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  1. Article ; Online: Toward Precision Medicine: Exploring the Landscape of Biomarkers in Acute Kidney Injury.

    Nourie, Nicole / Ghaleb, Rita / Lefaucheur, Carmen / Louis, Kevin

    Biomolecules

    2024  Volume 14, Issue 1

    Abstract: Acute kidney injury (AKI) remains a complex challenge with diverse underlying pathological mechanisms and etiologies. Current detection methods predominantly rely on serum creatinine, which exhibits substantial limitations in specificity and poses the ... ...

    Abstract Acute kidney injury (AKI) remains a complex challenge with diverse underlying pathological mechanisms and etiologies. Current detection methods predominantly rely on serum creatinine, which exhibits substantial limitations in specificity and poses the issue of late-stage detection of kidney injury. In this review, we propose an up-to-date and comprehensive summary of advancements that identified novel biomarker candidates in blood and urine and ideal criteria for AKI biomarkers such as renal injury specificity, mechanistic insight, prognostic capacity, and affordability. Recently identified biomarkers not only indicate injury location but also offer valuable insights into a range of pathological processes, encompassing reduced glomerular filtration rate, tubular function, inflammation, and adaptive response to injury. The clinical applications of AKI biomarkers are becoming extensive and serving as relevant tools in distinguishing acute tubular necrosis from other acute renal conditions. Also, these biomarkers can offer significant insights into the risk of progression to chronic kidney disease CKD and in the context of kidney transplantation. Integration of these biomarkers into clinical practice has the potential to improve early diagnosis of AKI and revolutionize the design of clinical trials, offering valuable endpoints for therapeutic interventions and enhancing patient care and outcomes.
    MeSH term(s) Humans ; Precision Medicine ; Acute Kidney Injury/diagnosis ; Kidney ; Biomarkers ; Body Fluids ; Renal Insufficiency, Chronic
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14010082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An Unusual Course of a 2,8-Dihydroxyadeninuria Crystalline Nephropathy Secondary to Adenine Phosphoribosyltransferase Deficiency.

    Nourié, Nicole / Nassereddine, Hussein / Azar, Hiba

    Nephron

    2021  Volume 145, Issue 5, Page(s) 503–507

    Abstract: Adenine phosphoribosyltransferase (APRT) deficiency is a rare disorder caused by an autosomal recessive genetic disease leading to the deposition of 2,8-dihydroxyadenine (2,8-DHA) in the kidney. The disease remains under-recognized, oftentimes diagnosed ... ...

    Abstract Adenine phosphoribosyltransferase (APRT) deficiency is a rare disorder caused by an autosomal recessive genetic disease leading to the deposition of 2,8-dihydroxyadenine (2,8-DHA) in the kidney. The disease remains under-recognized, oftentimes diagnosed in late stages of renal insufficiency or a failed kidney allograft with biopsy-proven disease recurrence. Here, we present the case of a 59-year-old middle eastern male patient diagnosed with 2,8-DHA nephropathy after a very unusual presentation, and we show how the initiation of an appropriate therapy slowed down his evolution toward kidney replacement therapies. His disease was found to be secondary to a specific APRT gene variant c.188G>A p (Gly63Asp) also described in 4 other patients, all from middle eastern origins.
    MeSH term(s) Adenine Phosphoribosyltransferase/deficiency ; Crystallization ; Febuxostat/therapeutic use ; Gout Suppressants/therapeutic use ; Humans ; Male ; Metabolism, Inborn Errors/drug therapy ; Metabolism, Inborn Errors/physiopathology ; Middle Aged ; Urolithiasis/drug therapy ; Urolithiasis/physiopathology
    Chemical Substances Gout Suppressants ; Febuxostat (101V0R1N2E) ; Adenine Phosphoribosyltransferase (EC 2.4.2.7)
    Language English
    Publishing date 2021-05-27
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000516281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Late antibody-mediated rejection in a kidney transplant recipient: COVID 19 induced?

    Nourié, Nicole / Nassereddine, Hussein / Mouawad, Sarah / Chebbou, Louaa / Ghaleb, Rita / Abbas, Fatmeh / Azar, Hiba

    BMC nephrology

    2022  Volume 23, Issue 1, Page(s) 91

    Abstract: Background: Antibody-mediated rejection (AMR) was described in kidney transplant patients after viral infections, such as the cytomegalovirus. Very few cases were recently reported after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ... ...

    Abstract Background: Antibody-mediated rejection (AMR) was described in kidney transplant patients after viral infections, such as the cytomegalovirus. Very few cases were recently reported after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, probably in the context of lowering of immunosuppressive therapy. To date, no direct immunological link was proved to explain a connection between the coronavirus disease 19 (COVID-19) infection and antibody-mediated rejection (AMR) if it exists.
    Case presentation: Here we try to find this association by presenting the case of a low immunological risk patient who presented, six years post-transplant, with c4d negative antibody mediated rejection due to an anti-HLA-C17 de novo donor specific antibody (DSA) after contracting the coronavirus disease 19. The HLA-Cw17 activated the antibody-dependent cell-mediated cytotoxicity via the KIR2DS1 positive NK cells.
    Discussion and conclusions: This case report may prove a direct role for COVID-19 infection in AMRs in the kidney transplant recipients, leading us to closely monitor kidney transplant recipients, especially if they have "at-risk" donor antigens.
    MeSH term(s) Antibodies/immunology ; COVID-19/complications ; Graft Rejection/etiology ; Graft Rejection/immunology ; Humans ; Kidney Transplantation ; Male ; Middle Aged ; Time Factors
    Chemical Substances Antibodies
    Language English
    Publishing date 2022-03-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-022-02713-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effective treatment with Tocilizumab in a COVID-19 patient on maintenance hemodialysis: A case report.

    Nourié, Nicole / Chamaa, Mohamed Ammar / Mouawad, Sarah / Kotait, Micheline Mia / Finianos, Serge / Azar, Hiba / Chelala, Dania

    CEN case reports

    2021  Volume 10, Issue 3, Page(s) 364–369

    Abstract: Coronavirus disease 2019 (COVID-19) is a rapidly spreading infective disease caused by the severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2). The management of this disease remains a challenge particularly in certain subgroups of ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is a rapidly spreading infective disease caused by the severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2). The management of this disease remains a challenge particularly in certain subgroups of patients such in hemodialysis patients who have higher exposure rates due to the nature of their in-hospital care, and higher mortality due to their burden of comorbidities. We report a case of a 52-year-old patient with Von Hippel Lindau syndrome and end-stage renal disease on hemodialysis who contracted COVID-19 infection. Despite the patient's rapidly deteriorating clinical status he was successfully treated with Tocilizumab, after which he showed rapid improvement in his clinical, biological and radiological parameters. Although few studies were available regarding the use of Tocilizumab in the dialysis population, its use proved to be effective and well tolerated in our patient.
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/complications ; COVID-19/drug therapy ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Renal Dialysis
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2021-01-27
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2660492-9
    ISSN 2192-4449 ; 2192-4449
    ISSN (online) 2192-4449
    ISSN 2192-4449
    DOI 10.1007/s13730-021-00577-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ureaplasma urealyticum-encrusted pyelitis in a kidney graft patient: A case report and narrative review on encrusted pyelitis.

    Kotait, Micheline Mia / Nourie, Nicole / Mouawad, Sarah / Alkassis, Marwan / Moukarzel, Maroun / Nehme Chelala, Dania / Azar, Hiba

    Transplant infectious disease : an official journal of the Transplantation Society

    2021  Volume 24, Issue 1, Page(s) e13755

    MeSH term(s) Humans ; Kidney/diagnostic imaging ; Kidney Transplantation/adverse effects ; Pyelitis/etiology ; Ureaplasma urealyticum
    Language English
    Publishing date 2021-12-14
    Publishing country Denmark
    Document type Case Reports ; Letter ; Review
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5100: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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