Article ; Online: Effective Use of Angiotensin II in Coronavirus Disease 19-Associated Mixed Shock State: A Case Report.
A&A practice
2020 Volume 14, Issue 6, Page(s) e01221
Abstract: The rapid spread of Coronavirus Disease 2019 (COVID-19) has sparked a search for effective therapies. The discovery that the virus binds the angiotensin-converting enzyme 2 (ACE2) receptor has led to investigation of the renin-angiotensin system for ... ...
| Abstract | The rapid spread of Coronavirus Disease 2019 (COVID-19) has sparked a search for effective therapies. The discovery that the virus binds the angiotensin-converting enzyme 2 (ACE2) receptor has led to investigation of the renin-angiotensin system for possible therapeutic targets. We present a case of an elderly woman with multiple comorbidities who developed severe acute respiratory distress syndrome (ARDS), a cardiomyopathy, and vasodilatory shock secondary to COVID-19 and was treated with exogenous angiotensin II. She rapidly demonstrated significant hemodynamic improvement without noted adverse effects. Thus, we propose further investigation into possible benefits of angiotensin II in shock secondary to COVID-19. |
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| MeSH term(s) | Aged, 80 and over ; Angiotensin II/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Female ; Humans ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2 ; Shock/drug therapy ; Shock/etiology ; Vasoconstrictor Agents/therapeutic use |
| Chemical Substances | Vasoconstrictor Agents ; Angiotensin II (11128-99-7) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-08-09 |
| Publishing country | United States |
| Document type | Case Reports ; Journal Article |
| ISSN | 2575-3126 |
| ISSN (online) | 2575-3126 |
| DOI | 10.1213/XAA.0000000000001221 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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