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Artikel ; Online: Reply to Brandon A. Mahal, Anthony V. D'Amico, and Paul L. Nguyen's Letter to the Editor re: Neal D. Shore, Fred Saad, Michael S. Cookson, et al. Oral Relugolix for Androgen Deprivation Therapy in Advanced Prostate Cancer. N Engl J Med 2020;382:2187-96.

Shore, Neal D / Dearnaley, David / Tombal, Bertrand

2020 Band 78, Heft 5, Seite(n) e196–e197

Mesh-Begriff(e)	Androgen Antagonists ; Androgens ; Humans ; Male ; Phenylurea Compounds ; Prostatic Neoplasms/drug therapy ; Pyrimidinones
Chemische Substanzen	Androgen Antagonists ; Androgens ; Phenylurea Compounds ; Pyrimidinones ; relugolix
Sprache	Englisch
Erscheinungsdatum	2020-08-21
Erscheinungsland	Switzerland
Dokumenttyp	Letter ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2020.07.034
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Reply.

Scott, Ingrid U / Oden, Neal L / VanVeldhuisen, Paul C / Ip, Michael S / Blodi, Barbara A

Ophthalmology

2024 Band 131, Heft 6, Seite(n) e25–e26

Mesh-Begriff(e)	Humans
Sprache	Englisch
Erscheinungsdatum	2024-04-01
Erscheinungsland	United States
Dokumenttyp	Letter
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/j.ophtha.2024.02.016
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Potential Costs and Benefits of Incorporating PGT-A Across Age Groups: A Canadian Clinic Perspective.

Davis, Ola S / Favetta, Laura A / Deniz, Stacy / Faghih, Mehrnoosh / Amin, Shilpa / Karnis, Megan / Neal, Michael S

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

2024 Band 46, Heft 5, Seite(n) 102361

Abstract: Objective: To assess the potential costs and benefits of preimplantation genetic testing for aneuploidy (PGT-A) across age groups, considering financial costs, total euploidy rates and the potential for morphology grading to predict a euploid embryo.: ...

Abstract	Objective: To assess the potential costs and benefits of preimplantation genetic testing for aneuploidy (PGT-A) across age groups, considering financial costs, total euploidy rates and the potential for morphology grading to predict a euploid embryo. Methods: This study is a blinded retrospective chart review of patients who incorporated PGT-A as part of their in vitro fertilization (IVF) treatment cycle at a university-affiliated fertility clinic. Patients between 25-44 years of age undergoing IVF with intracytoplasmic sperm injection and PGT-A with autologous oocytes (n = 220) were included in this study. Number of blastocysts achieved, euploidy rates and PGT-A costs were compared between 3 age groups: <35 years, 35-37, and ≥38. Additionally, agreement on the top-quality embryo based on morphology assessment alone versus PGT-A selection was analyzed and further compared based on the number of blastocysts achieved. Results: A significant negative correlation between patient age and number of embryos produced, PGT-A costs, and euploidy rates (P < 0.001) was observed. Additionally, morphology alone ratings were able to predict the top-quality euploid embryo 78% of the time in the <35 age group, but only 32% of the time in the ≥38 age group (P < 0.05), with a trend toward even lower agreement when 3 or fewer blastocysts were produced. Conclusion: Based on our cost analysis, it may be advantageous to incorporate PGT-A when maternal age is ≥38, given the lower financial costs associated with each cycle and the low likelihood of transferring a euploid embryo on the first attempt for this age group. Nevertheless, we acknowledge that PGT-A remains a complex decision influenced by a multitude of factors.
Sprache	Englisch
Erscheinungsdatum	2024-01-23
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	2171082-X
ISSN	1701-2163
ISSN	1701-2163
DOI	10.1016/j.jogc.2024.102361
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A Pilot Study: Do Children Who Run Marathons Have More Osteoarthritis in the Lower Extremities as Adults.

Roberts, William O / Kucera, Neal S / Miner, Michael H

Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

2023 Band 33, Heft 6, Seite(n) 618–622

Abstract: Objective: To compare self-reported osteoarthritis of the knee and hip in adults who ran at least 1 marathon as a child with adults who ran high-school cross country (HSCC).: Design: Subject self-recall retrospective survey.: Setting: Electronic ... ...

Abstract	Objective: To compare self-reported osteoarthritis of the knee and hip in adults who ran at least 1 marathon as a child with adults who ran high-school cross country (HSCC). Design: Subject self-recall retrospective survey. Setting: Electronic survey. Participants: 319 adults who either ran a marathon under age 18 or ran HSCC recruited from running clubs, marathon participants, and on-line interest groups. Interventions: Survey. Main outcome measures: Self-reported history of osteoarthritis (OA), joint pain, anterior cruciate ligament injury, still running or running marathons, and number of marathons as an adult. Results: One hundred twenty-three respondents ran a marathon under age 18 (26% female) and were 40 years old (sd 16) and 196 ran HSCC (53% female) and were 36 years old (sd 13). The mean age of first marathon was 15 (sd 2.3, range 5-17); 50% ran 1% and 50% ran >1 marathon. Child marathoners reported a family history of OA in knees or hips (26%) or a joint replacement (30%) compared with 24% and 28% of HSCC runners. 10% of child marathoners and 7% of HSCC reported OA and 24% and 21% reported daily or weekly joint pain. 91% of all respondents are still running; 78% of child marathoners (mean 17, range 1-91) and 80% HSCC ran ≥1 marathons as adults (mean 10, range 1-80). Conclusions: Adults who ran marathons as children compared with adults who ran HSCC self-report similar rates of the knee and hip OA, chose to participate of their own accord, continue to run as adults, played other sports, and did not "specialize" in marathons.
Mesh-Begriff(e)	Humans ; Adult ; Child ; Female ; Adolescent ; Male ; Pilot Projects ; Osteoarthritis, Hip ; Retrospective Studies ; Osteoarthritis, Knee ; Running ; Lower Extremity ; Arthralgia
Sprache	Englisch
Erscheinungsdatum	2023-09-15
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1062530-6
ISSN	1536-3724 ; 1050-642X
ISSN (online)	1536-3724
ISSN	1050-642X
DOI	10.1097/JSM.0000000000001190
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Transcatheter Aortic Valve Implantation: Long-Term Outcomes and Durability.

Desai, Parth V / Goel, Sachin S / Kleiman, Neal S / Reardon, Michael J

Methodist DeBakey cardiovascular journal

2023 Band 19, Heft 3, Seite(n) 15–25

Abstract: Transcatheter aortic valve implantation (TAVI) has become the standard of care in symptomatic older patients with severe aortic stenosis regardless of surgical risk. With the development of newer generation transcatheter bioprostheses, improved delivery ... ...

Abstract	Transcatheter aortic valve implantation (TAVI) has become the standard of care in symptomatic older patients with severe aortic stenosis regardless of surgical risk. With the development of newer generation transcatheter bioprostheses, improved delivery systems, better preprocedure planning with imaging guidance, increased operator experience, shorter hospital length of stay, and low short- and mid-term complication rates, TAVI is gaining popularity among younger patients at low or intermediate surgical risk. Long-term outcomes and durability of transcatheter heart valves have become substantially important for this younger population due to their longer life expectancy. The lack of standardized definitions of bioprosthetic valve dysfunction and disagreement about how to account for the competing risks made comparison of transcatheter heart valves with surgical bioprostheses challenging until recently. In this review, the authors discuss the mid- to long-term (≥ 5 years) clinical outcomes observed in the landmark TAVI trials and analyze the available long-term durability data emphasizing the importance of using standardized definitions of bioprosthetic valve dysfunction.
Mesh-Begriff(e)	Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis ; Treatment Outcome ; Bioprosthesis ; Prosthesis Failure
Sprache	Englisch
Erscheinungsdatum	2023-05-16
Erscheinungsland	United States
Dokumenttyp	Review ; Journal Article
ZDB-ID	2544079-2
ISSN	1947-6108 ; 1947-6108
ISSN (online)	1947-6108
ISSN	1947-6108
DOI	10.14797/mdcvj.1201
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Predictors of Pace-Terminable Rhythms in Patients with Subcutaneous Implantable Cardioverter-Defibrillators.

Rao, Birju R / Jain, Vardhmaan / Mekary, Wissam / Ibrahim, Rand / Bhatia, Neal K / El Chami, Mikhael / Knops, Reinoud E / Lloyd, Michael S

Heart rhythm

2024

Sprache	Englisch
Erscheinungsdatum	2024-05-03
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2024.05.002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Ensuring Optimal Outcomes for Preterm Infants after NICU Discharge: A Life Course Health Development Approach to High-Risk Infant Follow-Up.

Litt, Jonathan S / Halfon, Neal / Msall, Michael E / Russ, Shirley Ann / Hintz, Susan R

Children (Basel, Switzerland)

2024 Band 11, Heft 2

Abstract: Children born prematurely (<37 weeks' gestation) have an increased risk for chronic health problems and developmental challenges compared to their term-born peers. The threats to health and development posed by prematurity, the unintended effects of life- ...

Abstract	Children born prematurely (<37 weeks' gestation) have an increased risk for chronic health problems and developmental challenges compared to their term-born peers. The threats to health and development posed by prematurity, the unintended effects of life-sustaining neonatal intensive care, the associated neonatal morbidities, and the profound stressors to families affect well-being during infancy, childhood, adolescence, and beyond. Specialized clinical programs provide medical and developmental follow-up care for preterm infants after hospital discharge. High-risk infant follow-up, like most post-discharge health services, has many shortcomings, including unclear goals, inadequate support for infants, parents, and families, fragmented service provisions, poor coordination among providers, and an artificially foreshortened time horizon. There are well-documented inequities in care access and delivery. We propose applying a life course health development framework to clinical follow-up for children born prematurely that is contextually appropriate, developmentally responsive, and equitably deployed. The concepts of health development, unfolding, complexity, timing, plasticity, thriving, and harmony can be mapped to key components of follow-up care delivery to address pressing health challenges. This new approach envisions a more effective version of clinical follow-up to support the best possible functional outcomes and the opportunity for every premature infant to thrive within their family and community environments over their life course.
Sprache	Englisch
Erscheinungsdatum	2024-01-24
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children11020146
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Application of eprinomectin-containing parasiticides at label doses causes neurological toxicosis in cats homozygous for ABCB11930_1931del TC.

Mealey, Katrina L / Burke, Neal S / Villarino, Nicolas F / Court, Michael H / Heusser, Jennifer P

Journal of veterinary pharmacology and therapeutics

2024 Band 47, Heft 3, Seite(n) 226–230

Abstract: The feline MDR1 mutation (ABCB11930_1931delTC) has been associated with neurological toxicosis after topical application of eprinomectin products labeled for feline use. Information was collected from veterinarians who submitted samples for ... ...

Abstract	The feline MDR1 mutation (ABCB11930_1931delTC) has been associated with neurological toxicosis after topical application of eprinomectin products labeled for feline use. Information was collected from veterinarians who submitted samples for ABCB11930_1931delTC genotyping. In most cases, the submission form indicated an adverse event involving eprinomectin, in other cases submitting veterinarians were contacted to determine whether the patient had experienced an adverse drug event involving eprinomectin. If so, additional information was obtained to determine whether the case met inclusion criteria. 14 cases were highly consistent with eprinomectin toxicosis. Eight cats were homozygous for ABCB11930_1931del TC (3 died; 5 recovered). Six cats were homozygous wildtype (2 died; 4 recovered). The observed ABCB11930_1931delTC frequency (57%) was higher than the expected frequency (≤1%) in the feline population (Fisher Exact test, p < 0.01). Among wildtype cats, four were concurrently treated with potential competitive inhibitors of P-glycoprotein. Results indicate that topical eprinomectin products, should be avoided in cats homozygous for ABCB11930_1931delTC. This is a serious, preventable adverse event occurring in an identifiable subpopulation treated with FDA-approved products in accordance with label directions. Acquired P-glycoprotein deficiency resulting from drug interactions may enhance susceptibility to eprinomectin-induced neurological toxicosis in any cat, regardless of ABCB1 genotype.
Mesh-Begriff(e)	Animals ; Cats ; Ivermectin/analogs & derivatives ; Ivermectin/administration & dosage ; Cat Diseases/chemically induced ; Female ; Male ; Antiparasitic Agents/administration & dosage ; Homozygote ; ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics
Chemische Substanzen	Ivermectin (70288-86-7) ; eprinomectin (75KP30FD8O) ; Antiparasitic Agents ; ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache	Englisch
Erscheinungsdatum	2024-02-17
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	435216-6
ISSN	1365-2885 ; 0140-7783
ISSN (online)	1365-2885
ISSN	0140-7783
DOI	10.1111/jvp.13431
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Association of Retinal Thickness at Month 1 Post-Treatment with Later Thickness and Visual Acuity in Central Vein Occlusion.

Scott, Ingrid U / Oden, Neal L / Ip, Michael S / VanVeldhuisen, Paul C / Blodi, Barbara A

American journal of ophthalmology

2024

Abstract: Purpose: To investigate the association of retinal thickness 1 month post-randomization (1 month after first study injection with aflibercept or bevacizumab) with later retinal thickness, visual acuity, and number of treatments in eyes with central or ... ...

Abstract	Purpose: To investigate the association of retinal thickness 1 month post-randomization (1 month after first study injection with aflibercept or bevacizumab) with later retinal thickness, visual acuity, and number of treatments in eyes with central or hemiretinal vein occlusion enrolled in the SCORE2 trial. Design: Cohort study using data from a randomized multicenter clinical trial. Methods: Analysis included 350 SCORE2 participants through 2 years of follow-up. Main outcome measures are central subfield thickness (CST) on spectral domain optical coherence tomography, best-corrected visual acuity letter score (VALS), and number of treatments for macular edema. CST was classified as thin (≤216µm), medium (>216µm and ≤300µm), or thick (>300µm). Results: At Month 1, 15% (51/350) of study eyes were in the thin CST class, 57% (199/350) in the medium CST class, and 29% (100/350) in the thick CST class. Of eyes with thin CST at Month 1, 89-96% were also thin during Months 2-12. Over all visits studied, the VALS of eyes in the medium Month 1 CST class was significantly greater than the Month 1 thin class. During Months 6-12 (p<0.001) and 12-24 (p <0.001), but not during Months 0-6 (p=0.36) when monthly treatment was protocol-specified, the mean number of treatments for macular edema per study eye was highest in the thick CST class and lowest in the thin CST class. The thin CST class is significantly more likely to have disorganization of the retinal inner layers inside the central subfield, more paracentral acute middle maculopathy at Month 1, and a history of anti-VEGF treatment prior to trial enrollment. Conclusions: Eyes with a thin CST at Month 1 were more likely to be in their Month 1 CST class during Months 2-12 than eyes in the thick or medium Month 1 CST classes. Eyes in the medium CST class had the best VALS, with fewest treatments in the thin class after Month 6. These findings suggest that having a post-treatment thin CST can be as detrimental to visual acuity as having a post-treatment thick CST.
Sprache	Englisch
Erscheinungsdatum	2024-05-03
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2024.04.027
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Single-center study of outcomes of patients with hairy cell leukemia who contracted SARS-CoV-2.

Annunzio, Kaitlin / Ozga, Michael / Huang, Ying / Anghelina, Mirela / Bhat, Seema A / Blachly, James S / Grever, Michael R / Lozanski, Gerard / Neal, Jasmine / Shindiapina, Polina / Rogers, Kerry A

EJHaem

2023 Band 4, Heft 4, Seite(n) 1200–1202

Sprache	Englisch
Erscheinungsdatum	2023-08-31
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2688-6146
ISSN (online)	2688-6146
DOI	10.1002/jha2.764
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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