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  1. Article ; Online: Acceptance and User Experiences of a Wearable Device for the Management of Hospitalized Patients in COVID-19-Designated Wards in Ho Chi Minh City, Vietnam: Action Learning Project.

    Luu, An Phuoc / Nguyen, Truong Thanh / Cao, Van Thi Cam / Ha, Trinh Hoang Diem / Chung, Lien Thi Thu / Truong, Trung Ngoc / Nguyen Le Nhu, Tung / Dao, Khoa Bach / Nguyen, Hao Van / Khanh, Phan Nguyen Quoc / Le, Khanh Thuy Thuy / Tran, Luu Hoai Bao / Nhat, Phung Tran Huy / Tran, Duc Minh / Lam, Yen Minh / Thwaites, Catherine Louise / Mcknight, Jacob / Vinh Chau, Nguyen Van / Van Nuil, Jennifer Ilo

    JMIR human factors

    2024  Volume 11, Page(s) e44619

    Abstract: Background: Wearable devices have been used extensively both inside and outside of the hospital setting. During the COVID-19 pandemic, in some contexts, there was an increased need to remotely monitor pulse and saturated oxygen for patients due to the ... ...

    Abstract Background: Wearable devices have been used extensively both inside and outside of the hospital setting. During the COVID-19 pandemic, in some contexts, there was an increased need to remotely monitor pulse and saturated oxygen for patients due to the lack of staff and bedside monitors.
    Objective: A prototype of a remote monitoring system using wearable pulse oximeter devices was implemented at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam, from August to December 2021. The aim of this work was to support the ongoing implementation of the remote monitoring system.
    Methods: We used an action learning approach with rapid pragmatic methods, including informal discussions and observations as well as a feedback survey form designed based on the technology acceptance model to assess the use and acceptability of the system. Based on these results, we facilitated a meeting using user-centered design principles to explore user needs and ideas about its development in more detail.
    Results: In total, 21 users filled in the feedback form. The mean technology acceptance model scores ranged from 3.5 (for perceived ease of use) to 4.4 (for attitude) with behavioral intention (3.8) and perceived usefulness (4.2) scoring in between. Those working as nurses scored higher on perceived usefulness, attitude, and behavioral intention than did physicians. Based on informal discussions, we realized there was a mismatch between how we (ie, the research team) and the ward teams perceived the use and wider purpose of the technology.
    Conclusions: Designing and implementing the devices to be more nurse-centric from their introduction could have helped to increase their efficiency and use during the complex pandemic period.
    MeSH term(s) Humans ; Vietnam ; COVID-19 ; Pandemics ; Patients ; Hospitals
    Language English
    Publishing date 2024-01-05
    Publishing country Canada
    Document type Journal Article
    ISSN 2292-9495
    ISSN (online) 2292-9495
    DOI 10.2196/44619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of the social distancing measures on the spread of COVID-19 in 10 highly infected countries.

    Thu, Tran Phuoc Bao / Ngoc, Pham Nguyen Hong / Hai, Nguyen Minh / Tuan, Le Anh

    The Science of the total environment

    2020  Volume 742, Page(s) 140430

    Abstract: From the end of 2019, an unprecedented novel coronavirus, which was named COVID-19 by the World Health Organization (WHO) emerged from Wuhan city, China. Despite rigorous global containment and quarantine efforts, the incidence of COVID-19 has continued ... ...

    Abstract From the end of 2019, an unprecedented novel coronavirus, which was named COVID-19 by the World Health Organization (WHO) emerged from Wuhan city, China. Despite rigorous global containment and quarantine efforts, the incidence of COVID-19 has continued to rise, with over 4 million confirmed-cases and over 300,000 deaths worldwide until mid-May. This study aims to present the effect of the promulgation of social distancing measures on the spread of COVID-19 in the cases of 10 highly infected countries. The authors focus on the statistics of the COVID-19 confirmed-cases and deaths in 10 highly infected countries, including The U.S., Spain, Italy, The U.K., France, Germany, Russia, Turkey, Iran and China, and the response to the pandemic of these countries in the period from January 11 to May 2, 2020. The relationships between the social distancing measures and the statistics of COVID-19 confirmed-cases and deaths were analyzed in order to elucidate the effectiveness of the social distancing measures on the spread of COVID-19 in 10 highly infected countries. The results showed it took1-4 weeks since the highest level of social distancing measures promulgation until the daily confirmed-cases and deaths showed signs of decreasing. The effectiveness of the social distancing measures on the spread of COVID-19 was different between the 10 focused countries. This variation is due to the difference in the levels of promulgated social distancing measures, as well as the difference in the COVID-19 spread situation at the time of promulgation between the countries.
    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus Infections ; France ; Germany ; Humans ; Infection Control ; Iran ; Italy ; Pandemics ; Pneumonia, Viral ; Public Policy ; Quarantine ; Russia ; SARS-CoV-2 ; Spain ; Turkey
    Keywords covid19
    Language English
    Publishing date 2020-06-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2020.140430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The diagnostic performance of AFP and PIVKA-II models for non-B non-C hepatocellular carcinoma.

    Tran, Vinh Thanh / Phan, Thang Thanh / Nguyen, Tran Bao / Le, Thao Thi / Tran, Thanh-Tram Thi / Nguyen, Anh-Thu Thi / Nguyen, Hang Thuy / Nguyen, Ngoc-Diep Bui / Ho, Toan Trong / Pho, Suong Phuoc / Nguyen, Thuy-An Thi / Nguyen, Hue Thi / Mai, Huyen Thi / Pham, Bich-Tuyen Thi / Nguyen, Khoa Dinh / Le, Binh Thanh / Nguyen, Thuc Tri / Nguyen, Son Truong

    BMC research notes

    2023  Volume 16, Issue 1, Page(s) 317

    Abstract: Objective: This study aims to describe the diagnostic performance of alpha-fetoprotein (AFP), alpha-fetoprotein L3 isoform (AFP-L3), protein induced by vitamin K absence II (PIVKA-II), and combined biomarkers for non-B non-C hepatocellular carcinoma ( ... ...

    Abstract Objective: This study aims to describe the diagnostic performance of alpha-fetoprotein (AFP), alpha-fetoprotein L3 isoform (AFP-L3), protein induced by vitamin K absence II (PIVKA-II), and combined biomarkers for non-B non-C hepatocellular carcinoma (NBNC-HCC).
    Results: A total of 681 newly-diagnosed primary liver disease subjects (385 non-HCC, 296 HCC) who tested negativity for the hepatitis B surface antigen (HBsAg) and hepatitis C antibody (anti-HCV) enrolled in this study. At the cut-off point of 3.8 ng/mL, AFP helps to discriminate HCC from non-HCC with an area under the curve (AUC) value of 0.817 (95% confidence interval [CI]: 0.785-0.849). These values of AFP-L3 (cut-off 0.9%) and PIVKA-II (cut-off 57.7 mAU/mL) were 0.758 (95%CI: 0.725-0.791) and 0.866 (95%CI: 0.836-0.896), respectively. The Bayesian Model Averaging (BMA) statistic identified the optimal model, including patients' age, aspartate aminotransferase, AFP, and PIVKA-II combination, which helps to classify HCC with better performance (AUC = 0.896, 95%CI: 0.872-0.920, P < 0.001). The sensitivity and specificity of the optimal model reached 81.1% (95%CI: 76.1-85.4) and 83.2% (95%CI: 78.9-86.9), respectively. Further analyses indicated that AFP and PIVKA-II markers and combined models have good-to-excellent performance detecting curative resected HCC, separating HCC from chronic hepatitis, dysplastic, and hyperplasia nodules.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular ; alpha-Fetoproteins/analysis ; alpha-Fetoproteins/metabolism ; Liver Neoplasms/pathology ; Vitamin K ; Vitamins ; Bayes Theorem ; ROC Curve ; Biomarkers ; Biomarkers, Tumor
    Chemical Substances acarboxyprothrombin (53230-14-1) ; alpha-Fetoproteins ; Vitamin K (12001-79-5) ; Vitamins ; Biomarkers ; Biomarkers, Tumor
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-023-06600-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of the social distancing measures on the spread of COVID-19 in 10 highly infected countries

    Thu, Tran Phuoc Bao / Ngoc, Pham Nguyen Hong / Hai, Nguyen Minh / Tuan, Le Anh

    Science of The Total Environment

    2020  Volume 742, Page(s) 140430

    Keywords Environmental Engineering ; Waste Management and Disposal ; Pollution ; Environmental Chemistry ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2020.140430
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Smoking habit and chemo-radiotherapy and/or surgery affect the sensitivity of EGFR plasma test in non-small cell lung cancer.

    Tran, Vinh Thanh / Phan, Thang Thanh / Nguyen, Son Truong / Tran, Bich-Thu / Ho, Toan Trong / Pho, Suong Phuoc / Nguyen, Tran Bao / Pham, Tuyen Thi Bich / Le, Anh Tuan / Le, Vu Thuong / Nguyen, Hang Thuy

    BMC research notes

    2020  Volume 13, Issue 1, Page(s) 367

    Abstract: Objective: This study aimed to identify the influential factors for the sensitivity of epidermal growth factor receptor (EGFR) plasma test in non-small cell lung cancer (NSCLC). The mutations were detected in tumor tissue and matched plasma samples from ...

    Abstract Objective: This study aimed to identify the influential factors for the sensitivity of epidermal growth factor receptor (EGFR) plasma test in non-small cell lung cancer (NSCLC). The mutations were detected in tumor tissue and matched plasma samples from 125 newly diagnosed adenocarcinoma, clinical-stage IIIB-IV patients, and compared the diagnostic values of EGFR plasma test between groups of clinical characteristics. The influential factors for the sensitivity were identified and assessed by logistic regression.
    Results: EGFR mutations were detected in 65 (52.0%) tumor tissue and 50 (40.0%) matched plasma samples (P = 0.028). Compared to the tissue method, the concordance rate, sensitivity, and specificity of the EGFR plasma test were 86.4%, 75.4%, and 98.3%, respectively. Notably, we found that sensitivity of the test is higher in non-smokers (84.1%) compared to smokers (57.1%, P = 0.018), and in treatment naïve subjects (85.7%) compared to whom undergone chemo-radiotherapy with/without surgery before testing (56.5%, P = 0.009). Furthermore, the highest sensitivity was attained in patients without these two factors (90.3%), whilst the lowest value was noted in those with both factors (40.0%, P = 0.004). The multivariable analysis confirmed that smoking habit and treatment history have independently negative impacts on sensitivity (OR = 0.24, P = 0.019, and OR = 0.36, P = 0.047, respectively).
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/therapy ; Chemoradiotherapy ; ErbB Receptors/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/therapy ; Mutation ; Smoking
    Chemical Substances EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2020-08-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-020-05209-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The diagnostic performance of AFP and PIVKA-II models for non-B non-C hepatocellular carcinoma

    Vinh Thanh Tran / Thang Thanh Phan / Tran Bao Nguyen / Thao Thi Le / Thanh-Tram Thi Tran / Anh-Thu Thi Nguyen / Hang Thuy Nguyen / Ngoc-Diep Bui Nguyen / Toan Trong Ho / Suong Phuoc Pho / Thuy-An Thi Nguyen / Hue Thi Nguyen / Huyen Thi Mai / Bich-Tuyen Thi Pham / Khoa Dinh Nguyen / Binh Thanh Le / Thuc Tri Nguyen / Son Truong Nguyen

    BMC Research Notes, Vol 16, Iss 1, Pp 1-

    2023  Volume 6

    Abstract: Abstract Objective This study aims to describe the diagnostic performance of alpha-fetoprotein (AFP), alpha-fetoprotein L3 isoform (AFP-L3), protein induced by vitamin K absence II (PIVKA-II), and combined biomarkers for non-B non-C hepatocellular ... ...

    Abstract Abstract Objective This study aims to describe the diagnostic performance of alpha-fetoprotein (AFP), alpha-fetoprotein L3 isoform (AFP-L3), protein induced by vitamin K absence II (PIVKA-II), and combined biomarkers for non-B non-C hepatocellular carcinoma (NBNC-HCC). Results A total of 681 newly-diagnosed primary liver disease subjects (385 non-HCC, 296 HCC) who tested negativity for the hepatitis B surface antigen (HBsAg) and hepatitis C antibody (anti-HCV) enrolled in this study. At the cut-off point of 3.8 ng/mL, AFP helps to discriminate HCC from non-HCC with an area under the curve (AUC) value of 0.817 (95% confidence interval [CI]: 0.785–0.849). These values of AFP-L3 (cut-off 0.9%) and PIVKA-II (cut-off 57.7 mAU/mL) were 0.758 (95%CI: 0.725–0.791) and 0.866 (95%CI: 0.836–0.896), respectively. The Bayesian Model Averaging (BMA) statistic identified the optimal model, including patients’ age, aspartate aminotransferase, AFP, and PIVKA-II combination, which helps to classify HCC with better performance (AUC = 0.896, 95%CI: 0.872–0.920, P < 0.001). The sensitivity and specificity of the optimal model reached 81.1% (95%CI: 76.1–85.4) and 83.2% (95%CI: 78.9–86.9), respectively. Further analyses indicated that AFP and PIVKA-II markers and combined models have good-to-excellent performance detecting curative resected HCC, separating HCC from chronic hepatitis, dysplastic, and hyperplasia nodules.
    Keywords AFP ; AFP-L3 ; PIVKA-II ; NBNC-HCC ; Diagnosis ; Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Clinical validation of a ctDNA-Based Assay for Multi-Cancer Detection: An Interim Report from a Vietnamese Longitudinal Prospective Cohort Study of 2795 Participants.

    Nguyen, Thi Hue Hanh / Lu, Y-Thanh / Le, Van Hoi / Bui, Vinh Quang / Nguyen, Lan Hieu / Pham, Nhu Hiep / Phan, Thanh Hai / Nguyen, Huu Thinh / Tran, Van Song / Bui, Chi Viet / Vo, Van Kha / Nguyen, Pham Thanh Nhan / Dang, Ha Huu Phuoc / Pham, Van Dung / Cao, Van Thinh / Nguyen, Thanh Dat / Nguyen, Luu Hong Dang / Phan, Ngoc Minh / Nguyen, Trong Hieu /
    Nguyen, Van Thien Chi / Pham, Thi Mong Quynh / Tran, Vu Uyen / Le, Minh Phong / Vo, Dac Ho / Tran, Thi Minh Thu / Nguyen, Minh Nguyen / Nguyen, Thi Thanh / Tieu, Ba Linh / Nguyen, Huu Tam Phuc / Truong, Dinh Yen An / Cao, Chi Thuy Tien / Nguyen, Van Tung / Le, Thi Le Quyen / Luong, Thi Lan Anh / Doan, Thi Kim Phuong / Dao, Thi Trang / Phan, Canh Duy / Nguyen, Thanh Xuan / Pham, Nguyen Tuong / Nguyen, Bao Toan / Pham, Thi Thu Thuy / Le, Huu Linh / Truong, Cong Thanh / Jasmine, Thanh Xuan / Le, Minh Chi / Phan, Van Bau / Truong, Quang Binh / Tran, Thi Huong Ly / Huynh, Minh Thien / Tran, Tu Quy / Nguyen, Si Tuan / Tran, Vu / Tran, Van Khanh / Nguyen, Huu Nguyen / Nguyen, Duy Sinh / Nguyen, Thi Quynh Tho / Phan, Thi Van / Do, Thi Thanh-Thuy / Truong, Dinh-Kiet / Tang, Hung Sang / Phan, Minh Duy / Giang, Hoa / Nguyen, Hoai Nghia / Tran, Le Son

    Cancer investigation

    2023  , Page(s) 1–17

    Abstract: The SPOT-MAS assay "Screening for the Presence Of Tumor by Methylation And Size" detects the five most common cancers in Vietnam by evaluating circulating tumor DNA in the blood. Here, we validated its performance in a prospective multi-center clinical ... ...

    Abstract The SPOT-MAS assay "Screening for the Presence Of Tumor by Methylation And Size" detects the five most common cancers in Vietnam by evaluating circulating tumor DNA in the blood. Here, we validated its performance in a prospective multi-center clinical trial, K-DETEK. Our analysis of 2795 participants from 14 sites across Vietnam demonstrates its ability to detect cancers in asymptomatic individuals with a positive predictive value of 60%, with 83.3% accuracy in detecting tumor location. We present a case report to support further using SPOT-MAS as a complementary method to achieve early cancer detection and provide the opportunity for early treatment.
    Language English
    Publishing date 2023-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 604942-4
    ISSN 1532-4192 ; 0735-7907
    ISSN (online) 1532-4192
    ISSN 0735-7907
    DOI 10.1080/07357907.2023.2173773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Effect of the social distancing measures on the spread of COVID-19 in 10 highly infected countries

    Thu, Tran Phuoc Bao / Ngoc, Pham Nguyen Hong / Hai, Nguyen Minh / Tuan, Le Anh

    Sci Total Environ

    Abstract: From the end of 2019, an unprecedented novel coronavirus, which was named COVID-19 by the World Health Organization (WHO) emerged from Wuhan city, China. Despite rigorous global containment and quarantine efforts, the incidence of COVID-19 has continued ... ...

    Abstract From the end of 2019, an unprecedented novel coronavirus, which was named COVID-19 by the World Health Organization (WHO) emerged from Wuhan city, China. Despite rigorous global containment and quarantine efforts, the incidence of COVID-19 has continued to rise, with over 4 million confirmed-cases and over 300,000 deaths worldwide until mid-May. This study aims to present the effect of the promulgation of social distancing measures on the spread of COVID-19 in the cases of 10 highly infected countries. The authors focus on the statistics of the COVID-19 confirmed-cases and deaths in 10 highly infected countries, including The U.S., Spain, Italy, The U.K., France, Germany, Russia, Turkey, Iran and China, and the response to the pandemic of these countries in the period from January 11 to May 2, 2020. The relationships between the social distancing measures and the statistics of COVID-19 confirmed-cases and deaths were analyzed in order to elucidate the effectiveness of the social distancing measures on the spread of COVID-19 in 10 highly infected countries. The results showed it took1-4 weeks since the highest level of social distancing measures promulgation until the daily confirmed-cases and deaths showed signs of decreasing. The effectiveness of the social distancing measures on the spread of COVID-19 was different between the 10 focused countries. This variation is due to the difference in the levels of promulgated social distancing measures, as well as the difference in the COVID-19 spread situation at the time of promulgation between the countries.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #610242
    Database COVID19

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  9. Article ; Online: Genetic landscape of recessive diseases in the Vietnamese population from large-scale clinical exome sequencing.

    Tran, Ngoc Hieu / Nguyen Thi, Thanh-Huong / Tang, Hung-Sang / Hoang, Le-Phuc / Nguyen, Trung-Hieu Le / Tran, Nhat-Thang / Trinh, Thu-Huong Nhat / Nguyen, Van Thong / Nguyen, Bao-Han Huu / Nguyen, Hieu Trong / Doan, Loc Phuoc / Phan, Ngoc-Minh / Nguyen, Kim-Huong Thi / Nguyen, Hong-Dang Luu / Quach, Minh-Tam Thi / Nguyen, Thanh-Phuong Thi / Tran, Vu Uyen / Tran, Dinh-Vinh / Nguyen, Quynh-Tho Thi /
    Do, Thanh-Thuy Thi / Lam, Nien Vinh / Cao Thi Ngoc, Phuong / Truong, Dinh Kiet / Nguyen, Hoai-Nghia / Phan, Minh-Duy / Giang, Hoa

    Human mutation

    2021  Volume 42, Issue 10, Page(s) 1229–1238

    Abstract: Accurate profiling of population-specific recessive diseases is essential for the design of cost-effective carrier screening programs. However, minority populations and ethnic groups, including Vietnamese, are still underrepresented in existing genetic ... ...

    Abstract Accurate profiling of population-specific recessive diseases is essential for the design of cost-effective carrier screening programs. However, minority populations and ethnic groups, including Vietnamese, are still underrepresented in existing genetic studies. Here, we reported the first comprehensive study of recessive diseases in the Vietnamese population. Clinical exome sequencing data of 4503 disease-associated genes obtained from a cohort of 985 Vietnamese individuals was analyzed to identify pathogenic variants, associated diseases and their carrier frequencies in the population. A total of 118 recessive diseases associated with 164 pathogenic or likely pathogenic variants were identified, among which 28 diseases had carrier frequencies of at least 1% (1 in 100 individuals). Three diseases were prevalent in the Vietnamese population with carrier frequencies of 2-12 times higher than in the world populations, including beta-thalassemia (1 in 23), citrin deficiency (1 in 31), and phenylketonuria (1 in 40). Seven novel pathogenic and two likely pathogenic variants associated with nine recessive diseases were discovered. The comprehensive profile of recessive diseases identified in this study enables the design of cost-effective carrier screening programs specific to the Vietnamese population.
    MeSH term(s) Asians ; Cohort Studies ; Ethnicity ; Exome/genetics ; Humans ; Whole Exome Sequencing
    Language English
    Publishing date 2021-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1126646-6
    ISSN 1098-1004 ; 1059-7794
    ISSN (online) 1098-1004
    ISSN 1059-7794
    DOI 10.1002/humu.24253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Smoking habit and chemo-radiotherapy and/or surgery affect the sensitivity of EGFR plasma test in non-small cell lung cancer

    Vinh Thanh Tran / Thang Thanh Phan / Son Truong Nguyen / Bich-Thu Tran / Toan Trong Ho / Suong Phuoc Pho / Tran Bao Nguyen / Tuyen Thi Bich Pham / Anh Tuan Le / Vu Thuong Le / Hang Thuy Nguyen

    BMC Research Notes, Vol 13, Iss 1, Pp 1-

    2020  Volume 7

    Abstract: Abstract Objective This study aimed to identify the influential factors for the sensitivity of epidermal growth factor receptor (EGFR) plasma test in non-small cell lung cancer (NSCLC). The mutations were detected in tumor tissue and matched plasma ... ...

    Abstract Abstract Objective This study aimed to identify the influential factors for the sensitivity of epidermal growth factor receptor (EGFR) plasma test in non-small cell lung cancer (NSCLC). The mutations were detected in tumor tissue and matched plasma samples from 125 newly diagnosed adenocarcinoma, clinical-stage IIIB-IV patients, and compared the diagnostic values of EGFR plasma test between groups of clinical characteristics. The influential factors for the sensitivity were identified and assessed by logistic regression. Results EGFR mutations were detected in 65 (52.0%) tumor tissue and 50 (40.0%) matched plasma samples (P = 0.028). Compared to the tissue method, the concordance rate, sensitivity, and specificity of the EGFR plasma test were 86.4%, 75.4%, and 98.3%, respectively. Notably, we found that sensitivity of the test is higher in non-smokers (84.1%) compared to smokers (57.1%, P = 0.018), and in treatment naïve subjects (85.7%) compared to whom undergone chemo-radiotherapy with/without surgery before testing (56.5%, P = 0.009). Furthermore, the highest sensitivity was attained in patients without these two factors (90.3%), whilst the lowest value was noted in those with both factors (40.0%, P = 0.004). The multivariable analysis confirmed that smoking habit and treatment history have independently negative impacts on sensitivity (OR = 0.24, P = 0.019, and OR = 0.36, P = 0.047, respectively).
    Keywords EGFR mutations ; cfDNA ; NSCLC ; Sensitivity ; Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
    Subject code 616 ; 610
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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