobuaki / Imanishi, Akio / Hirai, Noriyuki / Ohta, Makoto / Takeda, Nobuakira

    Experimental and clinical cardiology

    2009  Band 10, Heft 2, Seite(n) 108–110

    Abstract: Objective: To examine risk factors for coronary artery sclerosis in patients with diabetes mellitus.: Methods: Patients with diabetes were divided into two groups based on whether their electrocardiogram (ECG) showed ischemic changes. In addition to ... ...

    Abstract Objective: To examine risk factors for coronary artery sclerosis in patients with diabetes mellitus.
    Methods: Patients with diabetes were divided into two groups based on whether their electrocardiogram (ECG) showed ischemic changes. In addition to traditional risk factors, other parameters (ie, serum levels of serotonin, homocysteine, thrombomodulin, plasminogen activator inhibitor-1, tissue plasminogen activator, vascular endothelial growth factor, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and endothelial-leukocyte adhesion molecule-1) were measured in both groups.
    Results: In the group with ischemic ECG changes (n=13), systolic blood pressure was significantly higher than in the group with no changes (n=18). There were no significant differences in the serum levels of other factors; however, body mass index, hemoglobin A1c, total cholesterol, low density lipoprotein cholesterol and triglyceride levels tended to be higher in the group with ischemic ECG changes.
    Conclusions: Although the sample of patients was limited, these results suggest that strict control of traditional risk factors, especially high blood pressure, is important for preventing coronary artery sclerosis in patients with diabetes mellitus.
    Sprache Englisch
    Erscheinungsdatum 2009-07-25
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 2061162-6
    ISSN 1205-6626
    ISSN 1205-6626
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Effect of an ACE inhibitor and an AT1 receptor antagonist on cardiac hypertrophy.

    Shikata, Chihiro / Takeda, Atsushi / Takeda, Nobuakira

    Molecular and cellular biochemistry

    2003  Band 248, Heft 1-2, Seite(n) 197–202

    Abstract: The effect of long-term administration of delapril, an angiotensin converting enzyme inhibitor, and candesartan, an angiotensin II receptor blocker, on cardiac hypertrophy was investigated in spontaneously hypertensive rats (SHR). Delapril (2 mg/kg/ day) ...

    Abstract The effect of long-term administration of delapril, an angiotensin converting enzyme inhibitor, and candesartan, an angiotensin II receptor blocker, on cardiac hypertrophy was investigated in spontaneously hypertensive rats (SHR). Delapril (2 mg/kg/ day) and candesartan (2 mg/kg/day) were administered for 5 weeks to 15-week-old male SHR. Echocardiographic estimation of cardiac morphology and function revealed cardiac hypertrophy in SHR compared with Wistar-Kyoto rats (WKY) which were used as normal controls. Both treated groups revealed regression of cardiac hypertrophy estimated by echocardiography. Heart to body weight ratio of treated SHR was also smaller than that of untreated SHR. Plasma BNP and ANP concentrations were increased in untreated SHR and decreased in the treated groups. Histological examination was performed using light microscopy and the area of fibrosis was estimated by computer. Reduction of the fibrotic area was observed in SHR treated with delapril and candesartan, although the latter was not statistically significant. Immunohistochemical examination using anti-collagen monoclonal antibody showed a decrease of type I collagen in treated SHR as compared with untreated SHR. It is concluded that both angiotensin converting enzyme inhibitor and angiotensin II receptor blocker sufficiently reduce blood pressure in SHR associated with regression of cardiac remodeling.
    Mesh-Begriff(e) Angiotensin II Type 1 Receptor Blockers ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Benzimidazoles/pharmacology ; Collagen Type I/biosynthesis ; Echocardiography ; Fibrosis ; Heart Rate/drug effects ; Hypertrophy ; Immunohistochemistry ; Indans/pharmacology ; Myocardium/pathology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Systole/drug effects ; Tetrazoles/pharmacology
    Chemische Substanzen Angiotensin II Type 1 Receptor Blockers ; Angiotensin-Converting Enzyme Inhibitors ; Benzimidazoles ; Collagen Type I ; Indans ; Tetrazoles ; candesartan (S8Q36MD2XX) ; delapril (W77UAL9THI)
    Sprache Englisch
    Erscheinungsdatum 2003-06
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1023/a:1024109007392
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Prediction of relaxin-3-induced downstream pathway resulting in anxiolytic-like behaviors in rats based on a microarray and peptidome analysis.

    Nakazawa, Chihiro Miyamoto / Shikata, Kohdoh / Uesugi, Mai / Katayama, Hiroyuki / Aoshima, Ken / Tahara, Kazuhiro / Takahashi, Eiki / Hida, Takayuki / Shibata, Hisashi / Ogura, Hiroo / Seiki, Takashi / Oda, Yoshiya / Kuromitsu, Junro / Miyamoto, Norimasa

    Journal of receptor and signal transduction research

    2013  Band 33, Heft 4, Seite(n) 224–233

    Abstract: The effect of the intracerebroventricular (i.c.v.) injection of relaxin-3 (RLX3) was evaluated using anxiety-related behavioral tests in rats. RLX3-injected animals showed normal locomotion activity in a habituated environment and declined anxiety ... ...

    Abstract The effect of the intracerebroventricular (i.c.v.) injection of relaxin-3 (RLX3) was evaluated using anxiety-related behavioral tests in rats. RLX3-injected animals showed normal locomotion activity in a habituated environment and declined anxiety cognition in the elevated plus maze test and the shock probe-burying test. The measurement of spontaneous locomotor activity in a novel environment also suggested that RLX3 reduced the stress response. To elucidate the regulatory mechanisms of the downstream signaling pathways underlying RLX3 activity and its relation to anxiolytic and hyperphagic behavior phenotypes, RLX3-i.c.v.-injected rat hypothalamic responses were examined using a microarray analysis. Ingenuity Pathway Analysis software listed the phenotype-relating genes and they showed characteristic expression patterns in the rat hypothalamus. When peptidome data sets for the same listed genes was analyzed using a semi-quantitative approach, the expressions of two neuropeptides were found to have increased. One of these neuropeptides, oxytocin (Oxt), exhibited increased expression in both the microarray and the peptidomic analysis, and a Western blot analysis validated the mass spectrometry results. A cross-omics data analysis is useful for predicting downstream signaling pathways, and the anxiolytic-like behavior of RLX3 may be mediated by an oxytocin signaling pathway in rats. These results suggest that RLX3 acts as an anxiolytic peptide and that the downstream pathways mediated by its receptors may be potential candidates for the treatment of anxieties in the future.
    Mesh-Begriff(e) Animals ; Anxiety/drug therapy ; Anxiety/physiopathology ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Hypothalamus/metabolism ; Injections, Intraventricular ; Maze Learning ; Microarray Analysis ; Nerve Tissue Proteins/administration & dosage ; Nerve Tissue Proteins/metabolism ; Neuropeptides/isolation & purification ; Neuropeptides/metabolism ; Oxytocin/metabolism ; Rats ; Relaxin/administration & dosage ; Relaxin/metabolism ; Signal Transduction ; Stress, Physiological/drug effects
    Chemische Substanzen Nerve Tissue Proteins ; Neuropeptides ; relaxin-3, rat ; Oxytocin (50-56-6) ; Relaxin (9002-69-1)
    Sprache Englisch
    Erscheinungsdatum 2013-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1230969-2
    ISSN 1532-4281 ; 1079-9893
    ISSN (online) 1532-4281
    ISSN 1079-9893
    DOI 10.3109/10799893.2012.756895
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Beneficial effect of combination therapy with antihypertensive drugs in patients with hypertension.

    Shikata, Chihiro / Sekikawa, Tetsuaki / Kimura, Nobuaki / Kojima, Akira / Seki, Shingo / Oka, Hisayoshi / Nishiyama, Akihiro / Takeda, Nobuakira

    Experimental and clinical cardiology

    2008  Band 12, Heft 1, Seite(n) 33–36

    Abstract: Background: Cardiac hypertrophy and failure are major complications of hypertension.: Objectives: The beneficial effect of treatment with antihypertensive drugs on serum levels of brain natriuretic peptide (BNP) was examined in patients with ... ...

    Abstract Background: Cardiac hypertrophy and failure are major complications of hypertension.
    Objectives: The beneficial effect of treatment with antihypertensive drugs on serum levels of brain natriuretic peptide (BNP) was examined in patients with essential hypertension.
    Methods: Antihypertensive drugs were administered to 88 hypertensive patients (44 diabetic and 44 nondiabetic) whose systolic blood pressure was greater than 140 mmHg and/or diastolic blood pressure was greater than 90 mmHg. Other antihypertensive drugs were added every two months until the blood pressure fell below 130/85 mmHg. Candesartan, benidipine, bisoprolol or celiprolol, and bunazosin were administered in this order.
    Results: The mean systolic blood pressure was reduced from 163.7+/-11.6 mmHg to 121.8+/-7.5 mmHg after 12 months in patients with diabetes and from 167.6+/-12.3 mmHg to 122.8+/-7.5 mmHg in patients without diabetes. The mean diastolic blood pressure was also significantly reduced in patients with and without diabetes. Serum BNP levels were reduced from 52.2+/-38.8 pg/mL to 38.8+/-30.9 pg/mL in patients with diabetes and from 47.1+/-34.2 pg/mL to 35.8+/-22.5 pg/mL in patients without diabetes. In patients older than 70 years of age, serum BNP levels were reduced from 56.3+/-39.3 pg/mL to 40.2+/-23.0 pg/mL in those with diabetes and from 54.6+/-32.9 pg/mL to 38.0+/-16.0 pg/mL in those without diabetes.
    Conclusions: These results indicate that combination therapy with antihypertensive drugs is usually necessary to reduce blood pressure to below 130/85 mmHg and to improve serum BNP levels.
    Sprache Englisch
    Erscheinungsdatum 2008-07-18
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 2061162-6
    ISSN 1205-6626
    ISSN 1205-6626
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Microscopic polyangiitis associated with marked systemic bleeding tendency caused by disseminated intravascular coagulation.

    Saito, Takatoshi / Tsuchiya, Masahito / Shikata, Chihiro / Yamaguchi, Hiroshi / Miyata, Shu-ichi / Matsuo, Sei-ichiro / Ishizawa, Sho / Yoshimura, Kunihiko

    Internal medicine (Tokyo, Japan)

    2003  Band 42, Heft 9, Seite(n) 850–855

    Abstract: A 57-year-old woman was admitted to our hospital because of severe dyspnea due to pulmonary hemorrhage and rapidly progressive renal failure. The patient was positive for perinuclear pattern anti-neutrophil cytoplasmic antibody (p-ANCA) and was ... ...

    Abstract A 57-year-old woman was admitted to our hospital because of severe dyspnea due to pulmonary hemorrhage and rapidly progressive renal failure. The patient was positive for perinuclear pattern anti-neutrophil cytoplasmic antibody (p-ANCA) and was manifested with gastrointestinal bleeding and brain hemorrhage. Thus, she was diagnosed as having microscopic polyangiitis (MPA). Laboratory examination demonstrated severe thrombocytopenia, increased prothrombin time and a high concentration of fibrin degradation products. In addition, the elevated plasma levels of D-dimer, thrombin-antithrombin complex and plasmin-plasmin inhibitor complex led us to make a diagnosis of disseminated intravascular coagulation (DIC). Complication of DIC was considered to have caused further deterioration in bleeding tendency due to MPA in the present case. The patient was treated with plasma exchange, hemodialysis, administration of corticosteroid including pulse therapy and cyclophosphamide. Continuous infusion of gabexate mesilate proved effective for improvement of systemic bleeding tendency. However, she finally died of severe infectious diseases. In conclusion, it is suggested that ANCA-associated vasculitis could be accompanied by DIC and gabexate mesilate may be a useful therapeutic agent for these disorders.
    Mesh-Begriff(e) Antibodies, Antineutrophil Cytoplasmic/immunology ; Anticoagulants/therapeutic use ; Disseminated Intravascular Coagulation/drug therapy ; Disseminated Intravascular Coagulation/etiology ; Disseminated Intravascular Coagulation/immunology ; Fatal Outcome ; Female ; Gabexate/therapeutic use ; Hemorrhage/etiology ; Hemorrhage/immunology ; Humans ; Middle Aged ; Vasculitis/complications ; Vasculitis/immunology
    Chemische Substanzen Antibodies, Antineutrophil Cytoplasmic ; Anticoagulants ; Gabexate (4V7M9137X9)
    Sprache Englisch
    Erscheinungsdatum 2003-09-28
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 0918-2918 ; 0021-5120
    ISSN 0918-2918 ; 0021-5120
    DOI 10.2169/internalmedicine.42.850
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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