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Article ; Online: Cancer symptom clusters: from the lab bench to clinical practice.

Lopes-Júnior, Luís Carlos

2022 Volume 75, Issue 5, Page(s) e2022v75n5inov

Abstract: Objective: to present and discuss the advancement of science in symptom management through research involving oncological symptom clusters (OSC).: Method: a reflective study, supported by the scientific literature on OSC.: Results: five key points ...

Abstract	Objective: to present and discuss the advancement of science in symptom management through research involving oncological symptom clusters (OSC). Method: a reflective study, supported by the scientific literature on OSC. Results: five key points are crucial to advancing the science of symptom management through research involving OSC: definition of OSC characteristics; underlying mechanisms and priority symptom clusters; OSC measurement; targeted and personalized interventions; new analytical strategies. Final considerations: a better understanding of the complex connections between different systems and biobehavioral aspects in patients, especially in the field of oncology nursing, is urgent. The study of these interactions has become increasingly promising and emerging for oncology nursing, since therapeutic interventions, whose target is the neuroimmunoendocrine axis, are relevant for personalized care, translating into greater scientific and nurse autonomy to care for patients.
MeSH term(s)	Humans ; Syndrome ; Neoplasms/complications ; Neoplasms/therapy ; Oncology Nursing
Language	Portuguese
Publishing date	2022-10-21
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731983-6
ISSN	1984-0446 ; 0034-7167
ISSN (online)	1984-0446
ISSN	0034-7167
DOI	10.1590/0034-7167-2022v75n5inov
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Personalized Nursing Care in Precision-Medicine Era.

Lopes-Júnior, Luís Carlos

SAGE open nursing

2021 Volume 7, Page(s) 23779608211064713

Abstract: The extensive investment and development of research in molecular biology in the last decades, mainly after the completion of the Human Genome Project, has raised many expectations regarding its impact on Precision-Medicine Era. To meet the new demands ... ...

Abstract	The extensive investment and development of research in molecular biology in the last decades, mainly after the completion of the Human Genome Project, has raised many expectations regarding its impact on Precision-Medicine Era. To meet the new demands for care, it is necessary that the omics sciences be integrated into nursing practice, especially in nursing care. Based on knowledge of structural genomics, it has been improved techniques that enabled the advancement of research related to functional genomics, which together comprising the "omics" sciences including the transcriptomics, proteomics, the epigenomics and metabolomics. The current challenge is to transform this expanded set of information into clinical benefits for patients, through more accurate diagnoses, treatments, and personalized care to the particularities of individuals and communities. For Nursing, the main challenge is the incorporation of the omics sciences in training and professional practice, so that nurses can safely, scientifically, and autonomously empower themselves to provide personalized care to individuals and families based on Precision-Medicine Era. In this paper, a debate on the impacts and challenges for Nursing to incorporate the Precision-Medicine into clinical practice is described.
Language	English
Publishing date	2021-12-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2865437-7
ISSN	2377-9608 ; 2377-9608
ISSN (online)	2377-9608
ISSN	2377-9608
DOI	10.1177/23779608211064713
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Article ; Online: Advanced Practice Nursing and the Expansion of the Role of Nurses in Primary Health Care in the Americas.

Lopes-Júnior, Luís Carlos

SAGE open nursing

2021 Volume 7, Page(s) 23779608211019491

Abstract: Nurses have an educational background particularly suited to the growing challenges of the 21st century, characterized by an accelerated demographic transition, accompanied by a scenario of triple disease burden: 1) the unsurpassed agenda for infectious ... ...

Abstract	Nurses have an educational background particularly suited to the growing challenges of the 21st century, characterized by an accelerated demographic transition, accompanied by a scenario of triple disease burden: 1) the unsurpassed agenda for infectious diseases; 2) the increase in deaths attributable to external causes; and 3) the predominance of chronic noncommunicable diseases. Advanced Practice Nurses (APN) already have regulations well-established in many countries such as Australia, Belgium, Canada, the USA, Finland, France, Ireland, Japan, Poland, the United Kingdom, and the Czech Republic, among others. This paper aimed to point out and to reflect on Advanced Practice Nursing and the expansion of the role of nurses in Primary Health Care (PHC) in the Americas. In the same year the Nursing Now Campaign was launched, Pan American Health Organization (PAHO) and World Health Organization (WHO) prepared the document Expanding the Role of Nurses in PHC which calls on governments and nurses from countries in the Americas to implement APN training for PHC and Nurses from Central and South America who already have specialization programs, residency, academic master's and doctoral degrees. Expansion is intended to provide greater coverage and assistance to users of the health system, take advantage of nurses' intellectual capacity, and retain good professionals in the profession. This is a crucial moment for nursing worldwide. However, it is imperative to ensure the voice and impact of nursing continues to reverberate long after the end of 2021. In this paper, a debate on the strengths and challenges for the expansion of the APN role in PHC in the Americas is discribed.
Language	English
Publishing date	2021-05-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2865437-7
ISSN	2377-9608 ; 2377-9608
ISSN (online)	2377-9608
ISSN	2377-9608
DOI	10.1177/23779608211019491
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Article ; Online: Personalized Care for Patients with Cancer in the Precision-Medicine Era.

Lopes-Júnior, Luís Carlos / Veronez, Luciana Chain

International journal of environmental research and public health

2023 Volume 20, Issue 4

Abstract: Important advances in cancer management have been made in the beginning of the 21st century [ ... ]. ...

Abstract	Important advances in cancer management have been made in the beginning of the 21st century [...].
MeSH term(s)	Humans ; Neoplasms ; Precision Medicine
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20043023
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Article: Circadian rhythms disruption in cancer

Lopes-Júnior, Luís Carlos / Veronez, Luciana Chain

Biological rhythm research. 2022 Sept. 02, v. 53, no. 9

2022

Abstract: Recent epidemiological evidence has linked circadian disruptions to several chronic conditions, including cancer. Experimental studies and clinical trials with cancer patients have shown that dysregulation of circadian rhythms acts as an important ... ...

Abstract	Recent epidemiological evidence has linked circadian disruptions to several chronic conditions, including cancer. Experimental studies and clinical trials with cancer patients have shown that dysregulation of circadian rhythms acts as an important inducer and promoter of cancer, and/or exacerbating cancer symptom clusters and consequently decreasing the quality of life of the patients. Poor efficacy of cancer therapies and early mortality are also associated with loss of circadian control. In addition to altered expression of clock genes, which have been reported in several tumor types, the putative association between circadian disruption and cancer may be driven, at least in part, by immune system dysregulation and changes in the secretion of cytokines that influence inflammation. In cancer, circadian disruptions can also be associated with a reaction of the host’s physiology to the presence of tumors or a result of neuroimmunoendocrine responses to the physical and emotional demands associated with the disease that may affect the -neuroendocrine axis and circadian rhythms, contributing to cancer progression. A better understanding of the circadian rhythms in cancer patients can contribute to delineation of cancer prevention strategies as well as pharmacological and non-pharmacological treatments, besides providing novel biological and behavioral targets for more effective interventions.
Keywords	cytokines ; immune system ; inflammation ; mortality ; neoplasm progression ; neoplasms ; quality of life ; research ; secretion
Language	English
Dates of publication	2022-0902
Size	p. 1382-1399.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	1185065-6
ISSN	1744-4179 ; 0929-1016
ISSN (online)	1744-4179
ISSN	0929-1016
DOI	10.1080/09291016.2021.1951470
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Carga global de câncer no contexto das doenças crônicas não transmissíveis nas próximas décadas

Luís Carlos Lopes-Júnior

Journal Health NPEPS, Vol 6, Iss 2, Pp 1-

2021 Volume 6

Keywords	neoplasias ; doenças não transmissíveis ; expectativa de vida ativa ; Nursing ; RT1-120 ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
Language	Portuguese
Publishing date	2021-11-01T00:00:00Z
Publisher	Universidade do Estado de Mato Grosso
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Poor diet quality is associated with biochemical parameters of protein nutritional status after Roux-en-Y gastric bypass.

de Brito, Beatriz Bobbio / Braga, Gabriela Bernabé / Martins, Cleodice Alves / Lopes-Júnior, Luís Carlos / Salaroli, Luciane Bresciani / Lopes, Andressa Bolsoni / Haraguchi, Fabiano Kenji

Nutrition (Burbank, Los Angeles County, Calif.)

2024 Volume 123, Page(s) 112419

Abstract: Objective: To assess diet quality and its association with body and biochemical parameters in patients who underwent Roux-en-Y gastric bypass (RYGB).: Methods: Prospective observational study with individuals of both sexes subjected to RYGB. Body ... ...

Abstract	Objective: To assess diet quality and its association with body and biochemical parameters in patients who underwent Roux-en-Y gastric bypass (RYGB). Methods: Prospective observational study with individuals of both sexes subjected to RYGB. Body composition, biochemical parameters, and diet quality were assessed before and six months after RYGB. Diet quality was assessed by the Healthy Eating Index (HEI). Data were analyzed by the paired t-test or Wilcoxon signed-rank test, with a significance level of 5%. Spearman's correlation and simple linear regression were performed between variables.. Results: The final sample included 34 patients. Their diet was classified as poor before and 6 mo after RYGB. BMI, fat mass, fat-free mass, waist perimeter, serum total protein, transthyretin, alpha-1-acid glycoprotein, and C-reactive protein decreased significantly (P < 0.05). Variations in the HEI score and caloric intake were associated with serum albumin and transthyretin (P < 0.05). Conclusion: Poor diet quality was present before and six months after RYGB, and the study data suggest that poor diet quality is associated to a risk of loss of lean body mass and visceral protein six months after RYGB.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2024.112419
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Article: Safety, Efficacy, and Immunogenicity of Therapeutic Vaccines for Patients with High-Grade Cervical Intraepithelial Neoplasia (CIN 2/3) Associated with Human Papillomavirus: A Systematic Review.

Gonçalves, Caroline Amélia / Pereira-da-Silva, Gabriela / Silveira, Renata Cristina Campos Pereira / Mayer, Paulo César Morales / Zilly, Adriana / Lopes-Júnior, Luís Carlos

Cancers

2024 Volume 16, Issue 3

Abstract: Despite the knowledge that HPV is responsible for high-grade CIN and cervical cancer, little is known about the use of therapeutic vaccines as a treatment. We aimed to synthesize and critically evaluate the evidence from clinical trials on the safety, ... ...

Abstract	Despite the knowledge that HPV is responsible for high-grade CIN and cervical cancer, little is known about the use of therapeutic vaccines as a treatment. We aimed to synthesize and critically evaluate the evidence from clinical trials on the safety, efficacy, and immunogenicity of therapeutic vaccines in the treatment of patients with high-grade CIN associated with HPV. A systematic review of clinical trials adhering to the PRISMA 2020 statement in MEDLINE/PubMed, Embase, CENTRAL Cochrane, Web of Science, Scopus, and LILACS was undertaken, with no data or language restrictions. Primary endpoints related to the safety, efficacy, and immunogenicity of these vaccines were assessed by reviewing the adverse/toxic effects associated with the therapeutic vaccine administration via histopathological regression of the lesion and/or regression of the lesion size and via viral clearance and through the immunological response of individuals who received treatment compared to those who did not or before and after receiving the vaccine, respectively. A total of 1184 studies were identified, and 16 met all the criteria. Overall, the therapeutic vaccines were heterogeneous regarding their formulation, dose, intervention protocol, and routes of administration, making a meta-analysis unfeasible. In most studies (n = 15), the vaccines were safe and well tolerated, with clinical efficacy regarding the lesions and histopathological regression or viral clearance. In addition, eleven studies showed favorable immunological responses against HPV, and seven studies showed a positive correlation between immunogenicity and the clinical response, indicating promising results that should be further investigated. In summary, therapeutic vaccines, although urgently needed to avoid progression of CIN 2/3 patients, still present sparse data, requiring greater investments in a well-designed phase III RCT.
Language	English
Publishing date	2024-02-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16030672
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Article ; Online: Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio and Their Relationship with Nutritional Status and Quality of Life of Hospitalized Women with Breast Cancer.

Silva, Roberto Júnio Gomes / Grippa, Wesley Rocha / Pessanha, Raphael Manhães / Enriquez-Martinez, Oscar Geovanny / Neto, Luiz Cláudio Barreto Silva / Lopes-Júnior, Luís Carlos

Nutrition and cancer

2024 Volume 76, Issue 3, Page(s) 296–304

Abstract: Blood cell biomarkers, such as the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR), have been recently used as prognostic markers in tumors. In this study, we investigated the association between NLR and PLR with ... ...

Abstract	Blood cell biomarkers, such as the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR), have been recently used as prognostic markers in tumors. In this study, we investigated the association between NLR and PLR with sociodemographic, clinical, anthropometric, and quality of life factors of hospitalized women with non-metastatic breast cancer. A cross-sectional observational study was conducted at a reference center for oncological treatment in Southeast Brazil. Female participants aged over 18 years, with a histopathological diagnosis of stage I, II or III breast cancer, in any phase of antineoplastic treatment, were included. Our study revealed a high risk for participants, with high mean values of NLR and PLR, indicating low antitumor activity and worse prognosis. The binary logistic regression model showed that there was a significant association of the NLR marker and marital status (OR = 3.1; 95%CI = 1.06-8.57;
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Neutrophils/pathology ; Nutritional Status ; Breast Neoplasms/drug therapy ; Quality of Life ; Cross-Sectional Studies ; Lymphocytes/pathology ; Prognosis ; Biomarkers ; Retrospective Studies
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	424433-3
ISSN	1532-7914 ; 0163-5581
ISSN (online)	1532-7914
ISSN	0163-5581
DOI	10.1080/01635581.2024.2304689
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Article ; Online: Incompleteness trends of epidemiological variables in a Brazilian high complexity cancer registry: An ecological time series study.

Grippa, Wesley Rocha / Dell'Antonio, Larissa Soares / Salaroli, Luciane Bresciani / Lopes-Júnior, Luís Carlos

Medicine

2023 Volume 102, Issue 31, Page(s) e34369

Abstract: Hospital Cancer Registries serve as a vital source of information for clinical and epidemiological research, allowing the evaluation of patient care outcomes through therapeutic protocol analysis and patient survival assessment. This study aims to assess ...

Abstract	Hospital Cancer Registries serve as a vital source of information for clinical and epidemiological research, allowing the evaluation of patient care outcomes through therapeutic protocol analysis and patient survival assessment. This study aims to assess the trend of incompleteness in the epidemiological variables within the Hospital Cancer Registry of a renowned oncology center in a Brazilian state. An ecological time-series study was conducted using secondary data from the Hospital Santa Rita de Cássia Cancer Registry in Espírito Santo between 2000 and 2016. Data completeness was categorized as follows: excellent (<5%), good (5%-10%), fair (10%-20%), poor (20%-50%), and very poor (>50%), based on the percentage of missing information. Descriptive and bivariate statistical analyses were performed using the free software RStudio (version 2022.07.2) and R (version 4.1.0). The Mann-Kendall test was used to assess temporal trends between the evaluated years, and the Friedman test was employed to evaluate quality scores across the years. Among the variables assessed, birthplace, race/color, education, occupation, origin, marital status, history of alcohol and tobacco consumption, previous diagnosis and treatment, the most important basis for tumor diagnosis, tumor-node-metastasis staging (TNM) staging, and clinical tumor staging by group (TNM) showed the highest levels of incompleteness. Conversely, other epidemiological variables demonstrated excellent completeness, reaching 100% throughout the study period. Significant trends were observed over the years for history of alcohol consumption (P < .001), history of tobacco consumption (P < .001), TNM staging (P = .016), clinical tumor staging by group (TNM) (P = .002), first treatment received at the hospital (P = .012), disease status at the end of the first treatment at the hospital (P < .001), and family history of cancer (P < .001), and tumor laterality (P = .032). While most epidemiological variables within the Hospital Santa Rita de Cássia Cancer Registry exhibited excellent completeness, some important variables, such as TNM staging and clinical staging, showed high levels of incompleteness. Ensuring high-quality data within Cancer Registries is crucial for a comprehensive understanding of the health-disease process.
MeSH term(s)	Humans ; Brazil/epidemiology ; Time Factors ; Neoplasms/epidemiology ; Registries ; Neoplasm Staging
Language	English
Publishing date	2023-08-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000034369
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