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  1. Article ; Online: Impact of a Hospitalist Co-Management Program on Medical Complications and Length of Stay in Neurosurgical Patients.

    Marchán-López, Álvaro / Lora-Tamayo, Jaime / de la Calle, Cristina / Jiménez Roldán, Luis / Moreno Gómez, Luis Miguel / Sáez de la Fuente, Ignacio / Chico Fernández, Mario / Lagares, Alfonso / Lumbreras, Carlos / García Reyne, Ana

    Joint Commission journal on quality and patient safety

    2024  Volume 50, Issue 5, Page(s) 318–325

    Abstract: Background: The impact of co-management on clinical outcomes in neurosurgical patients is uncertain. This study aims to describe the implementation of a hospitalist co-management program in a neurosurgery department and its impact on the incidence of ... ...

    Abstract Background: The impact of co-management on clinical outcomes in neurosurgical patients is uncertain. This study aims to describe the implementation of a hospitalist co-management program in a neurosurgery department and its impact on the incidence of complications, mortality, and length of stay.
    Methods: The authors used a quasi-experimental study design that compared a historical control period (July-December 2017) to a prospective intervention arm. During the intervention period, patients admitted to a neurosurgery inpatient unit who were older than 65 years, suffered certain conditions, or were admitted from ICUs were included in the co-management program. Two hospitalists joined the surgical staff and intervened in the diagnostic and therapeutical plan of patients, participating in clinical decisions and coordinating patient navigation with neurosurgeons. The incidence of moderate or severe complications measured by the Accordion Severity Grading System, in-hospital mortality, and length of stay of the two cohorts were compared. Multivariate regression was used to adjust for confounders, and the average treatment effect was estimated using inverse probability of treatment weighting.
    Results: The adjusted incidence of moderate or severe complications was lower among co-managed patients (odds ratio [OR] 0.60, 95% confidence interval [CI] 0.39-0.91). Mortality was unchanged (OR 0.83, 95% CI 0.15-4.17). Length of stay was lower in co-managed patients, with a 1.3-day reduction observed after inverse probability of treatment weighting analysis.
    Conclusion: Hospitalist co-management was associated with a reduced incidence of complications and length of stay in neurosurgical patients, but there was no difference in in-hospital mortality.
    MeSH term(s) Humans ; Length of Stay/statistics & numerical data ; Hospitalists ; Female ; Male ; Aged ; Hospital Mortality ; Neurosurgical Procedures ; Postoperative Complications/epidemiology ; Middle Aged ; Prospective Studies ; Incidence
    Language English
    Publishing date 2024-01-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1189890-2
    ISSN 1938-131X ; 1549-425X ; 1553-7250 ; 1070-3241 ; 1549-3741
    ISSN (online) 1938-131X ; 1549-425X
    ISSN 1553-7250 ; 1070-3241 ; 1549-3741
    DOI 10.1016/j.jcjq.2024.01.003
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  2. Article ; Online: Nitridation effect on lithium iron phosphate cathode for rechargeable batteries.

    Mayer, Sergio Federico / de la Calle, Cristina / Fernández-Díaz, María Teresa / Amarilla, José Manuel / Alonso, José Antonio

    RSC advances

    2022  Volume 12, Issue 6, Page(s) 3696–3707

    Abstract: A novel oxynitride ... ...

    Abstract A novel oxynitride Li
    Language English
    Publishing date 2022-01-28
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra07574h
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  3. Article ; Online: Younger Age in Adolescent Pregnancies Is Associated with Higher Risk of Adverse Outcomes.

    de la Calle, Maria / Bartha, Jose L / Lopez, Cristina M / Turiel, Miriam / Martinez, Nuria / Arribas, Silvia M / Ramiro-Cortijo, David

    International journal of environmental research and public health

    2021  Volume 18, Issue 16

    Abstract: ... La Paz (HULP, Madrid, Spain). The clinical history of 279 women who delivered between 2013 and 2018 ...

    Abstract Adolescent pregnancy remains a health issue worldwide also in developed countries, since it has been associated with adverse maternal and neonatal outcomes. Some data suggest that very young adolescents have higher risk, likely due to immaturity. Therefore, we aimed to assess the influence of maternal age on complications during gestation and labor in pregnant women between 13 and 19 years of age. In particular, we evaluated the possible association between maternal age and obstetric, fetal and labor complications. This is a retrospective, observational and exploratory study conducted at Hospital Universitario La Paz (HULP, Madrid, Spain). The clinical history of 279 women who delivered between 2013 and 2018 was analyzed. Maternal age and the presence of maternal, fetal and labor complications, as well as risk of postpartum depression and breastfeeding intention, were recorded. General regression models were used to analyze the contribution of maternal age on each complication. The percentage of adolescent pregnancies at HULP between 2013 and 2018 was 0.9%. The risk of all the maternal complications analyzed decreased significantly with every year of age of the mother (hyperemesis, lower back pain, anemia, gestational diabetes mellitus, and threat of premature labor and premature rupture of membranes). Every year of maternal age decreased 0.8-fold [0.8; 0.9] the prevalence of fetal complications and also reduced the risk of C-section, postpartum hemorrhage and obstetrical hysterectomy. Furthermore, higher maternal age increased 1.1-fold [1.0; 1.2] the breastfeeding intention. In conclusion, young adolescents are at higher risk of complications during pregnancy and labor.
    MeSH term(s) Adolescent ; Adult ; Cesarean Section ; Female ; Humans ; Infant, Newborn ; Obstetric Labor Complications ; Obstetric Labor, Premature ; Pregnancy ; Pregnancy Complications ; Pregnancy Outcome/epidemiology ; Pregnancy in Adolescence ; Premature Birth ; Retrospective Studies ; Young Adult
    Language English
    Publishing date 2021-08-12
    Publishing country Switzerland
    Document type Journal Article ; Observational Study
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18168514
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  4. Article: Nitridation effect on lithium iron phosphate cathode for rechargeable batteries

    Mayer, Sergio Federico / de la Calle, Cristina / Fernández-Díaz, María Teresa / Amarilla, José Manuel / Alonso, José Antonio

    RSC advances. 2022 Jan. 28, v. 12, no. 6

    2022  

    Abstract: A novel oxynitride Li₀.₉₄FePO₃.₈₄N₀.₁₆ with olivine structure (space group Pnma, no. 62) has been synthesized by heating a parent LiFePO₄ precursor obtained by citrate chemistry in flowing ammonia at 650 °C. The polycrystalline sample has been ... ...

    Abstract A novel oxynitride Li₀.₉₄FePO₃.₈₄N₀.₁₆ with olivine structure (space group Pnma, no. 62) has been synthesized by heating a parent LiFePO₄ precursor obtained by citrate chemistry in flowing ammonia at 650 °C. The polycrystalline sample has been characterized by X-ray and neutron powder diffraction (NPD), elemental and thermal analysis, scanning electron microscopy (SEM) and electrochemical measurements. Based on the existing contrast between the scattering lengths of the N and O species, a Rietveld refinement of the structure from NPD data revealed that N preferentially occupies the O2 positions, as likely required to fulfil the bonding power of N ions. The refined crystallographic formula implies an oxidation state of 2.2+ for Fe cations. The differential thermal analysis, in still air, shows a strong exothermic peak at 520–540 °C due to the combustion of C contents, which are embedding the olivine particles, as observed by SEM. The electrochemical measurements suggest a better performance for the nitrided sample relative to the unnitrided LiFePO₄ material, as far as capacity and cyclability are concerned. A bond-valence energy landscape study reveals a decrease in the percolation activation energy of about 6% upon nitridation, concomitant with the better electrochemical properties of the oxynitride compound. Additionally, ceramic samples prepared under NH₃ flow could be obtained as pure and well-crystallized olivine phases at milder temperatures (650 °C) than those usually described in literature.
    Keywords X-radiation ; activation energy ; air ; ammonia ; cathodes ; ceramics ; citrates ; combustion ; differential thermal analysis ; electrochemistry ; heat production ; iron phosphates ; lithium ; neutron diffraction ; olivine
    Language English
    Dates of publication 2022-0128
    Size p. 3696-3707.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/d1ra07574h
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Clonal architecture and evolutionary history of Waldenström's macroglobulinemia at the single-cell level.

    García-Sanz, Ramón / García-Álvarez, María / Medina, Alejandro / Askari, Elham / González-Calle, Verónica / Casanova, María / de la Torre-Loizaga, Igor / Escalante-Barrigón, Fernando / Bastos-Boente, Miguel / Bárez, Abelardo / Vidaña-Bedera, Nerea / Alonso, José María / Sarasquete, María Eugenia / González, Marcos / Chillón, María Carmen / Alcoceba, Miguel / Jiménez, Cristina

    Disease models & mechanisms

    2023  Volume 16, Issue 8

    Abstract: To provide insight into the subclonal architecture and co-dependency patterns of the alterations in Waldenström's macroglobulinemia (WM), we performed single-cell mutational and protein profiling of eight patients. A custom panel was designed to screen ... ...

    Abstract To provide insight into the subclonal architecture and co-dependency patterns of the alterations in Waldenström's macroglobulinemia (WM), we performed single-cell mutational and protein profiling of eight patients. A custom panel was designed to screen for mutations and copy number alterations at the single-cell level in samples taken from patients at diagnosis (n=5) or at disease progression (n=3). Results showed that in asymptomatic WM at diagnosis, MYD88L265P was the predominant clonal alteration; other events, if present, were secondary and subclonal to MYD88L265P. In symptomatic WM, clonal diversity was more evident, uncovering combinations of alterations that synergized to promote clonal expansion and dominance. At disease progression, a dominant clone was observed, sometimes accompanied by other less complex minor clones, which could be consistent with a clonal selection process. Clonal diversity was also reduced, probably due to the effect of treatment. Finally, we combined protein expression with mutational analysis to map somatic genotype with the immunophenotype. Our findings provide a comprehensive view of the clonality of tumor populations in WM and how clonal complexity can evolve and impact disease progression.
    MeSH term(s) Waldenstrom Macroglobulinemia/diagnosis ; Waldenstrom Macroglobulinemia/genetics ; Humans ; Single-Cell Analysis ; Clonal Evolution ; Protein Array Analysis ; Mutation ; DNA Copy Number Variations ; Myeloid Differentiation Factor 88/genetics ; DNA Mutational Analysis
    Chemical Substances MYD88 protein, human ; Myeloid Differentiation Factor 88
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050227
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  6. Article ; Online: Impact of viral load at admission on the development of respiratory failure in hospitalized patients with SARS-CoV-2 infection.

    de la Calle, Cristina / Lalueza, Antonio / Mancheño-Losa, Mikel / Maestro-de la Calle, Guillermo / Lora-Tamayo, Jaime / Arrieta, Estibaliz / García-Reyne, Ana / Losada, Irene / de Miguel, Borja / Díaz-Simón, Raquel / López-Medrano, Francisco / Fernández-Ruiz, Mario / Carretero, Octavio / San Juan, Rafael / Aguado, José María / Lumbreras, Carlos

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2021  Volume 40, Issue 6, Page(s) 1209–1216

    Abstract: The aim of our study was to elucidate if SARS-CoV-2 viral load on admission, measured by real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value on nasopharyngeal samples, was a marker of disease severity. All ... ...

    Abstract The aim of our study was to elucidate if SARS-CoV-2 viral load on admission, measured by real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value on nasopharyngeal samples, was a marker of disease severity. All hospitalized adult patients with a diagnosis of SARS-CoV-2 infection by rRT-PCR performed on a nasopharingeal sample from March 1 to March 18 in our institution were included. The study population was divided according to the Ct value obtained upon admission in patients with high viral load (Ct < 25), intermediate viral load (Ct: 25-30) and low viral load (Ct > 30). Demographic, clinical and laboratory variables of the different groups were analyzed to assess the influence of viral load on the development of respiratory failure during admission. Overall, 455 sequential patients were included. The median Ct value was 28 (IQR: 24-32). One hundred and thirty patients (28.6%) had a high viral load, 175 (38.5%) an intermediate viral load and 150 (33%) a low viral load. Advanced age, male sex, presence of cardiovascular disease and laboratory markers such as lactate dehydrogenase, lymphocyte count and C-reactive protein, as well as a high viral load on admission, were predictive of respiratory failure. A Ct value < 25 was associated with a higher risk of respiratory failure during admission (OR: 2.99, 95%IC: 1.57-5.69). SARS-CoV-2 viral load, measured through the Ct value on admission, is a valuable tool to predict the development of respiratory failure in COVID-19 inpatients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19 Nucleic Acid Testing ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Nasopharynx/virology ; Real-Time Polymerase Chain Reaction ; Respiratory Insufficiency/virology ; Viral Load
    Language English
    Publishing date 2021-01-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-020-04150-w
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  7. Article ; Online: Analysis of the factors predicting clinical response to tocilizumab therapy in patients with severe COVID-19.

    San-Juan, Rafael / Fernández-Ruiz, Mario / López-Medrano, Francisco / Carretero, Octavio / Lalueza, Antonio / Maestro de la Calle, Guillermo / Pérez-Jacoiste Asín, María Asunción / Bueno, Héctor / Caro-Teller, José Manuel / Catalán, Mercedes / de la Calle, Cristina / García-García, Rocío / Gómez, Carlos / Laguna-Goya, Rocío / Lizasoáin, Manuel / Martínez-López, Joaquín / Origüen, Julia / Sevillano, Ángel / Gutiérrez, Eduardo /
    de Miguel, Borja / Aguilar, Fernando / Parra, Patricia / Ripoll, Mar / Ruiz-Merlo, Tamara / Trujillo, Hernando / Pablos, José Luis / Paz-Artal, Estela / Lumbreras, Carlos / Aguado, José María

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2022  Volume 117, Page(s) 56–64

    Abstract: ... by a local committee and were admitted to the University Hospital "12 de Octubre" until May 2020. The primary ...

    Abstract Background: Controversy remains about the efficacy of tocilizumab (TCZ) for the treatment of severe COVID-19. We aimed to analyze the profile of TCZ-respondent patients.
    Methods: We retrospectively analyzed a cohort of patients with severe COVID-19 who received off-label TCZ after recommendation by a local committee and were admitted to the University Hospital "12 de Octubre" until May 2020. The primary end point was a significant clinical improvement (SCI) on day 14 after administration of TCZ. Factors independently related to SCI were analyzed by multivariate logistic regression models.
    Results: Of 428 (63.3%) patients treated with TCZ, 271 (63.3%) experienced SCI. After adjustment for factors related to unfavorable outcomes, TCZ administration within the first 48 hours from admission (odds ratio [OR]: 1.98, 95% confidence Interval [95% CI]: 1.1-3.55; P = 0.02) and ALT levels >100 UI/L at day 0 (OR: 3.28; 95% CI: 1.3-8.1; P = 0.01) were independently related to SCI. The rate of SCI significantly decreased according to the time of TCZ administration: 70.2% in the first 48 hours from admission, 58.5% on days 3-7, and 45.1% after day 7 (P = 0.03 and P = 0.001, respectively).
    Conclusion: TCZ improves the prognosis of patients with COVID-19 the most if treatment starts within the first 48 hours after admission.
    MeSH term(s) Antibodies, Monoclonal, Humanized ; COVID-19/drug therapy ; Humans ; Retrospective Studies ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2022-01-23
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2022.01.040
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    Zs.A 4516: Show issues Location:
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  8. Article ; Online: Younger Age in Adolescent Pregnancies Is Associated with Higher Risk of Adverse Outcomes

    Maria de la Calle / Jose L. Bartha / Cristina M. Lopez / Miriam Turiel / Nuria Martinez / Silvia M. Arribas / David Ramiro-Cortijo

    International Journal of Environmental Research and Public Health, Vol 18, Iss 8514, p

    2021  Volume 8514

    Abstract: ... La Paz (HULP, Madrid, Spain). The clinical history of 279 women who delivered between 2013 and 2018 ...

    Abstract Adolescent pregnancy remains a health issue worldwide also in developed countries, since it has been associated with adverse maternal and neonatal outcomes. Some data suggest that very young adolescents have higher risk, likely due to immaturity. Therefore, we aimed to assess the influence of maternal age on complications during gestation and labor in pregnant women between 13 and 19 years of age. In particular, we evaluated the possible association between maternal age and obstetric, fetal and labor complications. This is a retrospective, observational and exploratory study conducted at Hospital Universitario La Paz (HULP, Madrid, Spain). The clinical history of 279 women who delivered between 2013 and 2018 was analyzed. Maternal age and the presence of maternal, fetal and labor complications, as well as risk of postpartum depression and breastfeeding intention, were recorded. General regression models were used to analyze the contribution of maternal age on each complication. The percentage of adolescent pregnancies at HULP between 2013 and 2018 was 0.9%. The risk of all the maternal complications analyzed decreased significantly with every year of age of the mother (hyperemesis, lower back pain, anemia, gestational diabetes mellitus, and threat of premature labor and premature rupture of membranes). Every year of maternal age decreased 0.8-fold [0.8; 0.9] the prevalence of fetal complications and also reduced the risk of C-section, postpartum hemorrhage and obstetrical hysterectomy. Furthermore, higher maternal age increased 1.1-fold [1.0; 1.2] the breastfeeding intention. In conclusion, young adolescents are at higher risk of complications during pregnancy and labor.
    Keywords adolescent pregnancy ; maternal complications ; fetal complications ; labor complications ; obstetrical control ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The Relationship between Serum Adipokines, miR-222-3p, miR-103a-3p and Glucose Regulation in Pregnancy and Two to Three Years Post-Delivery in Women with Gestational Diabetes Mellitus Adhering to Mediterranean Diet Recommendations.

    Valerio, Johanna / Barabash, Ana / Garcia de la Torre, Nuria / De Miguel, Paz / Melero, Verónica / Del Valle, Laura / Moraga, Inmaculada / Familiar, Cristina / Durán, Alejandra / Torrejón, Maria Jose / Diaz, Angel / Jiménez, Inés / Matia, Pilar / Rubio, Miguel Angel / Calle-Pascual, Alfonso Luis

    Nutrients

    2022  Volume 14, Issue 22

    Abstract: The San Carlos Gestational Diabetes Mellitus (GDM) prevention study, a nutritional intervention RCT based on a Mediterranean Diet (MedDiet), has been shown to reduce the incidence of GDM. The objective of this study is to investigate the relationship of ... ...

    Abstract The San Carlos Gestational Diabetes Mellitus (GDM) prevention study, a nutritional intervention RCT based on a Mediterranean Diet (MedDiet), has been shown to reduce the incidence of GDM. The objective of this study is to investigate the relationship of leptin, adiponectin, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), insulin and HOMA-IRand circulating miRNAs (miR-29a-3p, miR-103a-3p, miR-132-3p, miR-222-3p) with the appearance of GDM and with MedDiet-based nutritional intervention, at 24−28 gestational weeks (GW), and in glucose regulation 2−3 years post-delivery (PD). A total of 313 pregnant women, 77 with GDM vs. 236 with normal glucose tolerance (NGT), 141 from the control group (CG, MedDiet restricting the consumption of dietary fat including EVOO and nuts during pregnancy) vs. 172 from the intervention group (IG, MedDiet supplemented with extra virgin olive oil (EVOO) and pistachios during pregnancy) were compared at Visit 1 (8−12 GW), Visit 2 (24−28 GW) and Visit 3 (2−3 years PD). Expression of miRNAs was determined by the Exiqon miRCURY LNA RT-PCR system. Leptin, adiponectin, IL-6 and TNF-α, were measured by Milliplex® immunoassays on Luminex 200 and insulin by RIA. Women with GDM vs. NTG had significantly higher leptin median (Q1−Q3) levels (14.6 (9.2−19.4) vs. 9.6 (6.0−15.1) ng/mL; p < 0.05) and insulin levels (11.4 (8.6−16.5) vs. 9.4 (7.0−12.8) µUI/mL; p < 0.001) and lower adiponectin (12.9 (9.8−17.2) vs. 17.0 (13.3−22.4) µg/mL; p < 0.001) at Visit 2. These findings persisted in Visit 3, with overexpression of miR-222-3p (1.45 (0.76−2.21) vs. 0.99 (0.21−1.70); p < 0.05)) and higher levels of Il-6 and TNF-α. When the IG is compared with the CG lower levels of insulin, HOMA-IR-IR, IL-6 levels at Visit 2 and 3 and leptin levels only at Visit 2 were observed. An overexpression of miR-222-3p and miR-103a-3p were also observed in IG at Visit 2 and 3. The miR-222-3p and miR103a-3p expression correlated with insulin levels, HOMA-IR, IL-6 and TNF-α at Visit 2 (all p < 0.05). These data support the association of leptin, adiponectin and insulin/HOMA-IR with GDM, as well as the association of insulin/HOMA-IR and IL-6 and miR-222-3p and miR-103a-3p expression with a MedDiet-based nutritional intervention.
    MeSH term(s) Pregnancy ; Female ; Humans ; Adipokines ; Diabetes, Gestational ; Leptin ; Glucose ; Diet, Mediterranean ; Adiponectin ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Insulin ; MicroRNAs/genetics ; Olive Oil
    Chemical Substances Adipokines ; Leptin ; Glucose (IY9XDZ35W2) ; Adiponectin ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Insulin ; MicroRNAs ; Olive Oil ; MIRN222 microRNA, human
    Language English
    Publishing date 2022-11-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14224712
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  10. Article ; Online: Association of anti-SARS-COV-2 vaccine with increased incidence of myositis-related anti-RNA-synthetases auto-antibodies.

    García-Bravo, Laura / Calle-Rubio, Myriam / Fernández-Arquero, Miguel / Mohamed Mohamed, Kauzar / Guerra-Galán, Teresa / Guzmán-Fulgencio, María / Rodríguez de la Peña, Antonia / Cañizares, Cristina / López, Bárbara / Vadillo, Cristina / Matías-Guiu, Jorge / Nieto Barbero, Asunción / Álvarez-Sala Walther, José Luis / Sánchez-Ramón, Silvia / Ochoa-Grullón, Juliana

    Journal of translational autoimmunity

    2022  Volume 5, Page(s) 100160

    Abstract: Introduction: SARS-CoV-2 is a RNA virus that associates with heterogeneous clinical manifestations and complications. Auto-antibodies are identified in approximately 50% of hospitalized COVID-19 patients.: Objectives: To determine the global ... ...

    Abstract Introduction: SARS-CoV-2 is a RNA virus that associates with heterogeneous clinical manifestations and complications. Auto-antibodies are identified in approximately 50% of hospitalized COVID-19 patients.
    Objectives: To determine the global incidence of myositis-related auto-antibodies (non Jo1-RNA synthetases: anti-PL7, anti-PL12, anti-EJ, anti-OJ and RNA-sensor: anti-MDA5) in our laboratory during COVID-19 pandemics, and to describe the clinical and laboratory features of these patients.
    Study design: A retrospective study was performed from 2015 to 2021 in a cohort of 444 patients with suspected inflammatory myopathy. The incidence of positive results for the MSA was expressed as absolute value per year for the reference population. Immunoblot analysis, indirect immunofluorescence and HLA typing of 36 patients with positivity for MSAs were collected and analyzed.
    Results: We observed MSA positive in 28 patients in 2020 and 36 patients in 2021, representing a mean increase of 6-fold respect to previous years since 2015 (range, 0 to 19). In 2020, the most common antibody detected was anti-MDA5 (68%). In contrast, in 2021 the most common antibodies were anti-PL7 and/or anti-PL12 (69%). All patients in 2021 with positive anti-synthetases were fully vaccinated, 4 had previous documented infection, with median time from vaccine to MSA positivity of 5 months. Eight out of 36 patients (22%) reported clinical onset after SARS-CoV-2 vaccination and 6 out of 36 (17%) presented clinical and/or radiological worsening after SARS-CoV-2 vaccination. All patients presented with a known human leukocyte antigen (HLA)-DRB1* allele associated with ASS. The most prevalent alleles identified were DRB1*03:01, DRB1*04, DRB1*11:01, corresponding to 70% (16/23) of our cohort.
    Conclusions: Our preliminary data show an increased incidence of anti-synthetase antibodies during COVID-19 pandemic and SARS-CoV-2 vaccination associated to HLA DRB1* risk allele. Differential profiles of MSA specificities were observed: mainly against RNA-sensors in 2020 and against RNA-synthetases in 2021. Further studies are needed to support the association between SARS-CoV-2 infection and/or vaccination and the occurrence of this autoimmune syndrome.
    Language English
    Publishing date 2022-06-30
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-9090
    ISSN (online) 2589-9090
    DOI 10.1016/j.jtauto.2022.100160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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