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  1. Book: Supplement copy on Indian guidelines on hypertension (IGH - IV) 2019

    Shah, Siddharth N.

    (Journal of the Association of Physicians of India ; vol. 67, issue no. 10, supplement (October 2019))

    2019  

    Title variant Indian guidelines on hypertension (IGH - IV) 2019
    Author's details guest editor: Dr. Siddharth N Shah
    Series title Journal of the Association of Physicians of India ; vol. 67, issue no. 10, supplement (October 2019)
    The Journal of the Association of Physicians of India
    Collection The Journal of the Association of Physicians of India
    Language English
    Size 48 Seiten
    Publisher The Association of Physicians of India
    Publishing place Mumbai
    Publishing country India
    Document type Book
    HBZ-ID HT020353222
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs B 313 -67,10,Suppl.- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Novel Therapies in Glioblastoma Treatment: Review of Glioblastoma; Current Treatment Options; and Novel Oncolytic Viral Therapies.

    Shah, Siddharth

    Medical sciences (Basel, Switzerland)

    2023  Volume 12, Issue 1

    Abstract: One of the most prevalent primary malignant brain tumors is glioblastoma (GB). About 6 incidents per 100,000 people are reported annually. Most frequently, these tumors are linked to a poor prognosis and poor quality of life. There has been little ... ...

    Abstract One of the most prevalent primary malignant brain tumors is glioblastoma (GB). About 6 incidents per 100,000 people are reported annually. Most frequently, these tumors are linked to a poor prognosis and poor quality of life. There has been little advancement in the treatment of GB. In recent years, some innovative medicines have been tested for the treatment of newly diagnosed cases of GB and recurrent cases of GB. Surgery, radiotherapy, and alkylating chemotherapy are all common treatments for GB. A few of the potential alternatives include immunotherapy, tumor-treating fields (TTFs), and medications that target specific cellular receptors. To provide new multimodal therapies that focus on the molecular pathways implicated in tumor initiation and progression in GB, novel medications, delivery technologies, and immunotherapy approaches are being researched. Of these, oncolytic viruses (OVs) are among the most recent. Coupling OVs with certain modern treatment approaches may have significant benefits for GB patients. Here, we discuss several OVs and how they work in conjunction with other therapies, as well as virotherapy for GB. The study was based on the PRISMA guidelines. Systematic retrieval of information was performed on PubMed. A total of 307 articles were found in a search on oncolytic viral therapies for glioblastoma. Out of these 83 articles were meta-analyses, randomized controlled trials, reviews, and systematic reviews. A total of 42 articles were from the years 2018 to 2023. Appropriate studies were isolated, and important information from each of them was understood and entered into a database from which the information was used in this article. One of the most prevalent malignant brain tumors is still GB. Significant promise and opportunity exist for oncolytic viruses in the treatment of GB and in boosting immune response. Making the most of OVs in the treatment of GB requires careful consideration and evaluation of a number of its application factors.
    MeSH term(s) Humans ; Glioblastoma/therapy ; Quality of Life ; Oncolytic Virotherapy ; Immunotherapy ; Oncolytic Viruses
    Language English
    Publishing date 2023-12-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2754473-4
    ISSN 2076-3271 ; 2076-3271
    ISSN (online) 2076-3271
    ISSN 2076-3271
    DOI 10.3390/medsci12010001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Special issue on re-appraisal of alpha-blockers in hypertension management

    Panchanatham, Manokar / Shah, Siddharth N.

    (Journal of the Association of Physicians of India ; supplement to September 2014, vol. 62, issue no. 9)

    2014  

    Title variant Re-appraisal of alpha-blockers in hypertension management
    Author's details guest editors: Manokar Panchanatham, Siddharth N Shah
    Series title Journal of the Association of Physicians of India ; supplement to September 2014, vol. 62, issue no. 9
    The Journal of the Association of Physicians of India
    Collection The Journal of the Association of Physicians of India
    Language English
    Size 44 Seiten
    Publisher Dr. Siddharth N. Shah
    Publishing place Mumbai
    Publishing country India
    Document type Book
    HBZ-ID HT018892606
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs B 313 -62,9,Suppl.- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Reply.

    Zamani, Mohammad / Mattay, Shivani Shah / Singh, Siddharth / Deepak, Parakkal

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2024  

    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Letter
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2024.01.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5836: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: After 25 years of computer-navigated total knee arthroplasty, where do we stand today?

    Shah, Siddharth M

    Arthroplasty (London, England)

    2021  Volume 3, Issue 1, Page(s) 41

    Abstract: Background: Limb and implant alignment along with soft tissue balance plays a vital role in the outcomes after total knee arthroplasty (TKA). Computer navigation for TKA was first introduced in 1997 with the aim of implanting the prosthetic components ... ...

    Abstract Background: Limb and implant alignment along with soft tissue balance plays a vital role in the outcomes after total knee arthroplasty (TKA). Computer navigation for TKA was first introduced in 1997 with the aim of implanting the prosthetic components with accuracy and precision. This review discusses the technique, current status, and scientific evidence pertaining to computer-navigated TKA. BODY: The adoption of navigated TKA has slowly but steadily increased across the globe since its inception 25 years ago. It has been more rapid in some countries like Australia than others, like the UK. Contemporary, large console-based navigation systems help control almost every aspect of TKA, including the depth and orientation of femoral and tibial resections, soft-tissue release, and customization of femoral and tibial implant positions in order to obtain desired alignment and balance. Navigated TKA results in better limb and implant alignment and reduces outliers as compared to conventional TKA. However, controversy still exists over whether improved alignment provides superior function and longevity. Surgeons may also be hesitant to adopt this technology due to the associated learning curve, slightly increased surgical time, fear of pin site complications, and the initial set-up cost. Furthermore, the recent advent of robotic-assisted TKA which provides benefits like precision in bone resections and avoiding soft-tissue damage due to uncontrolled sawing, in addition to those of computer navigation, might be responsible for the latter technology taking a backseat.
    Conclusion: This review summarizes the current state of computer-navigated TKA. The superiority of computer navigation to conventional TKA in improving accuracy is well established. Robotic-assisted TKA provides enhanced functionality as compared to computer navigation but is significantly more expensive. Whether robotic-assisted TKA offers any substantive advantages over navigation is yet to be conclusively proven. Irrespective of the form, the use of computer-assisted TKA is on the rise worldwide and is here to stay.
    Language English
    Publishing date 2021-11-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2524-7948
    ISSN (online) 2524-7948
    DOI 10.1186/s42836-021-00100-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: COL4A1 mutation in an Indian child presenting as 'Cerebral Palsy' mimic.

    Shah, Siddharth M / Patel, Drushi D

    The Indian journal of radiology & imaging

    2021  Volume 30, Issue 4, Page(s) 500–503

    Abstract: The COL4A1 gene ( ...

    Abstract The COL4A1 gene (
    Language English
    Publishing date 2021-01-13
    Publishing country India
    Document type Case Reports
    ZDB-ID 605869-3
    ISSN 0971-3026 ; 0970-2016
    ISSN 0971-3026 ; 0970-2016
    DOI 10.4103/ijri.IJRI_274_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 430: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Vision Deficit Due to Pituitary Apoplexy.

    Shah, Siddharth / Khan, Rumana / Bayrakdar, Keenan / Scott, Christian

    Cureus

    2023  Volume 15, Issue 5, Page(s) e38649

    Abstract: Pituitary apoplexy means "sudden death" of the pituitary gland, usually caused by hemorrhage or infarction and often occurring in a pre-existing pituitary adenoma. In many cases, pituitary apoplexy is a medical and surgical emergency. Fast, efficient ... ...

    Abstract Pituitary apoplexy means "sudden death" of the pituitary gland, usually caused by hemorrhage or infarction and often occurring in a pre-existing pituitary adenoma. In many cases, pituitary apoplexy is a medical and surgical emergency. Fast, efficient diagnosis and treatment are important in many cases. This case exemplifies an ideal lab workup and referral process to turn out best outcomes and prevent medical complications in our patient.
    Language English
    Publishing date 2023-05-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.38649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Diagnostic Adjuncts in Oral Cancer Evaluation.

    Goel, Daksh / Shah, Siddharth / Mair, Manish

    Critical reviews in oncogenesis

    2023  Volume 27, Issue 4, Page(s) 39–45

    Abstract: Oral cancer is a major health concern in developing countries like India which contributes one-third of the global oral cancer burden. Unlike other non-head and neck malignancies, oral cancer has a more curative treatment course. If detected early, oral ... ...

    Abstract Oral cancer is a major health concern in developing countries like India which contributes one-third of the global oral cancer burden. Unlike other non-head and neck malignancies, oral cancer has a more curative treatment course. If detected early, oral cancer has the best treatment outcomes. However, most oral cancer has a dismal five-year survival rate as the majority are diagnosed in late/advanced loco-regional stages. Current methods of assessment for oral cancer include, thorough clinical examination under white light and biopsy. Over the years, a number of diagnostic tools have been created as adjuncts to white light evaluation to help with the early diagnosis of oral cancer. This article's goal is to discuss the present diagnostic techniques for oral cancer as well as potential future uses of cutting-edge, innovative technology for the detection of the disease. This may expand our diagnostic choices and enhance our capacity to accurately identify and manage lesions associated with oral cancer.
    MeSH term(s) Humans ; Mouth Neoplasms/diagnosis ; Head and Neck Neoplasms
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1036388-9
    ISSN 0893-9675
    ISSN 0893-9675
    DOI 10.1615/CritRevOncog.2022047079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2587: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Immune checkpoint inhibitors in metastatic melanoma therapy (Review).

    Shah, Vedant / Panchal, Viraj / Shah, Abhi / Vyas, Bhavya / Agrawal, Siddharth / Bharadwaj, Sanket

    Medicine international

    2024  Volume 4, Issue 2, Page(s) 13

    Abstract: An increase in the incidence of melanoma has been observed in recent decades, which poses a significant challenge due to its poor prognosis in the advanced and metastatic stages. Previously, chemotherapy and high doses of interleukin-2 were available ... ...

    Abstract An increase in the incidence of melanoma has been observed in recent decades, which poses a significant challenge due to its poor prognosis in the advanced and metastatic stages. Previously, chemotherapy and high doses of interleukin-2 were available treatments for melanoma; however, they offered limited survival benefits and were associated with severe toxicities. The treatment of metastatic melanoma has been transformed by new developments in immunotherapy. Immune checkpoint inhibitors (ICIs), monoclonal antibodies that target cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), programmed cell death protein 1 (PD-1) and its ligand, PDL-1, have emerged as promising therapeutic options. Commonly used ICIs, such as ipilimumab, nivolumab and pembrolizumab, have been found to be associated with an improved median overall survival, recurrence-free survival and response rates compared to traditional chemotherapies. Combination therapies involving different types of ICIs, such as anti-PD1 with anti-CTLA-4, have further enhanced the overall survival and response rates by targeting various phases of T-cell activation. Additionally, the development of novel biomarkers has facilitated the assessment of responses to ICI therapy, with tissue and serum-based prognostic and predictive biomarkers now available. The increased response observed with ICIs also provides potential for immune-related adverse effects on various organ systems. Further research is required to evaluate the efficacy and safety of various combinations of ICIs, while ongoing clinical trials explore the potential of newer ICIs. Concerns regarding the development of resistance to ICIs also warrant attention. The present review summarizes and discusses the advent of ICIs with a marked significant breakthrough in the treatment of metastatic melanoma, providing improved outcomes compared to traditional therapies.
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2754-1304
    ISSN (online) 2754-1304
    DOI 10.3892/mi.2024.137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Survival and outcomes of different head sizes in primary total hip arthroplasty.

    Shah, Siddharth M

    Journal of orthopaedics

    2019  Volume 16, Issue 6, Page(s) A1–A3

    Abstract: The femoral head size influences dislocation, range of motion (ROM), functional outcome, wear, and survival after total hip arthroplasty (THA). These aspects of different head sizes with contemporary bearings in primary THA have been reviewed. Based on ... ...

    Abstract The femoral head size influences dislocation, range of motion (ROM), functional outcome, wear, and survival after total hip arthroplasty (THA). These aspects of different head sizes with contemporary bearings in primary THA have been reviewed. Based on the existing evidence, for highly-cross-linked polyethylene (HXLPE) bearings, a 32 mm cobalt chromium (CoCr) or ceramic head appears to be a suitable choice. If a 36 mm head with HXLPE is desired, a ceramic head may be preferable over CoCr due to reduced risk of fretting and corrosion with the former. For ceramic-on-ceramic (CoC) bearings, head sizes >36 mm do not appear to provide any significant benefit over 36 mm heads. Also, large ceramic heads may lead to increased risk of squeaking. If non-cross-linked PE bearing is considered for use, it would be prudent to opt for <32 mm head size.
    Language English
    Publishing date 2019-10-09
    Publishing country India
    Document type Editorial
    ZDB-ID 2240839-3
    ISSN 0972-978X
    ISSN 0972-978X
    DOI 10.1016/j.jor.2019.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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