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Article ; Online: Molecular profiling of skin test-induced inflammation to support the clinical diagnosis of delayed drug hypersensitivity reaction.

Mosnier, Amandine / Vocanson, Marc / Lefevre, Marine-Alexia

2023 Volume 33, Issue 1, Page(s) 64–66

MeSH term(s)	Humans ; Drug Hypersensitivity/etiology ; Drug Hypersensitivity/genetics ; Skin Tests ; Inflammation ; Hypersensitivity, Delayed/chemically induced ; Hypersensitivity, Delayed/diagnosis
Language	English
Publishing date	2023-06-09
Publishing country	France
Document type	Journal Article
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2023.4438
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Article ; Online: Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis.

Joshi, Aaroh Anand / Vocanson, Marc / Nicolas, Jean-Francois / Wolf, Peter / Patra, Vijaykumar

Frontiers in immunology

2023 Volume 14, Page(s) 1125635

Abstract: Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly affects the patient's quality of life. A disrupted skin barrier, type 2 cytokine-dominated inflammation, and microbial dysbiosis with ... ...

Abstract	Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly affects the patient's quality of life. A disrupted skin barrier, type 2 cytokine-dominated inflammation, and microbial dysbiosis with increased
MeSH term(s)	Humans ; Dermatitis, Atopic ; Antimicrobial Peptides ; Quality of Life ; Skin ; Inflammation/pathology ; Staphylococcus aureus ; Staphylococcal Infections/pathology
Chemical Substances	Antimicrobial Peptides
Language	English
Publishing date	2023-01-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1125635
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Article ; Online: Role of tissue-resident memory T cells in the pathophysiology of allergic contact dermatitis.

Lefevre, Marine-Alexia / Vocanson, Marc / Nosbaum, Audrey

Current opinion in allergy and clinical immunology

2021 Volume 21, Issue 4, Page(s) 355–360

Abstract: Purpose of review: We bring updated knowledge on tissue-resident memory T cells (TRM), underlining their major role in the recurrence and the severity of allergic contact dermatitis (ACD).: Recent findings: ACD is a frequently encountered skin ... ...

Abstract	Purpose of review: We bring updated knowledge on tissue-resident memory T cells (TRM), underlining their major role in the recurrence and the severity of allergic contact dermatitis (ACD). Recent findings: ACD is a frequently encountered skin disease. It is defined as a delayed-type hypersensitivity reaction initiated by the recruitment of antigen-specific T cells into the skin of sensitized patients. ACD lesions tend to develop on already-exposed areas and worsen over time. That clinical observation has raised questions on the contribution of TRM to ACD recurrence and severity. TRM are memory T cells that persist in peripheral tissues, such as the skin, without recirculating through the blood. These cells provide effective immune memory against pathogens, but they may also participate in the development or exacerbation of numerous inflammatory diseases, including skin allergies. Recent works have demonstrated a major role for TRM in ACD pathophysiology. Summary: In ACD, TRM accumulate preferentially at the allergen contact site during the sensitization phase. Thereafter, these cells cause a rapid and intense response to any new allergen exposure. They also play a key role in flare-ups of ACD and the chronicity and severity of the disease. These aspects suggest that TRM may have an interest as therapeutic targets.
MeSH term(s)	Allergens ; Dermatitis, Allergic Contact/immunology ; Humans ; Immunologic Memory ; Memory T Cells/immunology ; Skin/immunology
Chemical Substances	Allergens
Language	English
Publishing date	2021-06-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2088710-3
ISSN	1473-6322 ; 1528-4050
ISSN (online)	1473-6322
ISSN	1528-4050
DOI	10.1097/ACI.0000000000000763
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Article ; Online: Current perspective of the etiopathogenesis of delayed-type, and T-cell-mediated drug-related skin diseases.

Vocanson, Marc / Naisbitt, Dean J / Nicolas, Jean-François

The Journal of allergy and clinical immunology

2020 Volume 145, Issue 4, Page(s) 1142–1144

MeSH term(s)	Animals ; Cell Degranulation ; Drug Hypersensitivity/immunology ; Humans ; Hypersensitivity, Delayed/immunology ; Mast Cells/immunology ; Nerve Tissue Proteins/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Neuropeptide/metabolism ; T-Lymphocytes, Cytotoxic/immunology ; Urticaria/immunology ; Xenobiotics/adverse effects
Chemical Substances	MRGPRX2 protein, human ; Nerve Tissue Proteins ; Receptors, G-Protein-Coupled ; Receptors, Neuropeptide ; Xenobiotics
Language	English
Publishing date	2020-02-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2020.01.030
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Article ; Online: When Joints Fail: Identifying the Allergen Helps.

Nosbaum, Audrey / Nicolas, Jean-François / Lustig, Sébastien / Vocanson, Marc

The journal of allergy and clinical immunology. In practice

2021 Volume 9, Issue 8, Page(s) 3118–3119

MeSH term(s)	Allergens ; Asthma ; Humans
Chemical Substances	Allergens
Language	English
Publishing date	2021-03-18
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2021.03.009
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Article ; Online: The role of skin dysbiosis in atopic dermatitis

Braun, Camille / Patra, Vijeykumar / Lina, Gérard / Nicolas, Jean-François / Vocanson, Marc / Nosbaum, Audrey

European journal of dermatology : EJD

2022 Volume 32, Issue 4, Page(s) 439–444

Abstract: The cutaneous microbiota contributes to skin barrier function, ensuring effective protection against pathogens and contributing to the maintenance of epidermal integrity. Dysbiosis is frequently present in atopic dermatitis (AD), a chronic inflammatory ... ...

Title translation	The role of skin dysbiosis in atopic dermatitis.
Abstract	The cutaneous microbiota contributes to skin barrier function, ensuring effective protection against pathogens and contributing to the maintenance of epidermal integrity. Dysbiosis is frequently present in atopic dermatitis (AD), a chronic inflammatory disease associated with skin barrier defects. Dysbiosis is associated with reduced bacterial diversity and marked Staphylococcus aureus colonization, which is favoured in the case of certain local AD-specific properties such as reduced skin acidity, eased bacterial adhesion and decreased antimicrobial peptide production. Furthermore, S. aureus-associated skin dysbiosis, via the production of staphylococcal virulence factors, may also participate in the immunopathology of AD by altering the epidermal barrier and inducing an inflammatory response. However, there are currently no arguments for recommending screening for, and treatment of S. aureus-associated dysbiosis outside the setting of cutaneous superinfection. Nonetheless, modulation of the skin microbiota may hold promise for AD management. Here, we describe the relationships that exist between the skin microbiota and AD.
MeSH term(s)	Humans ; Dermatitis, Atopic/microbiology ; Dermatitis, Atopic/therapy ; Dysbiosis/complications ; Dysbiosis/microbiology ; Dysbiosis/therapy ; Microbiota ; Skin/microbiology ; Staphylococcus aureus
Language	English
Publishing date	2022-10-27
Publishing country	France
Document type	Journal Article
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2022.4289
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Article ; Online: Role of miR-24-3p and miR-146a-5p in dendritic cells' maturation process induced by contact sensitizers.

Galbiati, Valentina / Lefevre, Marine-Alexia / Maddalon, Ambra / Vocanson, Marc / Iulini, Martina / Marinovich, Marina / Corsini, Emanuela

Archives of toxicology

2023 Volume 97, Issue 8, Page(s) 2183–2191

Abstract: MiRNAs are non-coding RNA molecules that regulate gene expression at the post-transcriptional level. Although allergic contact dermatitis has been studied extensively, few studies addressed miRNA expression and their role in dendritic cell activation. ... ...

Abstract	MiRNAs are non-coding RNA molecules that regulate gene expression at the post-transcriptional level. Although allergic contact dermatitis has been studied extensively, few studies addressed miRNA expression and their role in dendritic cell activation. The main aim of this work was to investigate the role of miRNAs in the underlying mechanism of dendritic cell maturation induced by contact sensitizers of different potency. Experiments were conducted using THP-1-derived immature DCs (iDCs). Contact allergens of different potency were used: p-benzoquinone, Bandrowski's base, and 2,4-dinitrochlorobenzene as extreme; nickel sulfate hexahydrate, diethyl maleate and 2-mercaptobenzothiazole as moderate; and α-hexyl cinnamaldehyde, eugenol, and imidazolidinyl urea as weak. Selective inhibitor and mimic miRNAs were then used and several cell surface markers was evaluated as targets. Also, patients patch tested with nickel were analyzed to determine miRNAs expression. Results indicate an important role of miR-24-3p and miR-146a-5p in DCs activation. miR-24-3p was up-regulated by extreme and weak contact allergens, while miR-146a-5p was up-regulated by weak and moderate contact allergens and down-regulated only by the extreme ones. Also, the involvement of PKCβ in contact allergen-induced miR-24-3p and miR-146a-5p expression was demonstrated. Furthermore, the expression of the two miRNAs maintains the same trend of expression in both in vitro and in human conditions after nickel exposure. Results obtained suggest the involvement of miR-24 and miR-146a in DCs maturation process in the proposed in vitro model, supported also by human evidences.
MeSH term(s)	Humans ; Nickel/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Dermatitis, Allergic Contact/genetics ; Dermatitis, Allergic Contact/metabolism ; Allergens/toxicity ; Dendritic Cells/metabolism
Chemical Substances	Nickel (7OV03QG267) ; MicroRNAs ; Allergens ; MIRN24 microRNA, human
Language	English
Publishing date	2023-06-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124992-7
ISSN	1432-0738 ; 0340-5761
ISSN (online)	1432-0738
ISSN	0340-5761
DOI	10.1007/s00204-023-03542-z
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Article: Deciphering Differential Behavior of Immune Responses as the Foundation for Precision Dosing in Allergen Immunotherapy.

Magnan, Antoine / Nicolas, Jean-François / Caimmi, Davide / Vocanson, Marc / Haddad, Thierry / Colas, Luc / Scurati, Silvia / Mascarell, Laurent / Shamji, Mohamed H

Journal of personalized medicine

2023 Volume 13, Issue 2

Abstract: Like in many fields of medicine, the concept of precision dosing has re-emerged in routine practice in allergology. Only one retrospective study on French physicians' practice has addressed this topic so far and generated preliminary data supporting dose ...

Abstract	Like in many fields of medicine, the concept of precision dosing has re-emerged in routine practice in allergology. Only one retrospective study on French physicians' practice has addressed this topic so far and generated preliminary data supporting dose adaptation, mainly based on experience, patient profile understanding and response to treatment. Both intrinsic and extrinsic factors shape the individual immune system response to allergen immunotherapy (AIT). Herein, we focus on key immune cells (i.e., dendritic cells, innate lymphoid cells, B and T cells, basophils and mast cells) involved in allergic disease and its resolution to further understand the effect of AIT on the phenotype, frequency or polarization of these cells. We strive to discriminate differences in immune responses between responders and non-responders to AIT, and discuss the eligibility of a non/low-responder subset for dose adaptation. A differential behavior in immune cells is clearly observed in responders, highlighting the importance of conducting clinical trials with large cohorts of well-characterized subjects to decipher the immune mechanism of AIT. We conclude that there is a need for designing new clinical and mechanistic studies to support the scientific rationale of dose adaptation in the interest of patients who do not properly respond to AIT.
Language	English
Publishing date	2023-02-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13020324
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Article ; Online: Topical corticosteroids inhibit allergic skin inflammation but are ineffective in impeding the formation and expansion of resident memory T cells.

Ono, Emi / Lenief, Vanina / Lefevre, Marine-Alexia / Cuzin, Roxane / Guironnet-Paquet, Aurélie / Mosnier, Amandine / Nosbaum, Audrey / Nicolas, Jean-Francois / Vocanson, Marc

Allergy

2023 Volume 79, Issue 1, Page(s) 52–64

Abstract: Background: Tissue-resident memory T (T: Methods: We assessed the impact of a standard topical corticosteroid (TCS) treatment, triamcinolone acetonide (TA), on the formation, maintenance and reactivation of epidermal T: Results: The impact of TA ... ...

Abstract	Background: Tissue-resident memory T (T Methods: We assessed the impact of a standard topical corticosteroid (TCS) treatment, triamcinolone acetonide (TA), on the formation, maintenance and reactivation of epidermal T Results: The impact of TA on T Conclusions: Our results demonstrate that TCS successfully treat ACD inflammation, but are mostly ineffective in impeding the formation and expansion of allergen-specific T
MeSH term(s)	Humans ; Mice ; Animals ; Memory T Cells ; CD8-Positive T-Lymphocytes ; Skin/pathology ; Dermatitis, Allergic Contact/drug therapy ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/pathology ; Allergens ; Inflammation/drug therapy ; Inflammation/pathology ; Dermatologic Agents ; Haptens ; Adrenal Cortex Hormones ; Immunologic Memory
Chemical Substances	Allergens ; Dermatologic Agents ; Haptens ; Adrenal Cortex Hormones
Language	English
Publishing date	2023-08-04
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15819
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Article ; Online: Ultraviolet exposure regulates skin metabolome based on the microbiome.

Patra, Vijaykumar / Bordag, Natalie / Clement, Yohann / Köfeler, Harald / Nicolas, Jean-Francois / Vocanson, Marc / Ayciriex, Sophie / Wolf, Peter

Scientific reports

2023 Volume 13, Issue 1, Page(s) 7207

Abstract: Skin metabolites (< 1500 Da) play a critical role in barrier function, hydration, immune response, microbial invasion, and allergen penetration. We aimed to understand the global metabolic profile changes of the skin in relation to the microbiome and UV ... ...

Abstract	Skin metabolites (< 1500 Da) play a critical role in barrier function, hydration, immune response, microbial invasion, and allergen penetration. We aimed to understand the global metabolic profile changes of the skin in relation to the microbiome and UV exposure and exposed germ-free (devoid of microbiome), disinfected mice (partially devoid of skin microbiome) and control mice with intact microbiome to immunosuppressive doses of UVB radiation. Targeted and untargeted lipidome and metabolome profiling was performed with skin tissue by high-resolution mass spectrometry. UV differentially regulated various metabolites such as alanine, choline, glycine, glutamine, and histidine in germ-free mice compared to control mice. Membrane lipid species such as phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were also affected by UV in a microbiome-dependent manner. These results shed light on the dynamics and interactions between the skin metabolome, microbiome, and UV exposure and open new avenues for the development of metabolite- or lipid-based applications to maintain skin health.
MeSH term(s)	Mice ; Animals ; Microbiota ; Metabolome/physiology ; Skin ; Ultraviolet Rays ; Mass Spectrometry
Language	English
Publishing date	2023-05-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-34073-3
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