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  1. Article ; Online: Shane Crotty: exploring immune memory. Interview by Kira Heller.

    Crotty, Shane

    The Journal of experimental medicine

    2009  Volume 206, Issue 5, Page(s) 974–975

    MeSH term(s) Humans ; Immunologic Memory ; Laboratories/standards ; Research/standards ; T-Lymphocytes/immunology ; Vaccines/immunology ; Vaccines/therapeutic use
    Chemical Substances Vaccines
    Language English
    Publishing date 2009-05-11
    Publishing country United States
    Document type Interview
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.2065pi
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Revealing T follicular helper cells with BCL6.

    Crotty, Shane

    Nature reviews. Immunology

    2021  Volume 21, Issue 10, Page(s) 616–617

    Language English
    Publishing date 2021-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-021-00591-2
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  3. Article ; Online: Editorial overview: Vaccine immunology: what is seen and not seen.

    Crotty, Shane

    Current opinion in immunology

    2019  Volume 59, Page(s) iii–v

    MeSH term(s) Animals ; Antibody Formation ; CD4-Positive T-Lymphocytes/immunology ; Disease Models, Animal ; Germinal Center/immunology ; Humans ; Mice ; Protein Engineering ; Vaccination ; Vaccines/immunology
    Chemical Substances Vaccines
    Language English
    Publishing date 2019-06-21
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2019.05.010
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  4. Article: Cytokines in Follicular Helper T Cell Biology in Physiologic and Pathologic Conditions.

    Choi, Jinyong / Crotty, Shane / Choi, Youn Soo

    Immune network

    2024  Volume 24, Issue 1, Page(s) e8

    Abstract: Follicular helper T cells (Tfh) play a crucial role in generating high-affinity antibodies (Abs) and establishing immunological memory. Cytokines, among other functional molecules produced by Tfh, are central to germinal center (GC) reactions. This ... ...

    Abstract Follicular helper T cells (Tfh) play a crucial role in generating high-affinity antibodies (Abs) and establishing immunological memory. Cytokines, among other functional molecules produced by Tfh, are central to germinal center (GC) reactions. This review focuses on the role of cytokines, including IL-21 and IL-4, in regulating B cell responses within the GC, such as differentiation, affinity maturation, and plasma cell development. Additionally, this review explores the impact of other cytokines like CXCL13, IL-10, IL-9, and IL-2 on GC responses and their potential involvement in autoimmune diseases, allergies, and cancer. This review highlights contributions of Tfh-derived cytokines to both protective immunity and immunopathology across a spectrum of diseases. A deeper understanding of Tfh cytokine biology holds promise for insights into biomedical conditions.
    Language English
    Publishing date 2024-02-14
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2536191-0
    ISSN 2092-6685 ; 1598-2629
    ISSN (online) 2092-6685
    ISSN 1598-2629
    DOI 10.4110/in.2024.24.e8
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  5. Article ; Online: T Follicular Helper Cell Biology: A Decade of Discovery and Diseases.

    Crotty, Shane

    Immunity

    2019  Volume 50, Issue 5, Page(s) 1132–1148

    Abstract: Helping B cells and antibody responses is a major function of ... ...

    Abstract Helping B cells and antibody responses is a major function of CD4
    MeSH term(s) Atherosclerosis/immunology ; Autoimmune Diseases/immunology ; B-Lymphocytes/immunology ; Cell Differentiation/immunology ; Communicable Diseases/immunology ; Germinal Center/immunology ; Humans ; Hypersensitivity/immunology ; Proto-Oncogene Proteins c-bcl-6/metabolism ; T-Lymphocytes, Helper-Inducer/cytology ; T-Lymphocytes, Helper-Inducer/immunology
    Chemical Substances BCL6 protein, human ; Proto-Oncogene Proteins c-bcl-6
    Language English
    Publishing date 2019-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2019.04.011
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  6. Article ; Online: Raging evolution of a B cell response to a viral infection.

    Crotty, Shane

    Nature reviews. Immunology

    2018  Volume 18, Issue 2, Page(s) 79

    MeSH term(s) B-Lymphocytes ; Evolution, Molecular ; HIV-1 ; Humans ; Virus Diseases
    Language English
    Publishing date 2018-01-02
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/nri.2017.219
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  7. Article ; Online: Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? Complexities of Interpretation due to the Heterogeneity of Memory CD4 T Cells, Including T Follicular Helper Cells.

    Crotty, Shane

    Cold Spring Harbor perspectives in biology

    2018  Volume 10, Issue 3

    Abstract: Plasticity is the ability of a cell type to convert to another cell type. There are multiple effector CD4 T-cell subtypes, including ... ...

    Abstract Plasticity is the ability of a cell type to convert to another cell type. There are multiple effector CD4 T-cell subtypes, including T
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/physiology ; Cell Differentiation ; Cell Plasticity ; Cellular Reprogramming ; Humans ; Immunologic Memory ; T-Lymphocytes, Helper-Inducer/physiology
    Language English
    Publishing date 2018-03-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a032102
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  8. Article ; Online: Immunological memory to SARS-CoV-2 infection and COVID-19 vaccines.

    Sette, Alessandro / Crotty, Shane

    Immunological reviews

    2022  Volume 310, Issue 1, Page(s) 27–46

    Abstract: Immunological memory is the basis of protective immunity provided by vaccines and previous infections. Immunological memory can develop from multiple branches of the adaptive immune system, including CD4 T cells, CD8 T cells, B cells, and long-lasting ... ...

    Abstract Immunological memory is the basis of protective immunity provided by vaccines and previous infections. Immunological memory can develop from multiple branches of the adaptive immune system, including CD4 T cells, CD8 T cells, B cells, and long-lasting antibody responses. Extraordinary progress has been made in understanding memory to SARS-CoV-2 infection and COVID-19 vaccines, addressing development; quantitative and qualitative features of different cellular and anatomical compartments; and durability of each cellular component and antibodies. Given the sophistication of the measurements; the size of the human studies; the use of longitudinal samples and cross-sectional studies; and head-to-head comparisons between infection and vaccines or between multiple vaccines, the understanding of immune memory for 1 year to SARS-CoV-2 infection and vaccines already supersedes that of any other acute infectious disease. This knowledge may help inform public policies regarding COVID-19 and COVID-19 vaccines, as well as the scientific development of future vaccines against SARS-CoV-2 and other diseases.
    MeSH term(s) Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines ; Cross-Sectional Studies ; Humans ; Immunologic Memory ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13089
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  9. Article ; Online: T Cell Responses to SARS-CoV-2.

    Sette, Alessandro / Sidney, John / Crotty, Shane

    Annual review of immunology

    2023  Volume 41, Page(s) 343–373

    Abstract: A large body of evidence generated in the last two and a half years addresses the roles of T cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces multi-epitope CD4 and CD8 T cell responses with polyfunctionality. ... ...

    Abstract A large body of evidence generated in the last two and a half years addresses the roles of T cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces multi-epitope CD4 and CD8 T cell responses with polyfunctionality. Early T cell responses have been associated with mild COVID-19 outcomes. In concert with animal model data, these results suggest that while antibody responses are key to prevent infection, T cell responses may also play valuable roles in reducing disease severity and controlling infection. T cell memory after vaccination is sustained for at least six months. While neutralizing antibody responses are impacted by SARS-CoV-2 variants, most CD4 and CD8 T cell responses are preserved. This review highlights the extensive progress made, and the data and knowledge gaps that remain, in our understanding of T cell responses to SARS-CoV-2 and COVID-19 vaccines.
    MeSH term(s) Animals ; Humans ; SARS-CoV-2 ; COVID-19 ; COVID-19 Vaccines ; CD8-Positive T-Lymphocytes ; Antibodies, Viral
    Chemical Substances COVID-19 Vaccines ; Antibodies, Viral
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-101721-061120
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  10. Article ; Online: Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (T

    Choi, Jinyong / Crotty, Shane

    Trends in immunology

    2021  Volume 42, Issue 4, Page(s) 336–349

    Abstract: Follicular helper T cells ( ... ...

    Abstract Follicular helper T cells (T
    MeSH term(s) Cell Differentiation ; Gene Expression Regulation ; Germinal Center ; Proto-Oncogene Proteins c-bcl-6/genetics ; Proto-Oncogene Proteins c-bcl-6/metabolism ; T Follicular Helper Cells ; T-Lymphocytes, Helper-Inducer/metabolism
    Chemical Substances Proto-Oncogene Proteins c-bcl-6
    Language English
    Publishing date 2021-03-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2021.02.002
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