LIVIVO - Search results -

Search results

Result 1 - 10 of total 57

Search options

Article ; Online: Machine-learning prediction models for any blood component transfusion in hospitalized dengue patients.

Ansari, Md Shahid / Jain, Dinesh / Budhiraja, Sandeep

Hematology, transfusion and cell therapy

2023

Abstract: Background: Blood component transfusions are a common and often necessary medical practice during the epidemics of dengue. Transfusions are required for patients when they developed severe dengue fever or thrombocytopenia of 10×10: Methods: Eight ... ...

Abstract	Background: Blood component transfusions are a common and often necessary medical practice during the epidemics of dengue. Transfusions are required for patients when they developed severe dengue fever or thrombocytopenia of 10×10 Methods: Eight predictive models were developed based on retrospective data from a private group of hospitals in India. A python package SHAP (SHapley Additive exPlanations) was used to explain the output of the "XGBoost" model. Results: Sixteen vital variables were finally selected as having the most significant effects on blood component transfusion prediction. The XGBoost model presented significantly better predictive performance (area under the curve: 0.793; 95 % confidence interval: 0.699-0.795) than the other models. Conclusion: Predictive modelling techniques can be utilized to streamline blood component preparation procedures and can help in the triage of high-risk patients and readiness of caregivers to provide blood component transfusions when required. This study demonstrates the potential of multilayer algorithms to reasonably predict any blood component transfusion needs which may help healthcare providers make more informed decisions regarding patient care.
Language	English
Publishing date	2023-11-17
Publishing country	Brazil
Document type	Journal Article
ISSN	2531-1387
ISSN (online)	2531-1387
DOI	10.1016/j.htct.2023.09.2365
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Evaluation of ACS-NSQIP and CR-POSSUM risk calculators for the prediction of mortality after colorectal surgery: A retrospective cohort study.

Vashistha, Nitin / Singhal, Siddharth / Budhiraja, Sandeep / Singhal, Dinesh

Journal of minimal access surgery

2022 Volume 20, Issue 2, Page(s) 142–147

Abstract: Background: Several risk calculating tools have been introduced into clinical practice to provide patients and clinicians with objective, individualised estimates of procedure-related unfavourable outcomes. The currently available risk calculators (RCs) ...

Abstract	Background: Several risk calculating tools have been introduced into clinical practice to provide patients and clinicians with objective, individualised estimates of procedure-related unfavourable outcomes. The currently available risk calculators (RCs) have been developed by well-endowed health systems in Europe and the USA. Applicability of these RCs in low-middle income country (LMIC) settings with wide disparities in patient population, surgical practice and healthcare infrastructure has not been adequately examined. Patients and methods: Through this single tertiary care, LMIC-centre, retrospective cohort study, we investigated the accuracy of the two most widely validated RCs - American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) RC and ColoRectal Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity (CR-POSSUM) - for the prediction of mortality in patients undergoing elective and emergency colorectal surgery (CRS) from March 2013 to March 2020. Online RCs were used to predict mortality and other outcomes. Accuracy was assessed by Brier score and C statistic. Results: Of 105 patients, 69 (65.71%) underwent elective and 36 (34.28%) underwent emergency CRS. The 30-day overall mortality was 12 - elective 1 (1.4%) and emergency 11 (30.5%). ACS-NSQIP RC performed better for the prediction of overall ( C statistic 0.939, Brier score 0.065) and emergency ( C statistic 0.840, Brier score 0.152) mortality. However, for elective CRS mortality, Brier scores were similar for both models (0.014), whereas C statistic (0.934 vs. 0.890) value was better for ACS-NSQIP. Conclusions: Both ACS-NSQIP and CR-POSSUM were accurate for the prediction of CRS mortality. However, compared to CR-POSSUM, ACS-NSQIP performed better. The overall performance of both models is indicative of their wider applicability in LMIC centres also.
Language	English
Publishing date	2022-09-12
Publishing country	India
Document type	Journal Article
ZDB-ID	2186884-0
ISSN	1998-3921 ; 0972-9941
ISSN (online)	1998-3921
ISSN	0972-9941
DOI	10.4103/jmas.jmas_187_22
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Longitudinal study across SARS-CoV-2 variants identifies transcriptionally active microbes (TAMs) associated with Delta severity.

Devi, Priti / Kumari, Pallawi / Yadav, Aanchal / Tarai, Bansidhar / Budhiraja, Sandeep / Shamim, Uzma / Pandey, Rajesh

iScience

2023 Volume 26, Issue 10, Page(s) 107779

Abstract: Emergence of new SARS-CoV-2 VOCs jeopardize global vaccine and herd immunity safeguards. VOCs interactions with host microbiota might affect clinical course and outcome. This longitudinal investigation involving Pre-VOC and VOCs (Delta & Omicron) holo- ... ...

Abstract	Emergence of new SARS-CoV-2 VOCs jeopardize global vaccine and herd immunity safeguards. VOCs interactions with host microbiota might affect clinical course and outcome. This longitudinal investigation involving Pre-VOC and VOCs (Delta & Omicron) holo-transcriptome based nasopharyngeal microbiome at taxonomic levels followed by metabolic pathway analysis and integrative host-microbiome interaction. VOCs showed enrichment of
Language	English
Publishing date	2023-08-29
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107779
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: SARS-CoV-2 infection severity and mortality is modulated by repeat-mediated regulation of alternative splicing.

Mehta, Priyanka / Chattopadhyay, Partha / Ravi, Varsha / Tarai, Bansidhar / Budhiraja, Sandeep / Pandey, Rajesh

Microbiology spectrum

2023 , Page(s) e0135123

Abstract: Like single-stranded RNA viruses, SARS-CoV-2 hijacks the host transcriptional machinery for its own replication. Numerous traditional differential gene expression-based investigations have examined the diverse clinical symptoms caused by SARS-CoV-2 ... ...

Abstract	Like single-stranded RNA viruses, SARS-CoV-2 hijacks the host transcriptional machinery for its own replication. Numerous traditional differential gene expression-based investigations have examined the diverse clinical symptoms caused by SARS-CoV-2 infection. The virus, on the other hand, also affects the host splicing machinery, causing host transcriptional dysregulation, which can lead to diverse clinical outcomes. Hence, in this study, we performed host transcriptome sequencing of 125 hospital-admitted COVID-19 patients to understand the transcriptomic differences between the severity sub-phenotypes of mild, moderate, severe, and mortality. We performed transcript-level differential expression analysis, investigated differential isoform usage, looked at the splicing patterns within the differentially expressed transcripts (DET), and elucidated the possible genome regulatory features. Our DTE analysis showed evidence of diminished transcript length and diversity as well as altered promoter site usage in the differentially expressed protein-coding transcripts in the COVID-19 mortality patients. We also investigated the potential mechanisms driving the alternate splicing and discovered a compelling differential enrichment of repeats in the promoter region and a specific enrichment of SINE (Alu) near the splicing sites of differentially expressed transcripts. These findings suggested a repeat-mediated plausible regulation of alternative splicing as a potential modulator of COVID-19 disease severity. In this work, we emphasize the role of scarcely elucidated functional role of alternative splicing in influencing COVID-19 disease severity sub-phenotypes, clinical outcomes, and its putative mechanism. IMPORTANCE The wide range of clinical symptoms reported during the COVID-19 pandemic inherently highlights the numerous factors that influence the progression and prognosis of SARS-CoV-2 infection. While several studies have investigated the host response and discovered immunological dysregulation during severe infection, most of them have the common theme of focusing only up to the gene level. Viruses, especially RNA viruses, are renowned for hijacking the host splicing machinery for their own proliferation, which inadvertently puts pressure on the host transcriptome, exposing another side of the host response to the pathogen challenge. Therefore, in this study, we examine host response at the transcript-level to discover a transcriptional difference that culminates in differential gene-level expression. Importantly, this study highlights diminished transcript diversity and possible regulation of transcription by differentially abundant repeat elements near the promoter region and splicing sites in COVID-19 mortality patients, which together with differentially expressed isoforms hold the potential to elaborate disease severity and outcome.
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.01351-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Transcriptionally active nasopharyngeal commensals and opportunistic microbial dynamics define mild symptoms in the COVID 19 vaccination breakthroughs.

Devi, Priti / Kumari, Pallawi / Yadav, Aanchal / Tarai, Bansidhar / Budhiraja, Sandeep / Shamim, Uzma / Pandey, Rajesh

PLoS pathogens

2023 Volume 19, Issue 2, Page(s) e1011160

Abstract: The development of COVID 19 vaccines as an effort to mitigate the outbreak, has saved millions of lives globally. However, vaccination breakthroughs have continuously challenged the vaccines' effectiveness and provided incentives to explore facets ... ...

Abstract	The development of COVID 19 vaccines as an effort to mitigate the outbreak, has saved millions of lives globally. However, vaccination breakthroughs have continuously challenged the vaccines' effectiveness and provided incentives to explore facets holding potential to alter vaccination-induced immunity and protection from subsequent infection, especially VOCs (Variants Of Concern). We explored the functional dynamics of nasopharyngeal transcriptionally active microbes (TAMs) between vaccination breakthroughs and unvaccinated SARS-CoV-2 infected individuals. Microbial taxonomic communities were differentially altered with skewed enrichment of bacterial class/genera of Firmicutes and Gammaproteobacteria with grossly reduced phylum Bacteroidetes in vaccination breakthrough individuals. The Bacillus genus was abundant in Firmicutes in vaccination breakthrough whereas Prevotella among Bacteroides dominated the unvaccinated. Also, Pseudomonas and Salmonella of Gammaproteobacteria were overrepresented in vaccination breakthrough, whilst unvaccinated showed presence of several genera, Achromobacter, Bordetella, Burkholderia, Neisseria, Hemophilus, Salmonella and Pseudomonas, belonging to Proteobacteria. At species level, the microbiota of vaccination breakthrough exhibited relatively higher abundance of unique commensals, in comparison to potential opportunistic microbes enrichment in unvaccinated patients' microbiota. Functional metabolic pathways like amino acid biosynthesis, sulphate assimilation, fatty acid and beta oxidation, associated with generation of SCFAs (short chain fatty acids), were enriched in vaccination breakthroughs. Majorly, metabolic pathways of LCFAs biosynthesis (long chain fatty acids; oleate, dodecenoate, palmitoleate, gondoate) were found associated with the unvaccinated. Our research highlights that vaccination decreases the microbial diversity in terms of depleting opportunistic pathogens and increasing the preponderance of commensals with respect to unvaccinated patients. Metabolic pathway analysis substantiates the shift in diversity to functionally modulate immune response generation, which may be related to mild clinical manifestations and faster recovery times during vaccination breakthroughs.
MeSH term(s)	Humans ; COVID-19/prevention & control ; COVID-19 Vaccines ; SARS-CoV-2/genetics ; Vaccination ; Bacteroidetes ; Fatty Acids ; Gammaproteobacteria
Chemical Substances	COVID-19 Vaccines ; Fatty Acids
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1011160
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Clinical Associations of Liver Injury in COVID-19.

Madan, Kaushal / Bhargava, Richa / Dewan, Arun / Budhiraja, Sandeep / Aggarwal, Ritesh / Jadaun, Shekhar Singh / Raj, Vivek / Mishra, Ram Shankar / Indrayan, Abhaya

The Journal of the Association of Physicians of India

2023 Volume 70, Issue 10, Page(s) 11–12

MeSH term(s)	Humans ; COVID-19 ; Liver ; SARS-CoV-2 ; Liver Diseases/etiology
Language	English
Publishing date	2023-06-25
Publishing country	India
Document type	Journal Article
ZDB-ID	800766-4
ISSN	0004-5772
ISSN	0004-5772
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 313: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Amoxicillin+clavulanic acid in community acquired pneumonia

Sandeep Budhiraja / Akhil Agarwal / Yashpal Chugh / Alap Gandhi / Bhavesh Kotak

Asian Journal of Medical Sciences, Vol 13, Iss 8, Pp 235-

Past, present, and future from an Indian perspective

2022 Volume 244

Abstract: Community acquired pneumonia (CAP) is a major health problem in India with high morbidity and mortality. The threat posed by this infection is further intensified by the continued emergence of resistance to the currently available antibiotics. With a ... ...

Abstract	Community acquired pneumonia (CAP) is a major health problem in India with high morbidity and mortality. The threat posed by this infection is further intensified by the continued emergence of resistance to the currently available antibiotics. With a heritage of more than 24 years in India, amoxicillin+clavulanic acid is one of the most common antibiotics used for CAP. It was developed with an intent to sustain the efficacy of amoxicillin which was challenged due to the emergence of the beta-lactamase producing microorganism. Over a period, it has been included in national and international guidelines for the treatment of CAP. To assure the highest probability of clinical cure and to combat development of resistance: It is imperative for amoxicillin+clavulanic acid to reaffirm itself. Optimization of the PK/PD and higher dose of amoxicllin+clavulanic acid will tackle the burden of the future difficult to manage respiratory infections.
Keywords	amoxicillin ; amoxicillin clavulanic acid ; antimicrobial resistance ; antibiotic resistance ; cap ; community acquired pneumonia ; pneumonia ; Medicine ; R
Subject code	290
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Transcriptionally active nasopharyngeal commensals and opportunistic microbial dynamics define mild symptoms in the COVID 19 vaccination breakthroughs.

Priti Devi / Pallawi Kumari / Aanchal Yadav / Bansidhar Tarai / Sandeep Budhiraja / Uzma Shamim / Rajesh Pandey

PLoS Pathogens, Vol 19, Iss 2, p e

2023 Volume 1011160

Abstract	The development of COVID 19 vaccines as an effort to mitigate the outbreak, has saved millions of lives globally. However, vaccination breakthroughs have continuously challenged the vaccines' effectiveness and provided incentives to explore facets holding potential to alter vaccination-induced immunity and protection from subsequent infection, especially VOCs (Variants Of Concern). We explored the functional dynamics of nasopharyngeal transcriptionally active microbes (TAMs) between vaccination breakthroughs and unvaccinated SARS-CoV-2 infected individuals. Microbial taxonomic communities were differentially altered with skewed enrichment of bacterial class/genera of Firmicutes and Gammaproteobacteria with grossly reduced phylum Bacteroidetes in vaccination breakthrough individuals. The Bacillus genus was abundant in Firmicutes in vaccination breakthrough whereas Prevotella among Bacteroides dominated the unvaccinated. Also, Pseudomonas and Salmonella of Gammaproteobacteria were overrepresented in vaccination breakthrough, whilst unvaccinated showed presence of several genera, Achromobacter, Bordetella, Burkholderia, Neisseria, Hemophilus, Salmonella and Pseudomonas, belonging to Proteobacteria. At species level, the microbiota of vaccination breakthrough exhibited relatively higher abundance of unique commensals, in comparison to potential opportunistic microbes enrichment in unvaccinated patients' microbiota. Functional metabolic pathways like amino acid biosynthesis, sulphate assimilation, fatty acid and beta oxidation, associated with generation of SCFAs (short chain fatty acids), were enriched in vaccination breakthroughs. Majorly, metabolic pathways of LCFAs biosynthesis (long chain fatty acids; oleate, dodecenoate, palmitoleate, gondoate) were found associated with the unvaccinated. Our research highlights that vaccination decreases the microbial diversity in terms of depleting opportunistic pathogens and increasing the preponderance of commensals with respect to unvaccinated patients. Metabolic pathway ...
Keywords	Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Intertwined Dysregulation of Ribosomal Proteins and Immune Response Delineates SARS-CoV-2 Vaccination Breakthroughs.

Maurya, Ranjeet / Shamim, Uzma / Mishra, Pallavi / Swaminathan, Aparna / Raina, Aakarshan / Tarai, Bansidhar / Budhiraja, Sandeep / Pandey, Rajesh

Microbiology spectrum

2023 Volume 11, Issue 3, Page(s) e0429222

Abstract: Globally, COVID-19 vaccines have emerged as a boon, especially during the severe pandemic phases to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, saving millions of lives. However, mixed responses to ... ...

Abstract	Globally, COVID-19 vaccines have emerged as a boon, especially during the severe pandemic phases to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, saving millions of lives. However, mixed responses to vaccination with breakthrough challenges provided a rationale to explore the immune responses generated postvaccination, which plausibly alter the subsequent course of infection. In this regard, we comprehensively profiled the nasopharyngeal transcriptomic signature of double-dose-vaccinated individuals with breakthrough infections in comparison to unvaccinated infected persons. The vaccinated individuals demonstrated a gross downregulation of ribosomal proteins along with immune response genes and transcription/translational machinery that methodically modulated the entire innate immune landscape toward immune tolerance, a feature of innate immune memory. This coordinated response was orchestrated through 17 transcription factors captured as differentially expressed in the vaccination breakthroughs, including epigenetic modulators of
MeSH term(s)	Humans ; COVID-19 Vaccines ; SARS-CoV-2/genetics ; COVID-19/prevention & control ; Vaccination ; Immunity, Innate ; Breakthrough Infections
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.04292-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Effect of COVID-19 vaccine on long-COVID: A 2-year follow-up observational study from hospitals in north India

Budhiraja, Sandeep / INDRAYAN, ABHAYA / MAHAJAN, MONICA

medRxiv

Abstract: Introduction: Long-COVID syndrome encompasses a constellation of fluctuating, overlapping systemic symptoms after COVID. We know that vaccination reduces the risk of hospitalization and death but not of re-infections. How these vaccines impact long-COVID ...

Abstract	Introduction: Long-COVID syndrome encompasses a constellation of fluctuating, overlapping systemic symptoms after COVID. We know that vaccination reduces the risk of hospitalization and death but not of re-infections. How these vaccines impact long-COVID is under debate. The current study was designed to analyze the patterns of long-COVID amongst vaccinated and unvaccinated hospitalized patients during the three waves in India. Methods: The computerized medical records of the patients admitted to a group of hospitals in the National Capital Region of Delhi with a nasopharyngeal swab positive RT-PCR for SARS-CoV-2, during the three distinct COVID-19 waves, were accessed. Because of large numbers, every 3rd case from the data sheet for the wave-1 and wave-2 but all cases admitted during wave-3 were included because of small numbers (total 6676). The selected patients were telephonically contacted in April 2022 for symptoms and their duration of long-COVID and their vaccination status. Of these, 6056 (90.7%) responded. These were divided into fully vaccinated who received both doses of COVID vaccine at least 14 days before admission (913) and unvaccinated at the time of admission (4616). Others and deaths were excluded. symptom-weeks was calculated as the sum of weeks of symptoms in case of two or more symptoms. The statistical significance was tested, and odds ratio (unadjusted and adjusted) were calculated by logistic regression. Results: Nearly 90% of COVID-19 patients reported at least one symptom irrespective of their vaccination status. Almost three-fourths of these had symptoms lasting up to a month but nearly 15% reported a duration a least 4 weeks including 11% even exceeding one year. During wave-3, significantly more vaccinated patients reported short term post-acute sequelae of COVID-19 than did the unvaccinated group. The cases with diabetes and hypertension had higher odds of reporting at least one symptom when the effect of vaccination, age, sex, severity, and length of stay was adjusted. The fully vaccinated cases had reduced length of stay in the hospital and had a milder disease. Most common symptoms reported by both the groups were fatigue (17.0%), insomnia (15.1%) and myalgia (15%). There were significant differences in the duration and the type of long-COVID symptoms across the three waves, and the presence of comorbidities between the vaccinated and the unvaccinated groups but overall no difference could be detected. No significant difference was seen between the cases receiving covishield and covaxin. Conclusions: Nearly 15% reported symptoms of duration exceeding 4 weeks including 11% exceeding one year. There were significant differences in the specific symptoms with some more common in the vaccinated and some others more common in the unvaccinated but overall the vaccination or the type of vaccine did not significantly alter either the incidence or the duration of long COVID.
Keywords	covid19
Language	English
Publishing date	2022-07-22
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2022.07.18.22277740
Database	COVID19

Full text online

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

Kategorien

Inter-library loan at ZB MED