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  1. Book: Tumors and tumor-like lesions of the testis and adjacent tissues

    Ulbright, Thomas M. / Kao, Chia-Sui / Williamson, Sean R. / Idrees, Muhammad T.

    (AFIP atlas of tumor and non-tumor pathology ; fifth series, fasc. 1212)

    2022  

    Author's details Thomas M. Ulbright, Chia-Sui Kao, Sean R. Williamson, Muhammad T. Idrees
    Series title AFIP atlas of tumor and non-tumor pathology ; fifth series, fasc. 1212
    AFIP atlases of tumor and non-tumor pathology
    Collection AFIP atlases of tumor and non-tumor pathology
    Keywords Testis/Cancer ; Testis/Precancerous conditions ; Scrotum/Cancer ; Scrotum/Precancerous conditions
    Subject code 616.99463
    Language English
    Size xvii, 698 Seiten, Illustrationen
    Publisher American Registry of Pathology
    Publishing place Arlington
    Publishing country United States
    Document type Book
    HBZ-ID HT021691504
    ISBN 978-1-933477-22-0 ; 1-933477-22-9
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Nonlinear dynamics of estrogen receptor-positive breast cancer integrating experimental data: A novel spatial modeling approach.

    Alnahdi, Abeer S / Idrees, Muhammad

    Mathematical biosciences and engineering : MBE

    2024  Volume 20, Issue 12, Page(s) 21163–21185

    Abstract: Oncology research has focused extensively on estrogen hormones and their function in breast cancer proliferation. Mathematical modeling is essential for the analysis and simulation of breast cancers. This research presents a novel approach to examine the ...

    Abstract Oncology research has focused extensively on estrogen hormones and their function in breast cancer proliferation. Mathematical modeling is essential for the analysis and simulation of breast cancers. This research presents a novel approach to examine the therapeutic and inhibitory effects of hormone and estrogen therapies on the onset of breast cancer. Our proposed mathematical model comprises a nonlinear coupled system of partial differential equations, capturing intricate interactions among estrogen, cytotoxic T lymphocytes, dormant cancer cells, and active cancer cells. The model's parameters are meticulously estimated through experimental studies, and we conduct a comprehensive global sensitivity analysis to assess the uncertainty of these parameter values. Remarkably, our findings underscore the pivotal role of hormone therapy in curtailing breast tumor growth by blocking estrogen's influence on cancer cells. Beyond this crucial insight, our proposed model offers an integrated framework to delve into the complexity of tumor progression and immune response under hormone therapy. We employ diverse experimental datasets encompassing gene expression profiles, spatial tumor morphology, and cellular interactions. Integrating multidimensional experimental data with mathematical models enhances our understanding of breast cancer dynamics and paves the way for personalized treatment strategies. Our study advances our comprehension of estrogen receptor-positive breast cancer and exemplifies a transformative approach that merges experimental data with cutting-edge mathematical modeling. This framework promises to illuminate the complexities of cancer progression and therapy, with broad implications for oncology.
    MeSH term(s) Receptors, Estrogen/metabolism ; Breast Neoplasms/physiopathology ; Models, Biological ; Nonlinear Dynamics ; Humans ; Female ; Estrogens/metabolism ; Estrogens/therapeutic use ; Disease Progression
    Chemical Substances Receptors, Estrogen ; Estrogens
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2023936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploring the Concordance Between High-Risk Human Papillomavirus Infections in Cervical and Oral Sites Among Females: A Cross-Sectional Study in Punjab, Pakistan.

    Minhas, Sadia / Kashif, Muhammad / Idrees, Muhammad / Ansari, Farheen

    JCO global oncology

    2024  Volume 10, Page(s) e2300408

    Abstract: Purpose: Human papillomavirus (HPV) is widely recognized as a key contributing factor in cervical and oropharyngeal cancers. However, there has been limited research on the prevalence of concurrent HPV infections in various anatomic regions. This study ... ...

    Abstract Purpose: Human papillomavirus (HPV) is widely recognized as a key contributing factor in cervical and oropharyngeal cancers. However, there has been limited research on the prevalence of concurrent HPV infections in various anatomic regions. This study aimed to investigate the prevalence and specific types of high-risk HPV (HR-HPV) infections in the cervical and oral regions of females in Punjab, Pakistan.
    Methods: We conducted a cross-sectional study involving women seeking care for general gynecologic issues at the gynecologic Outpatient Department of Lady Wallington Hospital in Lahore. After interviews and clinical examinations, we collected whole-saliva samples and high vaginal swabs from each participant. HR-HPV detection and genotyping were performed using real-time polymerase chain reaction at both the anatomic sites.
    Results: In this study, 170 females, averaging 35.36 ± 8.305 years, participated. HR-HPV infection was more prevalent in the cervix (83/170 [48.8%]) than in the oral cavity (19/170 [11.2%]). Concordant HPV infections occurred in 10/170 participants (5.9%). HPV 16 was the most common genotype in cervical and oral locations, at rates of 21.8% and 5.3%, respectively, among concordant HR-HPV types. Socioeconomic status (
    Conclusion: This study suggests that HR-HPV cervical infections may increase the risk of oral transmission, especially during orogenital sexual practices. Thus, it is important to recognize that HPV infections may be linked in both areas. We emphasize the importance of comprehensive cervical and oral examinations and HPV vaccination in young women irrespective of their sexual practices.
    MeSH term(s) Humans ; Female ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/virology ; Cross-Sectional Studies ; Pakistan/epidemiology ; Adult ; Cervix Uteri/virology ; Middle Aged ; Mouth/virology ; Prevalence ; Young Adult ; Papillomaviridae/genetics ; Papillomaviridae/isolation & purification ; Risk Factors ; Genotype
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2687-8941
    ISSN (online) 2687-8941
    DOI 10.1200/GO.23.00408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Analysis and Human Health Risk from Selected Heavy Metals in Common Instant Noodles.

    Idrees, Muhammad

    Biological trace element research

    2020  Volume 198, Issue 1, Page(s) 339–343

    Abstract: A current study has been carried out to assess the level of selected heavy metals like Cr, Cd, Zn, Mn, Fe, Co, Pb, and Ni in six branded noodles, i.e., Maggi, Knorr, Shan shoop, Shinramayun, Indomie, and Mama. The concentration of Cr, Cd, Zn, Mn, Fe, and ...

    Abstract A current study has been carried out to assess the level of selected heavy metals like Cr, Cd, Zn, Mn, Fe, Co, Pb, and Ni in six branded noodles, i.e., Maggi, Knorr, Shan shoop, Shinramayun, Indomie, and Mama. The concentration of Cr, Cd, Zn, Mn, Fe, and Co was observed in the range of 3.3-9.7, 0.066-0.59, 6.2-11.4, 2.4-6.3, 4.8-17.5, and 0.39-0.74 mg kg
    MeSH term(s) Environmental Monitoring ; Humans ; Metals, Heavy/analysis ; Metals, Heavy/toxicity ; Pakistan ; Risk Assessment
    Chemical Substances Metals, Heavy
    Language English
    Publishing date 2020-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-020-02062-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Whole-genome analysis and evolutionary characterization of cervical and oral human papillomavirus 16.

    Minhas, Sadia / Kashif, Muhammad / Nisar, Haseeb / Idrees, Muhammad / Ansari, Farheen

    Experimental biology and medicine (Maywood, N.J.)

    2024  Volume 248, Issue 23, Page(s) 2332–2340

    Abstract: High-throughput genome-wide sequencing has revealed high genomic variability of HPV16 in different geographic regions which is the most predominant genotype in human papillomavirus (HPV)-associated malignancies. Analysis of the HPV16 by whole-genome ... ...

    Abstract High-throughput genome-wide sequencing has revealed high genomic variability of HPV16 in different geographic regions which is the most predominant genotype in human papillomavirus (HPV)-associated malignancies. Analysis of the HPV16 by whole-genome sequence (WGS) is an advanced method for the identification of mutations in the genome. There is limited information about HPV16 diversity in Pakistan, especially at the genomic level. Till now, WGS for HPV16 has not been previously reported in Pakistan. The current study has sequenced three HPV16 viral genomes, from two cervical and one oral cavity positive sample of women presented with general gynecological problems without any evidence of precancerous or cancerous lesions using an ion ampliseq customized panel. Sequencing analysis detected 38 variations, including single-nucleotide polymorphisms (SNPs) and two Indels, across three samples with the highest number of SNPs present in E1, E2, and L2, respectively. A total of 20 non-synonymous and 11 synonymous mutations with amino acid substitutions (T1421C, G1515A, T2223C, T1389C, G1483A, and T2191C) were identified. The phylogenetic analysis revealed the genomes of HPV16 are closely associated with those reported from Thailand and the United States. These are the first HPV16 WGS from Pakistan. However, more research is needed with a large sample size from diversified areas to assess the carcinogenic consequences and impact of HPV vaccinations.
    MeSH term(s) Humans ; Female ; Human papillomavirus 16/genetics ; Phylogeny ; Papillomavirus Infections/pathology ; Cervix Uteri/pathology ; Mutation ; Uterine Cervical Neoplasms/pathology
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.1177/15353702231211861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Income inequality, financial development, and ecological footprint: fresh evidence from an asymmetric analysis.

    Idrees, Muhammad / Majeed, Muhammad Tariq

    Environmental science and pollution research international

    2022  Volume 29, Issue 19, Page(s) 27924–27938

    Abstract: The emerging environmental concerns are entrenched in social issues, largely stem from income differences and power disparity. Income distribution and environmental disruption are increasingly pointed as obstacles in securing sustainable development ... ...

    Abstract The emerging environmental concerns are entrenched in social issues, largely stem from income differences and power disparity. Income distribution and environmental disruption are increasingly pointed as obstacles in securing sustainable development goals and environmental preservation. The existing empirical studies have explored the environmental pollution impact of income inequality. However, the results are conflicting, and little attention has been paid to explore the short and long-run environmental impacts from a national viewpoint. Similarly, the role of aggregate income and financial sector for environmental quality has attracted considerable attention and many studies have provided conflicting empirical evidence. The literature generally ignores the importance of relative income in explaining environmental outcomes and also assumes symmetric association, ignoring asymmetric shocks. The present study explores the role of nonlinear associations in forming the links between income distribution and environmental quality using linear and nonlinear autoregressive distributed lag models from 1972 to 2018. The study follows the extended environmental Kuznets curve (EKC) approach. The results suggest that inequality promotes environmental pollution. Further financial development also escalates carbon emissions. The nonlinear analysis confirms the asymmetric effect of inequality on ecological footprint. The EKC, however, is not validated for Pakistan. The results suggest important policy implications.
    MeSH term(s) Carbon ; Carbon Dioxide/analysis ; Economic Development ; Environmental Pollution/analysis ; Income
    Chemical Substances Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0)
    Language English
    Publishing date 2022-01-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-18288-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evolution of Testicular Germ Cell Tumors in the Molecular Era With Histogenetic Implications.

    Kilic, Irem / Acosta, Andres M / Idrees, Muhammad T

    Advances in anatomic pathology

    2024  Volume 31, Issue 3, Page(s) 206–214

    Abstract: The current WHO classification of testicular germ cell tumors is based on the pathogenesis of the tumors driven by different genomic events. The germ cell neoplasia in situ is the precursor lesion for all malignant germ cell tumors. The current ... ...

    Abstract The current WHO classification of testicular germ cell tumors is based on the pathogenesis of the tumors driven by different genomic events. The germ cell neoplasia in situ is the precursor lesion for all malignant germ cell tumors. The current understanding of pathogenesis is that the developmental and environmental factors with the erasure of parental genomic imprinting lead to the development of abnormal gonocytes that settle in the "spermatogonial Niche" in seminiferous tubules. The abnormal primordial germ cells in the seminiferous tubules give rise to pre-GCNIS cells under the influence of TPSY and OCT4 genes. The whole genome duplication events give rise to germ cell neoplasia in situ, which further acquires alterations in 12p along with NRAS and KRAS mutations to produce seminoma. A subset of seminomas acquires KIT mutation and does not differentiate further. The remaining KIT-stable seminomas differentiate to nonseminomatous GCTs after obtaining recurrent chromosomal losses, epigenetic modification, and posttranscriptional regulation by multiple genes. Nonseminomatous germ cell tumors also develop directly from differentiated germ cell neoplasia in situ. TP53 pathway with downstream drivers may give rise to somatic-type malignancies of GCT. The GCTs are remarkably sensitive to cisplatin-based combination chemotherapy; however, resistance to cisplatin develops in up to 8% of tumors and appears to be driven by TP53/MDM2 gene mutations. Serum and Plasma miRNAs show promise in diagnosing, managing, and following up on these tumors. The mechanisms underlying the development of most tumors have been elucidated; however, additional studies are required to pinpoint the events directing specific characteristics. Advances in identifying specific molecular markers have been seen recently and may be adopted as gold standards in the future.
    MeSH term(s) Male ; Humans ; Seminoma/metabolism ; Cisplatin ; Testicular Neoplasms/pathology ; Neoplasms, Germ Cell and Embryonal/genetics
    Chemical Substances Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212493-x
    ISSN 1533-4031 ; 1072-4109
    ISSN (online) 1533-4031
    ISSN 1072-4109
    DOI 10.1097/PAP.0000000000000438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Neillia pendryi (Rosaceae): A New Name for N. velutina

    Idrees, Muhammad

    Novon. 2021 Apr. 16, v. 29, no. 1

    2021  

    Abstract: A new name, Neillia pendryi Idrees, is proposed as a replacement name for N. velutina Pendry ...

    Abstract A new name, Neillia pendryi Idrees, is proposed as a replacement name for N. velutina Pendry (Rosaceae), which was discovered to be an illegitimate later homonym of N. velutina Bureau & Franch.
    Keywords Neillia ; homonym ; nomen novum
    Language English
    Dates of publication 2021-0416
    Size p. 77.
    Publishing place the Missouri Botanical Garden
    Document type Article
    ZDB-ID 2239681-0
    ISSN 1055-3177
    ISSN 1055-3177
    DOI 10.3417/2021690
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Income inequality, financial development, and ecological footprint: fresh evidence from an asymmetric analysis

    Idrees, Muhammad / Majeed, Muhammad Tariq

    Environ Sci Pollut Res. 2022 Apr., v. 29, no. 19 p.27924-27938

    2022  

    Abstract: The emerging environmental concerns are entrenched in social issues, largely stem from income differences and power disparity. Income distribution and environmental disruption are increasingly pointed as obstacles in securing sustainable development ... ...

    Abstract The emerging environmental concerns are entrenched in social issues, largely stem from income differences and power disparity. Income distribution and environmental disruption are increasingly pointed as obstacles in securing sustainable development goals and environmental preservation. The existing empirical studies have explored the environmental pollution impact of income inequality. However, the results are conflicting, and little attention has been paid to explore the short and long-run environmental impacts from a national viewpoint. Similarly, the role of aggregate income and financial sector for environmental quality has attracted considerable attention and many studies have provided conflicting empirical evidence. The literature generally ignores the importance of relative income in explaining environmental outcomes and also assumes symmetric association, ignoring asymmetric shocks. The present study explores the role of nonlinear associations in forming the links between income distribution and environmental quality using linear and nonlinear autoregressive distributed lag models from 1972 to 2018. The study follows the extended environmental Kuznets curve (EKC) approach. The results suggest that inequality promotes environmental pollution. Further financial development also escalates carbon emissions. The nonlinear analysis confirms the asymmetric effect of inequality on ecological footprint. The EKC, however, is not validated for Pakistan. The results suggest important policy implications.
    Keywords carbon ; ecological footprint ; environmental Kuznets curve ; environmental quality ; income ; income distribution ; issues and policy ; pollution ; social inequality ; sustainable development ; Pakistan
    Language English
    Dates of publication 2022-04
    Size p. 27924-27938.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-18288-3
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Antimicrobial Susceptibility and Genetic Prevalence of Extended-Spectrum β-Lactamases in Gram-Negative Rods Isolated from Clinical Specimens in Pakistan.

    Idrees, Muhammad Mubashar / Rimsha, Rimsha / Idrees, Muhammad Daoud / Saeed, Ali

    Antibiotics (Basel, Switzerland)

    2022  Volume 12, Issue 1

    Abstract: The prevalence of extended-spectrum β-lactamase (ESBL) genes has increased remarkably, resulting in multidrug-resistant gram-negative rods (GNRs) in clinical specimens. This cross-sectional study aimed to determine the antimicrobial susceptibility of ... ...

    Abstract The prevalence of extended-spectrum β-lactamase (ESBL) genes has increased remarkably, resulting in multidrug-resistant gram-negative rods (GNRs) in clinical specimens. This cross-sectional study aimed to determine the antimicrobial susceptibility of ESBL-producing GNRs and its correlation with corresponding genes. Two hundred and seventy-two (
    Language English
    Publishing date 2022-12-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12010029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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