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Article ; Online: Mutations of PsPALM1a and PsPALM1b associated with the afila phenotype in Pea.

Yuan, Zhuo / Xie, Xiaoting / Liu, Mingli / He, Yexin / He, Liangliang

2024 Volume 176, Issue 3, Page(s) e14310

Abstract: Semi-leafless represents an advantageous plant architecture in pea breeding due to its ability to enhance resistance to lodging and potentially to powdery mildew. The introduction of semi-leafless pea varieties is considered a seminal advancement in pea ... ...

Abstract	Semi-leafless represents an advantageous plant architecture in pea breeding due to its ability to enhance resistance to lodging and potentially to powdery mildew. The introduction of semi-leafless pea varieties is considered a seminal advancement in pea breeding over the past half-century. The afila (af) mutation leads to the replacement of lateral leaflets by highly branched tendrils; combined with the semi-dwarfing le mutation, it forms the semi-leafless cultivated variety. In this study, we identified that mutations in two tandemly-arrayed genes encoding Cys(2)His(2) zinc finger transcription factors, PsPALM1a and PsPALM1b, were closely associated with the afila phenotype. These two genes may be deleted in the af mutant. In situ hybridization showed that both genes exhibit specific expression in early leaflet primordia. Furthermore, suppression of PsPALM1a/PsPALM1b resulted in a high frequency of conversion of lateral leaflets into tendrils. In conclusion, our study provides genetic evidence demonstrating that mutations in PsPALM1a and PsPALM1b are responsible for the af locus, contributing to a better understanding of compound leaf formation in peas and offering new insights for breeding applications related to afila.
MeSH term(s)	Phenotype ; Pisum sativum/genetics ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Mutation/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Plant Leaves/genetics ; Gene Expression Regulation, Plant
Chemical Substances	Plant Proteins ; Transcription Factors
Language	English
Publishing date	2024-04-26
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	2020837-6
ISSN	1399-3054 ; 0031-9317
ISSN (online)	1399-3054
ISSN	0031-9317
DOI	10.1111/ppl.14310
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Diagnostic outcomes of radial endobronchial ultrasound bronchoscopy guided by manual navigation in the evaluation of peripheral pulmonary lesions: An observational study.

Yuan, Mingli / Hu, Yi / Wang, Liangchao / Yin, Wen / Xiao, Yang

The clinical respiratory journal

2024 Volume 18, Issue 5, Page(s) e13768

Abstract: Background and aims: Manual navigation (MN), drawing a bronchoscopic road map simply by looking at the consecutive computed tomography (CT), is feasible and economical. However, scant data about the use of MN in radial endobronchial ultrasound (r-EBUS) ... ...

Abstract	Background and aims: Manual navigation (MN), drawing a bronchoscopic road map simply by looking at the consecutive computed tomography (CT), is feasible and economical. However, scant data about the use of MN in radial endobronchial ultrasound (r-EBUS) bronchoscopy have been documented till now. We aimed to evaluate the diagnostic performance of r-EBUS bronchoscopy guided by MN for diagnosing peripheral pulmonary lesions (PPLs) and to determine clinical factors affecting the diagnostic yield. Methods: We performed a retrospective, cohort study of consecutive patients with PPLs who underwent r-EBUS bronchoscopic biopsy via guidance of MN from May 2020 to June 2021 in our Respiratory Endoscopic Division. The overall diagnostic yield of MN-guided r-EBUS, the factors affecting the yield, and the diagnostic performance for malignancy were evaluated. Results: A total of 102 patients (103 lesions) were evaluated. The overall diagnostic yield of MN-guided r-EBUS was 82.0%, and it ranged from 79.6% to 82.5%, assuming the undermined cases were all positive cases (79.6%) or negatives (82.5%). The sensitivity of MN-guided r-EBUS for malignancy was 71.4%, ranging from 68.2% to 71.4%, the specificity was 100%, the positive predictive value was 100%, and the negative predictive value was 67.3%, ranging from 63.8% to 69.0%. The multivariate logistic regression showed that "bronchus sign on CT" was the only predictor of the overall diagnostic yield (odds ratio = 11.5, 95% confidence interval: 1.9-70.9, P = 0.009). Conclusions: MN-guided r-EBUS is feasible in diagnosing PPLs, especially for lesions with bronchus sign on CT.
MeSH term(s)	Humans ; Male ; Bronchoscopy/methods ; Female ; Retrospective Studies ; Middle Aged ; Lung Neoplasms/pathology ; Lung Neoplasms/diagnostic imaging ; Aged ; Endosonography/methods ; Tomography, X-Ray Computed/methods ; Sensitivity and Specificity ; Adult ; Image-Guided Biopsy/methods
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13768
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Environmental, economic, and social sustainability assessment: A case of using contaminated tailings stabilized by waste-based geopolymer as road base.

Gao, Zhenghui / Li, Yuan / Qian, Hang / Wei, Mingli

The Science of the total environment

2023 Volume 888, Page(s) 164092

Abstract: Contaminated tailings, e.g., iron tailings, could be stabilized by low-carbon geopolymers for recycling as road base, but the sustainability has yet to be evaluated comprehensively. This study developed a sustainable framework from the life cycle ... ...

Abstract	Contaminated tailings, e.g., iron tailings, could be stabilized by low-carbon geopolymers for recycling as road base, but the sustainability has yet to be evaluated comprehensively. This study developed a sustainable framework from the life cycle perspective, consisting of quantitative indicators in environment, society, and economy, to assess five stabilization cases (i.e., M1, M2, C1, C2, and cement). Moreover, a modified AHP (Analytic Hierarchy Process)-CRITIC (CRiteria Importance Through Inter-criteria Correlation)-TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution) model was applied to select the most sustainable stabilization method. The sustainability scores of four cases using geopolymers were higher than that of the cement case (0.22), with C2 (0.75), C1 (0.64), M1 (0.56), and M2 (0.54), respectively. Sensitivity analysis confirmed that the assessment results were relatively stable, especially when the subjective weight of the economy was not the highest (the cement counterpart had economic advantages). This study constituted a novel approach to complement the selection of sustainable stabilization cases, bridging the gap of focusing exclusively on green stabilization performance.
Language	English
Publishing date	2023-05-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164092
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Article: A Theoretical Study on the Spatiotemporal Variation in the Temperature Field in Linings of High-Water-Temperature Tunnels.

Huang, Mingli / Huang, Meng / Li, Jiacheng / Qian, Yuan

Materials (Basel, Switzerland)

2023 Volume 16, Issue 22

Abstract: On the basis of the theory of unsteady heat conduction, discrete equations for the unsteady temperature field in the secondary linings of high-water-temperature tunnels when considering the hydration heat of lining concrete were derived and established. ... ...

Abstract	On the basis of the theory of unsteady heat conduction, discrete equations for the unsteady temperature field in the secondary linings of high-water-temperature tunnels when considering the hydration heat of lining concrete were derived and established. Spatiotemporal variation in the temperature field of tunnel linings was revealed through the analysis of numerical examples. Research demonstrates that the temperature of the secondary lining within a thickness range of approximately 15 cm near the tunnel clearance decreases sharply under the condition that the lining thickness is 35 cm. The higher the temperature on the lining's outer surface, the more drastically the lining temperature decreases. When considering the hydration heat of lining concrete, the lining temperature increases to a certain extent after a sudden drop, reaching stability after approximately 20 h, and the lining temperature is approximately 1-2 °C higher than that without taking concrete hydration heat into account. The temperature difference between the tunnel lining's core and its inner and outer surfaces is positively and negatively correlated with the temperature of the secondary lining's outer surface, respectively. When the temperature of the secondary lining's outer surface is not higher than 65 °C, the temperature difference between the tunnel lining's core and its inner and outer surfaces is less than 20 °C. Conversely, it partially or completely exceeds 20 °C, in which case an insulation method is recommended to utilize to prevent thermal cracks in secondary linings triggered via a high temperature difference.
Language	English
Publishing date	2023-11-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16227139
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Article: Bidirectional manipulation of iodine redox kinetics in aqueous Fe-I

Zhang, Weiwei / Wang, Mingli / Zhang, Hong / Fu, Lin / Zhang, Wenli / Yuan, Yupeng / Lu, Ke

Chemical science

2023 Volume 14, Issue 44, Page(s) 12730–12738

Abstract: Catalyzing conversion is a promising approach to unlock the theoretical potentials of the ... ...

Abstract	Catalyzing conversion is a promising approach to unlock the theoretical potentials of the I
Language	English
Publishing date	2023-10-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc04853e
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Article: Iodine-125 seed brachytherapy combined with pembrolizumab for advanced non-small-cell lung cancer after failure of first-line chemotherapy: A report of two cases and literature review.

Yuan, Mingli / Wang, Liangchao / Xiao, Yang / Guo, Xiaoqun / Hu, Yi

Journal of contemporary brachytherapy

2023 Volume 15, Issue 1, Page(s) 81–88

Abstract: Although immunotherapy regimens for advanced non-small-cell lung cancer (NSCLC) improve survival in selected sub-populations, their efficacy remains far from ideal due to underlying resistance; therefore, multimodal combination strategies are needed to ... ...

Abstract	Although immunotherapy regimens for advanced non-small-cell lung cancer (NSCLC) improve survival in selected sub-populations, their efficacy remains far from ideal due to underlying resistance; therefore, multimodal combination strategies are needed to optimize their efficacy. In our report, two patients with advanced NSCLC with negative targetable mutations, who had failed first-line chemotherapy were treated with combined therapy of computed tomography (CT)-guided percutaneous iodine-125 seed implantation and pembrolizumab. After combination treatment, both patients achieved partial response (PR), and sustained a long progression-free survival (PFS) without obvious therapy-related adverse reactions. Iodine-125 seeds bring no long-term adverse events and effectively amplify anti-tumor immune response induced by immunotherapy; thus, this combined therapy might be a promising alternative for NSCLC.
Language	English
Publishing date	2023-02-28
Publishing country	Poland
Document type	Case Reports
ZDB-ID	2627721-9
ISSN	2081-2841 ; 1689-832X
ISSN (online)	2081-2841
ISSN	1689-832X
DOI	10.5114/jcb.2023.125582
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Article ; Online: Research and Application of a Prefabricated Spatial Reticulated Shell Support System for Large Cross-Section Tunnel in a Complex Urban Environment

Mingli Huang / Yuan Song / Xudong Zhang

Applied Sciences, Vol 12, Iss 5058, p

2022 Volume 5058

Abstract: To solve the technical problems of slow construction progress, low mechanization and high risk of shallow buried large cross-section tunnels in a complex urban environment, a series of spatial reticulated shell (SRS) support structures are developed in ... ...

Abstract	To solve the technical problems of slow construction progress, low mechanization and high risk of shallow buried large cross-section tunnels in a complex urban environment, a series of spatial reticulated shell (SRS) support structures are developed in this paper. Moreover, the equipment of a multifunctional operation trolley is developed to install the SRS arch, and the construction technology system of the prefabricated SRS structure is proposed for a large cross-section tunnel. Therefore, the deformation characteristics of the end-plate joint component and jointless component are clarified by laboratory experiments. The construction mechanics’ simulation of the SRS arch is performed to obtain the tunnel deformation and structure stress based on the tunnel project of Panyu Square Station of Guangzhou Metro. A field application of the prefabricated SRS arch is carried out to realize the mechanized construction operation. The obtained results reveal that the end-plate joint component has better ductility, and its ultimate bearing capacity is basically consistent with the jointless component. The SRS arch can effectively control the deformation of the surrounding rock, improve the stress state of the structure, and reduce the plastic zone of shotcrete by numerical simulations. The overall stress of the SRS arch by field measurement represents the characteristics of “bigger on the upside and smaller on the downside” and “uneven symmetry”. Additionally, the successful application of the prefabricated SRS arch provides a scientific reference for mechanized construction of large cross-section tunnels.
Keywords	large cross-section tunnel ; prefabricated support ; spatial reticulated shell ; multifunctional operation trolley ; field measurement ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	690
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Experimental Study and Engineering Application of the Spatial Reticulated Grid Bolt-Shotcrete Support Structure for Excavation Tunnels

Mingli Huang / Yuan Song / Xudong Zhang / Tong Sun

Applied Sciences, Vol 12, Iss 8506, p

2022 Volume 8506

Abstract: In view of the problems of rapid construction and deformation control of large cross-section tunnels in complex urban environments, the concept of “timely high-strength support” was put forward to form strong support over time and bear the load of ... ...

Abstract	In view of the problems of rapid construction and deformation control of large cross-section tunnels in complex urban environments, the concept of “timely high-strength support” was put forward to form strong support over time and bear the load of surrounding rock in real time, and innovatively developed the spatial reticulated grid bolt-shotcrete support structure (SRGB). The research in this paper focuses on the supporting principle, bearing mechanical properties, snatch simulation test, construction process, and engineering application effects. The components of the SRGB and their respective functions were expounded in detail. The failure modes and deformation characteristics of the tested components were revealed through the indoor loading test, and the performance characteristics of the spatial reticulated grid concrete components with high strength and high rigidity were displayed. With the help of the multi-functional operation trolley, the assembly process test of the spatial reticulated grid was carried out, which verified the feasibility of mechanized construction and the rationality of structural design. Relying on the underground tunnel project of Guangzhou Metro, the spatial reticulated grid structure was successfully used as the initial support of the tunnel for the first time, forming a complete set of mechanized rapid construction technology for a large cross-section tunnel, and constructing a timely high-strength support system suitable for the complex urban environment. The research results provide a new idea and new technology for the mechanized rapid construction and efficient support of large cross-section tunnels.
Keywords	excavation tunnel ; spatial reticulated grid ; bolt-shotcrete support ; model test ; bearing performance ; mechanization ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	690
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tailoring S-vacancy concentration changes the type of the defect and photocatalytic activity in ZFS.

Xue, Yanei / Shao, Penghui / Lin, Mingli / Yuan, Yixing / Shi, Wenxin / Cui, Fuyi

Journal of hazardous materials

2022 Volume 428, Page(s) 128215

Abstract: Defect engineering is crucial in the development of semiconductor catalyst activity. However, the influence of defect/vacancy density and states on catalysis remains vague. Thus, the optimized sulfur vacancy ( ... ...

Abstract	Defect engineering is crucial in the development of semiconductor catalyst activity. However, the influence of defect/vacancy density and states on catalysis remains vague. Thus, the optimized sulfur vacancy (S
MeSH term(s)	Catalysis ; Sulfur
Chemical Substances	Sulfur (70FD1KFU70)
Language	English
Publishing date	2022-01-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.128215
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Feasibility of soil oxidation-reduction potential in judging shear behaviour of hydrocarbon-contaminated soil.

Li, Yuan / Wei, Mingli / Wei, Wei / Zhang, Wenwei / Liu, Lei

Journal of environmental management

2023 Volume 342, Page(s) 118303

Abstract: This study investigates the indicative role of oxidation-reduction potential (ORP) and pH of hydrocarbon-contaminated soils on their shear characteristics, contributing to safer and more efficient ex-situ remediation and management processes. The ... ...

Abstract	This study investigates the indicative role of oxidation-reduction potential (ORP) and pH of hydrocarbon-contaminated soils on their shear characteristics, contributing to safer and more efficient ex-situ remediation and management processes. The presence of hydrocarbons alters the soil's shear strength by affecting the hydration shell thickness, fluid's dielectric properties, and ion/electron exchange, as well as the soil's electrochemical force, which in turn affects the ORP and pH. The relationship between hydrocarbon concentrations in contaminated soils (0.1-15%) and corresponding ORP/pH values could be fitted linearly with a good correlation coefficient r (0.978), highlighting the potential of ORP/pH as an indicator for pollutant occurrence. Furthermore, the relationships between ORP/pH and shear strength, as tested in our study and obtained after processing from relevant literature sources, exhibited a strong fit (r = 0.976-0.995). The Mohr-Coulomb criterion modified using the ORP/pH parameter was established, which could improve the fitting effect of these relationships (r = 0.988-0.996), verifying the reliability of the novel criterion and application feasibility of ORP/pH. In future research, this modified criterion can be employed to conveniently assess the shear strength of contaminated soil by considering the shear behaviour of virgin soil and the ORP/pH values of the contaminated soil.
MeSH term(s)	Soil/chemistry ; Feasibility Studies ; Reproducibility of Results ; Hydrocarbons ; Oxidation-Reduction ; Soil Pollutants/chemistry
Chemical Substances	Soil ; Hydrocarbons ; Soil Pollutants
Language	English
Publishing date	2023-06-03
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.118303
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