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Article ; Online: Skin and soft tissue infections due to rapidly growing mycobacteria.

Sepulcri, Chiara / Vena, Antonio / Bassetti, Matteo

2023 Volume 36, Issue 2, Page(s) 74–80

Abstract: Purpose of review: The aim of this article is to review skin and soft tissue infections due to rapidly growing mycobacteria (RGM), with a particular focus on recently published literature (2021-2022).: Recent findings: RGM are increasingly reported ... ...

Abstract	Purpose of review: The aim of this article is to review skin and soft tissue infections due to rapidly growing mycobacteria (RGM), with a particular focus on recently published literature (2021-2022). Recent findings: RGM are increasingly reported as a cause of skin and soft tissue infections, both in the community setting and as a cause of nosocomial outbreaks. Recent advances in molecular methods have expanded the number of species of RGM and resulted in increased diagnosis. New treatment options are under evaluation particularly for Mycobacterium abscessus , the most difficult-to-treat among RGM. Summary: RGM are an uncommon cause of skin and soft tissue infections and a high clinical suspicion together with advanced laboratory facilities are required for diagnosis. Species identification and antimicrobial susceptibility testing are essential to drive appropriate treatment, which combines surgical debridement with prolonged antimycobacterial combination therapy.
MeSH term(s)	Humans ; Soft Tissue Infections/diagnosis ; Soft Tissue Infections/drug therapy ; Mycobacterium ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Skin/microbiology ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-01-30
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	645085-4
ISSN	1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
ISSN (online)	1473-6527 ; 1535-3877
ISSN	0951-7375 ; 1355-834X
DOI	10.1097/QCO.0000000000000905
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Zs.A 2462: Show issues

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Article ; Online: Re: A Prospective Head-to-Head Comparison of 18F-Fluciclovine With 68Ga-PSMA-11 in Biochemical Recurrence of Prostate Cancer in PET/CT.

Evangelista, Laura / Sepulcri, Matteo

Clinical nuclear medicine

2020 Volume 45, Issue 4, Page(s) e219–e220

MeSH term(s)	Edetic Acid ; Humans ; Male ; Membrane Glycoproteins ; Neoplasm Recurrence, Local ; Organometallic Compounds ; Positron Emission Tomography Computed Tomography ; Prospective Studies ; Prostatic Neoplasms
Chemical Substances	Membrane Glycoproteins ; Organometallic Compounds ; gallium 68 PSMA-11 ; Edetic Acid (9G34HU7RV0)
Language	English
Publishing date	2020-01-20
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000002907
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Zs.A 1276: Show issues

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Article ; Online: Triple antiviral treatment for COVID-19 in an immunocompromised patient.

Dentone, Chiara / Mikulska, Malgorzata / Sepulcri, Chiara / Balletto, Elisa / De Pace, Vanessa / Beltramini, Sabrina / Bassetti, Matteo

The Journal of antimicrobial chemotherapy

2023 Volume 78, Issue 8, Page(s) 2097–2099

MeSH term(s)	Humans ; Antiviral Agents/therapeutic use ; COVID-19 ; SARS-CoV-2 ; Treatment Outcome ; Immunocompromised Host
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Letter
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad159
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article: Additional Value of PET and CT Image-Based Features in the Detection of Occult Lymph Node Metastases in Lung Cancer: A Systematic Review of the Literature.

Guglielmo, Priscilla / Marturano, Francesca / Bettinelli, Andrea / Sepulcri, Matteo / Pasello, Giulia / Gregianin, Michele / Paiusco, Marta / Evangelista, Laura

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 13

Abstract: Lung cancer represents the second most common malignancy worldwide and lymph node (LN) involvement serves as a crucial prognostic factor for tailoring treatment approaches. Invasive methods, such as mediastinoscopy and endobronchial ultrasound-guided ... ...

Abstract	Lung cancer represents the second most common malignancy worldwide and lymph node (LN) involvement serves as a crucial prognostic factor for tailoring treatment approaches. Invasive methods, such as mediastinoscopy and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), are employed for preoperative LN staging. Among the preoperative non-invasive diagnostic methods, computed tomography (CT) and, recently, positron emission tomography (PET)/CT with fluorine-18-fludeoxyglucose ([
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13132153
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Article ; Online: Gas Chromatography Combustion Isotope Ratio Mass Spectrometry to Detect Differences in Four Compartments of Simmental Cows Fed on C3 and C4 Diets.

Pianezze, Silvia / Corazzin, Mirco / Bontempo, Luana / Sepulcri, Angela / Saccà, Elena / Perini, Matteo / Piasentier, Edi

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 7

Abstract: Fatty acids (FAs) metabolism in animals represents an important field of study since they influence the quality and the properties of the meat. The aim of this study is to assess the possibility to discriminate the diets of cows in different animal ... ...

Abstract	Fatty acids (FAs) metabolism in animals represents an important field of study since they influence the quality and the properties of the meat. The aim of this study is to assess the possibility to discriminate the diets of cows in different animal compartments and to study the fate of dietary FAs in the bovine organism, using carbon isotopic ratios. Five FAs, both essential (linoleic and linolenic) and non-essential (palmitic, stearic, and oleic) in four compartments (feed, rumen, liver, meat) of animals fed two different diets (based on either C3 or C4 plants) were considered. For all compartments, the carbon isotopic ratio (δ
MeSH term(s)	Animal Feed/analysis ; Animals ; Carbon Isotopes/metabolism ; Cattle ; Diet/veterinary ; Fatty Acids/metabolism ; Female ; Gas Chromatography-Mass Spectrometry/methods ; Rumen/metabolism
Chemical Substances	Carbon Isotopes ; Fatty Acids
Language	English
Publishing date	2022-04-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27072310
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Zs.MO 81: Show issues

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Article ; Online: Role of radiomic analysis of [

Marturano, Francesca / Guglielmo, Priscilla / Bettinelli, Andrea / Zattoni, Fabio / Novara, Giacomo / Zorz, Alessandra / Sepulcri, Matteo / Gregianin, Michele / Paiusco, Marta / Evangelista, Laura

European radiology

2023 Volume 33, Issue 10, Page(s) 7199–7208

Abstract: Aim: To study the feasibility of radiomic analysis of baseline [: Material and methods: Seventy-four patients were prospectively collected. We analyzed three prostate gland (PG) segmentations (i.e., PG: Results: The median baseline prostate- ... ...

Abstract	Aim: To study the feasibility of radiomic analysis of baseline [ Material and methods: Seventy-four patients were prospectively collected. We analyzed three prostate gland (PG) segmentations (i.e., PG Results: The median baseline prostate-specific antigen was 11 ng/mL, the Gleason score was > 7 for 54% of patients, and the clinical stage was T1/T2 for 89% and T3 for 9% of patients. The baseline clinical model achieved an area under the receiver operating characteristic curve (AUC) of 0.73. Performances improved when clinical data were combined with radiomic features, in particular for PG Conclusion: Radiomics reinforces clinical parameters in predicting BCR in intermediate and high-risk PCa patients. These first data strongly encourage further investigations on the use of radiomic analysis to identify patients at risk of BCR. Clinical relevance statement: The application of AI combined with radiomic analysis of [ Key points: • Stratification of patients with intermediate and high-risk prostate cancer at risk of biochemical recurrence before initial treatment would help determine the optimal curative strategy. • Artificial intelligence combined with radiomic analysis of [
MeSH term(s)	Male ; Humans ; Positron Emission Tomography Computed Tomography/methods ; Prostate-Specific Antigen ; Artificial Intelligence ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/therapy ; Retrospective Studies
Chemical Substances	fluoromethylcholine ; Prostate-Specific Antigen (EC 3.4.21.77) ; fluorocholine (6029HGL0QP)
Language	English
Publishing date	2023-04-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-09642-9
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Zs.A 3300: Show issues

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Article ; Online: Loiasis from where you don't expect it: an illustrative case of misled diagnosis.

Nicolini, Ambra Laura / Tamarozzi, Francesca / Pomari, Elena / Mistretta, Manuela / Camera, Marco / Sepulcri, Chiara / Bassetti, Matteo / Gobbi, Federico G

Journal of travel medicine

2022 Volume 29, Issue 7

MeSH term(s)	Humans ; Animals ; Loiasis/diagnosis ; Loiasis/drug therapy ; Loa
Language	English
Publishing date	2022-05-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taac060
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Zs.A 4120: Show issues

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Article ; Online: Lower (1,3)-beta-d-glucan sensitivity and in vitro levels in Candida auris and Candida parapsilosis strains.

Mikulska, Malgorzata / Ullah, Nadir / Magnasco, Laura / Codda, Giulia / Bartalucci, Claudia / Miletich, Franca / Sepulcri, Chiara / Willison, Edward / Vena, Antonio / Giacobbe, Daniele R / di Pilato, Vincenzo / Robba, Chiara / Ball, Lorenzo / Marchese, Anna / Bassetti, Matteo

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2024

Abstract: Objectives: The serum (1,3)-beta-d-glucan (BDG) assay gives quicker results and has higher sensitivity than blood cultures, therefore it is advised for early diagnosis of invasive candidemia and/or discontinuation of empirical therapy. Its sensitivity ... ...

Abstract	Objectives: The serum (1,3)-beta-d-glucan (BDG) assay gives quicker results and has higher sensitivity than blood cultures, therefore it is advised for early diagnosis of invasive candidemia and/or discontinuation of empirical therapy. Its sensitivity may depend on different factors. The aim of our study was to analyse the in vitro and in vivo BDG levels in clinical isolates of three species of Candida responsible for candidemia. Methods: C. albicans, C. parapsilosis, and C. auris strains were collected from blood cultures of patients who had a concurrent (-1 to +3 days) serum BDG test (Fungitell assay). Supernatants of all strains were tested in quadruplicate for BDG levels. Results: Twenty-two C. auris, 14 C. albicans, and ten C. parapsilosis strains were included. The median BDG levels in supernatants were 463 pg/mL (interquartile range [IQR] 379-648) for C. auris, 1080 pg/mL (IQR 830-1276) for C. albicans, and 755 pg/mL (IQR 511-930) for C. parapsilosis, with the significant difference among the species (p < 0.0001). Median serum BDG levels (IQR) were significantly lower in case C. auris and C. parapsilosis vs. C. albicans (p < 0.0001), respectively, 50 pg/mL (IQR 15-161) and 57 pg/mL (IQR 18-332), vs. 372 pg/mL (IQR 102-520). Sensitivity of serum BDG was 39% (95% confidence interval [CI], 18-64) in case of C. auris, 30% (95% CI, 8-65) C. parapsilosis and 78% (95% CI, 49-94) C. albicans candidemia. Discussion: In our centre C. auris and C. parapsilosis strains have lower BDG content as compared with C. albicans, with a potential impact on serum BDG performance for the diagnosis of candidemia.
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2024.02.012
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: Artificial Intelligence-suggested Predictive Model of Survival in Patients Treated With Stereotactic Radiotherapy for Early Lung Cancer.

Borghetti, Paolo / Costantino, Gianluca / Santoro, Valeria / Mataj, Eneida / Singh, Navdeep / Vitali, Paola / Greco, Diana / Volpi, Giulia / Sepulcri, Matteo / Guida, Cesare / Tomasi, Cesare / Buglione, Michela / Nardone, Valerio

In vivo (Athens, Greece)

2024 Volume 38, Issue 3, Page(s) 1359–1366

Abstract: Background/aim: Overall survival (OS)-predictive models to clinically stratify patients with stage I Non-Small Cell Lung Cancer (NSCLC) undergoing stereotactic body radiation therapy (SBRT) are still unavailable. The aim of this work was to build a ... ...

Abstract	Background/aim: Overall survival (OS)-predictive models to clinically stratify patients with stage I Non-Small Cell Lung Cancer (NSCLC) undergoing stereotactic body radiation therapy (SBRT) are still unavailable. The aim of this work was to build a predictive model of OS in this setting. Patients and methods: Clinical variables of patients treated in three Institutions with SBRT for stage I NSCLC were retrospectively collected into a reference cohort A (107 patients) and 2 comparative cohorts B1 (32 patients) and B2 (38 patients). A predictive model was built using Cox regression (CR) and artificial neural networks (ANN) on reference cohort A and then tested on comparative cohorts. Results: Cohort B1 patients were older and with worse chronic obstructive pulmonary disease (COPD) than cohort A. Cohort B2 patients were heavier smokers but had lower Charlson Comorbidity Index (CCI). At CR analysis for cohort A, only ECOG Performance Status 0-1 and absence of previous neoplasms correlated with better OS. The model was enhanced combining ANN and CR findings. The reference cohort was divided into prognostic Group 1 (0-2 score) and Group 2 (3-9 score) to assess model's predictions on OS: grouping was close to statistical significance (p=0.081). One and 2-year OS resulted higher for Group 1, lower for Group 2. In comparative cohorts, the model successfully predicted two groups of patients with divergent OS trends: higher for Group 1 and lower for Group 2. Conclusion: The produced model is a relevant tool to clinically stratify SBRT candidates into prognostic groups, even when applied to different cohorts. ANN are a valuable resource, providing useful data to build a prognostic model that deserves to be validated prospectively.
MeSH term(s)	Humans ; Radiosurgery/methods ; Lung Neoplasms/mortality ; Lung Neoplasms/radiotherapy ; Lung Neoplasms/surgery ; Lung Neoplasms/pathology ; Male ; Female ; Aged ; Prognosis ; Middle Aged ; Artificial Intelligence ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Carcinoma, Non-Small-Cell Lung/surgery ; Carcinoma, Non-Small-Cell Lung/pathology ; Neoplasm Staging ; Aged, 80 and over ; Retrospective Studies ; Neural Networks, Computer
Language	English
Publishing date	2024-04-30
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13576
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Zs.A 2288: Show issues

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Article ; Online: Frequency of Detection of

Magnasco, Laura / Mikulska, Malgorzata / Sepulcri, Chiara / Ullah, Nadir / Giacobbe, Daniele Roberto / Vena, Antonio / Di Pilato, Vincenzo / Willison, Edward / Orsi, Andrea / Icardi, Giancarlo / Marchese, Anna / Bassetti, Matteo

Journal of fungi (Basel, Switzerland)

2023 Volume 10, Issue 1

Abstract: ... Candida ... ...

Abstract	Candida auris
Language	English
Publishing date	2023-12-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof10010026
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