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  1. Article: Molecular Docking Analysis of Anti-Severe Acute Respiratory Syndrome-Coronavirus 2 Ligands against Spike Glycoprotein and the 3-Chymotrypsin-Like Protease.

    Janabi, Ali Hassan Daghir

    Journal of medical signals and sensors

    2021  Volume 11, Issue 1, Page(s) 31–36

    Abstract: Background: The severe acute respiratory syndrome-like disease coronavirus disease 2019 (COVID-19) is a disastrous global pandemic with 16,288,490 infected cases and 649,884 deaths. Until now, no effective treatments are found.: Methods: The virus ... ...

    Abstract Background: The severe acute respiratory syndrome-like disease coronavirus disease 2019 (COVID-19) is a disastrous global pandemic with 16,288,490 infected cases and 649,884 deaths. Until now, no effective treatments are found.
    Methods: The virus uses the 3-chymotrypsin-like protease for inducing the activity of the viral polyproteins and the spike (S) glycoprotein for human cell entry through the human angiotensin-converting enzyme 2 receptor. Blocking the active binding sites of these molecules might be beneficial for decreasing the activity of the virus and suppressing the viral entry to the human cells. Here, docking methods were used to identify a group of ligands may perform the blocking operations.
    Results: The results revealed the strongest binding affinities, sorted high to low, for tadalafil (Cialis) (phosphodiesterase type 5 inhibitor, tirofiban (antiplatelet), paraxanthine (central nervous system stimulant), dexamethasone, gentian violet cation (triphenylmethane), salbutamol, and amlodipine (calcium channel blocker).
    Conclusion: These substances may provide vital help for further clinical investigation in fighting against the current global pandemic of the COVID-19.
    Language English
    Publishing date 2021-01-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2651622-6
    ISSN 2228-7477
    ISSN 2228-7477
    DOI 10.4103/jmss.JMSS_25_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effective Anti-SARS-CoV-2 RNA Dependent RNA Polymerase Drugs Based on Docking Methods: The Case of Milbemycin, Ivermectin, and Baloxavir Marboxil.

    Daghir Janabi, Ali Hassan

    Avicenna journal of medical biotechnology

    2020  Volume 12, Issue 4, Page(s) 246–250

    Abstract: Background: Severe Acute Respiratory Syndrome-coronavirus 2 (SARS-CoV-2) is a new virus with a global pandemic. Yet, no vaccine or efficient treatments are found against the disease. The viral RNA dependent RNA Polymerase (RdRP) is a suitable target for ...

    Abstract Background: Severe Acute Respiratory Syndrome-coronavirus 2 (SARS-CoV-2) is a new virus with a global pandemic. Yet, no vaccine or efficient treatments are found against the disease. The viral RNA dependent RNA Polymerase (RdRP) is a suitable target for developing antiviral agents. SARS-CoV-2 RdRP was employed to test its binding activity with some drugs.
    Methods: Using some docking methods, RdRP was targeted by Milbemycins (MMs), Ivermectin (IMT), Baloxavir Marboxil (BM), and Tadalafil (TF), a phosphodiesterase type 5 inhibitor.
    Results: MM-A3 5-oxime (MMA35O), MM-A3 (MMA3), MM-A4 5-oxime (MMA45O), IMT, BM, and TF showed the highest binding affinity to RdRp.
    Conclusion: The drugs used in the present computational investigation are effective against the SARS-CoV-2 RdRP with high affinity values especially, milbemycins, ivermectin, and Baloxavir marboxil, which could further be studied in laboratory and clinical trials for saving millions of lives around the world.
    Keywords covid19
    Language English
    Publishing date 2020-09-20
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2520683-7
    ISSN 2008-4625 ; 2008-2835
    ISSN (online) 2008-4625
    ISSN 2008-2835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Detection the presence of Bdellovibrio bacteriovorus in the bacterial DNA extracts of Culex pipiens intestine using polymerase chain reaction

    Ali Hassan Daghir Janabi

    Al-Qadisiyah Journal of Veterinary Medicine Sciences, Vol 16, Iss 2, Pp 18-

    2017  Volume 21

    Abstract: Mosquitoes are tiny creatures but could do a lot of damages to the people life and especially by transmitting dangerous diseases such as dengue fever transported by Aedes aegypti. The control of these bugs is hostorically challenging and difficult. This ... ...

    Abstract Mosquitoes are tiny creatures but could do a lot of damages to the people life and especially by transmitting dangerous diseases such as dengue fever transported by Aedes aegypti. The control of these bugs is hostorically challenging and difficult. This difficulty increases after the emerging problems of insecticide resistance. The gut flora(GF) in different animals has been detected to place an important role on the physiology of the intestine. This study was conducted to discover if the Bdellovibrio bacteriovorus is a member of the GF of the mosquitoes. B. bacteriovorus is a bacterium that has been found in the intestine of animals and healthy and patient humans but not in mosquitoes. Seventy adult mosquitos of Culex pipiens were used for extraction of the bacterial DNA from their intestine. The 70 mosquitoes were assigned randomly to 7 groups, 10 mosquitoes for each group to pool the amount of DNA extracted. Each mosquito was dissected under the microscope to isolate the intestine and use it later for DNA extraction. After the DNA had been extracted using a phenol/chloroform method, I subjected the extracted DNA to polymerase chain reaction (PCR) to detect the presence of this bacterium among the bacteria of the intestine using the following specific primers: Bd529F (5’-GGTAAGACGAGGGATCCT-3’) and Bd1007R (5’-TCTTCCAGTACATGTCAAG-3’) that amplify a 481-bp of the 16S rRNA gene. By the amplification that happened in all 7 groups, the result indicates the presence of Bdellovibrio bacteriovorus in the intestine of the Culex pipiens. Because this bacterium preys on Gram-negative bacteria, our results help to use this bacterium to fight insecticide resistance that caused by the degradation of these chemicals by gram-negative bacteria in the ingestion of these mosquitoes.
    Keywords Veterinary medicine ; SF600-1100
    Subject code 630
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher College of Veterinary Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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