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Book ; Thesis: Mechanische Eigenschaften von Meniskus- und autologem Meniskusersatzgewebe sowie der Einfluß der Menisken auf das Kompressionsverhalten des Kniegelenks

Mussack, Thomas

1993

Author's details	vorgelegt von Thomas Mussack
Language	German
Size	159 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	München, Univ., Diss., 1993
HBZ-ID	HT006367199
Database	Catalogue ZB MED Medicine, Health

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Book ; Online ; Thesis: Perioperative Analyse initialer intra- und extrazellulärer Aktivierungsfaktoren bei Patienten mit kolorektalem Adenokarzinom

Rumpff, Dirk / Mussack, Thomas

2013

Author's details	Dirk Rumpff. Betreuer: Thomas Mussack
Language	German
Size	Online-Ressource (Online-Ressource)
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	München, Ludwig-Maximilians-Universität, Diss., 2013
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Liposomal polychemotherapy improves adrenocortical carcinoma treatment in a preclinical rodent model.

Hantel, Constanze / Jung, Sara / Mussack, Thomas / Reincke, Martin / Beuschlein, Felix

Endocrine-related cancer

2014 Volume 21, Issue 3, Page(s) 383–394

Abstract: Owing to high relapse rates and early metastatic spread, prognosis in adrenocortical carcinoma (ACC) patients remains poor, highlighting the importance of developing new treatment alternatives for them. Recently, polychemotherapy regimens including ... ...

Abstract	Owing to high relapse rates and early metastatic spread, prognosis in adrenocortical carcinoma (ACC) patients remains poor, highlighting the importance of developing new treatment alternatives for them. Recently, polychemotherapy regimens including etoposide, doxorubicin, and cisplatin together with mitotane (EDP-M) have been defined as the standard treatment for late-stage disease patients. Nevertheless, the administration of conventional cytostatic drugs is associated with severe and dose-limiting side effects. In an attempt to optimize existing clinical treatment regimens, in this study, we investigated the therapeutic efficacy of EDP-M in comparison with that of a paclitaxel-modified scheme (paclitaxel, doxorubicin, cisplatin plus mitotane (PDP-M)) in preclinical in vitro and in vivo models. In addition, based on an extraordinary uptake phenomenon of liposomes in ACC cells, we further evaluated liposomal variants of these protocols (etoposide, liposomal doxorubicin, liposomal cisplatin plus mitotane (LEDP-M) and nab-paclitaxel, liposomal doxorubicin, liposomal cisplatin plus mitotane (LPDP-M)). In vitro, PDP-M was more potent in the induction of apoptosis and inhibition of cell viability as well as cell proliferation than EDP-M. Following the administration of a single therapeutic cycle, we further demonstrated that LEDP-M and LPDP-M exerted significant antitumoral effects in vivo, which were not as evident upon EDP-M and PDP-M treatments. These results were confirmed in a long-term experiment, in which the highest and sustained antitumoral effects were observed for LEDP-M. In summary, liposomal cytostatic substances could represent a promising option that deserves testing in appropriate clinical protocols for the treatment of ACC patients.
MeSH term(s)	Adrenal Cortex Neoplasms/drug therapy ; Adrenal Cortex Neoplasms/metabolism ; Adrenal Cortex Neoplasms/pathology ; Adrenocortical Carcinoma/drug therapy ; Adrenocortical Carcinoma/metabolism ; Adrenocortical Carcinoma/pathology ; Albumins/administration & dosage ; Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Apoptosis/drug effects ; Blotting, Western ; Cell Proliferation/drug effects ; Cisplatin/administration & dosage ; Doxorubicin/administration & dosage ; Doxorubicin/analogs & derivatives ; Etoposide/administration & dosage ; Female ; Humans ; Immunoenzyme Techniques ; Mice ; Mice, Nude ; Mitotane/administration & dosage ; Paclitaxel/administration & dosage ; Polyethylene Glycols/administration & dosage ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Chemical Substances	130-nm albumin-bound paclitaxel ; Albumins ; liposomal doxorubicin ; Polyethylene Glycols (30IQX730WE) ; Etoposide (6PLQ3CP4P3) ; Mitotane (78E4J5IB5J) ; Doxorubicin (80168379AG) ; Paclitaxel (P88XT4IS4D) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2014-06
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1218450-0
ISSN	1479-6821 ; 1351-0088
ISSN (online)	1479-6821
ISSN	1351-0088
DOI	10.1530/ERC-13-0439
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Long term outcome and quality of life after open incisional hernia repair--light versus heavy weight meshes.

Ladurner, Roland / Chiapponi, Costanza / Linhuber, Quirin / Mussack, Thomas

BMC surgery

2011 Volume 11, Page(s) 25

Abstract: Background: Mesh repair of incisional hernia is superior to the conventional technique. From all available materials for open surgery polypropylene (PP) is the most widely used. Development resulted in meshes with larger pore size, decreased mesh ... ...

Abstract	Background: Mesh repair of incisional hernia is superior to the conventional technique. From all available materials for open surgery polypropylene (PP) is the most widely used. Development resulted in meshes with larger pore size, decreased mesh surface and lower weight. The aim of this retrospective non randomized study was to compare the quality of life in the long term follow up (> 72 month) after incisional hernia repair with "light weight"(LW) and "heavy weight"(HW) PP meshes. Methods: 12 patients who underwent midline open incisional hernia repair with a HW-PP mesh (Prolene® 109 g/m2 pore size 1.6 mm) between January 1996 and December 1997 were compared with 12 consecutive patients who underwent the same procedure with a LW-PP mesh (Vypro® 54 g/m2, pore size 4-5 mm) from January 1998. The standard technique was the sublay mesh-plasty with the retromuscular positioning of the mesh. The two groups were equal in BMI, age, gender and hernia size. Patients were routinely seen back in the clinic. Results: In the long term run (mean follow up 112 ± 22 months) patients of the HW mesh group revealed no significant difference in the SF-36 Health Survey domains compared to the LW group (mean follow up 75 ± 16 months). Conclusions: In this study the health related quality of life based on the SF 36 survey after open incisional hernia repair with light or heavy weight meshes is not related to the mesh type in the long term follow up.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Hernia, Ventral/psychology ; Hernia, Ventral/surgery ; Herniorrhaphy/methods ; Herniorrhaphy/psychology ; Humans ; Male ; Middle Aged ; Polypropylenes ; Prosthesis Design ; Quality of Life ; Retrospective Studies ; Surgical Mesh ; Time Factors ; Treatment Outcome ; Young Adult
Chemical Substances	Polypropylenes
Language	English
Publishing date	2011-09-14
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/1471-2482-11-25
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Perioperative Analyse initialer intra- und extrazellulärer Aktivierungsfaktoren bei Patienten mit kolorektalem Adenokarzinom

Rumpff, Dirk [Verfasser] / Mussack, Thomas [Akademischer Betreuer]

2013

Author's details	Dirk Rumpff. Betreuer: Thomas Mussack
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Ruolo della proteina S-100B nella valutazione del trauma cranico in pazienti con intossicazione alcolica.

Mussack, Thomas / Ladurner, Roland

Recenti progressi in medicina

2005 Volume 96, Issue 2, Page(s) 77–80

Abstract: The neuroprotein S-100B was identified as a possible marker for primary brain damage. The objective of this prospective study was to determine the diagnostic validity of plasma measurements of S-100B in patients with minor head injury and acute alcohol ... ...

Title translation	Role of S-100B for evaluation of traumatic brain injury in patients with alcohol intoxication.
Abstract	The neuroprotein S-100B was identified as a possible marker for primary brain damage. The objective of this prospective study was to determine the diagnostic validity of plasma measurements of S-100B in patients with minor head injury and acute alcohol intoxication. The results of S-100B plasma levels were compared to the Glasgow-Coma-Scale score, the neurological examination and the CCT data. Median S-100B levels of the CCT+ patients were significantly increased compared to those of the CCT- patients without being influenced by alcohol. Increased S-100B plasma levels seem to indicate a primary brain damage.
MeSH term(s)	Adult ; Alcoholic Intoxication/blood ; Alcoholic Intoxication/complications ; Biomarkers/blood ; Brain Injuries/blood ; Brain Injuries/complications ; Female ; Humans ; Male ; Middle Aged ; Nerve Growth Factors/blood ; Prospective Studies ; S100 Calcium Binding Protein beta Subunit ; S100 Proteins/blood
Chemical Substances	Biomarkers ; Nerve Growth Factors ; S100 Calcium Binding Protein beta Subunit ; S100 Proteins
Language	Italian
Publishing date	2005-02
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	138266-4
ISSN	0034-1193
ISSN	0034-1193
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The importance of national cooperation and centralized surgery for adrenocortical surgery.

Gaujoux, Sébastien / Jurowich, Christian / Ménégaux, Fabrice / Mussack, Thomas / Porpiglia, Francesco / Dousset, Bertrand

Surgery

2013 Volume 153, Issue 2, Page(s) 301

MeSH term(s)	Adrenal Cortex Neoplasms/surgery ; Adrenocortical Carcinoma/surgery ; Centralized Hospital Services ; Female ; Humans ; Male ; National Health Programs
Language	English
Publishing date	2013-02
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2012.10.006
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Book ; Online ; Thesis: Prädiktoren der Mortalität bei Abdominaltrauma

Fischer, Martina Sophie [Verfasser] / Mussack, Thomas [Akademischer Betreuer]

2012

Author's details	Martina Sophie Fischer. Betreuer: Thomas Mussack
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Comparison of color-Doppler and qualitative and quantitative strain-elastography for differentiation of thyroid nodules in daily practice.

Götzberger, Manuela / Krueger, Susanne / Gärtner, Roland / Reincke, Martin / Pichler, Matthias / Assmann, Gerald / Mussack, Thomas / Zimmermann, Michael / Gülberg, Veit

Hormones (Athens, Greece)

2016 Volume 15, Issue 2, Page(s) 197–204

Abstract: Objective: Strain-elastography provides a new ultrasound-based method that can offer information about the stiffness of thyroid nodules as an indicator of malignancy. The aim of our study was to compare the utility of color-Doppler and strain- ... ...

Abstract	Objective: Strain-elastography provides a new ultrasound-based method that can offer information about the stiffness of thyroid nodules as an indicator of malignancy. The aim of our study was to compare the utility of color-Doppler and strain-elastography in differentiating between benign and malignant nodules. Design and methods: 77 thyroid nodules (70 benign and 7 malignant) from 70 unselected patients (48 female/22 male, mean age 49.7±14.3 years) were evaluated with color-Doppler and elastography based on a five-scale elastogram score for qualitative elastography and strain ratio for quantitative elastography. As reference tissue we chose normal thyroid tissue [strain ratio a (SR a)] and cervical muscles [strain ratio b (SR b)]. The cytological or histological results were used as a reference standard. Diagnostic performances of qualitative and quantitative elastography were compared using ROC curves. Results: Vascularization score 3 or 4 was associated with malignancy (p=0.024) as well as elastogram score 4 or 5 (p=0.070, n.s.s.). SR a was indicatively higher and SR b lower in the group of malignant nodules (p=0.065 and p=0.246, n.s.s.). The best cut-off points predicting malignancy were 3.32 for SR a (66.7% sensitivity, 83.3% specificity) and 0.10 for SR b (71.4% sensitivity, 67.1% specificity). Conclusion: In our study, the accuracy of elastography did not surpass other sonographic parameters in differentiating thyroid nodules. The technique can play a role as a supplementary parameter in assessment of malignancy to improve diagnostic efficacy. The best parameter is SR a, but SR b can serve as an alternative if SR a is not assessable.
MeSH term(s)	Adult ; Area Under Curve ; Elasticity Imaging Techniques/methods ; Elasticity Imaging Techniques/standards ; Female ; Humans ; Male ; Middle Aged ; Neovascularization, Pathologic ; Predictive Value of Tests ; Prospective Studies ; ROC Curve ; Reference Standards ; Reproducibility of Results ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/pathology ; Ultrasonography, Doppler, Color/standards
Language	English
Publishing date	2016-06-29
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article
ZDB-ID	2581819-3
ISSN	2520-8721 ; 1109-3099
ISSN (online)	2520-8721
ISSN	1109-3099
DOI	10.14310/horm.2002.1673
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: TNF alpha signaling is associated with therapeutic responsiveness to vascular disrupting agents in endocrine tumors.

Hantel, Constanze / Ozimek, Alexandra / Lira, Regia / Ragazzon, Bruno / Jäckel, Carsten / Frantsev, Roman / Reincke, Martin / Bertherat, Jérôme / Mussack, Thomas / Beuschlein, Felix

Molecular and cellular endocrinology

2016 Volume 423, Page(s) 87–95

Abstract: ASA404 (Vadimezan) belongs to a class of agents with disrupting properties against tumor vasculature, which is partly mediated by TNFα-signaling. Preclinical and early clinical studies have indicated promising results for ASA404, while extended clinical ... ...

Abstract	ASA404 (Vadimezan) belongs to a class of agents with disrupting properties against tumor vasculature, which is partly mediated by TNFα-signaling. Preclinical and early clinical studies have indicated promising results for ASA404, while extended clinical trials performed poorly. Our aim was to investigate the potential therapeutic applicability of ASA404 against endocrine tumors. Moreover, as the reason for the unpredictable clinical anti-tumor activity of ASA 404 remained uncertain in previous studies, we compared two tumor models of endocrine origin with different responses to ASA404 treatment. Specifically, we determined anti-tumoral effects in preclinical models of neuroendocrine tumors of the gastroenteropancreatic system (BON) and adrenocortical cancer (NCI-H295R) in vitro and in xenograft models in vivo. Upon treatment of tumor bearing mice significant anti-tumoral effects, an increase in TNFα as well as activation of TNFα-specific downstream signaling were evident in the BON tumor model while no comparable effects were detectable for NCI-H295R. We identified TNFAIP3/A20, a key molecule of an inhibitory feedback-loop downstream of TNF-receptor 1, CD40, Toll-like receptors, NOD-like receptors and the interleukin-1 receptor signaling cascades, as overexpressed in the adrenocortical carcinoma tumor model. Subsequent analyses of clinical patient samples confirmed a correlation between tumor TNFAIP3 expression levels and overall survival in patients with ACC. Taken together our findings provide evidence that modulation of TNFα-signaling could be of relevance both for the clinical course of ACC patients and as a marker of treatment response.
MeSH term(s)	Adrenal Cortex Neoplasms/drug therapy ; Adrenal Cortex Neoplasms/metabolism ; Adrenal Cortex Neoplasms/mortality ; Adrenocortical Carcinoma/drug therapy ; Adrenocortical Carcinoma/metabolism ; Adrenocortical Carcinoma/mortality ; Angiogenesis Inhibitors/pharmacology ; Animals ; Cell Line, Tumor ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Humans ; Interleukin-1 Receptor-Associated Kinases/genetics ; Interleukin-1 Receptor-Associated Kinases/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Kaplan-Meier Estimate ; Mice, Nude ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Paclitaxel/pharmacology ; Proportional Hazards Models ; Signal Transduction ; Transcriptional Activation ; Tumor Necrosis Factor alpha-Induced Protein 3 ; Tumor Necrosis Factor-alpha/physiology ; Xanthones/pharmacology ; Xenograft Model Antitumor Assays
Chemical Substances	Angiogenesis Inhibitors ; DNA-Binding Proteins ; Intracellular Signaling Peptides and Proteins ; Nuclear Proteins ; TNF protein, human ; Tumor Necrosis Factor-alpha ; Xanthones ; vadimezan (0829J8133H) ; Interleukin-1 Receptor-Associated Kinases (EC 2.7.11.1) ; TNFAIP3 protein, human (EC 3.4.19.12) ; Tumor Necrosis Factor alpha-Induced Protein 3 (EC 3.4.19.12) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2016-03-05
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2015.12.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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