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  1. Article: Editorial: The Changing Panorama of Diabetes Outcomes: Novel Complications and Novelties in Classical Complication.

    Siddiqui, Khalid / Maddaloni, Ernesto

    Frontiers in endocrinology

    2022  Volume 12, Page(s) 816481

    Language English
    Publishing date 2022-01-13
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2021.816481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: New strategy to study the impact of ethnicity on diabetic neuropathy.

    Maddaloni, Ernesto

    Diabetes/metabolism research and reviews

    2018  Volume 35, Issue 1, Page(s) e3080

    MeSH term(s) Diabetes Mellitus, Type 2 ; Diabetic Neuropathies ; Ethnic Groups ; Humans ; Microscopy, Confocal ; Nerve Fibers ; Small Fiber Neuropathy ; United Kingdom
    Language English
    Publishing date 2018-10-16
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1470192-3
    ISSN 1520-7560 ; 1520-7552
    ISSN (online) 1520-7560
    ISSN 1520-7552
    DOI 10.1002/dmrr.3080
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    Zs.A 2119: Show issues Location:
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  3. Article: Updates on Glycaemic Control Strategies: A Range of Opportunities after Total Pancreatectomy.

    Pieralice, Silvia / Coppola, Alessandro / Maddaloni, Ernesto

    Journal of clinical medicine

    2023  Volume 12, Issue 9

    Abstract: In the past, indications for total pancreatectomy (TP) were rare, with several concerns about patients' postoperative quality of life due to exocrine and endocrine post-pancreatectomy management [ ... ]. ...

    Abstract In the past, indications for total pancreatectomy (TP) were rare, with several concerns about patients' postoperative quality of life due to exocrine and endocrine post-pancreatectomy management [...].
    Language English
    Publishing date 2023-05-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12093306
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  4. Article ; Online: Immune checkpoint modulators in early clinical development for the treatment of type 1 diabetes.

    Maddaloni, Ernesto / Amendolara, Rocco / Balena, Angela / Latino, Alessandro / Sessa, Rosario Luigi / Buzzetti, Raffaella

    Expert opinion on investigational drugs

    2024  Volume 33, Issue 4, Page(s) 303–318

    Abstract: Introduction: Despite the improvements of insulin therapy, people with type 1 diabetes (T1D) still suffer from a decreased quality of life and life expectancy. The search toward a cure for T1D is therefore still a scorching open field of research.: ... ...

    Abstract Introduction: Despite the improvements of insulin therapy, people with type 1 diabetes (T1D) still suffer from a decreased quality of life and life expectancy. The search toward a cure for T1D is therefore still a scorching open field of research.
    Areas covered: Tackling the immune checkpoint signaling pathways has gained importance in the field of cancer immunotherapy. The same pathways can be targeted in autoimmunity with an opposite principle: to dampen the exaggerated immune response. In this review, we report a comprehensive excursus on the cellular and molecular mechanisms that lead to loss of immunological tolerance, and recent evidence on the role of immune checkpoint molecules in the development of T1D and their potential application for the mitigation of autoimmune diabetes.
    Expert opinion: Contrasting results about the efficacy of immune checkpoint modulators for T1D have been published, with very few molecules from preclinical studies eligible for use in humans. The heterogeneous and complex pathophysiology of T1D may explain the conflicting evidence. Designing clinical trials that acknowledge the pathophysiological and clinical complexity of T1D and that forecast the need of simultaneously tackling different disease pathways will be crucial to enhance the benefits which may be gained by such compounds.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 1/drug therapy ; Quality of Life ; Immunotherapy/methods ; Autoimmunity ; Insulin/metabolism ; Immunologic Factors/therapeutic use
    Chemical Substances Insulin ; Immunologic Factors
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2024.2326036
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  5. Article ; Online: Covid-19 and diabetes mellitus: unveiling the interaction of two pandemics.

    Maddaloni, Ernesto / Buzzetti, Raffaella

    Diabetes/metabolism research and reviews

    2020  Volume 36, Issue 7, Page(s) e33213321

    Abstract: A novel RNA betacoronavirus causing coronavirus disease 2019 (Covid-19) has now been declared pandemic disease by WHO. Guo et al published the first report of biochemical features in patients with diabetes and the further risk that this disease can ... ...

    Abstract A novel RNA betacoronavirus causing coronavirus disease 2019 (Covid-19) has now been declared pandemic disease by WHO. Guo et al published the first report of biochemical features in patients with diabetes and the further risk that this disease can determine to the progression of Covid-19. Among different cytokines found significantly higher in patients with diabetes compared to those without, Interleukin-6 (IL-6), which is already increased in conditions of chronic inflammation, may play a more deleterious role in Covid-19 infection. Targeting the overexpression of Il-6 effects with a monoclonal antibody against IL-6 receptor or using Janus Kinase inhibitors may be particularly helpful for treatment of Covid-19 pneumonia in diabetes.
    Keywords covid19
    Language English
    Publishing date 2020-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1470192-3
    ISSN 1520-7560 ; 1520-7552
    ISSN (online) 1520-7560
    ISSN 1520-7552
    DOI 10.1002/dmrr.3321
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  6. Article ; Online: Investigational therapies targeting CD3 for prevention and treatment of type 1 diabetes.

    Mignogna, Carmen / Maddaloni, Ernesto / D'Onofrio, Luca / Buzzetti, Raffaella

    Expert opinion on investigational drugs

    2022  Volume 30, Issue 12, Page(s) 1209–1219

    MeSH term(s) Antibodies, Monoclonal/pharmacology ; CD3 Complex/antagonists & inhibitors ; Clinical Trials, Phase II as Topic ; Clinical Trials, Phase III as Topic ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/prevention & control ; Humans ; Immunotherapy ; T-Lymphocytes ; Therapies, Investigational
    Chemical Substances Antibodies, Monoclonal ; CD3 Complex
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2022.2022119
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  7. Article ; Online: Implementing the treatment of heart failure with SGLT-2 inhibitors and sacubitril-valsartan: does money matter?

    Cavallari, Ilaria / Maddaloni, Ernesto / Grigioni, Francesco

    European journal of preventive cardiology

    2021  Volume 28, Issue 15, Page(s) 1670–1672

    MeSH term(s) Aminobutyrates/adverse effects ; Biphenyl Compounds ; Drug Combinations ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Humans ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Valsartan
    Chemical Substances Aminobutyrates ; Biphenyl Compounds ; Drug Combinations ; Sodium-Glucose Transporter 2 Inhibitors ; sacubitril (17ERJ0MKGI) ; Valsartan (80M03YXJ7I)
    Language English
    Publishing date 2021-02-23
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwaa153
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  8. Article ; Online: Cardiovascular effects of SGLT-2 inhibitors: What we have learned from cardiovascular outcome trials and what we still need to understand.

    Cavallari, Ilaria / Maddaloni, Ernesto

    Diabetes/metabolism research and reviews

    2019  Volume 35, Issue 4, Page(s) e3124

    Abstract: The recent results of the DECLARE-TIMI 58 trial forces a profound reflection about the cardiovascular protection conferred by SGLT-2 inhibitors. DECLARE-TIMI 58, the largest cardiovascular outcome trial in diabetes, failed to show a significant reduction ...

    Abstract The recent results of the DECLARE-TIMI 58 trial forces a profound reflection about the cardiovascular protection conferred by SGLT-2 inhibitors. DECLARE-TIMI 58, the largest cardiovascular outcome trial in diabetes, failed to show a significant reduction in the risk of major adverse cardiovascular events (MACEs) conferred by dapagliflozin compared with placebo. However, a lower rate of hospitalization for heart failure was reported. Whilst the lack of benefits on MACE may seem in contrast with the results of previous SGLT-2 inhibitors cardiovascular outcome trials, DECLARE clearly delineates the real cardiovascular effects of SGLT-2 inhibitors, which mainly tackle heart failure. Differences in study design and population enrolled are crucial to correctly value each molecule and to translate results of clinical trials in daily clinical practise.
    MeSH term(s) Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/epidemiology ; Clinical Trials as Topic ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Incidence ; Prognosis ; Risk Factors ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2019-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1470192-3
    ISSN 1520-7560 ; 1520-7552
    ISSN (online) 1520-7560
    ISSN 1520-7552
    DOI 10.1002/dmrr.3124
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  9. Article ; Online: The complex combination of COVID-19 and diabetes: pleiotropic changes in glucose metabolism.

    Mahrooz, Abdolkarim / Muscogiuri, Giovanna / Buzzetti, Raffaella / Maddaloni, Ernesto

    Endocrine

    2021  Volume 72, Issue 2, Page(s) 317–325

    Abstract: Purpose: Angiotensin converting enzyme 2 (ACE2) is the door for SARS-CoV-2, expressed in critical metabolic tissues. So, it is rational that the new virus causes pleiotropic alterations in glucose metabolism, resulting in the complication of pre- ... ...

    Abstract Purpose: Angiotensin converting enzyme 2 (ACE2) is the door for SARS-CoV-2, expressed in critical metabolic tissues. So, it is rational that the new virus causes pleiotropic alterations in glucose metabolism, resulting in the complication of pre-existing diabetes's pathophysiology or creating new disease mechanisms. However, it seems that less attention has been paid to this issue. This review aimed to highlight the importance of long-term consequences and pleiotropic alterations in glucose metabolism following COVID-19 and emphasize the need for basic and clinical research in metabolism and endocrinology.
    Results: SARS-CoV-2 shifts cellular metabolism from oxidative phosphorylation to glycolysis, which leads to a decrease in ATP generation. Together with metabolic imbalance, the impaired immune system elevates the susceptibility of patients with diabetes to this deadly virus. SARS-CoV-2-induced metabolic alterations in immune cells can result in hyper inflammation and a cytokine storm. Metabolic dysfunction may affect therapies against SARS-CoV-2 infection. The effective control of metabolic complications could prove useful therapeutic targets for combating COVID-19. It is also necessary to understand the long-term consequences that will affect patients with diabetes who survived COVID-19.
    Conclusions: Since the pathophysiology of COVID-19 is still mostly unknown, identifying the metabolic mechanisms contributing to its progression is essential to provide specific ways to prevent and improve this dangerous virus's detrimental effects. The findings show that the new virus may induce new-onset diabetes with uncertain metabolic and clinical features, supporting a potential role of COVID-19 in the development of diabetes.
    MeSH term(s) COVID-19 ; Diabetes Mellitus ; Glucose ; Humans ; Inflammation ; SARS-CoV-2
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-04-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-021-02729-7
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  10. Article ; Online: Correction to: "H" for Heterogeneity in the Algorithm for Type 2 Diabetes Management.

    Pieralice, Silvia / Zampetti, Simona / Maddaloni, Ernesto / Buzzetti, Raffaella

    Current diabetes reports

    2020  Volume 20, Issue 7, Page(s) 27

    Abstract: The original version of this article unfortunately contained a mistake in the authorgroup section. The authors' given and family names were inadvertently interchanged. ...

    Abstract The original version of this article unfortunately contained a mistake in the authorgroup section. The authors' given and family names were inadvertently interchanged.
    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2065167-3
    ISSN 1539-0829 ; 1534-4827
    ISSN (online) 1539-0829
    ISSN 1534-4827
    DOI 10.1007/s11892-020-01312-0
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