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  1. Article ; Online: Scent of a vaccine.

    Lund, Frances E / Randall, Troy D

    Science (New York, N.Y.)

    2021  Volume 373, Issue 6553, Page(s) 397–399

    MeSH term(s) Administration, Intranasal ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; B-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Humans ; Immunity, Mucosal ; Immunoglobulin A/blood ; Immunoglobulin A/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunologic Memory ; Respiratory Mucosa/immunology ; Respiratory System/immunology ; SARS-CoV-2/immunology ; Vaccination/methods
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; Immunoglobulin A ; Immunoglobulin G
    Language English
    Publishing date 2021-08-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abg9857
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  2. Article ; Online: Compartmentalization of dendritic cell and T-cell interactions in the lymph node: Anatomy of T-cell fate decisions.

    León, Beatriz / Lund, Frances E

    Immunological reviews

    2019  Volume 289, Issue 1, Page(s) 84–100

    Abstract: Upon receiving cognate and co-stimulatory priming signals from antigen (Ag)-presenting dendritic cells (DCs) in secondary lymphoid tissues, naïve ... ...

    Abstract Upon receiving cognate and co-stimulatory priming signals from antigen (Ag)-presenting dendritic cells (DCs) in secondary lymphoid tissues, naïve CD4
    MeSH term(s) Animals ; Antigen Presentation ; Cell Communication ; Cell Compartmentation ; Cell Differentiation ; Cell Lineage ; Dendritic Cells/immunology ; Humans ; Lymph Nodes/immunology ; Lymphocyte Activation ; T-Lymphocytes/immunology ; Th1-Th2 Balance
    Language English
    Publishing date 2019-04-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.12758
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  3. Article ; Online: Chitinase-3-like 1 regulates T

    Curtiss, Miranda L / Rosenberg, Alexander F / Scharer, Christopher D / Mousseau, Betty / Benavides, Natalia A Ballesteros / Bradley, John E / León, Beatriz / Steele, Chad / Randall, Troy D / Lund, Frances E

    Frontiers in immunology

    2023  Volume 14, Page(s) 1158493

    Abstract: Introduction: Data from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma strongly support a role for chitinase-3-like-1 protein (CHI3L1) in allergic disease.: Methods: To address whether Chi3l1 also contributes to T: ... ...

    Abstract Introduction: Data from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma strongly support a role for chitinase-3-like-1 protein (CHI3L1) in allergic disease.
    Methods: To address whether Chi3l1 also contributes to T
    Results: As anticipated, we observed impaired T
    Discussion: These results suggest that
    MeSH term(s) Animals ; Mice ; Chitinases/metabolism ; Helminthiasis ; Helminths ; Immunoglobulin E ; Interleukin-4/metabolism ; T-Lymphocytes, Helper-Inducer
    Chemical Substances Chitinases (EC 3.2.1.14) ; Immunoglobulin E (37341-29-0) ; Interleukin-4 (207137-56-2) ; Chil1 protein, mouse
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1158493
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  4. Article ; Online: Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs.

    Silva-Sanchez, Aaron / Meza-Perez, Selene / Liu, Mingyong / Stone, Sara L / Flores-Romo, Leopoldo / Ubil, Eric / Lund, Frances E / Rosenberg, Alexander F / Randall, Troy D

    Science immunology

    2023  Volume 8, Issue 84, Page(s) eadc9081

    Abstract: Multiple mechanisms restrain inflammation in neonates, most likely to prevent tissue damage caused by overly robust immune responses against newly encountered pathogens. Here, we identify a population of pulmonary dendritic cells (DCs) that express ... ...

    Abstract Multiple mechanisms restrain inflammation in neonates, most likely to prevent tissue damage caused by overly robust immune responses against newly encountered pathogens. Here, we identify a population of pulmonary dendritic cells (DCs) that express intermediate levels of CD103 (CD103
    MeSH term(s) Mice ; Animals ; CD8-Positive T-Lymphocytes ; c-Mer Tyrosine Kinase/metabolism ; Dendritic Cells ; Lung ; Pneumonia ; Apoptosis
    Chemical Substances c-Mer Tyrosine Kinase (EC 2.7.10.1) ; Mertk protein, mouse (EC 2.7.10.1)
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adc9081
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  5. Article ; Online: IgM Memory Cells: First Responders in Malaria.

    Stone, Sara L / Lund, Frances E

    Immunity

    2016  Volume 45, Issue 2, Page(s) 235–237

    Abstract: Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after ... ...

    Abstract Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function as first responders by rapidly differentiating into T-cell-dependent plasmablasts and T-cell-independent plasma cells.
    MeSH term(s) Animals ; B-Lymphocytes/immunology ; Immunoglobulin M ; Immunologic Memory/immunology ; Malaria/immunology ; Mice ; T-Lymphocytes/immunology
    Chemical Substances Immunoglobulin M
    Language English
    Publishing date 2016--16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2016.08.005
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  6. Article: GABA and Combined GABA with GAD65-Alum Treatment Alters Th1 Cytokine Responses of PBMCs from Children with Recent-Onset Type 1 Diabetes.

    Heath, Katie E / Feduska, Joseph M / Taylor, Jared P / Houp, Julie A / Botta, Davide / Lund, Frances E / Mick, Gail J / McGwin, Gerald / McCormick, Kenneth L / Tse, Hubert M

    Biomedicines

    2023  Volume 11, Issue 7

    Abstract: Type 1 diabetes (T1D) is an autoimmune disease culminating in the destruction of insulin-producing pancreatic cells. There is a need for the development of novel antigen-specific strategies to delay cell destruction, including combinatorial strategies ... ...

    Abstract Type 1 diabetes (T1D) is an autoimmune disease culminating in the destruction of insulin-producing pancreatic cells. There is a need for the development of novel antigen-specific strategies to delay cell destruction, including combinatorial strategies that do not elicit systemic immunosuppression. Gamma-aminobutyric acid (GABA) is expressed by immune cells, β-cells, and gut bacteria and is immunomodulatory. Glutamic-acid decarboxylase 65 (GAD65), which catalyzes GABA from glutamate, is a T1D autoantigen. To test the efficacy of combinatorial GABA treatment with or without GAD65-immunization to dampen autoimmune responses, we enrolled recent-onset children with T1D in a one-year clinical trial (ClinicalTrials.gov NCT02002130) and examined T cell responses. We isolated peripheral blood mononuclear cells and evaluated cytokine responses following polyclonal activation and GAD65 rechallenge. Both GABA alone and GABA/GAD65-alum treatment inhibited Th1 cytokine responses over the 12-month study with both polyclonal and GAD65 restimulation. We also investigated whether patients with HLA-DR3-DQ2 and HLA-DR4-DQ8, the two highest-risk human leukocyte antigen (HLA) haplotypes in T1D, exhibited differences in response to GABA alone and GABA/GAD65-alum. HLA-DR4-DQ8 patients possessed a Th1-skewed response compared to HLA-DR3-DQ2 patients. We show that GABA and GABA/GAD65-alum present an attractive immunomodulatory treatment for children with T1D and that HLA haplotypes should be considered.
    Language English
    Publishing date 2023-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11071948
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  7. Article ; Online: Antigen-Specific CD4 T Cell and B Cell Responses to Borrelia burgdorferi.

    Hammond, Elizabeth M / Olsen, Kimberly J / Ram, Shivneel / Tran, Giang Vu Vi / Hall, Laura S / Bradley, John E / Lund, Frances E / Samuels, D Scott / Baumgarth, Nicole

    Journal of immunology (Baltimore, Md. : 1950)

    2023  Volume 211, Issue 6, Page(s) 994–1005

    Abstract: Long-lived T-dependent B cell responses fail to develop during persistent infection of mice with Borrelia burgdorferi, the causative agent of Lyme disease, raising questions about the induction and/or functionality of anti-B. burgdorferi adaptive immune ... ...

    Abstract Long-lived T-dependent B cell responses fail to develop during persistent infection of mice with Borrelia burgdorferi, the causative agent of Lyme disease, raising questions about the induction and/or functionality of anti-B. burgdorferi adaptive immune responses. Yet, a lack of reagents has limited investigations into B. burgdorferi-specific T and B cells. We attempted two approaches to track B. burgdorferi-induced CD4 T cells. First, a B. burgdorferi mutant was generated with an influenza hemagglutinin (HA) peptide, HA111-119, inserted into the B. burgdorferi arthritis-related protein (Arp) locus. Although this B. burgdorferi arp::HA strain remained infectious, peptide-specific TCR transgenic CD4 T cells in vitro, or adoptively transferred into B. burgdorferi arp::HA-infected BALB/c mice, did not clonally expand above those of recipients infected with the parental B. burgdorferi strain or a B. burgdorferi mutant containing an irrelevant peptide. Some expansion, however, occurred in B. burgdorferi arp::HA-infected BALB/c SCID mice. Second, a (to our knowledge) newly identified I-Ab-restricted CD4 T cell epitope, Arp152-166, was used to generate Arp MHC class II tetramers. Flow cytometry showed small numbers of Arp-specific CD4 T cells emerging in mice infected with B. burgdorferi but not with Arp-deficient Borrelia afzelii. Although up to 30% of Arp-specific CD4 T cells were ICOS+PD-1+CXCR5+BCL6+ T follicular helper cells, their numbers declined after day 12, before germinal centers (GCs) are prominent. Although some Arp-specific B cells, identified using fluorochrome-labeled rArp proteins, had the phenotype of GC B cells, their frequencies did not correlate with anti-Arp serum IgG. The data suggest a failure not in the induction, but in the maintenance of GC T follicular helper and/or B cells to B. burgdorferi.
    MeSH term(s) Mice ; Animals ; Borrelia burgdorferi ; CD4-Positive T-Lymphocytes ; Mice, SCID ; B-Lymphocytes ; Lyme Disease
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2200890
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  8. Article ; Online: A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans.

    Nellore, Anoma / Zumaquero, Esther / Scharer, Christopher D / Fucile, Christopher F / Tipton, Christopher M / King, R Glenn / Mi, Tian / Mousseau, Betty / Bradley, John E / Zhou, Fen / Mutneja, Stuti / Goepfert, Paul A / Boss, Jeremy M / Randall, Troy D / Sanz, Ignacio / Rosenberg, Alexander F / Lund, Frances E

    Immunity

    2023  Volume 56, Issue 4, Page(s) 847–863.e8

    Abstract: Seasonal influenza vaccination elicits hemagglutinin (HA)-specific memory B (Bmem) cells, and although multiple Bmem cell populations have been characterized, considerable heterogeneity exists. We found that HA-specific human Bmem cells differed in the ... ...

    Abstract Seasonal influenza vaccination elicits hemagglutinin (HA)-specific memory B (Bmem) cells, and although multiple Bmem cell populations have been characterized, considerable heterogeneity exists. We found that HA-specific human Bmem cells differed in the expression of surface marker FcRL5 and transcriptional factor T-bet. FcRL5
    MeSH term(s) Humans ; Influenza Vaccines ; Influenza, Human/prevention & control ; Antibody Formation ; Memory B Cells ; Vaccination ; Immunologic Memory ; Antibodies, Viral
    Chemical Substances Influenza Vaccines ; Antibodies, Viral
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.03.001
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  9. Article ; Online: IL-17-producing B cells combat parasites.

    León, Beatriz / Lund, Frances E

    Nature immunology

    2013  Volume 14, Issue 5, Page(s) 419–421

    MeSH term(s) Animals ; B-Lymphocytes/immunology ; Chagas Disease/immunology ; Glycoproteins/metabolism ; Humans ; Interleukin-17/immunology ; Neuraminidase/metabolism ; Trypanosoma cruzi/enzymology ; Trypanosoma cruzi/immunology
    Chemical Substances Glycoproteins ; Interleukin-17 ; trans-sialidase (EC 3.2.1.-) ; Neuraminidase (EC 3.2.1.18)
    Language English
    Publishing date 2013-04-18
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni.2593
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  10. Article: Cytokine-producing B lymphocytes-key regulators of immunity.

    Lund, Frances E

    Current opinion in immunology

    2008  Volume 20, Issue 3, Page(s) 332–338

    Abstract: The successful use of B cell depletion therapy for the treatment of autoimmune disease has led to a resurgent appreciation of B cells as powerful regulators of immunity. However, to the surprise of many, B cells appear to regulate autoimmune conditions ... ...

    Abstract The successful use of B cell depletion therapy for the treatment of autoimmune disease has led to a resurgent appreciation of B cells as powerful regulators of immunity. However, to the surprise of many, B cells appear to regulate autoimmune conditions independently of their ability to produce autoantibodies. Indeed, disturbances in the ability of B cell subsets to present antigen, produce cytokines, and regulate the activities of T cells is emerging as a key feature in many inflammatory diseases. Here we review the recent literature describing cytokine-producing regulatory and effector B cell subsets in health and disease and discuss how future B cell-directed therapies might target the pathologic cytokine-producing effector B cell subsets without impacting the protective regulatory subsets.
    MeSH term(s) Animals ; Autoimmunity ; B-Lymphocyte Subsets/immunology ; Cytokines/biosynthesis ; Cytokines/physiology ; Humans ; Immunologic Memory ; Mice ; Models, Immunological
    Chemical Substances Cytokines
    Language English
    Publishing date 2008-04-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2008.03.003
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