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  1. Article ; Online: Changes in physical and social activities among community-dwelling Japanese older adults during three years of the COVID-19 pandemic.

    Yamada, Minoru / Arai, Hidenori

    Geriatrics & gerontology international

    2023  Volume 24 Suppl 1, Page(s) 395–396

    MeSH term(s) Humans ; Aged ; COVID-19 ; Independent Living ; Japan/epidemiology ; Pandemics ; Physical Examination
    Language English
    Publishing date 2023-07-23
    Publishing country Japan
    Document type Letter
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5801: Show issues Location:
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  2. Article ; Online: Recovery from or progression to frailty during the second year of the COVID-19 pandemic.

    Yamada, Minoru / Arai, Hidenori

    Geriatrics & gerontology international

    2022  Volume 22, Issue 8, Page(s) 681–682

    MeSH term(s) COVID-19 ; Frailty/epidemiology ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-06-17
    Publishing country Japan
    Document type Letter ; Comment
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14421
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5801: Show issues Location:
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  3. Article ; Online: Understanding social frailty.

    Yamada, Minoru / Arai, Hidenori

    Archives of gerontology and geriatrics

    2023  Volume 115, Page(s) 105123

    Abstract: Social frailty, along with physical and psychological frailties, is one of the components of frailty that has been reported to increase the incidence of adverse health outcomes. Although the prevalence of social frailty is relatively high, consensus on ... ...

    Abstract Social frailty, along with physical and psychological frailties, is one of the components of frailty that has been reported to increase the incidence of adverse health outcomes. Although the prevalence of social frailty is relatively high, consensus on how to define and measure it is insufficient. In considering social frailty, living alone, interaction with neighbors, and social participation are important indicators, and interaction with neighbors and social participation, which are modifiable factors, are important countermeasures. The promotion of these social activities will contribute to extending healthy life expectancy-for example, by promoting physical activity. However, older people's physical and social activities have been severely constrained by the coronavirus pandemic since 2020. In the future, it will be necessary to fully understand the characteristics and significance of social frailty and develop appropriate countermeasures.
    MeSH term(s) Humans ; Aged ; Frailty/epidemiology ; Social Behavior ; Social Participation ; Frail Elderly ; Independent Living
    Language English
    Publishing date 2023-07-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2023.105123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1729: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Does the COVID-19 pandemic robustly influence the incidence of frailty?

    Yamada, Minoru / Arai, Hidenori

    Geriatrics & gerontology international

    2021  Volume 21, Issue 8, Page(s) 754–755

    MeSH term(s) COVID-19 ; Frailty/epidemiology ; Humans ; Incidence ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-07-03
    Publishing country Japan
    Document type Letter
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14233
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5801: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Implication of frailty and disability prevention measures during the COVID-19 pandemic.

    Yamada, Minoru / Arai, Hidenori

    Aging medicine (Milton (N.S.W))

    2021  Volume 4, Issue 4, Page(s) 242–246

    Language English
    Publishing date 2021-11-07
    Publishing country Australia
    Document type Editorial
    ISSN 2475-0360
    ISSN (online) 2475-0360
    DOI 10.1002/agm2.12182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A multiscale, vertical-flow perfusion system with integrated porous microchambers for upgrading multicellular spheroid culture.

    Takagi, Mai / Yamada, Masumi / Utoh, Rie / Seki, Minoru

    Lab on a chip

    2023  Volume 23, Issue 9, Page(s) 2257–2267

    Abstract: Spheroid formation assisted by microengineered chambers is a versatile approach for morphology-controlled three-dimensional (3D) cell cultivation with physiological relevance to human tissues. However, the limitation in diffusion-based oxygen/nutrient ... ...

    Abstract Spheroid formation assisted by microengineered chambers is a versatile approach for morphology-controlled three-dimensional (3D) cell cultivation with physiological relevance to human tissues. However, the limitation in diffusion-based oxygen/nutrient transport has been a critical issue for the densely packed cells in spheroids, preventing maximization of cellular functions and thus limiting their biomedical applications. Here, we have developed a multiscale microfluidic system for the perfusion culture of spheroids, in which porous microchambers, connected with microfluidic channels, were engineered. A newly developed process of centrifugation-assisted replica molding and salt-leaching enabled the formation of single micrometer-sized pores on the chamber surface and in the substrate. The porous configuration generates a vertical flow to directly supply the medium to the spheroids, while avoiding the formation of stagnant flow regions. We created seamlessly integrated, all PDMS/silicone-based microfluidic devices with an array of microchambers. Spheroids of human liver cells (HepG2 cells) were formed and cultured under vertical-flow perfusion, and the proliferation ability and liver cell-specific functions were compared with those of cells cultured in non-porous chambers with a horizontal flow. The presented system realizes both size-controlled formation of spheroids and direct medium supply, making it suitable as a precision cell culture platform for drug development, disease modelling, and regenerative medicine.
    MeSH term(s) Humans ; Spheroids, Cellular ; Microfluidics ; Hepatocytes ; Perfusion ; Liver
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2056646-3
    ISSN 1473-0189 ; 1473-0197
    ISSN (online) 1473-0189
    ISSN 1473-0197
    DOI 10.1039/d3lc00168g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Frailty and Environmental Attributes in Older Adults: Insight from an Ecological Model.

    Uemura, Kazuki / Kamitani, Tsukasa / Yamada, Minoru

    Physical therapy research

    2023  Volume 26, Issue 3, Page(s) 71–77

    Abstract: Many studies on frailty have primarily focused on individual-level risk factors such as demographics and lifestyle. While guidelines for frailty management recommend modifications to an individual's lifestyle, their lifestyle behaviors are significantly ... ...

    Abstract Many studies on frailty have primarily focused on individual-level risk factors such as demographics and lifestyle. While guidelines for frailty management recommend modifications to an individual's lifestyle, their lifestyle behaviors are significantly influenced by their surroundings. Recently, the association between frailty and environmental attributes has drawn attention as a result of the increase in evidence that multiple factors affect health conditions and behaviors associated with frailty. These findings can be organized based on an ecological model involving five nested levels that influence an individual's behaviors, namely, an intrapersonal/individual core (age, education, and attitude), an interpersonal level (persons and groups), an organizational/institutional level (organization and workplace), a community level (natural, built, and social environments), and a system/public policy level (public policies from local to national). This study reviewed possible factors associated with frailty from the onset and its progression at each level of the ecological model and their implications regarding frailty prevention. Additionally, we introduce a policy-level approach for frailty prevention in Japan-which encourages residents to engage in the local society by participating in community places or groups that are referred to as "Kayoi-no-ba"-and aggregate its status from a government report. This perspective on community building is consistent with the concept of an ecological model. However, few studies have verified the effects of policy- or system-level approaches on disability and frailty prevention. Further studies from an ecological perspective are needed to fulfill multilevel interventions for frailty prevention.
    Language English
    Publishing date 2023-11-18
    Publishing country Japan
    Document type Journal Article ; Review
    ISSN 2189-8448
    ISSN 2189-8448
    DOI 10.1298/ptr.R0027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Expansion of Chinese hamster ovary cells via a loose cluster-assisted suspension culture using cell-sized gelatin microcarriers.

    Hasebe, Yuken / Yamada, Masumi / Utoh, Rie / Seki, Minoru

    Journal of bioscience and bioengineering

    2023  Volume 135, Issue 5, Page(s) 417–422

    Abstract: Technologies for efficiently expanding Chinese hamster ovary (CHO) cells, the primary host cells for antibody production, are of growing industrial importance. Various processes for the use of microcarriers in CHO suspension cultures have been developed, ...

    Abstract Technologies for efficiently expanding Chinese hamster ovary (CHO) cells, the primary host cells for antibody production, are of growing industrial importance. Various processes for the use of microcarriers in CHO suspension cultures have been developed, but there have been very few studies on cell-adhesive microcarriers that are similar in size to cells. In this study, we proposed a new approach to suspension cultures of CHO cells using cell-sized condensed and crosslinked gelatin microparticles (GMPs) as carriers. Unlike commercially available carriers with sizes typically greater than 100 μm, each cell can adhere to the surface of multiple particles and form loose clusters with voids. We prepared GMPs of different average diameters (27 and 48 μm) and investigated their effects on cell adhesion and cluster formation. In particular, small GMPs promoted cell proliferation and increased IgG4 production by the antibody-producing CHO cell line. The data obtained in this study suggest that cell-sized particles, rather than larger ones, enhance cell proliferation and function, providing useful insights for improving suspension-culture-based cell expansion and cell-based biologics production for a wide range of applications.
    MeSH term(s) Cricetinae ; Animals ; Cricetulus ; CHO Cells ; Gelatin ; Cell Culture Techniques ; Cell Proliferation
    Chemical Substances Gelatin (9000-70-8) ; guanosine 5'-monophosphorothioate (76310-16-2)
    Language English
    Publishing date 2023-03-15
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1465387-4
    ISSN 1347-4421 ; 1389-1723
    ISSN (online) 1347-4421
    ISSN 1389-1723
    DOI 10.1016/j.jbiosc.2023.02.008
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    In stock of ZB MED Bonn / Germany

    Z 4728: Show issues

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  9. Article ; Online: Changes in mandibular position during midface distraction in patients with syndromic craniosynostosis.

    Yamada, Kahoko / Akita, Shinsuke / Ando, Nobuhiro / Tamura, Takeshi / Hayashi, Minoru / Isono, Shiroh / Mitsukawa, Nobuyuki

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2024  Volume 52, Issue 3, Page(s) 340–346

    Abstract: The purpose of this study was to evaluate changes in mandibular position during midface distraction. Midface distraction was performed in patients with syndromic craniosynostosis to increase upper airway volume. Although this treatment resulted in ... ...

    Abstract The purpose of this study was to evaluate changes in mandibular position during midface distraction. Midface distraction was performed in patients with syndromic craniosynostosis to increase upper airway volume. Although this treatment resulted in changes in occlusion, the concomitant changes in mandibular position were poorly understood. In this retrospective study, three-dimensional (3D) cephalograms were obtained before and after midface distraction in 15 patients with syndromic craniosynostosis. Perioperative polysomnography scores and changes in maxillary and mandibular position, mandibular volume, and upper airway volume were analyzed. Results showed a significant improvement in apnea-hypopnea index (AHI) (from 20.6 ± 21.3 to 6.9 ± 5.1, p < 0.05) and upper airway volume (from 2951.65 ± 2286.38 to 5218.04 ± 3150.05 mm
    MeSH term(s) Humans ; Retrospective Studies ; Cephalometry ; Craniosynostoses/diagnostic imaging ; Craniosynostoses/surgery ; Mandible/diagnostic imaging ; Mandible/surgery ; Maxilla/diagnostic imaging ; Maxilla/surgery ; Osteogenesis, Distraction/methods ; Treatment Outcome
    Language English
    Publishing date 2024-01-19
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2024.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 882: Show issues Location:
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  10. Article ; Online: Development of UTX-143, a selective sodium-hydrogen exchange subtype 5 inhibitor, using amiloride as a lead compound.

    Shinohara, Yusei / Komiya, Yuki / Morimoto, Kashin / Endo, Yoshio / Terashima, Minoru / Suzuki, Takeshi / Takino, Takahisa / Ninomiya, Itasu / Yamada, Hisatsugu / Uto, Yoshihiro

    Bioorganic & medicinal chemistry

    2024  Volume 99, Page(s) 117603

    Abstract: NHE5, an isoform of the ... ...

    Abstract NHE5, an isoform of the Na
    MeSH term(s) Amiloride/pharmacology ; Sodium/metabolism ; Sodium-Hydrogen Exchangers/metabolism ; Membrane Proteins/metabolism ; Hydrogen ; Hydrogen-Ion Concentration
    Chemical Substances Amiloride (7DZO8EB0Z3) ; Sodium (9NEZ333N27) ; Sodium-Hydrogen Exchangers ; Membrane Proteins ; Hydrogen (7YNJ3PO35Z)
    Language English
    Publishing date 2024-01-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2024.117603
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    Zs.A 3815: Show issues Location:
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